Psychiatric correlates of blood pressure variability in the elderly: The Three City cohort study.
Identifieur interne : 003E34 ( Ncbi/Merge ); précédent : 003E33; suivant : 003E35Psychiatric correlates of blood pressure variability in the elderly: The Three City cohort study.
Auteurs : Phillip J. Tully [Australie] ; Christophe Tzourio [France]Source :
- Physiology & behavior [ 1873-507X ] ; 2017.
Descripteurs français
- KwdFr :
- Femelle, Humains, Modèles linéaires, Mâle, Neuroleptiques (pharmacologie), Neuroleptiques (usage thérapeutique), Pression sanguine (), Pression sanguine (physiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Troubles mentaux (physiopathologie), Troubles mentaux (traitement médicamenteux), Vieillissement, Études de cohortes.
- MESH :
- pharmacologie : Neuroleptiques.
- physiologie : Pression sanguine.
- physiopathologie : Troubles mentaux.
- traitement médicamenteux : Troubles mentaux.
- usage thérapeutique : Neuroleptiques.
- Femelle, Humains, Modèles linéaires, Mâle, Pression sanguine, Sujet âgé, Sujet âgé de 80 ans ou plus, Vieillissement, Études de cohortes.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antipsychotic Agents.
- chemical , therapeutic use : Antipsychotic Agents.
- drug effects : Blood Pressure.
- drug therapy : Mental Disorders.
- physiology : Blood Pressure.
- physiopathology : Mental Disorders.
- Aged, Aged, 80 and over, Aging, Cohort Studies, Female, Humans, Linear Models, Male.
Abstract
The modifiable factors associated with blood pressure variability (BPV) are still being established and their clinical relevance is poorly understood. Generalized anxiety disorder (GAD) and depression have been implicated with higher BPV in the short term (e.g. hours, days) however their effects on BPV over longer periods are unknown.
DOI: 10.1016/j.physbeh.2016.10.024
PubMed: 27818215
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pubmed:27818215Le document en format XML
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<front><div type="abstract" xml:lang="en">The modifiable factors associated with blood pressure variability (BPV) are still being established and their clinical relevance is poorly understood. Generalized anxiety disorder (GAD) and depression have been implicated with higher BPV in the short term (e.g. hours, days) however their effects on BPV over longer periods are unknown.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27818215</PMID>
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<Month>11</Month>
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<Title>Physiology & behavior</Title>
<ISOAbbreviation>Physiol. Behav.</ISOAbbreviation>
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<ArticleTitle>Psychiatric correlates of blood pressure variability in the elderly: The Three City cohort study.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The modifiable factors associated with blood pressure variability (BPV) are still being established and their clinical relevance is poorly understood. Generalized anxiety disorder (GAD) and depression have been implicated with higher BPV in the short term (e.g. hours, days) however their effects on BPV over longer periods are unknown.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In a prospective cohort study, 1454 elderly participants (age 78.5±3.78years, 59% women) underwent structured interview for GAD and major depression. Participants performed home blood pressure monitoring (HBPM) over 3 consecutive days and underwent serial clinic BP measures on 4 separate follow-ups over an 8year period. Systolic and diastolic BPV was calculated using the coefficient of variation (CV) and standard deviation method. Generalized linear models assessed the association between GAD and depression with BPV over an 8year period.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">GAD was associated with significantly increased systolic BPV over 8years in age, sex and mean systolic BP (β=0.25, SE=0.09; p=0.007) and fully adjusted models (β=0.23, SE=0.10; p=0.017). BPV from HBPM was strongly associated with 8year systolic BPV in age-sex (β=3.10, SE=0.82; p<0.001) and fully adjusted models (β=3.09, SE=0.84; p<0.001). The association between GAD and longer term BPV was consistent when analyzing morning and evening HBPM measures of BPV. There was no association between diastolic BPV over 8years with GAD or depression.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">GAD but not depression was associated with increased systolic BPV over an 8year period controlling for HBPM. GAD has clinical relevance for control of systolic BPV in elderly participants.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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