AustralieFrV1, PascalFrancis, Checkpoint, bibRecord, 003424

Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana

Identifieur interne : 003424 ( PascalFrancis/Checkpoint ); précédent : 003423; suivant : 003425

Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana

Auteurs : Jérome Appenzeller [France] ; Ghezala Mihci [France] ; Marie-Thérèse Martin [France] ; Jean-Francois Gallard [France] ; Jean-Louis Menou ; Nicole Boury-Esnault [France] ; John Hooper [Australie] ; Sylvain Petek [France] ; Severine Chevalley [France] ; Alexis Valentin [France] ; Anne Zaparucha [France] ; Ali Al-Mourabit [France] ; Cécile Debitus [France]

Source :

Journal of natural products : (Print) [ 0163-3864 ] ; 2008.

RBID : Pascal:08-0502079

Descripteurs français

Pascal (Inist)
- Iles Salomon, Milieu marin, Eponge, Porifera, Isolement, Analyse structurale, Alcaloïde, Diterpène, Activité biologique, Antipaludique, Plasmodium falciparum, In vitro, Origine animale, Terpénoïde, Pharmacognosie, Cation organique, Antiparasitaire, Antiprotozoaire, Agelas, Agelasine J, Agelasine K, Agelasine L, Agelas mauritiana, Purinium composé, Clérodane dérivé.
Wicri :
- topic : Milieu marin.

English descriptors

KwdEn :
- Alkaloid, Animal origin, Antimalarial, Antiprotozoal agent, Biological activity, Diterpene, In vitro, Isolation, Marine environment, Organic cation, Parasiticide, Pharmacognosy, Plasmodium falciparum, Porifera, Solomon Islands, Sponge, Structural analysis, Terpenoid.

Abstract

Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activity against Plasmodium falciparum.

Affiliations:

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Pascal:08-0502079

Le document en format XML

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<author><name sortKey="Al Mourabit, Ali" sort="Al Mourabit, Ali" uniqKey="Al Mourabit A" first="Ali" last="Al-Mourabit">Ali Al-Mourabit</name>
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<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>UMR 152 IRD-Université Paul Sabotier Toulouse 111, Faculté des Sciences Pharmaceutiques</s1>
<s2>31062 Toulouse</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>31062 Toulouse</wicri:noRegion>
<placeName><settlement type="city">Toulouse</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Midi-Pyrénées</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of natural products : (Print)</title>
<title level="j" type="abbreviated">J. nat. prod. : (Print)</title>
<idno type="ISSN">0163-3864</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of natural products : (Print)</title>
<title level="j" type="abbreviated">J. nat. prod. : (Print)</title>
<idno type="ISSN">0163-3864</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alkaloid</term>
<term>Animal origin</term>
<term>Antimalarial</term>
<term>Antiprotozoal agent</term>
<term>Biological activity</term>
<term>Diterpene</term>
<term>In vitro</term>
<term>Isolation</term>
<term>Marine environment</term>
<term>Organic cation</term>
<term>Parasiticide</term>
<term>Pharmacognosy</term>
<term>Plasmodium falciparum</term>
<term>Porifera</term>
<term>Solomon Islands</term>
<term>Sponge</term>
<term>Structural analysis</term>
<term>Terpenoid</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Iles Salomon</term>
<term>Milieu marin</term>
<term>Eponge</term>
<term>Porifera</term>
<term>Isolement</term>
<term>Analyse structurale</term>
<term>Alcaloïde</term>
<term>Diterpène</term>
<term>Activité biologique</term>
<term>Antipaludique</term>
<term>Plasmodium falciparum</term>
<term>In vitro</term>
<term>Origine animale</term>
<term>Terpénoïde</term>
<term>Pharmacognosie</term>
<term>Cation organique</term>
<term>Antiparasitaire</term>
<term>Antiprotozoaire</term>
<term>Agelas</term>
<term>Agelasine J</term>
<term>Agelasine K</term>
<term>Agelasine L</term>
<term>Agelas mauritiana</term>
<term>Purinium composé</term>
<term>Clérodane dérivé</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Milieu marin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activity against Plasmodium falciparum.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0163-3864</s0>
</fA01>
<fA02 i1="01"><s0>JNPRDF</s0>
</fA02>
<fA03 i2="1"><s0>J. nat. prod. : (Print)</s0>
</fA03>
<fA05><s2>71</s2>
</fA05>
<fA06><s2>8</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>APPENZELLER (Jérome)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>MIHCI (Ghezala)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>MARTIN (Marie-Thérèse)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>GALLARD (Jean-Francois)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MENOU (Jean-Louis)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BOURY-ESNAULT (Nicole)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>HOOPER (John)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>PETEK (Sylvain)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>CHEVALLEY (Severine)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>VALENTIN (Alexis)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>ZAPARUCHA (Anne)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>AL-MOURABIT (Ali)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>DEBITUS (Cécile)</s1>
</fA11>
<fA14 i1="01"><s1>Institut de Chimie des Substances Naturelles du CNRS, Avenue de la Terrasse</s1>
<s2>91198 Gif-sur-Yvette</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>IRD, Centre de Nouméa, BPA5</s1>
<s2>Nouméa</s2>
<s3>NCL</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>CNRS, Station Marine d'Endoume, Rue de la Batterie des Lions</s1>
<s2>13007 Marseille</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Queensland Muséum, P.O. Box 3300</s1>
<s2>South Brisbane, Qld, 4101</s2>
<s3>AUS</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>UMR 152 IRD-Université Paul Sabotier Toulouse 111, Faculté des Sciences Pharmaceutiques</s1>
<s2>31062 Toulouse</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA20><s1>1451-1454</s1>
</fA20>
<fA21><s1>2008</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>4127</s2>
<s5>354000196334460230</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>18 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>08-0502079</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of natural products : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activity against Plasmodium falciparum.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02A04</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Iles Salomon</s0>
<s2>NG</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Solomon Islands</s0>
<s2>NG</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Islas Salomón</s0>
<s2>NG</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Milieu marin</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Marine environment</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Medio marino</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Eponge</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Sponge</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Esponja</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Porifera</s0>
<s2>NS</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Porifera</s0>
<s2>NS</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Porifera</s0>
<s2>NS</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Isolement</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Isolation</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Aislamiento</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Analyse structurale</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Structural analysis</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Análisis estructural</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Alcaloïde</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Alkaloid</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Alcaloide</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Diterpène</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Diterpene</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Diterpeno</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Activité biologique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Biological activity</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Actividad biológica</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Antipaludique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Antimalarial</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Antipalúdico</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Plasmodium falciparum</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Plasmodium falciparum</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Plasmodium falciparum</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>In vitro</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>In vitro</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>In vitro</s0>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Origine animale</s0>
<s5>32</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Animal origin</s0>
<s5>32</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Origen animal</s0>
<s5>32</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Terpénoïde</s0>
<s2>FX</s2>
<s5>33</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Terpenoid</s0>
<s2>FX</s2>
<s5>33</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Terpenoide</s0>
<s2>FX</s2>
<s5>33</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Pharmacognosie</s0>
<s5>35</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Pharmacognosy</s0>
<s5>35</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Farmacognosia</s0>
<s5>35</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Cation organique</s0>
<s5>36</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Organic cation</s0>
<s5>36</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Catión orgánico</s0>
<s5>36</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Antiparasitaire</s0>
<s5>38</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Parasiticide</s0>
<s5>38</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Antiparasitario</s0>
<s5>38</s5>
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<fC03 i1="18" i2="X" l="FRE"><s0>Antiprotozoaire</s0>
<s5>39</s5>
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<fC03 i1="18" i2="X" l="ENG"><s0>Antiprotozoal agent</s0>
<s5>39</s5>
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<fC03 i1="18" i2="X" l="SPA"><s0>Antiprotozoario</s0>
<s5>39</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>Agelas</s0>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Agelasine J</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>77</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Agelasine K</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC03 i1="22" i2="X" l="FRE"><s0>Agelasine L</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>79</s5>
</fC03>
<fC03 i1="23" i2="X" l="FRE"><s0>Agelas mauritiana</s0>
<s2>NS</s2>
<s4>INC</s4>
<s5>80</s5>
</fC03>
<fC03 i1="24" i2="X" l="FRE"><s0>Purinium composé</s0>
<s4>INC</s4>
<s5>81</s5>
</fC03>
<fC03 i1="25" i2="X" l="FRE"><s0>Clérodane dérivé</s0>
<s4>INC</s4>
<s5>82</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Mélanésie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Melanesia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Melanesia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Océanie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Oceania</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Oceania</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Invertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Invertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Invertebrata</s0>
<s2>NS</s2>
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<fC07 i1="04" i2="X" l="FRE"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>329</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
<li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
<li>Toulouse</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Menou, Jean Louis" sort="Menou, Jean Louis" uniqKey="Menou J" first="Jean-Louis" last="Menou">Jean-Louis Menou</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Appenzeller, Jerome" sort="Appenzeller, Jerome" uniqKey="Appenzeller J" first="Jérome" last="Appenzeller">Jérome Appenzeller</name>
</noRegion>
<name sortKey="Al Mourabit, Ali" sort="Al Mourabit, Ali" uniqKey="Al Mourabit A" first="Ali" last="Al-Mourabit">Ali Al-Mourabit</name>
<name sortKey="Boury Esnault, Nicole" sort="Boury Esnault, Nicole" uniqKey="Boury Esnault N" first="Nicole" last="Boury-Esnault">Nicole Boury-Esnault</name>
<name sortKey="Chevalley, Severine" sort="Chevalley, Severine" uniqKey="Chevalley S" first="Severine" last="Chevalley">Severine Chevalley</name>
<name sortKey="Debitus, Cecile" sort="Debitus, Cecile" uniqKey="Debitus C" first="Cécile" last="Debitus">Cécile Debitus</name>
<name sortKey="Gallard, Jean Francois" sort="Gallard, Jean Francois" uniqKey="Gallard J" first="Jean-Francois" last="Gallard">Jean-Francois Gallard</name>
<name sortKey="Martin, Marie Therese" sort="Martin, Marie Therese" uniqKey="Martin M" first="Marie-Thérèse" last="Martin">Marie-Thérèse Martin</name>
<name sortKey="Mihci, Ghezala" sort="Mihci, Ghezala" uniqKey="Mihci G" first="Ghezala" last="Mihci">Ghezala Mihci</name>
<name sortKey="Petek, Sylvain" sort="Petek, Sylvain" uniqKey="Petek S" first="Sylvain" last="Petek">Sylvain Petek</name>
<name sortKey="Valentin, Alexis" sort="Valentin, Alexis" uniqKey="Valentin A" first="Alexis" last="Valentin">Alexis Valentin</name>
<name sortKey="Zaparucha, Anne" sort="Zaparucha, Anne" uniqKey="Zaparucha A" first="Anne" last="Zaparucha">Anne Zaparucha</name>
</country>
<country name="Australie"><noRegion><name sortKey="Hooper, John" sort="Hooper, John" uniqKey="Hooper J" first="John" last="Hooper">John Hooper</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana

Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana

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