Viper Venom Botox: The Molecular Origin and Evolution of the Waglerin Peptides Used in Anti-Wrinkle Skin Cream.
Identifieur interne : 003F04 ( Ncbi/Merge ); précédent : 003F03; suivant : 003F05Viper Venom Botox: The Molecular Origin and Evolution of the Waglerin Peptides Used in Anti-Wrinkle Skin Cream.
Auteurs : Jordan Debono [Australie] ; Bing Xie [République populaire de Chine] ; Aude Violette [Belgique] ; Rudy Fourmy [Belgique] ; Marc Jaeger [France] ; Bryan G. Fry [Australie]Source :
- Journal of molecular evolution [ 1432-1432 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Crème pour la peau, Données de séquences moléculaires, Peptides (), Phylogénie, Séquence d'acides aminés (génétique), Venins de crotalidé (génétique), Venins de crotalidé (toxicité), Venins de crotalidé (usage thérapeutique), Venins de vipère (toxicité), Venins de vipère (usage thérapeutique), Évolution biologique, Évolution moléculaire.
- MESH :
- génétique : Séquence d'acides aminés, Venins de crotalidé.
- toxicité : Venins de crotalidé, Venins de vipère.
- usage thérapeutique : Venins de crotalidé, Venins de vipère.
- Animaux, Crème pour la peau, Données de séquences moléculaires, Peptides, Phylogénie, Évolution biologique, Évolution moléculaire.
English descriptors
- KwdEn :
- Amino Acid Sequence (genetics), Animals, Biological Evolution, Crotalid Venoms (genetics), Crotalid Venoms (therapeutic use), Crotalid Venoms (toxicity), Evolution, Molecular, Molecular Sequence Data, Peptides (chemistry), Phylogeny, Skin Cream, Viper Venoms (therapeutic use), Viper Venoms (toxicity).
- MESH :
- chemical , chemistry : Peptides.
- chemical , genetics : Crotalid Venoms.
- genetics : Amino Acid Sequence.
- chemical , therapeutic use : Crotalid Venoms, Viper Venoms.
- chemical , toxicity : Crotalid Venoms, Viper Venoms.
- Animals, Biological Evolution, Evolution, Molecular, Molecular Sequence Data, Phylogeny, Skin Cream.
Abstract
The molecular origin of waglerin peptides has remained enigmatic despite their industrial application in skin cream products to paralyse facial muscles and thus reduce the incidence of wrinkles. Here we show that these neurotoxic peptides are the result of de novo evolution within the prepro region of the C-type natriuretic peptide gene in Tropidolaemus venoms, at a site distinct from the domain encoding for the natriuretic peptide. It is the same region that yielded the azemiopsin peptides from Azemiops feae, indicative of a close relationship of this toxin gene between these two genera. The precursor region for the molecular evolution is a biodiversity hotspot that has yielded other novel bioactive peptides with novel activities. We detail the diversity of components in this and other species in order to explore what characteristics enable it to be such a biodiscovery treasure trove. The unusual function of Tropidolaemus venoms may have been selected for due to evolutionary pressures brought about by a high likelihood of prey escape.
DOI: 10.1007/s00239-016-9764-6
PubMed: 27864608
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001255
- to stream PubMed, to step Curation: 001244
- to stream PubMed, to step Checkpoint: 001244
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pubmed:27864608Le document en format XML
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Fry</name><affiliation wicri:level="1"><nlm:affiliation>Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072, Australia. bgfry@uq.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of molecular evolution</title><idno type="eISSN">1432-1432</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (genetics)</term><term>Animals</term><term>Biological Evolution</term><term>Crotalid Venoms (genetics)</term><term>Crotalid Venoms (therapeutic use)</term><term>Crotalid Venoms (toxicity)</term><term>Evolution, Molecular</term><term>Molecular Sequence Data</term><term>Peptides (chemistry)</term><term>Phylogeny</term><term>Skin Cream</term><term>Viper Venoms (therapeutic use)</term><term>Viper Venoms (toxicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Crème pour la peau</term><term>Données de séquences moléculaires</term><term>Peptides ()</term><term>Phylogénie</term><term>Séquence d'acides aminés (génétique)</term><term>Venins de crotalidé (génétique)</term><term>Venins de crotalidé (toxicité)</term><term>Venins de crotalidé (usage thérapeutique)</term><term>Venins de vipère (toxicité)</term><term>Venins de vipère (usage thérapeutique)</term><term>Évolution biologique</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Crotalid Venoms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Amino Acid Sequence</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Séquence d'acides aminés</term><term>Venins de crotalidé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Crotalid Venoms</term><term>Viper Venoms</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Crotalid Venoms</term><term>Viper Venoms</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Venins de crotalidé</term><term>Venins de vipère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Venins de crotalidé</term><term>Venins de vipère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Evolution</term><term>Evolution, Molecular</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Skin Cream</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Crème pour la peau</term><term>Données de séquences moléculaires</term><term>Peptides</term><term>Phylogénie</term><term>Évolution biologique</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The molecular origin of waglerin peptides has remained enigmatic despite their industrial application in skin cream products to paralyse facial muscles and thus reduce the incidence of wrinkles. Here we show that these neurotoxic peptides are the result of de novo evolution within the prepro region of the C-type natriuretic peptide gene in Tropidolaemus venoms, at a site distinct from the domain encoding for the natriuretic peptide. It is the same region that yielded the azemiopsin peptides from Azemiops feae, indicative of a close relationship of this toxin gene between these two genera. The precursor region for the molecular evolution is a biodiversity hotspot that has yielded other novel bioactive peptides with novel activities. We detail the diversity of components in this and other species in order to explore what characteristics enable it to be such a biodiscovery treasure trove. The unusual function of Tropidolaemus venoms may have been selected for due to evolutionary pressures brought about by a high likelihood of prey escape.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27864608</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>19</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>09</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1432</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of molecular evolution</Title><ISOAbbreviation>J. Mol. Evol.</ISOAbbreviation></Journal><ArticleTitle>Viper Venom Botox: The Molecular Origin and Evolution of the Waglerin Peptides Used in Anti-Wrinkle Skin Cream.</ArticleTitle><Pagination><MedlinePgn>8-11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00239-016-9764-6</ELocationID><Abstract><AbstractText>The molecular origin of waglerin peptides has remained enigmatic despite their industrial application in skin cream products to paralyse facial muscles and thus reduce the incidence of wrinkles. Here we show that these neurotoxic peptides are the result of de novo evolution within the prepro region of the C-type natriuretic peptide gene in Tropidolaemus venoms, at a site distinct from the domain encoding for the natriuretic peptide. It is the same region that yielded the azemiopsin peptides from Azemiops feae, indicative of a close relationship of this toxin gene between these two genera. The precursor region for the molecular evolution is a biodiversity hotspot that has yielded other novel bioactive peptides with novel activities. We detail the diversity of components in this and other species in order to explore what characteristics enable it to be such a biodiscovery treasure trove. The unusual function of Tropidolaemus venoms may have been selected for due to evolutionary pressures brought about by a high likelihood of prey escape.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Debono</LastName><ForeName>Jordan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen, 518083, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Violette</LastName><ForeName>Aude</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Alphabiotoxine Laboratory sprl, Barberie 15, 7911, Montroeul-au-bois, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fourmy</LastName><ForeName>Rudy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Alphabiotoxine Laboratory sprl, Barberie 15, 7911, Montroeul-au-bois, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jaeger</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Planet Exotica, 5, Avenue des Fleurs de la Paix, 17204, Royan Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fry</LastName><ForeName>Bryan G</ForeName><Initials>BG</Initials><AffiliationInfo><Affiliation>Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072, Australia. bgfry@uq.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Mol Evol</MedlineTA><NlmUniqueID>0360051</NlmUniqueID><ISSNLinking>0022-2844</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003435">Crotalid Venoms</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014757">Viper Venoms</NameOfSubstance></Chemical><Chemical><RegistryNumber>144856-56-4</RegistryNumber><NameOfSubstance UI="C077895">waglerin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mol Biol Evol. 2010 Feb;27(2):395-407</RefSource><PMID Version="1">19837656</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxicon. 1995 Aug;33(8):1043-9</RefSource><PMID Version="1">8533138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Aesthet Dermatol. 2009 Mar;2(3):38-43</RefSource><PMID Version="1">20729942</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxicon. 1995 Jan;33(1):111-4</RefSource><PMID Version="1">7778124</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2005 Mar;15(3):403-20</RefSource><PMID Version="1">15741511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Proteomics. 2008 Feb;7(2):215-46</RefSource><PMID Version="1">17855442</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Proteomics. 2013 Mar;12(3):651-63</RefSource><PMID Version="1">23242553</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pharmacol Exp Ther. 1999 Apr;289(1):543-50</RefSource><PMID Version="1">10087048</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxicon. 1992 Sep;30(9):1027-36</RefSource><PMID Version="1">1440639</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rapid Commun Mass Spectrom. 2003;17(18):2047-62</RefSource><PMID Version="1">12955733</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxins (Basel). 2016 Oct 18;8(10 ):null</RefSource><PMID Version="1">27763551</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2012 Aug 3;287(32):27079-86</RefSource><PMID Version="1">22613724</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dokl Biochem Biophys. 2012 Jan-Feb;442:33-5</RefSource><PMID Version="1">22419091</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005075" MajorTopicYN="N">Biological Evolution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003435" MajorTopicYN="N">Crotalid Venoms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D063465" MajorTopicYN="N">Skin Cream</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014757" MajorTopicYN="N">Viper Venoms</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27864608</ArticleId><ArticleId IdType="doi">10.1007/s00239-016-9764-6</ArticleId><ArticleId IdType="pii">10.1007/s00239-016-9764-6</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>République populaire de Chine</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Debono, Jordan" sort="Debono, Jordan" uniqKey="Debono J" first="Jordan" last="Debono">Jordan Debono</name></noRegion><name sortKey="Fry, Bryan G" sort="Fry, Bryan G" uniqKey="Fry B" first="Bryan G" last="Fry">Bryan G. Fry</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Xie, Bing" sort="Xie, Bing" uniqKey="Xie B" first="Bing" last="Xie">Bing Xie</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Violette, Aude" sort="Violette, Aude" uniqKey="Violette A" first="Aude" last="Violette">Aude Violette</name></noRegion><name sortKey="Fourmy, Rudy" sort="Fourmy, Rudy" uniqKey="Fourmy R" first="Rudy" last="Fourmy">Rudy Fourmy</name></country><country name="France"><noRegion><name sortKey="Jaeger, Marc" sort="Jaeger, Marc" uniqKey="Jaeger M" first="Marc" last="Jaeger">Marc Jaeger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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