Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
Identifieur interne : 004847 ( Ncbi/Merge ); précédent : 004846; suivant : 004848Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
Auteurs : Christos Rossios [Royaume-Uni] ; Stelios Pavlidis [Royaume-Uni] ; Uruj Hoda [Royaume-Uni] ; Chih-Hsi Kuo [Royaume-Uni] ; Coen Wiegman [Royaume-Uni] ; Kirsty Russell [Royaume-Uni] ; Kai Sun [Royaume-Uni] ; Matthew J. Loza [Royaume-Uni] ; Frederic Baribaud [Royaume-Uni] ; Andrew L. Durham [Royaume-Uni] ; Oluwaseun Ojo [Royaume-Uni] ; Rene Lutter [Pays-Bas] ; Anthony Rowe [Royaume-Uni] ; Aruna Bansal [Royaume-Uni] ; Charles Auffray [France] ; Ana Sousa [Royaume-Uni] ; Julie Corfield [Royaume-Uni] ; Ratko Djukanovic [Royaume-Uni] ; Yike Guo [Royaume-Uni] ; Peter J. Sterk [Pays-Bas] ; Kian Fan Chung [Royaume-Uni] ; Ian M. Adcock [Australie]Source :
- The Journal of allergy and clinical immunology [ 1097-6825 ] ; 2017.
Abstract
Sputum analysis in asthmatic patients is used to define airway inflammatory processes and might guide therapy.
DOI: 10.1016/j.jaci.2017.02.045
PubMed: 28528200
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Southampton, Southampton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, Southampton University, and the NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Yike" sort="Guo, Yike" uniqKey="Guo Y" first="Yike" last="Guo">Yike Guo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sterk, Peter J" sort="Sterk, Peter J" uniqKey="Sterk P" first="Peter J" last="Sterk">Peter J. 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Adcock</name><affiliation wicri:level="1"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia. Electronic address: ian.adcock@imperial.ac.uk.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28528200</idno><idno type="pmid">28528200</idno><idno type="doi">10.1016/j.jaci.2017.02.045</idno><idno type="wicri:Area/PubMed/Corpus">000C76</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C76</idno><idno type="wicri:Area/PubMed/Curation">000C73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C73</idno><idno type="wicri:Area/PubMed/Checkpoint">000C73</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C73</idno><idno type="wicri:Area/Ncbi/Merge">004847</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.</title><author><name sortKey="Rossios, Christos" sort="Rossios, Christos" uniqKey="Rossios C" first="Christos" last="Rossios">Christos Rossios</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pavlidis, Stelios" sort="Pavlidis, Stelios" uniqKey="Pavlidis S" first="Stelios" last="Pavlidis">Stelios Pavlidis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom; Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom; Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Hoda, Uruj" sort="Hoda, Uruj" uniqKey="Hoda U" first="Uruj" last="Hoda">Uruj Hoda</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kuo, Chih Hsi" sort="Kuo, Chih Hsi" uniqKey="Kuo C" first="Chih-Hsi" last="Kuo">Chih-Hsi Kuo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wiegman, Coen" sort="Wiegman, Coen" uniqKey="Wiegman C" first="Coen" last="Wiegman">Coen Wiegman</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Russell, Kirsty" sort="Russell, Kirsty" uniqKey="Russell K" first="Kirsty" last="Russell">Kirsty Russell</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sun, Kai" sort="Sun, Kai" uniqKey="Sun K" first="Kai" last="Sun">Kai Sun</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Loza, Matthew J" sort="Loza, Matthew J" uniqKey="Loza M" first="Matthew J" last="Loza">Matthew J. Loza</name><affiliation wicri:level="1"><nlm:affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Baribaud, Frederic" sort="Baribaud, Frederic" uniqKey="Baribaud F" first="Frederic" last="Baribaud">Frederic Baribaud</name><affiliation wicri:level="1"><nlm:affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Durham, Andrew L" sort="Durham, Andrew L" uniqKey="Durham A" first="Andrew L" last="Durham">Andrew L. Durham</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ojo, Oluwaseun" sort="Ojo, Oluwaseun" uniqKey="Ojo O" first="Oluwaseun" last="Ojo">Oluwaseun Ojo</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lutter, Rene" sort="Lutter, Rene" uniqKey="Lutter R" first="Rene" last="Lutter">Rene Lutter</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Medicine, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Rowe, Anthony" sort="Rowe, Anthony" uniqKey="Rowe A" first="Anthony" last="Rowe">Anthony Rowe</name><affiliation wicri:level="1"><nlm:affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Bansal, Aruna" sort="Bansal, Aruna" uniqKey="Bansal A" first="Aruna" last="Bansal">Aruna Bansal</name><affiliation wicri:level="1"><nlm:affiliation>Acclarogen, St John's Innovation Centre, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Acclarogen, St John's Innovation Centre, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name><affiliation wicri:level="3"><nlm:affiliation>European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Sousa, Ana" sort="Sousa, Ana" uniqKey="Sousa A" first="Ana" last="Sousa">Ana Sousa</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Therapeutic Unit, GSK, Stockley Park, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Therapeutic Unit, GSK, Stockley Park</wicri:regionArea><wicri:noRegion>Stockley Park</wicri:noRegion></affiliation></author><author><name sortKey="Corfield, Julie" sort="Corfield, Julie" uniqKey="Corfield J" first="Julie" last="Corfield">Julie Corfield</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca R&D, Molndal, Sweden, and Areteva R&D, Nottingham, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>AstraZeneca R&D, Molndal, Sweden, and Areteva R&D, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Djukanovic, Ratko" sort="Djukanovic, Ratko" uniqKey="Djukanovic R" first="Ratko" last="Djukanovic">Ratko Djukanovic</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Southampton University, and the NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, Southampton University, and the NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Yike" sort="Guo, Yike" uniqKey="Guo Y" first="Yike" last="Guo">Yike Guo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sterk, Peter J" sort="Sterk, Peter J" uniqKey="Sterk P" first="Peter J" last="Sterk">Peter J. Sterk</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Medicine, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Chung, Kian Fan" sort="Chung, Kian Fan" uniqKey="Chung K" first="Kian Fan" last="Chung">Kian Fan Chung</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Adcock, Ian M" sort="Adcock, Ian M" uniqKey="Adcock I" first="Ian M" last="Adcock">Ian M. Adcock</name><affiliation wicri:level="1"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia. Electronic address: ian.adcock@imperial.ac.uk.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of allergy and clinical immunology</title><idno type="eISSN">1097-6825</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sputum analysis in asthmatic patients is used to define airway inflammatory processes and might guide therapy.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28528200</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>21</Day></DateCreated><DateRevised><Year>2017</Year><Month>06</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6825</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>May</Month><Day>18</Day></PubDate></JournalIssue><Title>The Journal of allergy and clinical immunology</Title><ISOAbbreviation>J. Allergy Clin. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0091-6749(17)30764-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaci.2017.02.045</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Sputum analysis in asthmatic patients is used to define airway inflammatory processes and might guide therapy.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We sought to determine differential gene and protein expression in sputum samples from patients with severe asthma (SA) compared with nonsmoking patients with mild/moderate asthma.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Induced sputum was obtained from nonsmoking patients with SA, smokers/ex-smokers with severe asthma, nonsmoking patients with mild/moderate asthma (MMAs), and healthy nonsmoking control subjects. Differential cell counts, microarray analysis of cell pellets, and SOMAscan analysis of sputum analytes were performed. CRID3 was used to inhibit the inflammasome in a mouse model of SA.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eosinophilic and mixed neutrophilic/eosinophilic inflammation were more prevalent in patients with SA compared with MMAs. Forty-two genes probes were upregulated (>2-fold) in nonsmoking patients with severe asthma compared with MMAs, including IL-1 receptor (IL-1R) family and nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NRLP3) inflammasome members (false discovery rate < 0.05). The inflammasome proteins nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1 (NLRP1), NLRP3, and nucleotide-binding oligomerization domain (NOD)-like receptor C4 (NLRC4) were associated with neutrophilic asthma and with sputum IL-1β protein levels, whereas eosinophilic asthma was associated with an IL-13-induced TH2 signature and IL-1 receptor-like 1 (IL1RL1) mRNA expression. These differences were sputum specific because no activation of NLRP3 or enrichment of IL-1R family genes in bronchial brushings or biopsy specimens in patients with SA was observed. Expression of NLRP3 and of the IL-1R family genes was validated in the Airway Disease Endotyping for Personalized Therapeutics cohort. Inflammasome inhibition using CRID3 prevented airway hyperresponsiveness and airway inflammation (both neutrophilia and eosinophilia) in a mouse model of severe allergic asthma.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">IL1RL1 gene expression is associated with eosinophilic SA, whereas NLRP3 inflammasome expression is highest in patients with neutrophilic SA. TH2-driven eosinophilic inflammation and neutrophil-associated inflammasome activation might represent interacting pathways in patients with SA.</AbstractText><CopyrightInformation>Copyright © 2017. Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rossios</LastName><ForeName>Christos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pavlidis</LastName><ForeName>Stelios</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom; Janssen Research and Development, High Wycombe, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoda</LastName><ForeName>Uruj</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuo</LastName><ForeName>Chih-Hsi</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiegman</LastName><ForeName>Coen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Kirsty</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Kai</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loza</LastName><ForeName>Matthew J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baribaud</LastName><ForeName>Frederic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durham</LastName><ForeName>Andrew L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ojo</LastName><ForeName>Oluwaseun</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lutter</LastName><ForeName>Rene</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rowe</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bansal</LastName><ForeName>Aruna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Acclarogen, St John's Innovation Centre, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auffray</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sousa</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Respiratory Therapeutic Unit, GSK, Stockley Park, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corfield</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>AstraZeneca R&D, Molndal, Sweden, and Areteva R&D, Nottingham, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djukanovic</LastName><ForeName>Ratko</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, Southampton University, and the NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Yike</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sterk</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Kian Fan</ForeName><Initials>KF</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adcock</LastName><ForeName>Ian M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia. Electronic address: ian.adcock@imperial.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) Consortia Project Team</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Allergy Clin Immunol</MedlineTA><NlmUniqueID>1275002</NlmUniqueID><ISSNLinking>0091-6749</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">C-reactive protein</Keyword><Keyword MajorTopicYN="N">IL-1α</Keyword><Keyword MajorTopicYN="N">IL-1β</Keyword><Keyword MajorTopicYN="N">IL-33 receptor</Keyword><Keyword MajorTopicYN="N">Severe asthma</Keyword><Keyword MajorTopicYN="N">T(H)2</Keyword><Keyword MajorTopicYN="N">eosinophil</Keyword><Keyword MajorTopicYN="N">exhaled nitric oxide</Keyword><Keyword MajorTopicYN="N">inflammasome</Keyword><Keyword MajorTopicYN="N">neutrophil</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>01</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28528200</ArticleId><ArticleId IdType="pii">S0091-6749(17)30764-9</ArticleId><ArticleId IdType="doi">10.1016/j.jaci.2017.02.045</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Rhône-Alpes</li></region><settlement><li>Amsterdam</li><li>Londres</li><li>Lyon</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rossios, Christos" sort="Rossios, Christos" uniqKey="Rossios C" first="Christos" last="Rossios">Christos Rossios</name></region><name sortKey="Bansal, Aruna" sort="Bansal, Aruna" uniqKey="Bansal A" first="Aruna" last="Bansal">Aruna Bansal</name><name sortKey="Baribaud, Frederic" sort="Baribaud, Frederic" uniqKey="Baribaud F" first="Frederic" last="Baribaud">Frederic Baribaud</name><name sortKey="Chung, Kian Fan" sort="Chung, Kian Fan" uniqKey="Chung K" first="Kian Fan" last="Chung">Kian Fan Chung</name><name sortKey="Corfield, Julie" sort="Corfield, Julie" uniqKey="Corfield J" first="Julie" last="Corfield">Julie Corfield</name><name sortKey="Djukanovic, Ratko" sort="Djukanovic, Ratko" uniqKey="Djukanovic R" first="Ratko" last="Djukanovic">Ratko Djukanovic</name><name sortKey="Durham, Andrew L" sort="Durham, Andrew L" uniqKey="Durham A" first="Andrew L" last="Durham">Andrew L. Durham</name><name sortKey="Guo, Yike" sort="Guo, Yike" uniqKey="Guo Y" first="Yike" last="Guo">Yike Guo</name><name sortKey="Hoda, Uruj" sort="Hoda, Uruj" uniqKey="Hoda U" first="Uruj" last="Hoda">Uruj Hoda</name><name sortKey="Kuo, Chih Hsi" sort="Kuo, Chih Hsi" uniqKey="Kuo C" first="Chih-Hsi" last="Kuo">Chih-Hsi Kuo</name><name sortKey="Loza, Matthew J" sort="Loza, Matthew J" uniqKey="Loza M" first="Matthew J" last="Loza">Matthew J. Loza</name><name sortKey="Ojo, Oluwaseun" sort="Ojo, Oluwaseun" uniqKey="Ojo O" first="Oluwaseun" last="Ojo">Oluwaseun Ojo</name><name sortKey="Pavlidis, Stelios" sort="Pavlidis, Stelios" uniqKey="Pavlidis S" first="Stelios" last="Pavlidis">Stelios Pavlidis</name><name sortKey="Rowe, Anthony" sort="Rowe, Anthony" uniqKey="Rowe A" first="Anthony" last="Rowe">Anthony Rowe</name><name sortKey="Russell, Kirsty" sort="Russell, Kirsty" uniqKey="Russell K" first="Kirsty" last="Russell">Kirsty Russell</name><name sortKey="Sousa, Ana" sort="Sousa, Ana" uniqKey="Sousa A" first="Ana" last="Sousa">Ana Sousa</name><name sortKey="Sun, Kai" sort="Sun, Kai" uniqKey="Sun K" first="Kai" last="Sun">Kai Sun</name><name sortKey="Wiegman, Coen" sort="Wiegman, Coen" uniqKey="Wiegman C" first="Coen" last="Wiegman">Coen Wiegman</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Lutter, Rene" sort="Lutter, Rene" uniqKey="Lutter R" first="Rene" last="Lutter">Rene Lutter</name></region><name sortKey="Sterk, Peter J" sort="Sterk, Peter J" uniqKey="Sterk P" first="Peter J" last="Sterk">Peter J. Sterk</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name></region></country><country name="Australie"><noRegion><name sortKey="Adcock, Ian M" sort="Adcock, Ian M" uniqKey="Adcock I" first="Ian M" last="Adcock">Ian M. Adcock</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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