AustralieFrV1, PascalFrancis, Checkpoint, bibRecord, 004331

The development of a plant-based vaccine for measles

Identifieur interne : 004331 ( PascalFrancis/Checkpoint ); précédent : 004330; suivant : 004332

The development of a plant-based vaccine for measles

Auteurs : D. E. Webster [Australie] ; M. C. Thomas [Australie] ; Z. Huang [Australie] ; S. L. Wesselingh [Australie]

Source :

Vaccine [ 0264-410X ] ; 2005.

RBID : Pascal:06-0198087

Descripteurs français

Pascal (Inist)
- Vaccin, Vaccination, Rougeole.
Wicri :
- topic : Vaccin, Vaccination.

English descriptors

KwdEn :
- Measles, Vaccination, Vaccine.

Abstract

Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.

Affiliations:

Australie

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.</div>
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The development of a plant-based vaccine for measles

The development of a plant-based vaccine for measles

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri