Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms
Identifieur interne : 001278 ( PascalFrancis/Checkpoint ); précédent : 001277; suivant : 001279Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms
Auteurs : Hervé Ghesquieres [France] ; Guillaume Cartron [France] ; John Francis Seymour [Australie] ; Marie-Hélène Delfau-Larue [France] ; Fritz Offner [Belgique] ; Pierre Soubeyran [France] ; Aurore Perrot [France] ; Pauline Brice [France] ; Réda Bouabdallah [France] ; Anne Sonet [Belgique] ; Jehan Dupuis [France] ; Olivier Casasnovas [France] ; John Vincent Catalano [Australie] ; Alain Delmer [France] ; Fabrice Jardin [France] ; Aurélie Verney [France] ; Peggy Dartigues [France] ; Gilles Salles [France]Source :
- Blood [ 0006-4971 ] ; 2012.
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Abstract
In patients with follicular lymphoma treated with single-agent rituximab, single nucleotide polymorphisms in the FCGR3A gene are known to influence response and progression-free survival. The prognostic role of FCGR3A and FCGR2A polymorphisms in patients with follicular lymphoma treated with rituximab and chemotherapy combination remains controversial and has not been evaluated in the context of rituximab maintenance. FCGR3A and FCGR2A single nucleotide polymorphisms were evaluated in, respectively, 460 and 455 patients treated in the PRIMA study to investigate whether these were associated with response rate and patient outcome after rituximab chemotherapy induction and 2-year rituximab maintenance. In this representative patient cohort, complete and unconfirmed complete responses after rituximab chemotherapy were observed in 65%, 67%, 66% (P = .86) and 60%, 72%, 66% (P = .21) of FCGR3A VV, VF, FF and FCGR2A HH, HR, RR carriers, respectively. After 2 years of rituximab maintenance (or observation), response rates did not differ among the different genotypes. Progression-free survival measured from either treatment initiation or randomization to observation or maintenance was not influenced by these polymorphisms. These data indicate that FCGR3A and FCGR2A polymorphisms do not influence response rate and outcome when rituximab is combined with chemotherapy or used as maintenance treatment. The PRIMA study is registered at www.clinicaltrials.gov as NCT00140582.
Affiliations:
- Australie, Belgique, France
- Aquitaine, Auvergne-Rhône-Alpes, Bourgogne, Bourgogne-Franche-Comté, Champagne-Ardenne, Grand Est, Haute-Normandie, Languedoc-Roussillon, Lorraine (région), Nouvelle-Aquitaine, Occitanie (région administrative), Provence-Alpes-Côte d'Azur, Province de Flandre-Orientale, Rhône-Alpes, Région Normandie, Région flamande, Victoria (État), Île-de-France
- Bordeaux, Créteil, Dijon, Gand, Lyon, Marseille, Melbourne, Montpellier, Nancy, Paris, Reims, Rouen
- Université de Gand, Université de Melbourne
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type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bouabdallah, Reda" sort="Bouabdallah, Reda" uniqKey="Bouabdallah R" first="Réda" last="Bouabdallah">Réda Bouabdallah</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institut Paoli Calmettes</s1><s2>Marseille</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>UCL, MT-Godinne</s1><s2>Yvoir</s2><s3>BEL</s3><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Yvoir</wicri:noRegion></affiliation></author><author><name sortKey="Dupuis, Jehan" sort="Dupuis, Jehan" uniqKey="Dupuis J" 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Vincent" last="Catalano">John Vincent Catalano</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Frankston Hospital</s1><s2>Frankston</s2><s3>AUS</s3><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Frankston Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Delmer, Alain" sort="Delmer, Alain" uniqKey="Delmer A" first="Alain" last="Delmer">Alain Delmer</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>CHU de Reims</s1><s2>Reims</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Jardin, Fabrice" sort="Jardin, Fabrice" uniqKey="Jardin F" first="Fabrice" last="Jardin">Fabrice Jardin</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Centre Henri Becquerel and UMR Inserm U918</s1><s2>Rouen</s2><s3>FRA</s3><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Verney, Aurelie" sort="Verney, Aurelie" uniqKey="Verney A" first="Aurélie" last="Verney">Aurélie Verney</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dartigues, Peggy" sort="Dartigues, Peggy" uniqKey="Dartigues P" first="Peggy" last="Dartigues">Peggy Dartigues</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Hospices Civils de Lyon</s1><s2>Pierre-Benite</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre-Benite</wicri:noRegion><wicri:noRegion>Hospices Civils de Lyon</wicri:noRegion><wicri:noRegion>Hospices Civils de Lyon</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0398695</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0398695 INIST</idno><idno type="RBID">Pascal:12-0398695</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F42</idno><idno type="wicri:Area/PascalFrancis/Curation">004F79</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001278</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms</title><author><name sortKey="Ghesquieres, Herve" sort="Ghesquieres, Herve" uniqKey="Ghesquieres H" first="Hervé" last="Ghesquieres">Hervé Ghesquieres</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre Leon Bérard</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Cartron, Guillaume" sort="Cartron, Guillaume" uniqKey="Cartron G" first="Guillaume" last="Cartron">Guillaume Cartron</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département d'Hématologie, Centre Hospitalier Universitaire (CHU), Montpellier UMR-CNRS5235</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Seymour, John Francis" sort="Seymour, John Francis" uniqKey="Seymour J" first="John Francis" last="Seymour">John Francis Seymour</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Peter MacCallum Cancer Centre and University of Melbourne</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Delfau Larue, Marie Helene" sort="Delfau Larue, Marie Helene" uniqKey="Delfau Larue M" first="Marie-Hélène" last="Delfau-Larue">Marie-Hélène Delfau-Larue</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>CHU Henri Mondor</s1><s2>Créteil</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Offner, Fritz" sort="Offner, Fritz" uniqKey="Offner F" first="Fritz" last="Offner">Fritz Offner</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Ghent University</s1><s2>Ghent</s2><s3>BEL</s3><sZ>5 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Soubeyran, Pierre" sort="Soubeyran, Pierre" uniqKey="Soubeyran P" first="Pierre" last="Soubeyran">Pierre Soubeyran</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Institut Bergonié and Université Victor Segalen Bordeaux 2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Perrot, Aurore" sort="Perrot, Aurore" uniqKey="Perrot A" first="Aurore" last="Perrot">Aurore Perrot</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>CHU de Nancy</s1><s2>Nancy</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Brice, Pauline" sort="Brice, Pauline" uniqKey="Brice P" first="Pauline" last="Brice">Pauline Brice</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bouabdallah, Reda" sort="Bouabdallah, Reda" uniqKey="Bouabdallah R" first="Réda" last="Bouabdallah">Réda Bouabdallah</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institut Paoli Calmettes</s1><s2>Marseille</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>UCL, MT-Godinne</s1><s2>Yvoir</s2><s3>BEL</s3><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Yvoir</wicri:noRegion></affiliation></author><author><name sortKey="Dupuis, Jehan" sort="Dupuis, Jehan" uniqKey="Dupuis J" first="Jehan" last="Dupuis">Jehan Dupuis</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>CHU Henri Mondor</s1><s2>Créteil</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Casasnovas, Olivier" sort="Casasnovas, Olivier" uniqKey="Casasnovas O" first="Olivier" last="Casasnovas">Olivier Casasnovas</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>CHU de Dijon</s1><s2>Dijon</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Catalano, John Vincent" sort="Catalano, John Vincent" uniqKey="Catalano J" first="John Vincent" last="Catalano">John Vincent Catalano</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Frankston Hospital</s1><s2>Frankston</s2><s3>AUS</s3><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Frankston Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Delmer, Alain" sort="Delmer, Alain" uniqKey="Delmer A" first="Alain" last="Delmer">Alain Delmer</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>CHU de Reims</s1><s2>Reims</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Jardin, Fabrice" sort="Jardin, Fabrice" uniqKey="Jardin F" first="Fabrice" last="Jardin">Fabrice Jardin</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Centre Henri Becquerel and UMR Inserm U918</s1><s2>Rouen</s2><s3>FRA</s3><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Verney, Aurelie" sort="Verney, Aurelie" uniqKey="Verney A" first="Aurélie" last="Verney">Aurélie Verney</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dartigues, Peggy" sort="Dartigues, Peggy" uniqKey="Dartigues P" first="Peggy" last="Dartigues">Peggy Dartigues</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Hospices Civils de Lyon</s1><s2>Pierre-Benite</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre-Benite</wicri:noRegion><wicri:noRegion>Hospices Civils de Lyon</wicri:noRegion><wicri:noRegion>Hospices Civils de Lyon</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>B cell neoplasm</term><term>Follicular lymphoma</term><term>Genetic variability</term><term>Genotype</term><term>Hematology</term><term>Human</term><term>Lymphoid neoplasm</term><term>Polymorphism</term><term>Prognosis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lymphome folliculaire</term><term>Pronostic</term><term>Homme</term><term>Polymorphisme</term><term>Variabilité génétique</term><term>Génotype</term><term>Hématologie</term><term>Gène FCGR3A</term><term>Gène FCGR2A</term><term>Hémopathie maligne lymphoïde</term><term>Hémopathie lymphoïde B</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In patients with follicular lymphoma treated with single-agent rituximab, single nucleotide polymorphisms in the FCGR3A gene are known to influence response and progression-free survival. The prognostic role of FCGR3A and FCGR2A polymorphisms in patients with follicular lymphoma treated with rituximab and chemotherapy combination remains controversial and has not been evaluated in the context of rituximab maintenance. FCGR3A and FCGR2A single nucleotide polymorphisms were evaluated in, respectively, 460 and 455 patients treated in the PRIMA study to investigate whether these were associated with response rate and patient outcome after rituximab chemotherapy induction and 2-year rituximab maintenance. In this representative patient cohort, complete and unconfirmed complete responses after rituximab chemotherapy were observed in 65%, 67%, 66% (P = .86) and 60%, 72%, 66% (P = .21) of FCGR3A VV, VF, FF and FCGR2A HH, HR, RR carriers, respectively. After 2 years of rituximab maintenance (or observation), response rates did not differ among the different genotypes. Progression-free survival measured from either treatment initiation or randomization to observation or maintenance was not influenced by these polymorphisms. These data indicate that FCGR3A and FCGR2A polymorphisms do not influence response rate and outcome when rituximab is combined with chemotherapy or used as maintenance treatment. The PRIMA study is registered at www.clinicaltrials.gov as NCT00140582.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0006-4971</s0></fA01><fA03 i2="1"><s0>Blood</s0></fA03><fA05><s2>120</s2></fA05><fA06><s2>13</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms</s1></fA08><fA11 i1="01" i2="1"><s1>GHESQUIERES (Hervé)</s1></fA11><fA11 i1="02" i2="1"><s1>CARTRON (Guillaume)</s1></fA11><fA11 i1="03" i2="1"><s1>SEYMOUR (John Francis)</s1></fA11><fA11 i1="04" i2="1"><s1>DELFAU-LARUE (Marie-Hélène)</s1></fA11><fA11 i1="05" i2="1"><s1>OFFNER (Fritz)</s1></fA11><fA11 i1="06" i2="1"><s1>SOUBEYRAN (Pierre)</s1></fA11><fA11 i1="07" i2="1"><s1>PERROT (Aurore)</s1></fA11><fA11 i1="08" i2="1"><s1>BRICE (Pauline)</s1></fA11><fA11 i1="09" i2="1"><s1>BOUABDALLAH (Réda)</s1></fA11><fA11 i1="10" i2="1"><s1>SONET (Anne)</s1></fA11><fA11 i1="11" i2="1"><s1>DUPUIS (Jehan)</s1></fA11><fA11 i1="12" i2="1"><s1>CASASNOVAS (Olivier)</s1></fA11><fA11 i1="13" i2="1"><s1>CATALANO (John Vincent)</s1></fA11><fA11 i1="14" i2="1"><s1>DELMER (Alain)</s1></fA11><fA11 i1="15" i2="1"><s1>JARDIN (Fabrice)</s1></fA11><fA11 i1="16" i2="1"><s1>VERNEY (Aurélie)</s1></fA11><fA11 i1="17" i2="1"><s1>DARTIGUES (Peggy)</s1></fA11><fA11 i1="18" i2="1"><s1>SALLES (Gilles)</s1></fA11><fA14 i1="01"><s1>Centre Leon Bérard</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="03"><s1>Département d'Hématologie, Centre Hospitalier Universitaire (CHU), Montpellier UMR-CNRS5235</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Peter MacCallum Cancer Centre and University of Melbourne</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>CHU Henri Mondor</s1><s2>Créteil</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="06"><s1>Ghent University</s1><s2>Ghent</s2><s3>BEL</s3><sZ>5 aut.</sZ></fA14><fA14 i1="07"><s1>Institut Bergonié and Université Victor Segalen Bordeaux 2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>6 aut.</sZ></fA14><fA14 i1="08"><s1>CHU de Nancy</s1><s2>Nancy</s2><s3>FRA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="09"><s1>Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="10"><s1>Institut Paoli Calmettes</s1><s2>Marseille</s2><s3>FRA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="11"><s1>UCL, MT-Godinne</s1><s2>Yvoir</s2><s3>BEL</s3><sZ>10 aut.</sZ></fA14><fA14 i1="12"><s1>CHU de Dijon</s1><s2>Dijon</s2><s3>FRA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="13"><s1>Frankston Hospital</s1><s2>Frankston</s2><s3>AUS</s3><sZ>13 aut.</sZ></fA14><fA14 i1="14"><s1>CHU de Reims</s1><s2>Reims</s2><s3>FRA</s3><sZ>14 aut.</sZ></fA14><fA14 i1="15"><s1>Centre Henri Becquerel and UMR Inserm U918</s1><s2>Rouen</s2><s3>FRA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="16"><s1>Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="17"><s1>Hospices Civils de Lyon</s1><s2>Pierre-Benite</s2><s3>FRA</s3><sZ>18 aut.</sZ></fA14><fA20><s1>2650-2657</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>3178</s2><s5>354000505325150170</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>48 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0398695</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Blood</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>In patients with follicular lymphoma treated with single-agent rituximab, single nucleotide polymorphisms in the FCGR3A gene are known to influence response and progression-free survival. The prognostic role of FCGR3A and FCGR2A polymorphisms in patients with follicular lymphoma treated with rituximab and chemotherapy combination remains controversial and has not been evaluated in the context of rituximab maintenance. FCGR3A and FCGR2A single nucleotide polymorphisms were evaluated in, respectively, 460 and 455 patients treated in the PRIMA study to investigate whether these were associated with response rate and patient outcome after rituximab chemotherapy induction and 2-year rituximab maintenance. In this representative patient cohort, complete and unconfirmed complete responses after rituximab chemotherapy were observed in 65%, 67%, 66% (P = .86) and 60%, 72%, 66% (P = .21) of FCGR3A VV, VF, FF and FCGR2A HH, HR, RR carriers, respectively. After 2 years of rituximab maintenance (or observation), response rates did not differ among the different genotypes. Progression-free survival measured from either treatment initiation or randomization to observation or maintenance was not influenced by these polymorphisms. These data indicate that FCGR3A and FCGR2A polymorphisms do not influence response rate and outcome when rituximab is combined with chemotherapy or used as maintenance treatment. The PRIMA study is registered at www.clinicaltrials.gov as NCT00140582.</s0></fC01><fC02 i1="01" i2="X"><s0>002B19B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Lymphome folliculaire</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Follicular lymphoma</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Linfoma folicular</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pronostic</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Prognosis</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Pronóstico</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Homme</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Human</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Hombre</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Polymorphisme</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Polymorphism</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Polimorfismo</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Variabilité génétique</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Genetic variability</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Variabilidad genética</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Génotype</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Genotype</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Genotipo</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Hématologie</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Hematology</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Hematología</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Gène FCGR3A</s0><s4>INC</s4><s5>86</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Gène FCGR2A</s0><s4>INC</s4><s5>87</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Hémopathie maligne lymphoïde</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Lymphoid neoplasm</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Hémopathie lymphoïde B</s0><s4>CD</s4><s5>97</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>B cell neoplasm</s0><s4>CD</s4><s5>97</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Hémopathie maligne</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Malignant hemopathy</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hemopatía maligna</s0><s2>NM</s2><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Cáncer</s0><s2>NM</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Lymphome non hodgkinien</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Non Hodgkin lymphoma</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Linfoma no Hodgkin</s0><s5>38</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Syndrome lymphoprolifératif</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Lymphoproliferative syndrome</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Linfoproliferativo síndrome</s0><s2>NM</s2><s5>39</s5></fC07><fN21><s1>310</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li></country><region><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Champagne-Ardenne</li><li>Grand Est</li><li>Haute-Normandie</li><li>Languedoc-Roussillon</li><li>Lorraine (région)</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li><li>Provence-Alpes-Côte d'Azur</li><li>Province de Flandre-Orientale</li><li>Rhône-Alpes</li><li>Région Normandie</li><li>Région flamande</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Bordeaux</li><li>Créteil</li><li>Dijon</li><li>Gand</li><li>Lyon</li><li>Marseille</li><li>Melbourne</li><li>Montpellier</li><li>Nancy</li><li>Paris</li><li>Reims</li><li>Rouen</li></settlement><orgName><li>Université de Gand</li><li>Université de Melbourne</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Ghesquieres, Herve" sort="Ghesquieres, Herve" uniqKey="Ghesquieres H" first="Hervé" last="Ghesquieres">Hervé Ghesquieres</name></region><name sortKey="Bouabdallah, Reda" sort="Bouabdallah, Reda" uniqKey="Bouabdallah R" first="Réda" last="Bouabdallah">Réda Bouabdallah</name><name sortKey="Brice, Pauline" sort="Brice, Pauline" uniqKey="Brice P" first="Pauline" last="Brice">Pauline Brice</name><name sortKey="Cartron, Guillaume" sort="Cartron, Guillaume" uniqKey="Cartron G" first="Guillaume" last="Cartron">Guillaume Cartron</name><name sortKey="Casasnovas, Olivier" sort="Casasnovas, Olivier" uniqKey="Casasnovas O" first="Olivier" last="Casasnovas">Olivier Casasnovas</name><name sortKey="Dartigues, Peggy" sort="Dartigues, Peggy" uniqKey="Dartigues P" first="Peggy" last="Dartigues">Peggy Dartigues</name><name sortKey="Delfau Larue, Marie Helene" sort="Delfau Larue, Marie Helene" uniqKey="Delfau Larue M" first="Marie-Hélène" last="Delfau-Larue">Marie-Hélène Delfau-Larue</name><name sortKey="Delmer, Alain" sort="Delmer, Alain" uniqKey="Delmer A" first="Alain" last="Delmer">Alain Delmer</name><name sortKey="Dupuis, Jehan" sort="Dupuis, Jehan" uniqKey="Dupuis J" first="Jehan" last="Dupuis">Jehan Dupuis</name><name sortKey="Ghesquieres, Herve" sort="Ghesquieres, Herve" uniqKey="Ghesquieres H" first="Hervé" last="Ghesquieres">Hervé Ghesquieres</name><name sortKey="Jardin, Fabrice" sort="Jardin, Fabrice" uniqKey="Jardin F" first="Fabrice" last="Jardin">Fabrice Jardin</name><name sortKey="Perrot, Aurore" sort="Perrot, Aurore" uniqKey="Perrot A" first="Aurore" last="Perrot">Aurore Perrot</name><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><name sortKey="Soubeyran, Pierre" sort="Soubeyran, Pierre" uniqKey="Soubeyran P" first="Pierre" last="Soubeyran">Pierre Soubeyran</name><name sortKey="Verney, Aurelie" sort="Verney, Aurelie" uniqKey="Verney A" first="Aurélie" last="Verney">Aurélie Verney</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Seymour, John Francis" sort="Seymour, John Francis" uniqKey="Seymour J" first="John Francis" last="Seymour">John Francis Seymour</name></region><name sortKey="Catalano, John Vincent" sort="Catalano, John Vincent" uniqKey="Catalano J" first="John Vincent" last="Catalano">John Vincent Catalano</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Offner, Fritz" sort="Offner, Fritz" uniqKey="Offner F" first="Fritz" last="Offner">Fritz Offner</name></region><name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name></country></tree></affiliations></record>Pour 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