AustralieFrV1, PascalFrancis, Corpus, bibRecord, 000A05

Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression

Identifieur interne : 000A05 ( PascalFrancis/Corpus ); précédent : 000A04; suivant : 000A06

Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression

Auteurs : Michael Maes ; Marta Kubera ; Ivana Mihaylova ; Michel Geffard ; Piotr Galecki ; Jean-Clude Leunis ; Michael Berk

Source :

Journal of affective disorders [ 0165-0327 ] ; 2013.

RBID : Pascal:13-0218171

Descripteurs français

Pascal (Inist)
- Autoimmunité, Déterminant antigénique, Etat dépressif, Chronique, Stress oxydatif, Inflammation, Cytokine, Syndrome de fatigue chronique.

English descriptors

KwdEn :
- Antigenic determinant, Autoimmunity, Chronic, Chronic fatigue syndrome, Cytokine, Depression, Inflammation, Oxidative stress.

Abstract

Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 JADID7`
A03		`1`		`@0 J. affect. disord.`
A05				`@2 149`
A06				`@2 1-3`
A08	`01`	`1`	`ENG`	`@1 Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression`
A11	`01`	`1`		`@1 MAES (Michael)`
A11	`02`	`1`		`@1 KUBERA (Marta)`
A11	`03`	`1`		`@1 MIHAYLOVA (Ivana)`
A11	`04`	`1`		`@1 GEFFARD (Michel)`
A11	`05`	`1`		`@1 GALECKI (Piotr)`
A11	`06`	`1`		`@1 LEUNIS (Jean-Clude)`
A11	`07`	`1`		`@1 BERK (Michael)`
A14	`01`			`@1 Maes Clinics @ TRIA @2 Bangkok @3 THA @Z 1 aut.`
A14	`02`			`@1 Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Sciences @3 POL @Z 2 aut.`
A14	`03`			`@1 Foundation of Biological Psychiatry @2 Sofia @3 BGR @Z 3 aut.`
A14	`04`			`@1 Association Institute for Research & Development in Human Pathology and Therapy @2 Talence @3 FRA @Z 4 aut.`
A14	`05`			`@1 Department of Adult Psychiatry, University of Lodz @2 Lodz @3 POL @Z 5 aut.`
A14	`06`			`@1 Laboratoire Ategis @2 Wavre @3 BEL @Z 6 aut.`
A14	`07`			`@1 Deakin University @2 Geelong @3 AUS @Z 7 aut.`
A20				`@1 23-29`
A21				`@1 2013`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18006 @5 354000503041210030`
A44				`@0 0000 @1 © 2013 INIST-CNRS. All rights reserved.`
A45				`@0 1 p.1/4`
A47	`01`	`1`		`@0 13-0218171`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of affective disorders`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.
C02	`01`	`X`		`@0 002B18C07A`
C03	`01`	`X`	`FRE`	`@0 Autoimmunité @5 01`
C03	`01`	`X`	`ENG`	`@0 Autoimmunity @5 01`
C03	`01`	`X`	`SPA`	`@0 Autoinmunidad @5 01`
C03	`02`	`X`	`FRE`	`@0 Déterminant antigénique @5 02`
C03	`02`	`X`	`ENG`	`@0 Antigenic determinant @5 02`
C03	`02`	`X`	`SPA`	`@0 Determinante antigénico @5 02`
C03	`03`	`X`	`FRE`	`@0 Etat dépressif @5 03`
C03	`03`	`X`	`ENG`	`@0 Depression @5 03`
C03	`03`	`X`	`SPA`	`@0 Estado depresivo @5 03`
C03	`04`	`X`	`FRE`	`@0 Chronique @5 04`
C03	`04`	`X`	`ENG`	`@0 Chronic @5 04`
C03	`04`	`X`	`SPA`	`@0 Crónico @5 04`
C03	`05`	`X`	`FRE`	`@0 Stress oxydatif @5 05`
C03	`05`	`X`	`ENG`	`@0 Oxidative stress @5 05`
C03	`05`	`X`	`SPA`	`@0 Estrés oxidativo @5 05`
C03	`06`	`X`	`FRE`	`@0 Inflammation @5 06`
C03	`06`	`X`	`ENG`	`@0 Inflammation @5 06`
C03	`06`	`X`	`SPA`	`@0 Inflamación @5 06`
C03	`07`	`X`	`FRE`	`@0 Cytokine @5 07`
C03	`07`	`X`	`ENG`	`@0 Cytokine @5 07`
C03	`07`	`X`	`SPA`	`@0 Citoquina @5 07`
C03	`08`	`X`	`FRE`	`@0 Syndrome de fatigue chronique @2 NM @5 08`
C03	`08`	`X`	`ENG`	`@0 Chronic fatigue syndrome @2 NM @5 08`
C03	`08`	`X`	`SPA`	`@0 Fatiga crónica síndrome @2 NM @5 08`
C07	`01`	`X`	`FRE`	`@0 Trouble de l'humeur @5 37`
C07	`01`	`X`	`ENG`	`@0 Mood disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Trastorno humor @5 37`
N21				`@1 203`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 13-0218171 INIST
ET :	Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression
AU :	MAES (Michael); KUBERA (Marta); MIHAYLOVA (Ivana); GEFFARD (Michel); GALECKI (Piotr); LEUNIS (Jean-Clude); BERK (Michael)
AF :	Maes Clinics @ TRIA/Bangkok/Thaïlande (1 aut.); Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Sciences/Pologne (2 aut.); Foundation of Biological Psychiatry/Sofia/Bulgarie (3 aut.); Association Institute for Research & Development in Human Pathology and Therapy/Talence/France (4 aut.); Department of Adult Psychiatry, University of Lodz/Lodz/Pologne (5 aut.); Laboratoire Ategis/Wavre/Belgique (6 aut.); Deakin University/Geelong/Australie (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of affective disorders; ISSN 0165-0327; Coden JADID7; Royaume-Uni; Da. 2013; Vol. 149; No. 1-3; Pp. 23-29; Bibl. 1 p.1/4
LA :	Anglais
EA :	Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.
CC :	002B18C07A
FD :	Autoimmunité; Déterminant antigénique; Etat dépressif; Chronique; Stress oxydatif; Inflammation; Cytokine; Syndrome de fatigue chronique
FG :	Trouble de l'humeur
ED :	Autoimmunity; Antigenic determinant; Depression; Chronic; Oxidative stress; Inflammation; Cytokine; Chronic fatigue syndrome
EG :	Mood disorder
SD :	Autoinmunidad; Determinante antigénico; Estado depresivo; Crónico; Estrés oxidativo; Inflamación; Citoquina; Fatiga crónica síndrome
LO :	INIST-18006.354000503041210030
ID :	13-0218171

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Pascal:13-0218171

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.</div>
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<fC01 i1="01" l="ENG"><s0>Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.</s0>
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<s2>NM</s2>
<s5>08</s5>
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<s5>37</s5>
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<fC07 i1="01" i2="X" l="SPA"><s0>Trastorno humor</s0>
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<server><NO>PASCAL 13-0218171 INIST</NO>
<ET>Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression</ET>
<AU>MAES (Michael); KUBERA (Marta); MIHAYLOVA (Ivana); GEFFARD (Michel); GALECKI (Piotr); LEUNIS (Jean-Clude); BERK (Michael)</AU>
<AF>Maes Clinics @ TRIA/Bangkok/Thaïlande (1 aut.); Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Sciences/Pologne (2 aut.); Foundation of Biological Psychiatry/Sofia/Bulgarie (3 aut.); Association Institute for Research & Development in Human Pathology and Therapy/Talence/France (4 aut.); Department of Adult Psychiatry, University of Lodz/Lodz/Pologne (5 aut.); Laboratoire Ategis/Wavre/Belgique (6 aut.); Deakin University/Geelong/Australie (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of affective disorders; ISSN 0165-0327; Coden JADID7; Royaume-Uni; Da. 2013; Vol. 149; No. 1-3; Pp. 23-29; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Objective: There is evidence that major depression is characterized by oxidative and nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression. Methods: Serum IgM antibodies directed against conjugated oleic and azelaic acid, malondialdehyde (MDA), phosphatidyl inositol (Pi), and conjugated nitric-oxide (NO) adducts, i.e., NO-tryptophan, NO-tyrosine, NO-arginine, and NO-cysteinyl, were determined in 33 healthy controls and 74 depressed patients subdivided into 28 patients with chronic (duration > 2 year) and 46 without chronic depression. Results: Serum IgM levels against all neoepitopes were significantly higher in depressed patients than in healthy controls. Moreover, the IgM levels were significantly higher, except Pi, in chronically depressed patients than in non-chronically depressed patients. Conclusions: Depression is characterized by IgM-related autoimmune responses directed against neo-epitopes that are normally hidden from the immune system but that became immunogenic secondary to damage by O&NS. The results show that the generation of neoantigenic determinants that lead to (auto)immune responses is strongly associated with chronic depression. Discussion: The damage caused by O&NS to auto-epitopes and the consequent formation of O&NS modified neoantigenic determinants may increase the risk to develop depression and in particular chronic depression through transition to autoimmune reactions. This has implications for understanding the immuno-inlfammatory and oxidative-autoimmune pathways that lead to chronic depression and neuroprogression in that illness.</EA>
<CC>002B18C07A</CC>
<FD>Autoimmunité; Déterminant antigénique; Etat dépressif; Chronique; Stress oxydatif; Inflammation; Cytokine; Syndrome de fatigue chronique</FD>
<FG>Trouble de l'humeur</FG>
<ED>Autoimmunity; Antigenic determinant; Depression; Chronic; Oxidative stress; Inflammation; Cytokine; Chronic fatigue syndrome</ED>
<EG>Mood disorder</EG>
<SD>Autoinmunidad; Determinante antigénico; Estado depresivo; Crónico; Estrés oxidativo; Inflamación; Citoquina; Fatiga crónica síndrome</SD>
<LO>INIST-18006.354000503041210030</LO>
<ID>13-0218171</ID>
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Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression

Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression

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