Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant
Identifieur interne : 004B09 ( PascalFrancis/Checkpoint ); précédent : 004B08; suivant : 004B10Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant
Auteurs : Carl Kirkwood [Australie, Royaume-Uni, Pays-Bas, France, Espagne, Allemagne, Danemark, Suède, Slovénie, Hongrie] ; Ben Lopman ; Harry Vennema ; Evelyne Kohli ; Pierre Pothier ; Alicia Sanchez ; Anabel Negredo ; Javier Buesa ; Eckart Schreier ; Mark Reacher ; David Brown ; Jim Gray ; Miren Iturriza ; Chris Gallimore ; Blenda Bottiger ; Kjell-Olof Hedlund ; Maria Torven ; Carl-Henrik Von Bonsdorff ; Leena Maunula ; Mateja Poljsak-Prijatelj ; Janet Zimsek ; Gabor Reuter ; György Szücs ; Béla Melegh ; Lennart Svennson ; Yvonne Van DuijnhovenSource :
- Lancet : (British edition) [ 0140-6736 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Santé publique.
English descriptors
- KwdEn :
Abstract
Background Highly publicised outbreaks of norovirus gastroenteritis in hospitals in the UK and Ireland and cruise ships in the USA sparked speculation about whether this reported activity was unusual. Methods We analysed data collected through a collaborative research and surveillance network of viral gastroenteritis in ten European countries (England and Wales were analysed as one region). We compiled data on total number of outbreaks by month, and compared genetic sequences from the isolated viruses. Data were compared with historic data from a systematic retrospective review of surveillance systems and with a central database of viral sequences. Findings Three regions (England and Wales, Germany, and the Netherlands) had sustained epidemiological and viral characterisation data from 1995 to 2002. In all three, we noted a striking increase in norovirus outbreaks in 2002 that coincided with the detection and emergence of a new predominant norovirus variant of genogroup 114, which had a consistent mutation in the polymerase gene. Eight of nine regions had an annual peak in 2002 and the new genogroup 114 variant was detected in nine countries. Also, the detection of the new variant preceded an atypical spring and summer peak of outbreaks in three countries. Interpretation Our data from ten European countries show a striking increase and unusual seasonal pattern of norovirus gastroenteritis in 2002 that occurred concurrently with the emergence of a novel genetic variant. In addition to showing the added value of an international network for viral gastroenteritis outbreaks, these observations raise questions about the biological properties of the variant and the mechanisms for its rapid dissemination.
Affiliations:
- Allemagne, Australie, Danemark, Espagne, France, Hongrie, Pays-Bas, Royaume-Uni, Slovénie, Suède
- Angleterre, Berlin, Bourgogne, Bourgogne-Franche-Comté, Communauté de Madrid, Grand Londres, Hovedstaden
- Berlin, Copenhague, Dijon, Londres, Madrid
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epidemic spread of new norovirus variant</title><author><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Enteric Virus Research Group, Murdoch Childrens Research Institute, Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital</s1><s2>Melbourne, Victoria 3052</s2><s3>AUS</s3></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria 3052</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Health Protection Agency</s1><s2>London</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Public Health and the Environment</s1><s2>Bilthoven</s2><s3>NLD</s3></inist:fA14><country>Pays-Bas</country><wicri:noRegion>National Institute for Public Health and the Environment</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Laboratoire de Virologie</s1><s2>Dijon</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Instituto de Salud Carlos III</s1><s2>Madrid</s2><s3>ESP</s3></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University of Valencia</s1><s3>ESP</s3></inist:fA14><country>Espagne</country><wicri:noRegion>University of Valencia</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Robert Koch Institute</s1><s2>Berlin</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Statens Serum Institute</s1><s2>Copenhagen</s2><s3>DNK</s3></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Swedish Institute for Infectious Disease Control</s1><s2>Solna, Helsinki</s2><s3>SWE</s3></inist:fA14><country>Suède</country><wicri:noRegion>Swedish Institute for Infectious Disease Control</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>University Helsinki, Institute of Microbiology and Immunology</s1><s2>Ljubljana</s2><s3>SVN</s3></inist:fA14><country>Slovénie</country><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institute of State Public Health Service, Pécs University</s1><s2>Pécs</s2><s3>HUN</s3></inist:fA14><country>Hongrie</country><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>University of Linköping</s1><s3>SWE</s3></inist:fA14><country>Suède</country><wicri:noRegion>University of Linköping</wicri:noRegion></affiliation></author><author><name sortKey="Lopman, Ben" sort="Lopman, Ben" uniqKey="Lopman B" first="Ben" last="Lopman">Ben Lopman</name></author><author><name sortKey="Vennema, Harry" sort="Vennema, Harry" uniqKey="Vennema H" first="Harry" last="Vennema">Harry Vennema</name></author><author><name sortKey="Kohli, Evelyne" sort="Kohli, Evelyne" uniqKey="Kohli E" first="Evelyne" last="Kohli">Evelyne Kohli</name></author><author><name sortKey="Pothier, Pierre" sort="Pothier, Pierre" uniqKey="Pothier P" first="Pierre" last="Pothier">Pierre Pothier</name></author><author><name sortKey="Sanchez, Alicia" sort="Sanchez, Alicia" uniqKey="Sanchez A" first="Alicia" last="Sanchez">Alicia Sanchez</name></author><author><name sortKey="Negredo, Anabel" sort="Negredo, Anabel" uniqKey="Negredo A" first="Anabel" last="Negredo">Anabel Negredo</name></author><author><name sortKey="Buesa, Javier" sort="Buesa, Javier" uniqKey="Buesa J" first="Javier" last="Buesa">Javier Buesa</name></author><author><name sortKey="Schreier, Eckart" sort="Schreier, Eckart" uniqKey="Schreier E" first="Eckart" last="Schreier">Eckart Schreier</name></author><author><name sortKey="Reacher, Mark" sort="Reacher, Mark" uniqKey="Reacher M" first="Mark" last="Reacher">Mark Reacher</name></author><author><name sortKey="Brown, David" sort="Brown, David" uniqKey="Brown D" first="David" last="Brown">David Brown</name></author><author><name sortKey="Gray, Jim" sort="Gray, Jim" uniqKey="Gray J" first="Jim" last="Gray">Jim Gray</name></author><author><name sortKey="Iturriza, Miren" sort="Iturriza, Miren" uniqKey="Iturriza M" first="Miren" last="Iturriza">Miren Iturriza</name></author><author><name sortKey="Gallimore, Chris" sort="Gallimore, Chris" uniqKey="Gallimore C" first="Chris" last="Gallimore">Chris Gallimore</name></author><author><name sortKey="Bottiger, Blenda" sort="Bottiger, Blenda" uniqKey="Bottiger B" first="Blenda" last="Bottiger">Blenda Bottiger</name></author><author><name sortKey="Hedlund, Kjell Olof" sort="Hedlund, Kjell Olof" uniqKey="Hedlund K" first="Kjell-Olof" last="Hedlund">Kjell-Olof Hedlund</name></author><author><name sortKey="Torven, Maria" sort="Torven, Maria" uniqKey="Torven M" first="Maria" last="Torven">Maria Torven</name></author><author><name sortKey="Von Bonsdorff, Carl Henrik" sort="Von Bonsdorff, Carl Henrik" uniqKey="Von Bonsdorff C" first="Carl-Henrik" last="Von Bonsdorff">Carl-Henrik Von Bonsdorff</name></author><author><name sortKey="Maunula, Leena" sort="Maunula, Leena" uniqKey="Maunula L" first="Leena" last="Maunula">Leena Maunula</name></author><author><name sortKey="Poljsak Prijatelj, Mateja" sort="Poljsak Prijatelj, Mateja" uniqKey="Poljsak Prijatelj M" first="Mateja" last="Poljsak-Prijatelj">Mateja Poljsak-Prijatelj</name></author><author><name sortKey="Zimsek, Janet" sort="Zimsek, Janet" uniqKey="Zimsek J" first="Janet" last="Zimsek">Janet Zimsek</name></author><author><name sortKey="Reuter, Gabor" sort="Reuter, Gabor" uniqKey="Reuter G" first="Gabor" last="Reuter">Gabor Reuter</name></author><author><name sortKey="Szucs, Gyorgy" sort="Szucs, Gyorgy" uniqKey="Szucs G" first="György" last="Szücs">György Szücs</name></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Béla" last="Melegh">Béla Melegh</name></author><author><name sortKey="Svennson, Lennart" sort="Svennson, Lennart" uniqKey="Svennson L" first="Lennart" last="Svennson">Lennart Svennson</name></author><author><name sortKey="Van Duijnhoven, Yvonne" sort="Van Duijnhoven, Yvonne" uniqKey="Van Duijnhoven Y" first="Yvonne" last="Van Duijnhoven">Yvonne Van Duijnhoven</name></author></analytic><series><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2002</term><term>Epidemic</term><term>Europe</term><term>Gastroenteritis</term><term>Genetic variant</term><term>Increase</term><term>Public health</term><term>Viral disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virose</term><term>Augmentation</term><term>Santé publique</term><term>Gastroentérite</term><term>Europe</term><term>Epidémie</term><term>Variant génétique</term><term>2002</term><term>Norovirus</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Highly publicised outbreaks of norovirus gastroenteritis in hospitals in the UK and Ireland and cruise ships in the USA sparked speculation about whether this reported activity was unusual. Methods We analysed data collected through a collaborative research and surveillance network of viral gastroenteritis in ten European countries (England and Wales were analysed as one region). We compiled data on total number of outbreaks by month, and compared genetic sequences from the isolated viruses. Data were compared with historic data from a systematic retrospective review of surveillance systems and with a central database of viral sequences. Findings Three regions (England and Wales, Germany, and the Netherlands) had sustained epidemiological and viral characterisation data from 1995 to 2002. In all three, we noted a striking increase in norovirus outbreaks in 2002 that coincided with the detection and emergence of a new predominant norovirus variant of genogroup 114, which had a consistent mutation in the polymerase gene. Eight of nine regions had an annual peak in 2002 and the new genogroup 114 variant was detected in nine countries. Also, the detection of the new variant preceded an atypical spring and summer peak of outbreaks in three countries. Interpretation Our data from ten European countries show a striking increase and unusual seasonal pattern of norovirus gastroenteritis in 2002 that occurred concurrently with the emergence of a novel genetic variant. In addition to showing the added value of an international network for viral gastroenteritis outbreaks, these observations raise questions about the biological properties of the variant and the mechanisms for its rapid dissemination.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0140-6736</s0></fA01><fA02 i1="01"><s0>LANCAO</s0></fA02><fA03 i2="1"><s0>Lancet : (Br. ed.)</s0></fA03><fA05><s2>363</s2></fA05><fA06><s2>9410</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant</s1></fA08><fA11 i1="01" i2="1"><s1>KIRKWOOD (Carl)</s1></fA11><fA11 i1="02" i2="1"><s1>LOPMAN (Ben)</s1></fA11><fA11 i1="03" i2="1"><s1>VENNEMA (Harry)</s1></fA11><fA11 i1="04" i2="1"><s1>KOHLI (Evelyne)</s1></fA11><fA11 i1="05" i2="1"><s1>POTHIER (Pierre)</s1></fA11><fA11 i1="06" i2="1"><s1>SANCHEZ (Alicia)</s1></fA11><fA11 i1="07" i2="1"><s1>NEGREDO (Anabel)</s1></fA11><fA11 i1="08" i2="1"><s1>BUESA (Javier)</s1></fA11><fA11 i1="09" i2="1"><s1>SCHREIER (Eckart)</s1></fA11><fA11 i1="10" i2="1"><s1>REACHER (Mark)</s1></fA11><fA11 i1="11" i2="1"><s1>BROWN (David)</s1></fA11><fA11 i1="12" i2="1"><s1>GRAY (Jim)</s1></fA11><fA11 i1="13" i2="1"><s1>ITURRIZA (Miren)</s1></fA11><fA11 i1="14" i2="1"><s1>GALLIMORE (Chris)</s1></fA11><fA11 i1="15" i2="1"><s1>BOTTIGER (Blenda)</s1></fA11><fA11 i1="16" i2="1"><s1>HEDLUND (Kjell-Olof)</s1></fA11><fA11 i1="17" i2="1"><s1>TORVEN (Maria)</s1></fA11><fA11 i1="18" i2="1"><s1>VON BONSDORFF (Carl-Henrik)</s1></fA11><fA11 i1="19" i2="1"><s1>MAUNULA (Leena)</s1></fA11><fA11 i1="20" i2="1"><s1>POLJSAK-PRIJATELJ (Mateja)</s1></fA11><fA11 i1="21" i2="1"><s1>ZIMSEK (Janet)</s1></fA11><fA11 i1="22" i2="1"><s1>REUTER (Gabor)</s1></fA11><fA11 i1="23" i2="1"><s1>SZÜCS (György)</s1></fA11><fA11 i1="24" i2="1"><s1>MELEGH (Béla)</s1></fA11><fA11 i1="25" i2="1"><s1>SVENNSON (Lennart)</s1></fA11><fA11 i1="26" i2="1"><s1>VAN DUIJNHOVEN (Yvonne)</s1></fA11><fA14 i1="01"><s1>Enteric Virus Research Group, Murdoch Childrens Research Institute, Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital</s1><s2>Melbourne, Victoria 3052</s2><s3>AUS</s3></fA14><fA14 i1="02"><s1>Health Protection Agency</s1><s2>London</s2><s3>GBR</s3></fA14><fA14 i1="03"><s1>National Institute for Public Health and the Environment</s1><s2>Bilthoven</s2><s3>NLD</s3></fA14><fA14 i1="04"><s1>Laboratoire de Virologie</s1><s2>Dijon</s2><s3>FRA</s3></fA14><fA14 i1="05"><s1>Instituto de Salud Carlos III</s1><s2>Madrid</s2><s3>ESP</s3></fA14><fA14 i1="06"><s1>University of Valencia</s1><s3>ESP</s3></fA14><fA14 i1="07"><s1>Robert Koch Institute</s1><s2>Berlin</s2><s3>DEU</s3></fA14><fA14 i1="08"><s1>Statens Serum Institute</s1><s2>Copenhagen</s2><s3>DNK</s3></fA14><fA14 i1="09"><s1>Swedish Institute for Infectious Disease Control</s1><s2>Solna, Helsinki</s2><s3>SWE</s3></fA14><fA14 i1="10"><s1>University Helsinki, Institute of Microbiology and Immunology</s1><s2>Ljubljana</s2><s3>SVN</s3></fA14><fA14 i1="11"><s1>Institute of State Public Health Service, Pécs University</s1><s2>Pécs</s2><s3>HUN</s3></fA14><fA14 i1="12"><s1>University of Linköping</s1><s3>SWE</s3></fA14><fA17 i1="01" i2="1"><s1>European Food-borne Viruses Network</s1><s3>INC</s3></fA17><fA20><s2>671-672,682-688 [9 p.]</s2></fA20><fA21><s1>2004</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>5004</s2><s5>354000116558680040</s5></fA43><fA44><s0>0000</s0><s1>© 2004 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>04-0252274</s0></fA47><fA60><s1>P</s1><s3>AR</s3><s3>CT</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Lancet : (British edition)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Background Highly publicised outbreaks of norovirus gastroenteritis in hospitals in the UK and Ireland and cruise ships in the USA sparked speculation about whether this reported activity was unusual. Methods We analysed data collected through a collaborative research and surveillance network of viral gastroenteritis in ten European countries (England and Wales were analysed as one region). We compiled data on total number of outbreaks by month, and compared genetic sequences from the isolated viruses. Data were compared with historic data from a systematic retrospective review of surveillance systems and with a central database of viral sequences. Findings Three regions (England and Wales, Germany, and the Netherlands) had sustained epidemiological and viral characterisation data from 1995 to 2002. In all three, we noted a striking increase in norovirus outbreaks in 2002 that coincided with the detection and emergence of a new predominant norovirus variant of genogroup 114, which had a consistent mutation in the polymerase gene. Eight of nine regions had an annual peak in 2002 and the new genogroup 114 variant was detected in nine countries. Also, the detection of the new variant preceded an atypical spring and summer peak of outbreaks in three countries. Interpretation Our data from ten European countries show a striking increase and unusual seasonal pattern of norovirus gastroenteritis in 2002 that occurred concurrently with the emergence of a novel genetic variant. In addition to showing the added value of an international network for viral gastroenteritis outbreaks, these observations raise questions about the biological properties of the variant and the mechanisms for its rapid dissemination.</s0></fC01><fC02 i1="01" i2="X"><s0>002B05C02F</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Virose</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Viral disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Virosis</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Augmentation</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Increase</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Aumentación</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Santé publique</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Public health</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Salud pública</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Gastroentérite</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Gastroenteritis</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Gastroenteritis</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Europe</s0><s2>NG</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Europe</s0><s2>NG</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Europa</s0><s2>NG</s2><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Epidémie</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Epidemic</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Epidemia</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Variant génétique</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Genetic variant</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Variante genética</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>2002</s0><s5>17</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>2002</s0><s5>17</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>2002</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Norovirus</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Infection</s0><s2>NM</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Infection</s0><s2>NM</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Infección</s0><s2>NM</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Appareil digestif pathologie</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Digestive diseases</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Aparato digestivo patología</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Estomac pathologie</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Gastric disease</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Estómago patología</s0><s5>38</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Intestin pathologie</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Intestinal disease</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Intestino patología</s0><s5>39</s5></fC07><fN21><s1>159</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Slovénie</li><li>Suède</li></country><region><li>Angleterre</li><li>Berlin</li><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Hovedstaden</li></region><settlement><li>Berlin</li><li>Copenhague</li><li>Dijon</li><li>Londres</li><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Bottiger, Blenda" sort="Bottiger, Blenda" uniqKey="Bottiger B" first="Blenda" last="Bottiger">Blenda Bottiger</name><name sortKey="Brown, David" sort="Brown, David" uniqKey="Brown D" first="David" last="Brown">David Brown</name><name sortKey="Buesa, Javier" sort="Buesa, Javier" uniqKey="Buesa J" first="Javier" last="Buesa">Javier Buesa</name><name sortKey="Gallimore, Chris" sort="Gallimore, Chris" uniqKey="Gallimore C" first="Chris" last="Gallimore">Chris Gallimore</name><name sortKey="Gray, Jim" sort="Gray, Jim" uniqKey="Gray J" first="Jim" last="Gray">Jim Gray</name><name sortKey="Hedlund, Kjell Olof" sort="Hedlund, Kjell Olof" uniqKey="Hedlund K" first="Kjell-Olof" last="Hedlund">Kjell-Olof Hedlund</name><name sortKey="Iturriza, Miren" sort="Iturriza, Miren" uniqKey="Iturriza M" first="Miren" last="Iturriza">Miren Iturriza</name><name sortKey="Kohli, Evelyne" sort="Kohli, Evelyne" uniqKey="Kohli E" first="Evelyne" last="Kohli">Evelyne Kohli</name><name sortKey="Lopman, Ben" sort="Lopman, Ben" uniqKey="Lopman B" first="Ben" last="Lopman">Ben Lopman</name><name sortKey="Maunula, Leena" sort="Maunula, Leena" uniqKey="Maunula L" first="Leena" last="Maunula">Leena Maunula</name><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Béla" last="Melegh">Béla Melegh</name><name sortKey="Negredo, Anabel" sort="Negredo, Anabel" uniqKey="Negredo A" first="Anabel" last="Negredo">Anabel Negredo</name><name sortKey="Poljsak Prijatelj, Mateja" sort="Poljsak Prijatelj, Mateja" uniqKey="Poljsak Prijatelj M" first="Mateja" last="Poljsak-Prijatelj">Mateja Poljsak-Prijatelj</name><name sortKey="Pothier, Pierre" sort="Pothier, Pierre" uniqKey="Pothier P" first="Pierre" last="Pothier">Pierre Pothier</name><name sortKey="Reacher, Mark" sort="Reacher, Mark" uniqKey="Reacher M" first="Mark" last="Reacher">Mark Reacher</name><name sortKey="Reuter, Gabor" sort="Reuter, Gabor" uniqKey="Reuter G" first="Gabor" last="Reuter">Gabor Reuter</name><name sortKey="Sanchez, Alicia" sort="Sanchez, Alicia" uniqKey="Sanchez A" first="Alicia" last="Sanchez">Alicia Sanchez</name><name sortKey="Schreier, Eckart" sort="Schreier, Eckart" uniqKey="Schreier E" first="Eckart" last="Schreier">Eckart Schreier</name><name sortKey="Svennson, Lennart" sort="Svennson, Lennart" uniqKey="Svennson L" first="Lennart" last="Svennson">Lennart Svennson</name><name sortKey="Szucs, Gyorgy" sort="Szucs, Gyorgy" uniqKey="Szucs G" first="György" last="Szücs">György Szücs</name><name sortKey="Torven, Maria" sort="Torven, Maria" uniqKey="Torven M" first="Maria" last="Torven">Maria Torven</name><name sortKey="Van Duijnhoven, Yvonne" sort="Van Duijnhoven, Yvonne" uniqKey="Van Duijnhoven Y" first="Yvonne" last="Van Duijnhoven">Yvonne Van Duijnhoven</name><name sortKey="Vennema, Harry" sort="Vennema, Harry" uniqKey="Vennema H" first="Harry" last="Vennema">Harry Vennema</name><name sortKey="Von Bonsdorff, Carl Henrik" sort="Von Bonsdorff, Carl Henrik" uniqKey="Von Bonsdorff C" first="Carl-Henrik" last="Von Bonsdorff">Carl-Henrik Von Bonsdorff</name><name sortKey="Zimsek, Janet" sort="Zimsek, Janet" uniqKey="Zimsek J" first="Janet" last="Zimsek">Janet Zimsek</name></noCountry><country name="Australie"><noRegion><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></region></country><country name="Pays-Bas"><noRegion><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></noRegion></country><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></region><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></region></country><country name="Suède"><noRegion><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></noRegion><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></country><country name="Slovénie"><noRegion><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></noRegion></country><country name="Hongrie"><noRegion><name sortKey="Kirkwood, Carl" sort="Kirkwood, Carl" uniqKey="Kirkwood C" first="Carl" last="Kirkwood">Carl Kirkwood</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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