Mesothelin-related predictive and prognostic factors in malignant mesothelioma : A nested case-control study
Identifieur interne : 003074 ( PascalFrancis/Checkpoint ); précédent : 003073; suivant : 003075Mesothelin-related predictive and prognostic factors in malignant mesothelioma : A nested case-control study
Auteurs : Oluf Dimitri Roe [Norvège] ; Jenette Creaney [Australie] ; Steinar Lundgren [Norvège] ; Erik Larsson [Norvège] ; Helmut Sandeck [Norvège] ; Paolo Boffetta [France] ; Tom Ivar Nilsen [Norvège] ; Bruce Robinson [Australie] ; Kristina Kjaerheim [Norvège]Source :
- Lung cancer [ 0169-5002 ] ; 2008.
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- Pascal (Inist)
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Abstract
Soluble mesothelin-related protein (SMRP) in serum is potentially a sensitive marker of malignant mesothelioma (MM) diagnosis and progression, and may be useful as screening marker. Mesothelin expression in tumors is regarded as a sensitive marker for diagnosis and disease progression, and is a candidate prognostic marker. Levels of SMRP, CA125 and CYFRA 21-1 in pre-diagnostic (1-30 years) serum samples from 47 mesothelioma cases and 141 matched controls were analysed. Mesothelin expression in tumors was assessed. The association between biomarker level and mesothelioma risk and survival was analysed, adjusting for asbestos exposure. Survival related to tumor mesothelin expression, age, sex, histological type, location, asbestos exposure and pre-clinical SMRP was analysed. There was no significant association between biomarker levels and mesothelioma risk when analysed as continuous variables or as tertiles. Biomarker levels <10, 10-19 and ≥20 years before diagnosis were not significantly associated to mesothelioma risk. Mesothelin expressed in >50% of tumor cells was seen in 36 of 47 (77%) tumors. Mesothelin expression in <50% of tumor cells was a significant negative prognostic marker in all cases of malignant mesothelioma (median survival=6 months vs. 12 months, hazard ratio (HR)=2.49, 95%CI 1.17-5.27), and also when only epithelial mesothelioma was analysed (median =6 months vs. 14 months, HR=2.36, 95%CI 1.07-5.22). When adjusted for age and gender, the prognosis was still dismal, but non-significant (HR=1.85, 95%CI 0.85-4.05). High age (>65 years) was an independent negative prognostic factor that was related to both mesothelin expression and asbestos exposure. Mesothelioma of the epithelial type of the peritoneum had a significantly longer survival than epithelial type in pleura and was also related to mesothelin expression.
Affiliations:
- Australie, France, Norvège
- Auvergne-Rhône-Alpes, Rhône-Alpes, Trøndelag, Østlandet
- Lyon, Oslo, Trondheim
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wicri:step="Checkpoint">003074</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Mesothelin-related predictive and prognostic factors in malignant mesothelioma : A nested case-control study</title><author><name sortKey="Roe, Oluf Dimitri" sort="Roe, Oluf Dimitri" uniqKey="Roe O" first="Oluf Dimitri" last="Roe">Oluf Dimitri Roe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Oncology, St. Olavs Hospital, Trondheim University Hospital</s1><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Department of Oncology, St. Olavs Hospital, Trondheim University Hospital</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Norwegian University of Science and Technology (NTNU), Department of Cancer Research and Molecular Medicine</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Creaney, Jenette" sort="Creaney, Jenette" uniqKey="Creaney J" first="Jenette" last="Creaney">Jenette Creaney</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Medicine and Pharmacology, University of Western Australia, QfEII Medical Centre Nedlands</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Lundgren, Steinar" sort="Lundgren, Steinar" uniqKey="Lundgren S" first="Steinar" last="Lundgren">Steinar Lundgren</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Oncology, St. Olavs Hospital, Trondheim University Hospital</s1><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Department of Oncology, St. Olavs Hospital, Trondheim University Hospital</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Norwegian University of Science and Technology (NTNU), Department of Cancer Research and Molecular Medicine</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Larsson, Erik" sort="Larsson, Erik" uniqKey="Larsson E" first="Erik" last="Larsson">Erik Larsson</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Norwegian University of Science and Technology (NTNU), Department of Laboratory Medicine, Children's and Women's Health</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>4 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Sandeck, Helmut" sort="Sandeck, Helmut" uniqKey="Sandeck H" first="Helmut" last="Sandeck">Helmut Sandeck</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Medical Genetics, St. Olavs Hospital, Trondheim University Hospital</s1><s3>NOR</s3><sZ>5 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Department of Pathology and Medical Genetics, St. Olavs Hospital, Trondheim University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Nilsen, Tom Ivar" sort="Nilsen, Tom Ivar" uniqKey="Nilsen T" first="Tom Ivar" last="Nilsen">Tom Ivar Nilsen</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Norwegian University of Science and Technology (NTNU), Human Movement Science Programme</s1><s3>NOR</s3><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Norwegian University of Science and Technology (NTNU), Human Movement Science Programme</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Bruce" sort="Robinson, Bruce" uniqKey="Robinson B" first="Bruce" last="Robinson">Bruce Robinson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Medicine and Pharmacology, University of Western Australia, QfEII Medical Centre Nedlands</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Kjaerheim, Kristina" sort="Kjaerheim, Kristina" uniqKey="Kjaerheim K" first="Kristina" last="Kjaerheim">Kristina Kjaerheim</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>The Cancer Registry of Norway</s1><s2>Oslo</s2><s3>NOR</s3><sZ>9 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Lung cancer</title><title level="j" type="abbreviated">Lung cancer</title><idno type="ISSN">0169-5002</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lung cancer</title><title level="j" type="abbreviated">Lung cancer</title><idno type="ISSN">0169-5002</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Case control study</term><term>Immunohistochemistry</term><term>Malignant mesothelioma</term><term>Pneumology</term><term>Predictive factor</term><term>Prognosis</term><term>Respiratory disease</term><term>Tumoral marker</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mésothéliome malin</term><term>Pathologie de l'appareil respiratoire</term><term>Facteur prédictif</term><term>Pronostic</term><term>Etude cas témoin</term><term>Immunohistochimie</term><term>Marqueur tumoral</term><term>Cancérologie</term><term>Pneumologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Soluble mesothelin-related protein (SMRP) in serum is potentially a sensitive marker of malignant mesothelioma (MM) diagnosis and progression, and may be useful as screening marker. Mesothelin expression in tumors is regarded as a sensitive marker for diagnosis and disease progression, and is a candidate prognostic marker. Levels of SMRP, CA125 and CYFRA 21-1 in pre-diagnostic (1-30 years) serum samples from 47 mesothelioma cases and 141 matched controls were analysed. Mesothelin expression in tumors was assessed. The association between biomarker level and mesothelioma risk and survival was analysed, adjusting for asbestos exposure. Survival related to tumor mesothelin expression, age, sex, histological type, location, asbestos exposure and pre-clinical SMRP was analysed. There was no significant association between biomarker levels and mesothelioma risk when analysed as continuous variables or as tertiles. Biomarker levels <10, 10-19 and ≥20 years before diagnosis were not significantly associated to mesothelioma risk. Mesothelin expressed in >50% of tumor cells was seen in 36 of 47 (77%) tumors. Mesothelin expression in <50% of tumor cells was a significant negative prognostic marker in all cases of malignant mesothelioma (median survival=6 months vs. 12 months, hazard ratio (HR)=2.49, 95%CI 1.17-5.27), and also when only epithelial mesothelioma was analysed (median =6 months vs. 14 months, HR=2.36, 95%CI 1.07-5.22). When adjusted for age and gender, the prognosis was still dismal, but non-significant (HR=1.85, 95%CI 0.85-4.05). High age (>65 years) was an independent negative prognostic factor that was related to both mesothelin expression and asbestos exposure. Mesothelioma of the epithelial type of the peritoneum had a significantly longer survival than epithelial type in pleura and was also related to mesothelin expression.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0169-5002</s0></fA01><fA02 i1="01"><s0>LUCAE5</s0></fA02><fA03 i2="1"><s0>Lung cancer</s0></fA03><fA05><s2>61</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Mesothelin-related predictive and prognostic factors in malignant mesothelioma : A nested case-control study</s1></fA08><fA11 i1="01" i2="1"><s1>ROE (Oluf Dimitri)</s1></fA11><fA11 i1="02" i2="1"><s1>CREANEY (Jenette)</s1></fA11><fA11 i1="03" i2="1"><s1>LUNDGREN (Steinar)</s1></fA11><fA11 i1="04" i2="1"><s1>LARSSON (Erik)</s1></fA11><fA11 i1="05" i2="1"><s1>SANDECK (Helmut)</s1></fA11><fA11 i1="06" i2="1"><s1>BOFFETTA (Paolo)</s1></fA11><fA11 i1="07" i2="1"><s1>NILSEN (Tom Ivar)</s1></fA11><fA11 i1="08" i2="1"><s1>ROBINSON (Bruce)</s1></fA11><fA11 i1="09" i2="1"><s1>KJAERHEIM (Kristina)</s1></fA11><fA14 i1="01"><s1>Department of Oncology, St. Olavs Hospital, Trondheim University Hospital</s1><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Norwegian University of Science and Technology (NTNU), Department of Cancer Research and Molecular Medicine</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>School of Medicine and Pharmacology, University of Western Australia, QfEII Medical Centre Nedlands</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="04"><s1>Norwegian University of Science and Technology (NTNU), Department of Laboratory Medicine, Children's and Women's Health</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Pathology and Medical Genetics, St. Olavs Hospital, Trondheim University Hospital</s1><s3>NOR</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Norwegian University of Science and Technology (NTNU), Human Movement Science Programme</s1><s3>NOR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="08"><s1>The Cancer Registry of Norway</s1><s2>Oslo</s2><s3>NOR</s3><sZ>9 aut.</sZ></fA14><fA20><s1>235-243</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>21159</s2><s5>354000196288910130</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>65 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>08-0401056</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Lung cancer</s0></fA64><fA66 i1="01"><s0>IRL</s0></fA66><fC01 i1="01" l="ENG"><s0>Soluble mesothelin-related protein (SMRP) in serum is potentially a sensitive marker of malignant mesothelioma (MM) diagnosis and progression, and may be useful as screening marker. Mesothelin expression in tumors is regarded as a sensitive marker for diagnosis and disease progression, and is a candidate prognostic marker. Levels of SMRP, CA125 and CYFRA 21-1 in pre-diagnostic (1-30 years) serum samples from 47 mesothelioma cases and 141 matched controls were analysed. Mesothelin expression in tumors was assessed. The association between biomarker level and mesothelioma risk and survival was analysed, adjusting for asbestos exposure. Survival related to tumor mesothelin expression, age, sex, histological type, location, asbestos exposure and pre-clinical SMRP was analysed. There was no significant association between biomarker levels and mesothelioma risk when analysed as continuous variables or as tertiles. Biomarker levels <10, 10-19 and ≥20 years before diagnosis were not significantly associated to mesothelioma risk. Mesothelin expressed in >50% of tumor cells was seen in 36 of 47 (77%) tumors. Mesothelin expression in <50% of tumor cells was a significant negative prognostic marker in all cases of malignant mesothelioma (median survival=6 months vs. 12 months, hazard ratio (HR)=2.49, 95%CI 1.17-5.27), and also when only epithelial mesothelioma was analysed (median =6 months vs. 14 months, HR=2.36, 95%CI 1.07-5.22). When adjusted for age and gender, the prognosis was still dismal, but non-significant (HR=1.85, 95%CI 0.85-4.05). High age (>65 years) was an independent negative prognostic factor that was related to both mesothelin expression and asbestos exposure. Mesothelioma of the epithelial type of the peritoneum had a significantly longer survival than epithelial type in pleura and was also related to mesothelin expression.</s0></fC01><fC02 i1="01" i2="X"><s0>002B04</s0></fC02><fC02 i1="02" i2="X"><s0>002B11A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Mésothéliome malin</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Malignant mesothelioma</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Mesotelioma maligno</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Facteur prédictif</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Predictive factor</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Factor predictivo</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pronostic</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Prognosis</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Pronóstico</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Etude cas témoin</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Case control study</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Estudio caso control</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Immunohistochimie</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Immunohistochemistry</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Inmunohistoquímica</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Marqueur tumoral</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Tumoral marker</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Marcador tumoral</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Cancérologie</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Cancerology</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Cancerología</s0><s5>14</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Pneumologie</s0><s5>15</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Pneumology</s0><s5>15</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Neumología</s0><s5>15</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Tumeur maligne</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Malignant tumor</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Tumor maligno</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Cáncer</s0><s2>NM</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Anatomopathologie</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Anatomic pathology</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Anatomía patológica</s0><s5>38</s5></fC07><fN21><s1>259</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Australie</li><li>France</li><li>Norvège</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li><li>Trøndelag</li><li>Østlandet</li></region><settlement><li>Lyon</li><li>Oslo</li><li>Trondheim</li></settlement></list><tree><country name="Norvège"><noRegion><name sortKey="Roe, Oluf Dimitri" sort="Roe, Oluf Dimitri" uniqKey="Roe O" first="Oluf Dimitri" last="Roe">Oluf Dimitri Roe</name></noRegion><name sortKey="Kjaerheim, Kristina" sort="Kjaerheim, Kristina" uniqKey="Kjaerheim K" first="Kristina" last="Kjaerheim">Kristina Kjaerheim</name><name sortKey="Larsson, Erik" sort="Larsson, Erik" uniqKey="Larsson E" first="Erik" last="Larsson">Erik Larsson</name><name sortKey="Lundgren, Steinar" sort="Lundgren, Steinar" uniqKey="Lundgren S" first="Steinar" last="Lundgren">Steinar Lundgren</name><name sortKey="Lundgren, Steinar" sort="Lundgren, Steinar" uniqKey="Lundgren S" first="Steinar" last="Lundgren">Steinar Lundgren</name><name sortKey="Nilsen, Tom Ivar" sort="Nilsen, Tom Ivar" uniqKey="Nilsen T" first="Tom Ivar" last="Nilsen">Tom Ivar Nilsen</name><name sortKey="Roe, Oluf Dimitri" sort="Roe, Oluf Dimitri" uniqKey="Roe O" first="Oluf Dimitri" last="Roe">Oluf Dimitri Roe</name><name sortKey="Sandeck, Helmut" sort="Sandeck, Helmut" uniqKey="Sandeck H" first="Helmut" last="Sandeck">Helmut Sandeck</name></country><country name="Australie"><noRegion><name sortKey="Creaney, Jenette" sort="Creaney, Jenette" uniqKey="Creaney J" first="Jenette" last="Creaney">Jenette Creaney</name></noRegion><name sortKey="Robinson, Bruce" sort="Robinson, Bruce" uniqKey="Robinson B" first="Bruce" last="Robinson">Bruce Robinson</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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