Blood DNA methylation as a potential biomarker of dementia: A systematic review.
Identifieur interne : 005201 ( Ncbi/Merge ); précédent : 005200; suivant : 005202Blood DNA methylation as a potential biomarker of dementia: A systematic review.
Auteurs : Peter D. Fransquet [Australie] ; Paul Lacaze [Australie] ; Richard Saffery [Australie] ; John Mcneil [Australie] ; Robyn Woods [Australie] ; Joanne Ryan [France]Source :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5279 ] ; 2017.
Abstract
Dementia is a major public health issue with rising prevalence rates, but many individuals remain undiagnosed. Accurate and timely diagnosis is key for the optimal targeting of interventions. A noninvasive, easily measurable peripheral biomarker would have greatest utility in population-wide diagnostic screening. Epigenetics, including DNA methylation, is implicated in dementia; however, it is unclear whether epigenetic changes can be detected in peripheral tissue. This study aimed to systematically review the evidence for an association between dementia and peripheral DNA methylation. Forty-eight studies that measured DNA methylation in peripheral blood were identified, and 67% reported significant associations with dementia. However, most studies were underpowered and limited by their case-control design. We emphasize the need for future longitudinal studies on large well-characterized populations, measuring epigenetic patterns in asymptomatic individuals. A biomarker detectable in the preclinical stages of the disease would have the greatest utility in future intervention and treatment trials.
DOI: 10.1016/j.jalz.2017.10.002
PubMed: 29127806
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<front><div type="abstract" xml:lang="en">Dementia is a major public health issue with rising prevalence rates, but many individuals remain undiagnosed. Accurate and timely diagnosis is key for the optimal targeting of interventions. A noninvasive, easily measurable peripheral biomarker would have greatest utility in population-wide diagnostic screening. Epigenetics, including DNA methylation, is implicated in dementia; however, it is unclear whether epigenetic changes can be detected in peripheral tissue. This study aimed to systematically review the evidence for an association between dementia and peripheral DNA methylation. Forty-eight studies that measured DNA methylation in peripheral blood were identified, and 67% reported significant associations with dementia. However, most studies were underpowered and limited by their case-control design. We emphasize the need for future longitudinal studies on large well-characterized populations, measuring epigenetic patterns in asymptomatic individuals. A biomarker detectable in the preclinical stages of the disease would have the greatest utility in future intervention and treatment trials.</div>
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