AustralieFrV1, PascalFrancis, Checkpoint, bibRecord, 001637

Synaptic plasticity based model for epileptic seizures

Identifieur interne : 001637 ( PascalFrancis/Checkpoint ); précédent : 001636; suivant : 001638

Synaptic plasticity based model for epileptic seizures

Auteurs : Mazen Alamir [France] ; James S. Welsh [Australie] ; Graham C. Goodwin [Australie]

Source :

Automatica : (Oxford) [ 0005-1098 ] ; 2011.

RBID : Pascal:11-0301283

Descripteurs français

Pascal (Inist)
- Homme, Commande boucle fermée, Synchronisation, Plasticité synaptique, Système nerveux central, Epilepsie, Cerveau, Encéphale, Oscillateur couplé, Modèle non linéaire, Synapse, Electroencéphalographie, Modélisation, Modèle dynamique, Bifurcation, Etude expérimentale, Rétroaction, ..
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Bifurcation, Brain, Central nervous system, Closed feedback, Coupled oscillator, Dynamic model, Electroencephalography, Encephalon, Epilepsy, Experimental study, Feedback regulation, Human, Modeling, Non linear model, Synapse, Synaptic plasticity, Synchronization.

Abstract

In this paper, a new dynamic model describing the epileptic seizure initiation through transition from interictal to ictal state in a brain predisposed to epilepsy is suggested. The model follows Freeman's approach where the brain is viewed as a network of interconnected oscillators. The proposed nonlinear model is experimentally motivated and relies on changes in synaptic strength in response to excitatory spikes. This model exhibits a threshold beyond which a bifurcation toward a short-term plasticity state occurs leading to seizure onset. A resulting explanatory assumption is that when considering epilepsy, brain regions are characterized by abnormally low thresholds toward short-term synaptic plasticity. It is shown by simulation that the proposed model enables some experimentally observed qualitative features to be reproduced. Moreover, a preliminary discussion on the impact of the underlying assumptions on the fundamental issue of seizure control is proposed through an EEG based feedback control scheme.

Affiliations:

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Le document en format XML

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Synaptic plasticity based model for epileptic seizures

Synaptic plasticity based model for epileptic seizures

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Descripteurs français

English descriptors

Abstract

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