Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study
Identifieur interne : 002C45 ( PascalFrancis/Checkpoint ); précédent : 002C44; suivant : 002C46Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study
Auteurs : David R. Murdoch [Nouvelle-Zélande] ; G. Ralph Corey [États-Unis] ; Bruno Hoen [France] ; José M. Miro [Espagne] ; Vance G. Jr Fowler [États-Unis] ; Arnold S. Bayer [États-Unis] ; Adolf W. Karchmer [États-Unis] ; Lars Olaison [Suède] ; Paul A. Pappas [États-Unis] ; Philippe Moreillon [Suisse] ; Stephen T. Chambers [Nouvelle-Zélande] ; Vivian H. Chu [États-Unis] ; Vicenc Falco [Espagne] ; David J. Holland [Nouvelle-Zélande] ; Philip Jones [Australie] ; John L. Klein [Royaume-Uni] ; Nigel J. Raymond [Nouvelle-Zélande] ; Kerry M. Read [Nouvelle-Zélande] ; Marie Francoise Tripodi [Italie] ; Riccardo Utili [Italie] ; Andrew Wang [États-Unis] ; Christopher W. Woods [États-Unis] ; Christopher H. Cabell [États-Unis]Source :
- Archives of internal medicine : (1960) [ 0003-9926 ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective, Santé publique, Médecine, Homme.
English descriptors
- KwdEn :
Abstract
Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.
Affiliations:
- Australie, Espagne, France, Italie, Nouvelle-Zélande, Royaume-Uni, Suisse, Suède, États-Unis
- Angleterre, Bourgogne-Franche-Comté, Canton de Vaud, Caroline du Nord, Catalogne, Franche-Comté, Grand Londres, Massachusetts, Nouvelle-Galles du Sud
- Barcelone, Besançon, Lausanne, Londres, Sydney
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Chambers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Otago</s1><s2>Christchurch</s2><s3>NZL</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. 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Holland</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Middlemore Hospital</s1><s3>NZL</s3><sZ>14 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Middlemore Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Philip" sort="Jones, Philip" uniqKey="Jones P" first="Philip" last="Jones">Philip Jones</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Klein, John L" sort="Klein, John L" uniqKey="Klein J" first="John L." last="Klein">John L. Klein</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Infection, St Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Raymond, Nigel J" sort="Raymond, Nigel J" uniqKey="Raymond N" first="Nigel J." last="Raymond">Nigel J. Raymond</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Wellington Hospital</s1><s2>Wellington</s2><s3>NZL</s3><sZ>17 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Wellington Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Read, Kerry M" sort="Read, Kerry M" uniqKey="Read K" first="Kerry M." last="Read">Kerry M. Read</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>North Shore Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>18 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>North Shore Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Francoise Tripodi, Marie" sort="Francoise Tripodi, Marie" uniqKey="Francoise Tripodi M" first="Marie" last="Francoise Tripodi">Marie Francoise Tripodi</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Utili, Riccardo" sort="Utili, Riccardo" uniqKey="Utili R" first="Riccardo" last="Utili">Riccardo Utili</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Andrew" sort="Wang, Andrew" uniqKey="Wang A" first="Andrew" last="Wang">Andrew Wang</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Cabell, Christopher H" sort="Cabell, Christopher H" uniqKey="Cabell C" first="Christopher H." last="Cabell">Christopher H. Cabell</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1><s2>Durham</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duke Clinical Research Institute</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0127281</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0127281 INIST</idno><idno type="RBID">Pascal:09-0127281</idno><idno type="wicri:Area/PascalFrancis/Corpus">002F57</idno><idno type="wicri:Area/PascalFrancis/Curation">003061</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002C45</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002C45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study</title><author><name sortKey="Murdoch, David R" sort="Murdoch, David R" uniqKey="Murdoch D" first="David R." last="Murdoch">David R. Murdoch</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Otago</s1><s2>Christchurch</s2><s3>NZL</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Corey, G Ralph" sort="Corey, G Ralph" uniqKey="Corey G" first="G. Ralph" last="Corey">G. Ralph Corey</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1><s2>Durham</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duke Clinical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Departments of Infectious Diseases, Hôpital Saint-Jacques</s1><s2>Besancon</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Miro, Jose M" sort="Miro, Jose M" uniqKey="Miro J" first="José M." last="Miro">José M. Miro</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Hospital Clinic-Institut d'lnvestigacions Biomèdiques August Pi I Sunyer, University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fowler, Vance G Jr" sort="Fowler, Vance G Jr" uniqKey="Fowler V" first="Vance G. Jr" last="Fowler">Vance G. Jr Fowler</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1><s2>Durham</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duke Clinical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S." last="Bayer">Arnold S. Bayer</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Divisions of Infectious Diseases, University of California, Los Angeles, Harbor Medical Center</s1><s2>Torrance</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Torrance</wicri:noRegion></affiliation></author><author><name sortKey="Karchmer, Adolf W" sort="Karchmer, Adolf W" uniqKey="Karchmer A" first="Adolf W." last="Karchmer">Adolf W. Karchmer</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Beth Israel-Deaconess Medical Center</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Olaison, Lars" sort="Olaison, Lars" uniqKey="Olaison L" first="Lars" last="Olaison">Lars Olaison</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Sahlgrenska University Hospital</s1><s2>Goteborg</s2><s3>SWE</s3><sZ>8 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Sahlgrenska University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Pappas, Paul A" sort="Pappas, Paul A" uniqKey="Pappas P" first="Paul A." last="Pappas">Paul A. Pappas</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1><s2>Durham</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duke Clinical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Moreillon, Philippe" sort="Moreillon, Philippe" uniqKey="Moreillon P" first="Philippe" last="Moreillon">Philippe Moreillon</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre Hospitalier Universitaire, University of Lausanne</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>10 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Chambers, Stephen T" sort="Chambers, Stephen T" uniqKey="Chambers S" first="Stephen T." last="Chambers">Stephen T. Chambers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, University of Otago</s1><s2>Christchurch</s2><s3>NZL</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Falco, Vicenc" sort="Falco, Vicenc" uniqKey="Falco V" first="Vicenc" last="Falco">Vicenc Falco</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Hospital Universitari Vall D'Hebron</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Holland, David J" sort="Holland, David J" uniqKey="Holland D" first="David J." last="Holland">David J. Holland</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Middlemore Hospital</s1><s3>NZL</s3><sZ>14 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Middlemore Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Philip" sort="Jones, Philip" uniqKey="Jones P" first="Philip" last="Jones">Philip Jones</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Klein, John L" sort="Klein, John L" uniqKey="Klein J" first="John L." last="Klein">John L. Klein</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Infection, St Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Raymond, Nigel J" sort="Raymond, Nigel J" uniqKey="Raymond N" first="Nigel J." last="Raymond">Nigel J. Raymond</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Wellington Hospital</s1><s2>Wellington</s2><s3>NZL</s3><sZ>17 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Wellington Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Read, Kerry M" sort="Read, Kerry M" uniqKey="Read K" first="Kerry M." last="Read">Kerry M. Read</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>North Shore Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>18 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>North Shore Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Francoise Tripodi, Marie" sort="Francoise Tripodi, Marie" uniqKey="Francoise Tripodi M" first="Marie" last="Francoise Tripodi">Marie Francoise Tripodi</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Utili, Riccardo" sort="Utili, Riccardo" uniqKey="Utili R" first="Riccardo" last="Utili">Riccardo Utili</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Andrew" sort="Wang, Andrew" uniqKey="Wang A" first="Andrew" last="Wang">Andrew Wang</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Cabell, Christopher H" sort="Cabell, Christopher H" uniqKey="Cabell C" first="Christopher H." last="Cabell">Christopher H. Cabell</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Duke Clinical Research Institute</s1><s2>Durham</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duke Clinical Research Institute</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Archives of internal medicine : (1960)</title><title level="j" type="abbreviated">Arch. intern. med. : (1960)</title><idno type="ISSN">0003-9926</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of internal medicine : (1960)</title><title level="j" type="abbreviated">Arch. intern. med. : (1960)</title><idno type="ISSN">0003-9926</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Century 21st</term><term>Cohort study</term><term>Endocarditis</term><term>Etiology</term><term>Evolution</term><term>Human</term><term>International</term><term>Medicine</term><term>Prognosis</term><term>Prospective</term><term>Public health</term><term>Symptomatology</term><term>World</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Endocardite</term><term>Symptomatologie</term><term>Etiologie</term><term>Evolution</term><term>Pronostic</term><term>Siècle 21eme</term><term>International</term><term>Monde</term><term>Prospective</term><term>Etude cohorte</term><term>Santé publique</term><term>Médecine</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term><term>Santé publique</term><term>Médecine</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0003-9926</s0></fA01><fA02 i1="01"><s0>AIMDAP</s0></fA02><fA03 i2="1"><s0>Arch. intern. med. : (1960)</s0></fA03><fA05><s2>169</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century : The International Collaboration on Endocarditis-Prospective Cohort Study</s1></fA08><fA11 i1="01" i2="1"><s1>MURDOCH (David R.)</s1></fA11><fA11 i1="02" i2="1"><s1>COREY (G. Ralph)</s1></fA11><fA11 i1="03" i2="1"><s1>HOEN (Bruno)</s1></fA11><fA11 i1="04" i2="1"><s1>MIRO (José M.)</s1></fA11><fA11 i1="05" i2="1"><s1>FOWLER (Vance G. JR)</s1></fA11><fA11 i1="06" i2="1"><s1>BAYER (Arnold S.)</s1></fA11><fA11 i1="07" i2="1"><s1>KARCHMER (Adolf W.)</s1></fA11><fA11 i1="08" i2="1"><s1>OLAISON (Lars)</s1></fA11><fA11 i1="09" i2="1"><s1>PAPPAS (Paul A.)</s1></fA11><fA11 i1="10" i2="1"><s1>MOREILLON (Philippe)</s1></fA11><fA11 i1="11" i2="1"><s1>CHAMBERS (Stephen T.)</s1></fA11><fA11 i1="12" i2="1"><s1>CHU (Vivian H.)</s1></fA11><fA11 i1="13" i2="1"><s1>FALCO (Vicenc)</s1></fA11><fA11 i1="14" i2="1"><s1>HOLLAND (David J.)</s1></fA11><fA11 i1="15" i2="1"><s1>JONES (Philip)</s1></fA11><fA11 i1="16" i2="1"><s1>KLEIN (John L.)</s1></fA11><fA11 i1="17" i2="1"><s1>RAYMOND (Nigel J.)</s1></fA11><fA11 i1="18" i2="1"><s1>READ (Kerry M.)</s1></fA11><fA11 i1="19" i2="1"><s1>FRANCOISE TRIPODI (Marie)</s1></fA11><fA11 i1="20" i2="1"><s1>UTILI (Riccardo)</s1></fA11><fA11 i1="21" i2="1"><s1>WANG (Andrew)</s1></fA11><fA11 i1="22" i2="1"><s1>WOODS (Christopher W.)</s1></fA11><fA11 i1="23" i2="1"><s1>CABELL (Christopher H.)</s1></fA11><fA14 i1="01"><s1>Department of Pathology, University of Otago</s1><s2>Christchurch</s2><s3>NZL</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="02"><s1>Departments of Medicine, Duke University Medical Center</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="03"><s1>Duke Clinical Research Institute</s1><s2>Durham</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="04"><s1>Departments of Infectious Diseases, Hôpital Saint-Jacques</s1><s2>Besancon</s2><s3>FRA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Hospital Clinic-Institut d'lnvestigacions Biomèdiques August Pi I Sunyer, University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>4 aut.</sZ></fA14><fA14 i1="06"><s1>Divisions of Infectious Diseases, University of California, Los Angeles, Harbor Medical Center</s1><s2>Torrance</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Beth Israel-Deaconess Medical Center</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="08"><s1>Sahlgrenska University Hospital</s1><s2>Goteborg</s2><s3>SWE</s3><sZ>8 aut.</sZ></fA14><fA14 i1="09"><s1>Centre Hospitalier Universitaire, University of Lausanne</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>10 aut.</sZ></fA14><fA14 i1="10"><s1>Hospital Universitari Vall D'Hebron</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ></fA14><fA14 i1="11"><s1>Middlemore Hospital</s1><s3>NZL</s3><sZ>14 aut.</sZ></fA14><fA14 i1="12"><s1>University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>15 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Infection, St Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></fA14><fA14 i1="14"><s1>Wellington Hospital</s1><s2>Wellington</s2><s3>NZL</s3><sZ>17 aut.</sZ></fA14><fA14 i1="15"><s1>North Shore Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>18 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Cardiothoracic and Respiratory Services, Second University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators</s1><s3>INC</s3></fA17><fA20><s1>463-473</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>2040</s2><s5>354000187278500070</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>41 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0127281</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Archives of internal medicine : (1960)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Methods: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. Results: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hall-marks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. Conclusions: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.</s0></fC01><fC02 i1="01" i2="X"><s0>002B30A03C</s0></fC02><fC02 i1="02" i2="X"><s0>002B01</s0></fC02><fC02 i1="03" i2="X"><s0>002B12A04</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Endocardite</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Endocarditis</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Endocarditis</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Symptomatologie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Symptomatology</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sintomatología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Etiologie</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Etiology</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Etiología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Evolution</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Evolution</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Evolución</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Pronostic</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Prognosis</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Pronóstico</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Siècle 21eme</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Century 21st</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Siglo 21</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>International</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>International</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Internacional</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Monde</s0><s2>NG</s2><s5>11</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>World</s0><s2>NG</s2><s5>11</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Mundo</s0><s2>NG</s2><s5>11</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Prospective</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Prospective</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Prospectiva</s0><s5>12</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Etude cohorte</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Cohort study</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Estudio cohorte</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Santé publique</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Public health</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Salud pública</s0><s5>18</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Médecine</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Medicine</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Medicina</s0><s5>19</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Homme</s0><s5>25</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Human</s0><s5>25</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Hombre</s0><s5>25</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Cardiopathie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Heart disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Cardiopatía</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'endocarde</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Endocardial disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Endocardio patología</s0><s5>39</s5></fC07><fN21><s1>089</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bourgogne-Franche-Comté</li><li>Canton de Vaud</li><li>Caroline du Nord</li><li>Catalogne</li><li>Franche-Comté</li><li>Grand Londres</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Barcelone</li><li>Besançon</li><li>Lausanne</li><li>Londres</li><li>Sydney</li></settlement></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Murdoch, David R" sort="Murdoch, David R" uniqKey="Murdoch D" first="David R." last="Murdoch">David R. Murdoch</name></noRegion><name sortKey="Chambers, Stephen T" sort="Chambers, Stephen T" uniqKey="Chambers S" first="Stephen T." last="Chambers">Stephen T. Chambers</name><name sortKey="Holland, David J" sort="Holland, David J" uniqKey="Holland D" first="David J." last="Holland">David J. Holland</name><name sortKey="Raymond, Nigel J" sort="Raymond, Nigel J" uniqKey="Raymond N" first="Nigel J." last="Raymond">Nigel J. Raymond</name><name sortKey="Read, Kerry M" sort="Read, Kerry M" uniqKey="Read K" first="Kerry M." last="Read">Kerry M. Read</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Corey, G Ralph" sort="Corey, G Ralph" uniqKey="Corey G" first="G. Ralph" last="Corey">G. Ralph Corey</name></region><name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S." last="Bayer">Arnold S. Bayer</name><name sortKey="Cabell, Christopher H" sort="Cabell, Christopher H" uniqKey="Cabell C" first="Christopher H." last="Cabell">Christopher H. Cabell</name><name sortKey="Cabell, Christopher H" sort="Cabell, Christopher H" uniqKey="Cabell C" first="Christopher H." last="Cabell">Christopher H. Cabell</name><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name><name sortKey="Corey, G Ralph" sort="Corey, G Ralph" uniqKey="Corey G" first="G. Ralph" last="Corey">G. Ralph Corey</name><name sortKey="Fowler, Vance G Jr" sort="Fowler, Vance G Jr" uniqKey="Fowler V" first="Vance G. Jr" last="Fowler">Vance G. Jr Fowler</name><name sortKey="Fowler, Vance G Jr" sort="Fowler, Vance G Jr" uniqKey="Fowler V" first="Vance G. Jr" last="Fowler">Vance G. Jr Fowler</name><name sortKey="Karchmer, Adolf W" sort="Karchmer, Adolf W" uniqKey="Karchmer A" first="Adolf W." last="Karchmer">Adolf W. Karchmer</name><name sortKey="Karchmer, Adolf W" sort="Karchmer, Adolf W" uniqKey="Karchmer A" first="Adolf W." last="Karchmer">Adolf W. Karchmer</name><name sortKey="Pappas, Paul A" sort="Pappas, Paul A" uniqKey="Pappas P" first="Paul A." last="Pappas">Paul A. Pappas</name><name sortKey="Wang, Andrew" sort="Wang, Andrew" uniqKey="Wang A" first="Andrew" last="Wang">Andrew Wang</name><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name></country><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Miro, Jose M" sort="Miro, Jose M" uniqKey="Miro J" first="José M." last="Miro">José M. Miro</name></region><name sortKey="Falco, Vicenc" sort="Falco, Vicenc" uniqKey="Falco V" first="Vicenc" last="Falco">Vicenc Falco</name></country><country name="Suède"><noRegion><name sortKey="Olaison, Lars" sort="Olaison, Lars" uniqKey="Olaison L" first="Lars" last="Olaison">Lars Olaison</name></noRegion></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Moreillon, Philippe" sort="Moreillon, Philippe" uniqKey="Moreillon P" first="Philippe" last="Moreillon">Philippe Moreillon</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Jones, Philip" sort="Jones, Philip" uniqKey="Jones P" first="Philip" last="Jones">Philip Jones</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Klein, John L" sort="Klein, John L" uniqKey="Klein J" first="John L." last="Klein">John L. Klein</name></region></country><country name="Italie"><noRegion><name sortKey="Francoise Tripodi, Marie" sort="Francoise Tripodi, Marie" uniqKey="Francoise Tripodi M" first="Marie" last="Francoise Tripodi">Marie Francoise Tripodi</name></noRegion><name sortKey="Utili, Riccardo" sort="Utili, Riccardo" uniqKey="Utili R" first="Riccardo" last="Utili">Riccardo Utili</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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