Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock.
Identifieur interne : 003D19 ( Ncbi/Merge ); précédent : 003D18; suivant : 003D20Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock.
Auteurs : Olivier Huet [États-Unis] ; Raelene J. Pickering ; Chris Tikellis ; Celine Latouche ; Fenella Long ; Bronwyn Kingwell ; Bryan Dickinson ; Chris J. Chang ; Seth Masters ; Fabienne Mackay ; Mark E. Cooper ; Judy B. De HaanSource :
- Critical care medicine [ 1530-0293 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Antioxydants (usage thérapeutique), Choc septique (anatomopathologie), Choc septique (physiopathologie), Espèces réactives de l'oxygène (métabolisme), Femelle, Glutathione peroxidase (métabolisme), Infections à Klebsiella (physiopathologie), Inflammasomes (physiologie), Klebsiella pneumoniae, Modèles animaux de maladie humaine, Mâle, Peroxyde d'hydrogène (métabolisme), Pneumopathie bactérienne (anatomopathologie), Pneumopathie bactérienne (physiopathologie), Poumon (anatomopathologie), Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée C57BL, Souris knockout, Technique de Western.
- MESH :
- anatomopathologie : Choc septique, Pneumopathie bactérienne, Poumon.
- métabolisme : Espèces réactives de l'oxygène, Glutathione peroxidase, Peroxyde d'hydrogène.
- physiologie : Inflammasomes.
- physiopathologie : Choc septique, Infections à Klebsiella, Pneumopathie bactérienne.
- usage thérapeutique : Antioxydants.
- Animaux, Femelle, Klebsiella pneumoniae, Modèles animaux de maladie humaine, Mâle, Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée C57BL, Souris knockout, Technique de Western.
English descriptors
- KwdEn :
- Animals, Antioxidants (therapeutic use), Blotting, Western, Disease Models, Animal, Female, Glutathione Peroxidase (metabolism), Hydrogen Peroxide (metabolism), Inflammasomes (physiology), Klebsiella Infections (physiopathology), Klebsiella pneumoniae, Lung (pathology), Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Pneumonia, Bacterial (pathology), Pneumonia, Bacterial (physiopathology), Reactive Oxygen Species (metabolism), Real-Time Polymerase Chain Reaction, Shock, Septic (pathology), Shock, Septic (physiopathology).
- MESH :
- chemical , metabolism : Glutathione Peroxidase, Hydrogen Peroxide, Reactive Oxygen Species.
- chemical , physiology : Inflammasomes.
- chemical , therapeutic use : Antioxidants.
- pathology : Lung, Pneumonia, Bacterial, Shock, Septic.
- physiopathology : Klebsiella Infections, Pneumonia, Bacterial, Shock, Septic.
- Animals, Blotting, Western, Disease Models, Animal, Female, Klebsiella pneumoniae, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Real-Time Polymerase Chain Reaction.
Abstract
To study the effect of a lack of antioxidant defenses during lethal pneumonia induced by Klebsiella pneumonia, compared to wild-type mice.
DOI: 10.1097/CCM.0000000000002070
PubMed: 27749344
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001175
- to stream PubMed, to step Curation: 001172
- to stream PubMed, to step Checkpoint: 001172
Links to Exploration step
pubmed:27749344Le document en format XML
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<series><title level="j">Critical care medicine</title>
<idno type="eISSN">1530-0293</idno>
<imprint><date when="2017" type="published">2017</date>
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<term>Antioxidants (therapeutic use)</term>
<term>Blotting, Western</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Glutathione Peroxidase (metabolism)</term>
<term>Hydrogen Peroxide (metabolism)</term>
<term>Inflammasomes (physiology)</term>
<term>Klebsiella Infections (physiopathology)</term>
<term>Klebsiella pneumoniae</term>
<term>Lung (pathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Pneumonia, Bacterial (pathology)</term>
<term>Pneumonia, Bacterial (physiopathology)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Shock, Septic (pathology)</term>
<term>Shock, Septic (physiopathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antioxydants (usage thérapeutique)</term>
<term>Choc septique (anatomopathologie)</term>
<term>Choc septique (physiopathologie)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Femelle</term>
<term>Glutathione peroxidase (métabolisme)</term>
<term>Infections à Klebsiella (physiopathologie)</term>
<term>Inflammasomes (physiologie)</term>
<term>Klebsiella pneumoniae</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Peroxyde d'hydrogène (métabolisme)</term>
<term>Pneumopathie bactérienne (anatomopathologie)</term>
<term>Pneumopathie bactérienne (physiopathologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Technique de Western</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione Peroxidase</term>
<term>Hydrogen Peroxide</term>
<term>Reactive Oxygen Species</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Inflammasomes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antioxidants</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Choc septique</term>
<term>Pneumopathie bactérienne</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term>
<term>Glutathione peroxidase</term>
<term>Peroxyde d'hydrogène</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Pneumonia, Bacterial</term>
<term>Shock, Septic</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Inflammasomes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Choc septique</term>
<term>Infections à Klebsiella</term>
<term>Pneumopathie bactérienne</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Klebsiella Infections</term>
<term>Pneumonia, Bacterial</term>
<term>Shock, Septic</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antioxydants</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Blotting, Western</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Klebsiella pneumoniae</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Klebsiella pneumoniae</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Technique de Western</term>
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<front><div type="abstract" xml:lang="en">To study the effect of a lack of antioxidant defenses during lethal pneumonia induced by Klebsiella pneumonia, compared to wild-type mice.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27749344</PMID>
<DateCreated><Year>2016</Year>
<Month>10</Month>
<Day>17</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>05</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-0293</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>45</Volume>
<Issue>2</Issue>
<PubDate><Year>2017</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Critical care medicine</Title>
<ISOAbbreviation>Crit. Care Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock.</ArticleTitle>
<Pagination><MedlinePgn>e184-e194</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/CCM.0000000000002070</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To study the effect of a lack of antioxidant defenses during lethal pneumonia induced by Klebsiella pneumonia, compared to wild-type mice.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">Laboratory experiments.</AbstractText>
<AbstractText Label="SUBJECTS" NlmCategory="METHODS">C57Bl6 and glutathione peroxidase 1 knockout mice.</AbstractText>
<AbstractText Label="INTERVENTION" NlmCategory="METHODS">Murine acute pneumonia model induced by Klebsiella pneumonia.</AbstractText>
<AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">We show here that despite a lack of one of the major antioxidant defense enzymes, glutathione peroxidase 1 knockout mice are protected during lethal pneumonia induced by Klebsiella pneumonia, compared to wild-type mice. Furthermore, this protective effect was suppressed when antioxidant defenses were restored. Infected glutathione peroxidase 1 mice showed an early and significant, albeit transient, increase in the activity of the NOD-like receptor family, pyrin domain containing 3 inflammasome when compared with wild-type mice. The key role of the NOD-like receptor family, pyrin domain containing 3 inflammasome during acute pneumonia was confirmed in vivo when the protective effect was suppressed by treating glutathione peroxidase 1 mice with an interleukin-1 receptor antagonist. Additionally we report, in vitro, that increased concentrations of active caspase-1 and interleukin-1β are related to an increased concentration of hydrogen peroxide in bacterially infected glutathione peroxidase 1 macrophages and that restoring hydrogen peroxide antioxidant defenses suppressed this effect.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings demonstrate that, contrary to current thinking, an early intervention targeting NOD-like receptor family, pyrin domain containing 3 inflammasome activity induces a timely and efficient activation of the innate immune response during acute infection. Our findings also demonstrate a role for hydrogen peroxide in the mechanisms tightly regulating NOD-like receptor family, pyrin domain containing 3 activation.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Huet</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>1Diabetes Complications, BakerIDI Heart and Diabetes Institute, Melbourne, VIC, Australia. 2Department of Anaesthesia and Intensive Care, CHRU La Cavale Blanche, Université de Bretagne Ouest, Brest, France. 3Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. 4Inflammation Division, The Walter and Eliza Hall Institute, Parkville, VIC, Australia. 5Departments of Chemistry and Molecular and Cell Biology and the Howard Hughes Medical Institute, University of California, Berkeley, CA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pickering</LastName>
<ForeName>Raelene J</ForeName>
<Initials>RJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tikellis</LastName>
<ForeName>Chris</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Latouche</LastName>
<ForeName>Celine</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Long</LastName>
<ForeName>Fenella</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kingwell</LastName>
<ForeName>Bronwyn</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Dickinson</LastName>
<ForeName>Bryan</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Chris J</ForeName>
<Initials>CJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Masters</LastName>
<ForeName>Seth</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mackay</LastName>
<ForeName>Fabienne</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cooper</LastName>
<ForeName>Mark E</ForeName>
<Initials>ME</Initials>
</Author>
<Author ValidYN="Y"><LastName>de Haan</LastName>
<ForeName>Judy B</ForeName>
<Initials>JB</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
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</PublicationTypeList>
</Article>
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<MedlineTA>Crit Care Med</MedlineTA>
<NlmUniqueID>0355501</NlmUniqueID>
<ISSNLinking>0090-3493</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D058847">Inflammasomes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>BBX060AN9V</RegistryNumber>
<NameOfSubstance UI="D006861">Hydrogen Peroxide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.-</RegistryNumber>
<NameOfSubstance UI="C117216">glutathione peroxidase GPX1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber>
<NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance>
</Chemical>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005979" MajorTopicYN="N">Glutathione Peroxidase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006861" MajorTopicYN="N">Hydrogen Peroxide</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058847" MajorTopicYN="N">Inflammasomes</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007710" MajorTopicYN="N">Klebsiella Infections</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007711" MajorTopicYN="N">Klebsiella pneumoniae</DescriptorName>
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<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018410" MajorTopicYN="N">Pneumonia, Bacterial</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
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<MeshHeading><DescriptorName UI="D012772" MajorTopicYN="N">Shock, Septic</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
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<name sortKey="Cooper, Mark E" sort="Cooper, Mark E" uniqKey="Cooper M" first="Mark E" last="Cooper">Mark E. Cooper</name>
<name sortKey="De Haan, Judy B" sort="De Haan, Judy B" uniqKey="De Haan J" first="Judy B" last="De Haan">Judy B. De Haan</name>
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<name sortKey="Masters, Seth" sort="Masters, Seth" uniqKey="Masters S" first="Seth" last="Masters">Seth Masters</name>
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