The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease.
Identifieur interne : 004515 ( Ncbi/Merge ); précédent : 004514; suivant : 004516The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease.
Auteurs : Alyce C. Russell [Australie] ; Mirna Šimurina [Croatie] ; Monique T. Garcia [Australie] ; Mislav Novokmet [Croatie] ; Youxin Wang [République populaire de Chine] ; Igor Rudan [Royaume-Uni] ; Harry Campbell [Royaume-Uni] ; Gordan Lauc [Australie] ; Meghan G. Thomas [Australie] ; Wei Wang [Australie]Source :
- Glycobiology [ 1460-2423 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Cytotoxicité à médiation cellulaire dépendante des anticorps (génétique), Femelle, Glycomique, Glycosylation, Humains, Immunoglobuline G (sang), Maladie de Parkinson (anatomopathologie), Maladie de Parkinson (génétique), Maladie de Parkinson (sang), Marqueurs biologiques (sang), Mâle, Polyosides (sang), Sujet âgé, Évolution de la maladie.
- MESH :
- anatomopathologie : Maladie de Parkinson.
- génétique : Cytotoxicité à médiation cellulaire dépendante des anticorps, Maladie de Parkinson.
- sang : Immunoglobuline G, Maladie de Parkinson, Marqueurs biologiques, Polyosides.
- Adulte d'âge moyen, Femelle, Glycomique, Glycosylation, Humains, Mâle, Sujet âgé, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Biomarkers, Immunoglobulin G, Polysaccharides.
- blood : Parkinson Disease.
- genetics : Antibody-Dependent Cell Cytotoxicity, Parkinson Disease.
- pathology : Parkinson Disease.
- Aged, Disease Progression, Female, Glycomics, Glycosylation, Humans, Male, Middle Aged.
Abstract
The use of the emerging "omics" technologies for large scale population screening is promising in terms of predictive, preventive and personalized medicine. For Parkinson's disease, it is essential that an accurate diagnosis is obtained and disease progression can be monitored. Immunoglobulin G (IgG) has the ability to exert both anti-inflammatory and pro-inflammatory effects, and the N-glycosylation of the fragment crystallizable portion of IgG is involved in this process. This study aimed to determine whether the IgG glycome could be a candidate biomarker for Parkinson's disease. Ninety-four community-based individuals with Parkinson's disease and a sex-, age- and ethnically-matched cohort of 102 individuals with mixed phenotypes, representative of a "normally" aged Caucasian controls, were investigated. Plasma IgG glycans were analyzed by ultra-performance liquid chromatography. Overall, seven glycan peaks and 11 derived traits had statistically significant differences (P < 8.06 × 10-4) between Parkinson's disease cases and healthy controls. Out of the seven significantly different glycan peaks, four were selected by Akaike's Information Criterion to be included in the logistic regression model, with a sensitivity of 87.2% and a specificity of 92.2%. The study suggested that there may be a reduced capacity for the IgG to inhibit Fcγ-RIIIa binding, which would allow an increased ability for the IgG to cause antibody-dependent cell cytotoxicity and a possible state of low-grade inflammation in individuals with Parkinson's disease.
DOI: 10.1093/glycob/cwx022
PubMed: 28334832
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Russell</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Simurina, Mirna" sort="Simurina, Mirna" uniqKey="Simurina M" first="Mirna" last="Šimurina">Mirna Šimurina</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovacica 1, 10000, Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovacica 1, 10000, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Monique T" sort="Garcia, Monique T" uniqKey="Garcia M" first="Monique T" last="Garcia">Monique T. 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Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Centre, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Parkinson's Centre, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author></analytic><series><title level="j">Glycobiology</title><idno type="eISSN">1460-2423</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antibody-Dependent Cell Cytotoxicity (genetics)</term><term>Biomarkers (blood)</term><term>Disease Progression</term><term>Female</term><term>Glycomics</term><term>Glycosylation</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Polysaccharides (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Cytotoxicité à médiation cellulaire dépendante des anticorps (génétique)</term><term>Femelle</term><term>Glycomique</term><term>Glycosylation</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Maladie de Parkinson (anatomopathologie)</term><term>Maladie de Parkinson (génétique)</term><term>Maladie de Parkinson (sang)</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Polyosides (sang)</term><term>Sujet âgé</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Immunoglobulin G</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Antibody-Dependent Cell Cytotoxicity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytotoxicité à médiation cellulaire dépendante des anticorps</term><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline G</term><term>Maladie de Parkinson</term><term>Marqueurs biologiques</term><term>Polyosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Glycomics</term><term>Glycosylation</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Glycomique</term><term>Glycosylation</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The use of the emerging "omics" technologies for large scale population screening is promising in terms of predictive, preventive and personalized medicine. For Parkinson's disease, it is essential that an accurate diagnosis is obtained and disease progression can be monitored. Immunoglobulin G (IgG) has the ability to exert both anti-inflammatory and pro-inflammatory effects, and the N-glycosylation of the fragment crystallizable portion of IgG is involved in this process. This study aimed to determine whether the IgG glycome could be a candidate biomarker for Parkinson's disease. Ninety-four community-based individuals with Parkinson's disease and a sex-, age- and ethnically-matched cohort of 102 individuals with mixed phenotypes, representative of a "normally" aged Caucasian controls, were investigated. Plasma IgG glycans were analyzed by ultra-performance liquid chromatography. Overall, seven glycan peaks and 11 derived traits had statistically significant differences (P < 8.06 × 10-4) between Parkinson's disease cases and healthy controls. Out of the seven significantly different glycan peaks, four were selected by Akaike's Information Criterion to be included in the logistic regression model, with a sensitivity of 87.2% and a specificity of 92.2%. The study suggested that there may be a reduced capacity for the IgG to inhibit Fcγ-RIIIa binding, which would allow an increased ability for the IgG to cause antibody-dependent cell cytotoxicity and a possible state of low-grade inflammation in individuals with Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28334832</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>23</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>31</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2423</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>5</Issue><PubDate><Year>2017</Year><Month>May</Month><Day>01</Day></PubDate></JournalIssue><Title>Glycobiology</Title><ISOAbbreviation>Glycobiology</ISOAbbreviation></Journal><ArticleTitle>The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>501-510</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/glycob/cwx022</ELocationID><Abstract><AbstractText>The use of the emerging "omics" technologies for large scale population screening is promising in terms of predictive, preventive and personalized medicine. For Parkinson's disease, it is essential that an accurate diagnosis is obtained and disease progression can be monitored. Immunoglobulin G (IgG) has the ability to exert both anti-inflammatory and pro-inflammatory effects, and the N-glycosylation of the fragment crystallizable portion of IgG is involved in this process. This study aimed to determine whether the IgG glycome could be a candidate biomarker for Parkinson's disease. Ninety-four community-based individuals with Parkinson's disease and a sex-, age- and ethnically-matched cohort of 102 individuals with mixed phenotypes, representative of a "normally" aged Caucasian controls, were investigated. Plasma IgG glycans were analyzed by ultra-performance liquid chromatography. Overall, seven glycan peaks and 11 derived traits had statistically significant differences (P < 8.06 × 10-4) between Parkinson's disease cases and healthy controls. Out of the seven significantly different glycan peaks, four were selected by Akaike's Information Criterion to be included in the logistic regression model, with a sensitivity of 87.2% and a specificity of 92.2%. The study suggested that there may be a reduced capacity for the IgG to inhibit Fcγ-RIIIa binding, which would allow an increased ability for the IgG to cause antibody-dependent cell cytotoxicity and a possible state of low-grade inflammation in individuals with Parkinson's disease.</AbstractText><CopyrightInformation>© The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Alyce C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Parkinson's Centre, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Šimurina</LastName><ForeName>Mirna</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovacica 1, 10000, Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia</LastName><ForeName>Monique T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novokmet</LastName><ForeName>Mislav</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Genos Glycoscience Research Laboratory, Hondlova 2/11, I.V. kat, 10000, Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Youxin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Fengtai Qu, Beijing Shi, 100054, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudan</LastName><ForeName>Igor</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Global Health Research, The Usher Institute, University of Edinburgh, 9 Little France Road, Edinburgh, EH16 4UX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Harry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Centre for Global Health Research, The Usher Institute, University of Edinburgh, 9 Little France Road, Edinburgh, EH16 4UX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lauc</LastName><ForeName>Gordan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000, Zagreb, Croatia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Genos Glycoscience Research Laboratory, Hondlova 2/11, I.V. kat, 10000, Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Meghan G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Parkinson's Centre, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Fengtai Qu, Beijing Shi, 100054, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Glycobiology</MedlineTA><NlmUniqueID>9104124</NlmUniqueID><ISSNLinking>0959-6658</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011134">Polysaccharides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000920" MajorTopicYN="N">Antibody-Dependent Cell Cytotoxicity</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054794" MajorTopicYN="N">Glycomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006031" MajorTopicYN="N">Glycosylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011134" MajorTopicYN="N">Polysaccharides</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">biomarker</Keyword><Keyword MajorTopicYN="N">glycomics</Keyword><Keyword MajorTopicYN="N">immunoglobulin G</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28334832</ArticleId><ArticleId IdType="pii">3051947</ArticleId><ArticleId IdType="doi">10.1093/glycob/cwx022</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Croatie</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><region><li>Écosse</li></region><settlement><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Russell, Alyce C" sort="Russell, Alyce C" uniqKey="Russell A" first="Alyce C" last="Russell">Alyce C. Russell</name></noRegion><name sortKey="Garcia, Monique T" sort="Garcia, Monique T" uniqKey="Garcia M" first="Monique T" last="Garcia">Monique T. Garcia</name><name sortKey="Lauc, Gordan" sort="Lauc, Gordan" uniqKey="Lauc G" first="Gordan" last="Lauc">Gordan Lauc</name><name sortKey="Thomas, Meghan G" sort="Thomas, Meghan G" uniqKey="Thomas M" first="Meghan G" last="Thomas">Meghan G. Thomas</name><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name></country><country name="Croatie"><noRegion><name sortKey="Simurina, Mirna" sort="Simurina, Mirna" uniqKey="Simurina M" first="Mirna" last="Šimurina">Mirna Šimurina</name></noRegion><name sortKey="Novokmet, Mislav" sort="Novokmet, Mislav" uniqKey="Novokmet M" first="Mislav" last="Novokmet">Mislav Novokmet</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Youxin" sort="Wang, Youxin" uniqKey="Wang Y" first="Youxin" last="Wang">Youxin Wang</name></noRegion></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name></region><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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