Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses
Identifieur interne : 000A82 ( PascalFrancis/Checkpoint ); précédent : 000A81; suivant : 000A83Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses
Auteurs : Bruno Bezerril Andrade [France] ; Katherine Huppler Hullsiek [États-Unis] ; David R. Boulware [États-Unis] ; Adam Rupert [États-Unis] ; Martyn A. French [Australie] ; Kiat Ruxrungtham [Thaïlande] ; Marisa Luisa Montes [Espagne] ; Huw Price [Royaume-Uni] ; Pablo Barreiro [Espagne] ; Jennifer Audsley [Australie] ; Alan Sher [France] ; Sharon R. Lewin [Australie] ; Irini Sereti [France]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
Abstract
Background. Hepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation. Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/ or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated. Results. Forty-eight deaths and 50 hepatitis flares occurred. Nonsurvivors were older, had more prior AIDS-defining events, and had higher pre-ART triglycerides and aspartate transaminase levels. Detectable hyaluronic acid and higher D-dimer, interleukin 6, interleukin 8, and soluble CD14 levels were associated with death in uni-variate models and with a composite biomarker risk score. The risk of hepatitis flares was higher with HBV coinfection only (24.3%) and with HBV and HCV coinfection (50%) than with HCV coinfection only (13.5%). Higher levels of alanine transaminase and interleukin 10 were also associated with hepatitis flares. Conclusions. Among HIV-positive patients coinfected with HBV and/or HCV who are initiating ART, biomarkers of inflammation and coagulation are associated with an increased risk of death, whereas HBV coinfection and higher pre-ART interleukin 10 levels are associated with hepatitis flares.
Affiliations:
- Australie, Espagne, France, Royaume-Uni, Thaïlande, États-Unis
- Angleterre, Communauté de Madrid, Grand Londres, Maryland, Victoria (État)
- Londres, Madrid, Melbourne
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Pascal:13-0155987Le document en format XML
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<author><name sortKey="Bezerril Andrade, Bruno" sort="Bezerril Andrade, Bruno" uniqKey="Bezerril Andrade B" first="Bruno" last="Bezerril Andrade">Bruno Bezerril Andrade</name>
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<author><name sortKey="Huppler Hullsiek, Katherine" sort="Huppler Hullsiek, Katherine" uniqKey="Huppler Hullsiek K" first="Katherine" last="Huppler Hullsiek">Katherine Huppler Hullsiek</name>
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<author><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R." last="Boulware">David R. Boulware</name>
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<author><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A." last="French">Martyn A. French</name>
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<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Monash University</s1>
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<author><name sortKey="Sher, Alan" sort="Sher, Alan" uniqKey="Sher A" first="Alan" last="Sher">Alan Sher</name>
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<author><name sortKey="Sereti, Irini" sort="Sereti, Irini" uniqKey="Sereti I" first="Irini" last="Sereti">Irini Sereti</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses</title>
<author><name sortKey="Bezerril Andrade, Bruno" sort="Bezerril Andrade, Bruno" uniqKey="Bezerril Andrade B" first="Bruno" last="Bezerril Andrade">Bruno Bezerril Andrade</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health</s1>
<s2>Bethesda</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Bethesda</wicri:noRegion>
<wicri:noRegion>National Institutes of Health</wicri:noRegion>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huppler Hullsiek, Katherine" sort="Huppler Hullsiek, Katherine" uniqKey="Huppler Hullsiek K" first="Katherine" last="Huppler Hullsiek">Katherine Huppler Hullsiek</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Minnesota</s1>
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<author><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R." last="Boulware">David R. Boulware</name>
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<author><name sortKey="Rupert, Adam" sort="Rupert, Adam" uniqKey="Rupert A" first="Adam" last="Rupert">Adam Rupert</name>
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</placeName>
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<author><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A." last="French">Martyn A. French</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
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</affiliation>
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<author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name>
<affiliation><inist:fA14 i1="05"><s1>Faculty of Medicine, Chulalongkorn University</s1>
<s3>INC</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<wicri:noCountry>INC</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>HIV-NAT, Thai Red Cross AIDS Research Center</s1>
<s2>Bangkok</s2>
<s3>THA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Thaïlande</country>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montes, Marisa Luisa" sort="Montes, Marisa Luisa" uniqKey="Montes M" first="Marisa Luisa" last="Montes">Marisa Luisa Montes</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Hospital La Paz</s1>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Hospital La Paz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Price, Huw" sort="Price, Huw" uniqKey="Price H" first="Huw" last="Price">Huw Price</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>MRC Clinical Trials Unit</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barreiro, Pablo" sort="Barreiro, Pablo" uniqKey="Barreiro P" first="Pablo" last="Barreiro">Pablo Barreiro</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hospital Carlos III</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Audsley, Jennifer" sort="Audsley, Jennifer" uniqKey="Audsley J" first="Jennifer" last="Audsley">Jennifer Audsley</name>
<affiliation><inist:fA14 i1="11"><s1>The Alfred Hospital</s1>
<s3>INC</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<wicri:noCountry>INC</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Monash University</s1>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Monash University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sher, Alan" sort="Sher, Alan" uniqKey="Sher A" first="Alan" last="Sher">Alan Sher</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health</s1>
<s2>Bethesda</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Bethesda</wicri:noRegion>
<wicri:noRegion>National Institutes of Health</wicri:noRegion>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. Lewin</name>
<affiliation><inist:fA14 i1="11"><s1>The Alfred Hospital</s1>
<s3>INC</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<wicri:noCountry>INC</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Monash University</s1>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Monash University</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Burnet Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sereti, Irini" sort="Sereti, Irini" uniqKey="Sereti I" first="Irini" last="Sereti">Irini Sereti</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy Infectious Diseases, National Institutes of Health</s1>
<s2>Bethesda</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Bethesda</wicri:noRegion>
<wicri:noRegion>National Institutes of Health</wicri:noRegion>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological marker</term>
<term>Hepatitis</term>
<term>Human</term>
<term>Human immunodeficiency virus</term>
<term>Infection</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Virus immunodéficience humaine</term>
<term>Marqueur biologique</term>
<term>Inflammation</term>
<term>Infection</term>
<term>Hépatite</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Hepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation. Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/ or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated. Results. Forty-eight deaths and 50 hepatitis flares occurred. Nonsurvivors were older, had more prior AIDS-defining events, and had higher pre-ART triglycerides and aspartate transaminase levels. Detectable hyaluronic acid and higher <sub>D</sub>
-dimer, interleukin 6, interleukin 8, and soluble CD14 levels were associated with death in uni-variate models and with a composite biomarker risk score. The risk of hepatitis flares was higher with HBV coinfection only (24.3%) and with HBV and HCV coinfection (50%) than with HCV coinfection only (13.5%). Higher levels of alanine transaminase and interleukin 10 were also associated with hepatitis flares. Conclusions. Among HIV-positive patients coinfected with HBV and/or HCV who are initiating ART, biomarkers of inflammation and coagulation are associated with an increased risk of death, whereas HBV coinfection and higher pre-ART interleukin 10 levels are associated with hepatitis flares.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0>
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<fA08 i1="01" i2="1" l="ENG"><s1>Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BEZERRIL ANDRADE (Bruno)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>HUPPLER HULLSIEK (Katherine)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BOULWARE (David R.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>RUPERT (Adam)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>FRENCH (Martyn A.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>RUXRUNGTHAM (Kiat)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>MONTES (Marisa Luisa)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>PRICE (Huw)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>BARREIRO (Pablo)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>AUDSLEY (Jennifer)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>SHER (Alan)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>LEWIN (Sharon R.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>SERETI (Irini)</s1>
</fA11>
<fA14 i1="01"><s1>Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health</s1>
<s2>Bethesda</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy Infectious Diseases, National Institutes of Health</s1>
<s2>Bethesda</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>SAIC Frederick, National Cancer Institute</s1>
<s2>Frederick, Maryland</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>University of Minnesota</s1>
<s2>Minneapolis</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Faculty of Medicine, Chulalongkorn University</s1>
<s3>INC</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>HIV-NAT, Thai Red Cross AIDS Research Center</s1>
<s2>Bangkok</s2>
<s3>THA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Hospital La Paz</s1>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Hospital Carlos III</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>MRC Clinical Trials Unit</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>The Alfred Hospital</s1>
<s3>INC</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Monash University</s1>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Burnet Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>INSIGHT Study Group</s1>
<s3>INC</s3>
</fA17>
<fA20><s1>1379-1388</s1>
</fA20>
<fA21><s1>2013</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>2052</s2>
<s5>354000173316130040</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2013 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>48 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>13-0155987</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background. Hepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation. Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/ or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated. Results. Forty-eight deaths and 50 hepatitis flares occurred. Nonsurvivors were older, had more prior AIDS-defining events, and had higher pre-ART triglycerides and aspartate transaminase levels. Detectable hyaluronic acid and higher <sub>D</sub>
-dimer, interleukin 6, interleukin 8, and soluble CD14 levels were associated with death in uni-variate models and with a composite biomarker risk score. The risk of hepatitis flares was higher with HBV coinfection only (24.3%) and with HBV and HCV coinfection (50%) than with HCV coinfection only (13.5%). Higher levels of alanine transaminase and interleukin 10 were also associated with hepatitis flares. Conclusions. Among HIV-positive patients coinfected with HBV and/or HCV who are initiating ART, biomarkers of inflammation and coagulation are associated with an increased risk of death, whereas HBV coinfection and higher pre-ART interleukin 10 levels are associated with hepatitis flares.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05C10</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Homme</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Human</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Virus immunodéficience humaine</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Marqueur biologique</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Biological marker</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Marcador biológico</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Inflammation</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Inflammation</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Inflamación</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Infection</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Infection</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Infección</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Hépatite</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Hepatitis</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Hepatitis</s0>
<s5>14</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'appareil digestif</s0>
<s5>13</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Digestive diseases</s0>
<s5>13</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Aparato digestivo patología</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du foie</s0>
<s5>16</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Hepatic disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Hígado patología</s0>
<s5>16</s5>
</fC07>
<fN21><s1>133</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Thaïlande</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Communauté de Madrid</li>
<li>Grand Londres</li>
<li>Maryland</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Londres</li>
<li>Madrid</li>
<li>Melbourne</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Bezerril Andrade, Bruno" sort="Bezerril Andrade, Bruno" uniqKey="Bezerril Andrade B" first="Bruno" last="Bezerril Andrade">Bruno Bezerril Andrade</name>
</noRegion>
<name sortKey="Sereti, Irini" sort="Sereti, Irini" uniqKey="Sereti I" first="Irini" last="Sereti">Irini Sereti</name>
<name sortKey="Sher, Alan" sort="Sher, Alan" uniqKey="Sher A" first="Alan" last="Sher">Alan Sher</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Huppler Hullsiek, Katherine" sort="Huppler Hullsiek, Katherine" uniqKey="Huppler Hullsiek K" first="Katherine" last="Huppler Hullsiek">Katherine Huppler Hullsiek</name>
</noRegion>
<name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R." last="Boulware">David R. Boulware</name>
<name sortKey="Rupert, Adam" sort="Rupert, Adam" uniqKey="Rupert A" first="Adam" last="Rupert">Adam Rupert</name>
</country>
<country name="Australie"><noRegion><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A." last="French">Martyn A. French</name>
</noRegion>
<name sortKey="Audsley, Jennifer" sort="Audsley, Jennifer" uniqKey="Audsley J" first="Jennifer" last="Audsley">Jennifer Audsley</name>
<name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. Lewin</name>
<name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. Lewin</name>
</country>
<country name="Thaïlande"><noRegion><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name>
</noRegion>
</country>
<country name="Espagne"><noRegion><name sortKey="Montes, Marisa Luisa" sort="Montes, Marisa Luisa" uniqKey="Montes M" first="Marisa Luisa" last="Montes">Marisa Luisa Montes</name>
</noRegion>
<name sortKey="Barreiro, Pablo" sort="Barreiro, Pablo" uniqKey="Barreiro P" first="Pablo" last="Barreiro">Pablo Barreiro</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Price, Huw" sort="Price, Huw" uniqKey="Price H" first="Huw" last="Price">Huw Price</name>
</region>
</country>
</tree>
</affiliations>
</record>
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