Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease.
Identifieur interne : 003E22 ( Ncbi/Merge ); précédent : 003E21; suivant : 003E23Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease.
Auteurs : Emil Hagström [Suède] ; Claes Held [Suède] ; Ralph A H. Stewart [Nouvelle-Zélande] ; Philip E. Aylward [Australie] ; Andrzej Budaj [Pologne] ; Christopher P. Cannon [États-Unis] ; Wolfgang Koenig [Allemagne] ; Sue Krug-Gourley [États-Unis] ; Emile R. Mohler [États-Unis] ; Philippe Gabriel Steg [France] ; Elizabeth Tarka [États-Unis] ; Ollie Östlund [Suède] ; Harvey D. White [Nouvelle-Zélande] ; Agneta Siegbahn [Suède] ; Lars Wallentin [Suède]Source :
- Clinical chemistry [ 1530-8561 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Facteur-15 de croissance et de différenciation (sang), Facteurs de risque, Femelle, Humains, Maladie coronarienne (diagnostic), Maladie coronarienne (mortalité), Maladie coronarienne (sang), Marqueurs biologiques (sang), Morbidité, Mâle, Sujet âgé, Taux de survie, Études prospectives.
- MESH :
- diagnostic : Maladie coronarienne.
- mortalité : Maladie coronarienne.
- sang : Facteur-15 de croissance et de différenciation, Maladie coronarienne, Marqueurs biologiques.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Morbidité, Mâle, Sujet âgé, Taux de survie, Études prospectives.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Biomarkers, Growth Differentiation Factor 15.
- blood : Coronary Disease.
- diagnosis : Coronary Disease.
- mortality : Coronary Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Morbidity, Prospective Studies, Risk Factors, Survival Rate.
Abstract
Higher growth differentiation factor 15 (GDF-15) concentrations are associated with cardiovascular (CV) and non-CV morbidity and mortality. However, information on associations between GDF-15 and the risk of specific CV and non-CV events in stable coronary heart disease (CHD) patients is limited.
DOI: 10.1373/clinchem.2016.260570
PubMed: 27811204
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pubmed:27811204Le document en format XML
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Stewart</name><affiliation wicri:level="1"><nlm:affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, and University of Auckland, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Green Lane Cardiovascular Service, Auckland City Hospital, and University of Auckland, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, Flinders University and Medical Centre, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, Flinders University and Medical Centre, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Postgraduate Medical School, Grochowski Hospital, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P" last="Cannon">Christopher P. Cannon</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, and Harvard Clinical Research Institute, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Division, Brigham and Women's Hospital, and Harvard Clinical Research Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Krug Gourley, Sue" sort="Krug Gourley, Sue" uniqKey="Krug Gourley S" first="Sue" last="Krug-Gourley">Sue Krug-Gourley</name><affiliation wicri:level="2"><nlm:affiliation>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mohler, Emile R" sort="Mohler, Emile R" uniqKey="Mohler E" first="Emile R" last="Mohler">Emile R. Mohler</name><affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation wicri:level="3"><nlm:affiliation>Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tarka, Elizabeth" sort="Tarka, Elizabeth" uniqKey="Tarka E" first="Elizabeth" last="Tarka">Elizabeth Tarka</name><affiliation wicri:level="2"><nlm:affiliation>former employee of Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>former employee of Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ostlund, Ollie" sort="Ostlund, Ollie" uniqKey="Ostlund O" first="Ollie" last="Östlund">Ollie Östlund</name><affiliation wicri:level="4"><nlm:affiliation>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D" last="White">Harvey D. White</name><affiliation wicri:level="1"><nlm:affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, and University of Auckland, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Green Lane Cardiovascular Service, Auckland City Hospital, and University of Auckland, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Siegbahn, Agneta" sort="Siegbahn, Agneta" uniqKey="Siegbahn A" first="Agneta" last="Siegbahn">Agneta Siegbahn</name><affiliation wicri:level="4"><nlm:affiliation>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Cardiology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author></analytic><series><title level="j">Clinical chemistry</title><idno type="eISSN">1530-8561</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomarkers (blood)</term><term>Coronary Disease (blood)</term><term>Coronary Disease (diagnosis)</term><term>Coronary Disease (mortality)</term><term>Female</term><term>Growth Differentiation Factor 15 (blood)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Morbidity</term><term>Prospective Studies</term><term>Risk Factors</term><term>Survival Rate</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteur-15 de croissance et de différenciation (sang)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Maladie coronarienne (diagnostic)</term><term>Maladie coronarienne (mortalité)</term><term>Maladie coronarienne (sang)</term><term>Marqueurs biologiques (sang)</term><term>Morbidité</term><term>Mâle</term><term>Sujet âgé</term><term>Taux de survie</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Growth Differentiation Factor 15</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronary Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronary Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie coronarienne</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronary Disease</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Maladie coronarienne</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Facteur-15 de croissance et de différenciation</term><term>Maladie coronarienne</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Morbidity</term><term>Prospective Studies</term><term>Risk Factors</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Morbidité</term><term>Mâle</term><term>Sujet âgé</term><term>Taux de survie</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Higher growth differentiation factor 15 (GDF-15) concentrations are associated with cardiovascular (CV) and non-CV morbidity and mortality. However, information on associations between GDF-15 and the risk of specific CV and non-CV events in stable coronary heart disease (CHD) patients is limited.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27811204</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>04</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>06</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1530-8561</ISSN><JournalIssue CitedMedium="Internet"><Volume>63</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Clinical chemistry</Title><ISOAbbreviation>Clin. Chem.</ISOAbbreviation></Journal><ArticleTitle>Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease.</ArticleTitle><Pagination><MedlinePgn>325-333</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1373/clinchem.2016.260570</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Higher growth differentiation factor 15 (GDF-15) concentrations are associated with cardiovascular (CV) and non-CV morbidity and mortality. However, information on associations between GDF-15 and the risk of specific CV and non-CV events in stable coronary heart disease (CHD) patients is limited.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In 14 577 patients with stable CHD participating in the Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial (STABILITY), GDF-15 and other prognostic biomarkers (N-terminal pro-B-type natriuretic peptide, high-sensitivity troponin T, cystatin C, and high-sensitivity C-reactive protein) were measured. In adjusted Cox regression models, the associations between GDF-15 and the composite CV end point [CV death, myocardial infarction (MI), and stroke], as well as other CV and non-CV events, were assessed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The median concentration (interquartile range) of GDF-15 at baseline was 1253 (915-1827) ng/L. The hazard ratio for the composite end point for the highest compared to the lowest quartile of GDF-15 was 1.8 (95% CI, 1.5-2.2); for CV death, 2.63 (1.9-3.6); for sudden death, 3.06 (1.9-4.8); for heart failure (HF) death, 4.3 (1.3-14); for cancer death, 2.5 (1.3-4.7); for hospitalization for HF, 5.8 (3.2-10); for MI 1.4 (95% CI, 1.1-1.9); and for stroke, 1.8 (95% CI, 1.1-2.8). After adjustment for other prognostic biomarkers, GDF-15 remained significantly associated with all outcomes except for MI.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In stable CHD, GDF-15 was independently associated with CV, non-CV, and cancer mortality, as well as with MI and stroke. When also adjusting for other prognostic biomarkers, the associations to all fatal and nonfatal events were maintained except for MI. Information on GDF-15, therefore, might be helpful when assessing the risk of adverse outcomes in patients with stable CHD. ClinicalTrials.gov Identifier: NCT00799903.</AbstractText><CopyrightInformation>© 2016 American Association for Clinical Chemistry.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hagström</LastName><ForeName>Emil</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; emil.hagstrom@ucr.uu.se.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Held</LastName><ForeName>Claes</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stewart</LastName><ForeName>Ralph A H</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, and University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aylward</LastName><ForeName>Philip E</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, Flinders University and Medical Centre, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Budaj</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cannon</LastName><ForeName>Christopher P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, and Harvard Clinical Research Institute, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koenig</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krug-Gourley</LastName><ForeName>Sue</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohler</LastName><ForeName>Emile R</ForeName><Initials>ER</Initials><Suffix>3rd</Suffix><AffiliationInfo><Affiliation>University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steg</LastName><ForeName>Philippe Gabriel</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Sorbonne Paris Cité, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NHLI Imperial College, ICMS, Royal Brompton Hospital, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>FACT (French Alliance for Cardiovascular Trials), an F-CRIN network, INSERM U1148, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tarka</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>former employee of Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Östlund</LastName><ForeName>Ollie</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Harvey D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, and University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siegbahn</LastName><ForeName>Agneta</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallentin</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>STABILITY Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00799903</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Chem</MedlineTA><NlmUniqueID>9421549</NlmUniqueID><ISSNLinking>0009-9147</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C526140">GDF15 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055436">Growth Differentiation Factor 15</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003327" MajorTopicYN="N">Coronary Disease</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055436" MajorTopicYN="N">Growth Differentiation Factor 15</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009017" MajorTopicYN="N">Morbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27811204</ArticleId><ArticleId IdType="pii">clinchem.2016.260570</ArticleId><ArticleId IdType="doi">10.1373/clinchem.2016.260570</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Nouvelle-Zélande</li><li>Pologne</li><li>Suède</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>East Middle Sweden</li><li>Massachusetts</li><li>Pennsylvanie</li><li>Svealand</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Ulm</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Hagstrom, Emil" sort="Hagstrom, Emil" uniqKey="Hagstrom E" first="Emil" last="Hagström">Emil Hagström</name></region><name sortKey="Held, Claes" sort="Held, Claes" uniqKey="Held C" first="Claes" last="Held">Claes Held</name><name sortKey="Ostlund, Ollie" sort="Ostlund, Ollie" uniqKey="Ostlund O" first="Ollie" last="Östlund">Ollie Östlund</name><name sortKey="Siegbahn, Agneta" sort="Siegbahn, Agneta" uniqKey="Siegbahn A" first="Agneta" last="Siegbahn">Agneta Siegbahn</name><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Stewart, Ralph A H" sort="Stewart, Ralph A H" uniqKey="Stewart R" first="Ralph A H" last="Stewart">Ralph A H. Stewart</name></noRegion><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D" last="White">Harvey D. White</name></country><country name="Australie"><noRegion><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P" last="Cannon">Christopher P. Cannon</name></region><name sortKey="Krug Gourley, Sue" sort="Krug Gourley, Sue" uniqKey="Krug Gourley S" first="Sue" last="Krug-Gourley">Sue Krug-Gourley</name><name sortKey="Mohler, Emile R" sort="Mohler, Emile R" uniqKey="Mohler E" first="Emile R" last="Mohler">Emile R. Mohler</name><name sortKey="Tarka, Elizabeth" sort="Tarka, Elizabeth" uniqKey="Tarka E" first="Elizabeth" last="Tarka">Elizabeth Tarka</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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