Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: An expanded and updated international cohort study
Identifieur interne : 006785 ( PascalFrancis/Checkpoint ); précédent : 006784; suivant : 006786Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: An expanded and updated international cohort study
Auteurs : M. Kogevinas [France, Espagne] ; H. Becher [Allemagne] ; T. Benn [Royaume-Uni] ; P. A. Bertazzi [Italie] ; P. Boffetta [France] ; H. Bas Bueno-De-Mesquita [Pays-Bas] ; D. Coggon [Royaume-Uni] ; D. Colin [France] ; D. Flesch-Janys [Allemagne] ; M. Fingerhut [États-Unis] ; L. Green [Canada] ; T. Kauppinen [Finlande] ; M. Littorin [Suède] ; E. Lynge [Danemark] ; J. D. Mathews [Australie] ; M. Neuberger [Autriche] ; N. Pearce [Nouvelle-Zélande] ; R. Saracci [France, Italie]Source :
- American journal of epidemiology [ 0002-9262 ] ; 1997.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Pesticide, Herbicide, Homme, Mortalité, Santé publique.
English descriptors
- KwdEn :
Abstract
The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries. Subjects in this updated and expanded multinational study coordinated by the Intemational Agency for Research on Cancer were followed from 1939 to 1992. Exposure was reconstructed using job records, company exposure questionnaires, and serum and adipose tissue dioxin levels. Among workers exposed to phenoxy herbicides contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or higher chlorinated dioxins, mortality from soft-tissue sarcoma (6 deaths; standardized mortality ratio (SMR) = 2.03, 95% confidence interval (Cl) 0.75-4.43) was higher than expected from national mortality rates. Mortality from all malignant neoplasms (710 deaths; SMR = 1.12, 95% Cl 1.04-1.21), non-Hodgkin's lymphoma (24 deaths; SMR = 1.39, 95% Cl 0.89-2.06), and lung cancer (225 deaths; SMR = 1.12, 95% Cl 0.98-1.28) was slightly elevated. Risks for all neoplasms, for sarcomas, and for lymphomas increased with time since first exposure. In workers exposed to phenoxy herbicides with minimal or no contamination by TCDD and higher chlorinated dioxins, mortality from all neoplasms (398 deaths; SMR = 0.96, 95% Cl 0.87-1.06), non-Hodgkin's lymphoma (9 deaths; SMR = 1.00), and lung cancer (148 deaths; SMR = 1.03) was similar to that expected, and mortality from soft-tissue sarcoma was slightly elevated (2 deaths; SMR = 1.35). In a Poisson regression analysis, workers exposed to TCDD or higher chlorinated dioxins had an increased risk for all neoplasms (rate ratio = 1.29, 95% Cl 0.94-1.76) compared with workers from the same cohort exposed to phenoxy herbicides and chlorophenols but with minimal or no exposure to TCDD and higher chlorinated dioxins. These findings indicate that exposure to herbicides contaminated with TCDD and higher chlorinated dioxins may be associated with a small increase in overall cancer risk and in risk for specific cancers.
Affiliations:
- Allemagne, Australie, Autriche, Canada, Danemark, Espagne, Finlande, France, Italie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, Catalogne, District de Karlsruhe, Hambourg, Hovedstaden, Lombardie, Ohio, Rhône-Alpes, Toscane, Vienne (Autriche)
- Barcelone, Copenhague, Hambourg, Heidelberg, Lyon, Milan, Pise, Vienne (Autriche)
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Kogevinas</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Becher, H" sort="Becher, H" uniqKey="Becher H" first="H." last="Becher">H. 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Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Chronic Disease and Environmental Epidemiology, National Institute of Public Health and the Environment</s1><s2>Bilthoven</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Coggon, D" sort="Coggon, D" uniqKey="Coggon D" first="D." last="Coggon">D. Coggon</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Medical Research Council Environmental Epidemiology Unit</s1><s2>Southampton</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Medical Research Council Environmental Epidemiology Unit</wicri:noRegion></affiliation></author><author><name sortKey="Colin, D" sort="Colin, D" uniqKey="Colin D" first="D." last="Colin">D. Colin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Flesch Janys, D" sort="Flesch Janys, D" uniqKey="Flesch Janys D" first="D." last="Flesch-Janys">D. Flesch-Janys</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Medical Center for Chemical Workers' Health</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Fingerhut, M" sort="Fingerhut, M" uniqKey="Fingerhut M" first="M." last="Fingerhut">M. Fingerhut</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Industrywide Studies Branch, National Institute of Occupational Safety and Health</s1><s2>Cincinnati, Ohio</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Green, L" sort="Green, L" uniqKey="Green L" first="L." last="Green">L. Green</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Health Services Department, Ontario Hydro</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kauppinen, T" sort="Kauppinen, T" uniqKey="Kauppinen T" first="T." last="Kauppinen">T. Kauppinen</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, Finnish Institute of Occupational Health</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>12 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Littorin, M" sort="Littorin, M" uniqKey="Littorin M" first="M." last="Littorin">M. Littorin</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Occupational and Environmental Medicine, Lund University</s1><s2>Lund</s2><s3>SWE</s3><sZ>13 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Lynge, E" sort="Lynge, E" uniqKey="Lynge E" first="E." last="Lynge">E. Lynge</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Danish Cancer Society</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>14 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mathews, J D" sort="Mathews, J D" uniqKey="Mathews J" first="J. D." last="Mathews">J. D. Mathews</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Menzies School of Health Research</s1><s2>Casuarina NT</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Menzies School of Health Research</wicri:noRegion></affiliation></author><author><name sortKey="Neuberger, M" sort="Neuberger, M" uniqKey="Neuberger M" first="M." last="Neuberger">M. Neuberger</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Preventive Medicine, University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Pearce, N" sort="Pearce, N" uniqKey="Pearce N" first="N." last="Pearce">N. Pearce</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Medicine, Wellington School of Medicine</s1><s2>Wellington</s2><s3>NZL</s3><sZ>17 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Saracci, R" sort="Saracci, R" uniqKey="Saracci R" first="R." last="Saracci">R. Saracci</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>National Research Council</s1><s2>Pisa</s2><s3>ITA</s3><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">97-0367758</idno><date when="1997">1997</date><idno type="stanalyst">PASCAL 97-0367758 INIST</idno><idno type="RBID">Pascal:97-0367758</idno><idno type="wicri:Area/PascalFrancis/Corpus">006984</idno><idno type="wicri:Area/PascalFrancis/Curation">006685</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">006785</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">006785</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: An expanded and updated international cohort study</title><author><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. Kogevinas</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Becher, H" sort="Becher, H" uniqKey="Becher H" first="H." last="Becher">H. Becher</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Division of Epidemiology, German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Benn, T" sort="Benn, T" uniqKey="Benn T" first="T." last="Benn">T. Benn</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Epidemiology and Medical Statistics Unit, Health and Safety Executive</s1><s2>Bootle</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bootle</wicri:noRegion></affiliation></author><author><name sortKey="Bertazzi, P A" sort="Bertazzi, P A" uniqKey="Bertazzi P" first="P. A." last="Bertazzi">P. A. Bertazzi</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institute of Occupational Health, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Chronic Disease and Environmental Epidemiology, National Institute of Public Health and the Environment</s1><s2>Bilthoven</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Coggon, D" sort="Coggon, D" uniqKey="Coggon D" first="D." last="Coggon">D. Coggon</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Medical Research Council Environmental Epidemiology Unit</s1><s2>Southampton</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Medical Research Council Environmental Epidemiology Unit</wicri:noRegion></affiliation></author><author><name sortKey="Colin, D" sort="Colin, D" uniqKey="Colin D" first="D." last="Colin">D. Colin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Flesch Janys, D" sort="Flesch Janys, D" uniqKey="Flesch Janys D" first="D." last="Flesch-Janys">D. Flesch-Janys</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Medical Center for Chemical Workers' Health</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Fingerhut, M" sort="Fingerhut, M" uniqKey="Fingerhut M" first="M." last="Fingerhut">M. Fingerhut</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Industrywide Studies Branch, National Institute of Occupational Safety and Health</s1><s2>Cincinnati, Ohio</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Green, L" sort="Green, L" uniqKey="Green L" first="L." last="Green">L. Green</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Health Services Department, Ontario Hydro</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kauppinen, T" sort="Kauppinen, T" uniqKey="Kauppinen T" first="T." last="Kauppinen">T. Kauppinen</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, Finnish Institute of Occupational Health</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>12 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Littorin, M" sort="Littorin, M" uniqKey="Littorin M" first="M." last="Littorin">M. Littorin</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Occupational and Environmental Medicine, Lund University</s1><s2>Lund</s2><s3>SWE</s3><sZ>13 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Lynge, E" sort="Lynge, E" uniqKey="Lynge E" first="E." last="Lynge">E. Lynge</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Danish Cancer Society</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>14 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mathews, J D" sort="Mathews, J D" uniqKey="Mathews J" first="J. D." last="Mathews">J. D. Mathews</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Menzies School of Health Research</s1><s2>Casuarina NT</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Menzies School of Health Research</wicri:noRegion></affiliation></author><author><name sortKey="Neuberger, M" sort="Neuberger, M" uniqKey="Neuberger M" first="M." last="Neuberger">M. Neuberger</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Preventive Medicine, University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Pearce, N" sort="Pearce, N" uniqKey="Pearce N" first="N." last="Pearce">N. Pearce</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Medicine, Wellington School of Medicine</s1><s2>Wellington</s2><s3>NZL</s3><sZ>17 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Saracci, R" sort="Saracci, R" uniqKey="Saracci R" first="R." last="Saracci">R. Saracci</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>National Research Council</s1><s2>Pisa</s2><s3>ITA</s3><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName></affiliation></author></analytic><series><title level="j" type="main">American journal of epidemiology</title><title level="j" type="abbreviated">Am. j. epidemiol.</title><idno type="ISSN">0002-9262</idno><imprint><date when="1997">1997</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of epidemiology</title><title level="j" type="abbreviated">Am. j. epidemiol.</title><idno type="ISSN">0002-9262</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinogen</term><term>Epidemiology</term><term>Herbicide</term><term>Human</term><term>International</term><term>Malignant tumor</term><term>Mortality</term><term>Occupational exposure</term><term>Occupational medicine</term><term>Pesticides</term><term>Phytohormone</term><term>Public health</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pesticide</term><term>Herbicide</term><term>Phytohormone</term><term>Dibenzo-p-dioxine(polychloro)</term><term>Phénol(polychloro)</term><term>Carcinogène</term><term>Exposition professionnelle</term><term>Homme</term><term>Tumeur maligne</term><term>Mortalité</term><term>Epidémiologie</term><term>Toxicité</term><term>International</term><term>Santé publique</term><term>Médecine travail</term><term>Acétique acide(aryloxy)</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Pesticide</term><term>Herbicide</term><term>Homme</term><term>Mortalité</term><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries. Subjects in this updated and expanded multinational study coordinated by the Intemational Agency for Research on Cancer were followed from 1939 to 1992. Exposure was reconstructed using job records, company exposure questionnaires, and serum and adipose tissue dioxin levels. Among workers exposed to phenoxy herbicides contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or higher chlorinated dioxins, mortality from soft-tissue sarcoma (6 deaths; standardized mortality ratio (SMR) = 2.03, 95% confidence interval (Cl) 0.75-4.43) was higher than expected from national mortality rates. Mortality from all malignant neoplasms (710 deaths; SMR = 1.12, 95% Cl 1.04-1.21), non-Hodgkin's lymphoma (24 deaths; SMR = 1.39, 95% Cl 0.89-2.06), and lung cancer (225 deaths; SMR = 1.12, 95% Cl 0.98-1.28) was slightly elevated. Risks for all neoplasms, for sarcomas, and for lymphomas increased with time since first exposure. In workers exposed to phenoxy herbicides with minimal or no contamination by TCDD and higher chlorinated dioxins, mortality from all neoplasms (398 deaths; SMR = 0.96, 95% Cl 0.87-1.06), non-Hodgkin's lymphoma (9 deaths; SMR = 1.00), and lung cancer (148 deaths; SMR = 1.03) was similar to that expected, and mortality from soft-tissue sarcoma was slightly elevated (2 deaths; SMR = 1.35). In a Poisson regression analysis, workers exposed to TCDD or higher chlorinated dioxins had an increased risk for all neoplasms (rate ratio = 1.29, 95% Cl 0.94-1.76) compared with workers from the same cohort exposed to phenoxy herbicides and chlorophenols but with minimal or no exposure to TCDD and higher chlorinated dioxins. These findings indicate that exposure to herbicides contaminated with TCDD and higher chlorinated dioxins may be associated with a small increase in overall cancer risk and in risk for specific cancers.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0002-9262</s0></fA01><fA02 i1="01"><s0>AJEPAS</s0></fA02><fA03 i2="1"><s0>Am. j. epidemiol.</s0></fA03><fA05><s2>145</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: An expanded and updated international cohort study</s1></fA08><fA11 i1="01" i2="1"><s1>KOGEVINAS (M.)</s1></fA11><fA11 i1="02" i2="1"><s1>BECHER (H.)</s1></fA11><fA11 i1="03" i2="1"><s1>BENN (T.)</s1></fA11><fA11 i1="04" i2="1"><s1>BERTAZZI (P. A.)</s1></fA11><fA11 i1="05" i2="1"><s1>BOFFETTA (P.)</s1></fA11><fA11 i1="06" i2="1"><s1>BAS BUENO-DE-MESQUITA (H.)</s1></fA11><fA11 i1="07" i2="1"><s1>COGGON (D.)</s1></fA11><fA11 i1="08" i2="1"><s1>COLIN (D.)</s1></fA11><fA11 i1="09" i2="1"><s1>FLESCH-JANYS (D.)</s1></fA11><fA11 i1="10" i2="1"><s1>FINGERHUT (M.)</s1></fA11><fA11 i1="11" i2="1"><s1>GREEN (L.)</s1></fA11><fA11 i1="12" i2="1"><s1>KAUPPINEN (T.)</s1></fA11><fA11 i1="13" i2="1"><s1>LITTORIN (M.)</s1></fA11><fA11 i1="14" i2="1"><s1>LYNGE (E.)</s1></fA11><fA11 i1="15" i2="1"><s1>MATHEWS (J. D.)</s1></fA11><fA11 i1="16" i2="1"><s1>NEUBERGER (M.)</s1></fA11><fA11 i1="17" i2="1"><s1>PEARCE (N.)</s1></fA11><fA11 i1="18" i2="1"><s1>SARACCI (R.)</s1></fA11><fA14 i1="01"><s1>Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="02"><s1>Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Division of Epidemiology, German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Epidemiology and Medical Statistics Unit, Health and Safety Executive</s1><s2>Bootle</s2><s3>GBR</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Institute of Occupational Health, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Chronic Disease and Environmental Epidemiology, National Institute of Public Health and the Environment</s1><s2>Bilthoven</s2><s3>NLD</s3><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Medical Research Council Environmental Epidemiology Unit</s1><s2>Southampton</s2><s3>GBR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="08"><s1>Medical Center for Chemical Workers' Health</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>9 aut.</sZ></fA14><fA14 i1="09"><s1>Industrywide Studies Branch, National Institute of Occupational Safety and Health</s1><s2>Cincinnati, Ohio</s2><s3>USA</s3><sZ>10 aut.</sZ></fA14><fA14 i1="10"><s1>Health Services Department, Ontario Hydro</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>11 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, Finnish Institute of Occupational Health</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>12 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Occupational and Environmental Medicine, Lund University</s1><s2>Lund</s2><s3>SWE</s3><sZ>13 aut.</sZ></fA14><fA14 i1="13"><s1>Danish Cancer Society</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>14 aut.</sZ></fA14><fA14 i1="14"><s1>Menzies School of Health Research</s1><s2>Casuarina NT</s2><s3>AUS</s3><sZ>15 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Preventive Medicine, University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>16 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Medicine, Wellington School of Medicine</s1><s2>Wellington</s2><s3>NZL</s3><sZ>17 aut.</sZ></fA14><fA14 i1="17"><s1>National Research Council</s1><s2>Pisa</s2><s3>ITA</s3><sZ>18 aut.</sZ></fA14><fA20><s1>1061-1075</s1></fA20><fA21><s1>1997</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>663</s2><s5>354000044962130010</s5></fA43><fA44><s0>0000</s0><s1>© 1997 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>54 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>97-0367758</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>American journal of epidemiology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries. Subjects in this updated and expanded multinational study coordinated by the Intemational Agency for Research on Cancer were followed from 1939 to 1992. Exposure was reconstructed using job records, company exposure questionnaires, and serum and adipose tissue dioxin levels. Among workers exposed to phenoxy herbicides contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or higher chlorinated dioxins, mortality from soft-tissue sarcoma (6 deaths; standardized mortality ratio (SMR) = 2.03, 95% confidence interval (Cl) 0.75-4.43) was higher than expected from national mortality rates. Mortality from all malignant neoplasms (710 deaths; SMR = 1.12, 95% Cl 1.04-1.21), non-Hodgkin's lymphoma (24 deaths; SMR = 1.39, 95% Cl 0.89-2.06), and lung cancer (225 deaths; SMR = 1.12, 95% Cl 0.98-1.28) was slightly elevated. Risks for all neoplasms, for sarcomas, and for lymphomas increased with time since first exposure. In workers exposed to phenoxy herbicides with minimal or no contamination by TCDD and higher chlorinated dioxins, mortality from all neoplasms (398 deaths; SMR = 0.96, 95% Cl 0.87-1.06), non-Hodgkin's lymphoma (9 deaths; SMR = 1.00), and lung cancer (148 deaths; SMR = 1.03) was similar to that expected, and mortality from soft-tissue sarcoma was slightly elevated (2 deaths; SMR = 1.35). In a Poisson regression analysis, workers exposed to TCDD or higher chlorinated dioxins had an increased risk for all neoplasms (rate ratio = 1.29, 95% Cl 0.94-1.76) compared with workers from the same cohort exposed to phenoxy herbicides and chlorophenols but with minimal or no exposure to TCDD and higher chlorinated dioxins. These findings indicate that exposure to herbicides contaminated with TCDD and higher chlorinated dioxins may be associated with a small increase in overall cancer risk and in risk for specific cancers.</s0></fC01><fC02 i1="01" i2="X"><s0>002B04B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Pesticide</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Pesticides</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Plaguicida</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Herbicide</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Herbicide</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Herbicida</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Phytohormone</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Phytohormone</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Fitohormona</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Dibenzo-p-dioxine(polychloro)</s0><s2>NK</s2><s2>FX</s2><s5>10</s5><s6>Dibenzo-«p»-dioxine(polychloro)</s6></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Phénol(polychloro)</s0><s2>NK</s2><s2>FX</s2><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Carcinogène</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Carcinogen</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Carcinógeno</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Exposition professionnelle</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Occupational exposure</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Exposición profesional</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0><s5>16</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>16</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>16</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Tumeur maligne</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Malignant tumor</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Tumor maligno</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Mortalité</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Mortality</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Mortalidad</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Epidemiology</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Epidemiología</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Toxicité</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Toxicity</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="GER"><s0>Giftigkeit</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Toxicidad</s0><s5>20</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>International</s0><s5>21</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>International</s0><s5>21</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Internacional</s0><s5>21</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Santé publique</s0><s5>22</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>Public health</s0><s5>22</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Salud pública</s0><s5>22</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Médecine travail</s0><s5>78</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Occupational medicine</s0><s5>78</s5></fC03><fC03 i1="15" i2="X" l="GER"><s0>Arbeitsmedizin</s0><s5>78</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Medicina ocupacional</s0><s5>78</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>Acétique acide(aryloxy)</s0><s4>INC</s4><s5>86</s5></fC03><fN21><s1>216</s1></fN21></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Catalogne</li><li>District de Karlsruhe</li><li>Hambourg</li><li>Hovedstaden</li><li>Lombardie</li><li>Ohio</li><li>Rhône-Alpes</li><li>Toscane</li><li>Vienne (Autriche)</li></region><settlement><li>Barcelone</li><li>Copenhague</li><li>Hambourg</li><li>Heidelberg</li><li>Lyon</li><li>Milan</li><li>Pise</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. Kogevinas</name></region><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><name sortKey="Colin, D" sort="Colin, D" uniqKey="Colin D" first="D." last="Colin">D. Colin</name><name sortKey="Saracci, R" sort="Saracci, R" uniqKey="Saracci R" first="R." last="Saracci">R. Saracci</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. Kogevinas</name></region></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Becher, H" sort="Becher, H" uniqKey="Becher H" first="H." last="Becher">H. Becher</name></region><name sortKey="Flesch Janys, D" sort="Flesch Janys, D" uniqKey="Flesch Janys D" first="D." last="Flesch-Janys">D. Flesch-Janys</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Benn, T" sort="Benn, T" uniqKey="Benn T" first="T." last="Benn">T. Benn</name></noRegion><name sortKey="Coggon, D" sort="Coggon, D" uniqKey="Coggon D" first="D." last="Coggon">D. Coggon</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Bertazzi, P A" sort="Bertazzi, P A" uniqKey="Bertazzi P" first="P. A." last="Bertazzi">P. A. Bertazzi</name></region><name sortKey="Saracci, R" sort="Saracci, R" uniqKey="Saracci R" first="R." last="Saracci">R. Saracci</name></country><country name="Pays-Bas"><noRegion><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name></noRegion></country><country name="États-Unis"><region name="Ohio"><name sortKey="Fingerhut, M" sort="Fingerhut, M" uniqKey="Fingerhut M" first="M." last="Fingerhut">M. Fingerhut</name></region></country><country name="Canada"><noRegion><name sortKey="Green, L" sort="Green, L" uniqKey="Green L" first="L." last="Green">L. Green</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Kauppinen, T" sort="Kauppinen, T" uniqKey="Kauppinen T" first="T." last="Kauppinen">T. Kauppinen</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Littorin, M" sort="Littorin, M" uniqKey="Littorin M" first="M." last="Littorin">M. Littorin</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Lynge, E" sort="Lynge, E" uniqKey="Lynge E" first="E." last="Lynge">E. Lynge</name></region></country><country name="Australie"><noRegion><name sortKey="Mathews, J D" sort="Mathews, J D" uniqKey="Mathews J" first="J. D." last="Mathews">J. D. Mathews</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Neuberger, M" sort="Neuberger, M" uniqKey="Neuberger M" first="M." last="Neuberger">M. Neuberger</name></region></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Pearce, N" sort="Pearce, N" uniqKey="Pearce N" first="N." last="Pearce">N. Pearce</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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