Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.
Identifieur interne : 003C13 ( Ncbi/Merge ); précédent : 003C12; suivant : 003C14Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.
Auteurs : Sanjay Mehta [Canada] ; Bhagavatula Kutumba Srinivasa Sastry [Inde] ; Rogério Souza [Brésil] ; Adam Torbicki [Pologne] ; Hossein-Ardeschir Ghofrani [Royaume-Uni] ; Richard N. Channick [États-Unis] ; Marion Delcroix [Belgique] ; Tomás Pulido [Mexique] ; Gérald Simonneau [France] ; John Wlodarczyk [Australie] ; Lewis J. Rubin [États-Unis] ; Pavel Jansa [République tchèque] ; Elke Hunsche [Suisse] ; Nazzareno Galiè [Italie] ; Loïc Perchenet [Suisse] ; Olivier Sitbon [France]Source :
- Chest [ 1931-3543 ] ; 2017.
Descripteurs français
- KwdFr :
- Acuité des besoins du patient, Adulte, Adulte d'âge moyen, Antagonistes du récepteur de type B de l'endothéline (administration et posologie), Antagonistes du récepteur de type B de l'endothéline (effets indésirables), Femelle, Humains, Hypertension pulmonaire (diagnostic), Hypertension pulmonaire (physiopathologie), Hypertension pulmonaire (psychologie), Hypertension pulmonaire (traitement médicamenteux), Mâle, Pyrimidines (administration et posologie), Pyrimidines (effets indésirables), Qualité de vie, Relation dose-effet des médicaments, Résultat thérapeutique, Sulfonamides (administration et posologie), Sulfonamides (effets indésirables), Surveillance pharmacologique ().
- MESH :
- administration et posologie : Antagonistes du récepteur de type B de l'endothéline, Pyrimidines, Sulfonamides.
- diagnostic : Hypertension pulmonaire.
- effets indésirables : Antagonistes du récepteur de type B de l'endothéline, Pyrimidines, Sulfonamides.
- physiopathologie : Hypertension pulmonaire.
- psychologie : Hypertension pulmonaire.
- traitement médicamenteux : Hypertension pulmonaire.
- Acuité des besoins du patient, Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Qualité de vie, Relation dose-effet des médicaments, Résultat thérapeutique, Surveillance pharmacologique.
English descriptors
- KwdEn :
- Adult, Dose-Response Relationship, Drug, Drug Monitoring (methods), Endothelin B Receptor Antagonists (administration & dosage), Endothelin B Receptor Antagonists (adverse effects), Female, Humans, Hypertension, Pulmonary (diagnosis), Hypertension, Pulmonary (drug therapy), Hypertension, Pulmonary (physiopathology), Hypertension, Pulmonary (psychology), Male, Middle Aged, Patient Acuity, Pyrimidines (administration & dosage), Pyrimidines (adverse effects), Quality of Life, Sulfonamides (administration & dosage), Sulfonamides (adverse effects), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Endothelin B Receptor Antagonists, Pyrimidines, Sulfonamides.
- chemical , adverse effects : Endothelin B Receptor Antagonists, Pyrimidines, Sulfonamides.
- diagnosis : Hypertension, Pulmonary.
- drug therapy : Hypertension, Pulmonary.
- methods : Drug Monitoring.
- physiopathology : Hypertension, Pulmonary.
- psychology : Hypertension, Pulmonary.
- Adult, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Patient Acuity, Quality of Life, Treatment Outcome.
Abstract
Pulmonary arterial hypertension (PAH) leads to reduced health-related quality of life (HRQoL). The objectives of this analysis were to evaluate the effect of macitentan on HRQoL in patients with PAH in the Study with an Endothelin Receptor Antagonist in Pulmonary Arterial Hypertension to Improve Clinical Outcome (SERAPHIN) study. The association between baseline HRQoL and long-term outcomes was also investigated.
DOI: 10.1016/j.chest.2016.08.1473
PubMed: 27671974
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Rubin</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Diego Medical School, San Diego, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of California, San Diego Medical School, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Jansa, Pavel" sort="Jansa, Pavel" uniqKey="Jansa P" first="Pavel" last="Jansa">Pavel Jansa</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Hunsche, Elke" sort="Hunsche, Elke" uniqKey="Hunsche E" first="Elke" last="Hunsche">Elke Hunsche</name><affiliation wicri:level="1"><nlm:affiliation>Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Actelion Pharmaceuticals Ltd, Allschwil</wicri:regionArea><wicri:noRegion>Allschwil</wicri:noRegion></affiliation></author><author><name sortKey="Galie, Nazzareno" sort="Galie, Nazzareno" uniqKey="Galie N" first="Nazzareno" last="Galiè">Nazzareno Galiè</name><affiliation wicri:level="1"><nlm:affiliation>Bologna University Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Bologna University Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Perchenet, Loic" sort="Perchenet, Loic" uniqKey="Perchenet L" first="Loïc" last="Perchenet">Loïc Perchenet</name><affiliation wicri:level="1"><nlm:affiliation>Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Actelion Pharmaceuticals Ltd, Allschwil</wicri:regionArea><wicri:noRegion>Allschwil</wicri:noRegion></affiliation></author><author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name><affiliation wicri:level="4"><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea><wicri:noRegion>Le Plessis Robinson</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27671974</idno><idno type="pmid">27671974</idno><idno type="doi">10.1016/j.chest.2016.08.1473</idno><idno type="wicri:Area/PubMed/Corpus">001375</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001375</idno><idno type="wicri:Area/PubMed/Curation">001353</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001353</idno><idno type="wicri:Area/PubMed/Checkpoint">001353</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001353</idno><idno type="wicri:Area/Ncbi/Merge">003C13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.</title><author><name sortKey="Mehta, Sanjay" sort="Mehta, Sanjay" uniqKey="Mehta S" first="Sanjay" last="Mehta">Sanjay Mehta</name><affiliation wicri:level="1"><nlm:affiliation>London Health Sciences Centre, Victoria Hospital, Western University, London, ON, Canada. Electronic address: sanjay.mehta@lhsc.on.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>London Health Sciences Centre, Victoria Hospital, Western University, London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Sastry, Bhagavatula Kutumba Srinivasa" sort="Sastry, Bhagavatula Kutumba Srinivasa" uniqKey="Sastry B" first="Bhagavatula Kutumba Srinivasa" last="Sastry">Bhagavatula Kutumba Srinivasa Sastry</name><affiliation wicri:level="1"><nlm:affiliation>CARE Hospitals, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>CARE Hospitals, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Souza, Rogerio" sort="Souza, Rogerio" uniqKey="Souza R" first="Rogério" last="Souza">Rogério Souza</name><affiliation wicri:level="3"><nlm:affiliation>Heart Institute, University of São Paulo Medical School, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Heart Institute, University of São Paulo Medical School, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Torbicki, Adam" sort="Torbicki, Adam" uniqKey="Torbicki A" first="Adam" last="Torbicki">Adam Torbicki</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Postgraduate Medical Education, Europejskie Centrum Zdrowia, Otwock, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Centre of Postgraduate Medical Education, Europejskie Centrum Zdrowia, Otwock</wicri:regionArea><wicri:noRegion>Otwock</wicri:noRegion></affiliation></author><author><name sortKey="Ghofrani, Hossein Ardeschir" sort="Ghofrani, Hossein Ardeschir" uniqKey="Ghofrani H" first="Hossein-Ardeschir" last="Ghofrani">Hossein-Ardeschir Ghofrani</name><affiliation wicri:level="2"><nlm:affiliation>University of Giessen and Marburg Lung Center, Giessen, Germany, Member of the German Center of Lung Research (DZL), Giessen, Germany, and Department of Medicine, Imperial College London, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Giessen and Marburg Lung Center, Giessen, Germany, Member of the German Center of Lung Research (DZL), Giessen, Germany, and Department of Medicine, Imperial College London, London</wicri:cityArea></affiliation></author><author><name sortKey="Channick, Richard N" sort="Channick, Richard N" uniqKey="Channick R" first="Richard N" last="Channick">Richard N. Channick</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Delcroix, Marion" sort="Delcroix, Marion" uniqKey="Delcroix M" first="Marion" last="Delcroix">Marion Delcroix</name><affiliation wicri:level="1"><nlm:affiliation>Gasthuisberg University Hospital, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Gasthuisberg University Hospital, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Pulido, Tomas" sort="Pulido, Tomas" uniqKey="Pulido T" first="Tomás" last="Pulido">Tomás Pulido</name><affiliation wicri:level="1"><nlm:affiliation>Ignacio Chávez National Heart Institute, Mexico City, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Ignacio Chávez National Heart Institute, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name><affiliation wicri:level="4"><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea><wicri:noRegion>Le Plessis Robinson</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Wlodarczyk, John" sort="Wlodarczyk, John" uniqKey="Wlodarczyk J" first="John" last="Wlodarczyk">John Wlodarczyk</name><affiliation wicri:level="1"><nlm:affiliation>John Wlodarczyk Consulting Services, Newcastle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Wlodarczyk Consulting Services, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Rubin, Lewis J" sort="Rubin, Lewis J" uniqKey="Rubin L" first="Lewis J" last="Rubin">Lewis J. Rubin</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Diego Medical School, San Diego, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of California, San Diego Medical School, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Jansa, Pavel" sort="Jansa, Pavel" uniqKey="Jansa P" first="Pavel" last="Jansa">Pavel Jansa</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Hunsche, Elke" sort="Hunsche, Elke" uniqKey="Hunsche E" first="Elke" last="Hunsche">Elke Hunsche</name><affiliation wicri:level="1"><nlm:affiliation>Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Actelion Pharmaceuticals Ltd, Allschwil</wicri:regionArea><wicri:noRegion>Allschwil</wicri:noRegion></affiliation></author><author><name sortKey="Galie, Nazzareno" sort="Galie, Nazzareno" uniqKey="Galie N" first="Nazzareno" last="Galiè">Nazzareno Galiè</name><affiliation wicri:level="1"><nlm:affiliation>Bologna University Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Bologna University Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Perchenet, Loic" sort="Perchenet, Loic" uniqKey="Perchenet L" first="Loïc" last="Perchenet">Loïc Perchenet</name><affiliation wicri:level="1"><nlm:affiliation>Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Actelion Pharmaceuticals Ltd, Allschwil</wicri:regionArea><wicri:noRegion>Allschwil</wicri:noRegion></affiliation></author><author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name><affiliation wicri:level="4"><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea><wicri:noRegion>Le Plessis Robinson</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j">Chest</title><idno type="eISSN">1931-3543</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Dose-Response Relationship, Drug</term><term>Drug Monitoring (methods)</term><term>Endothelin B Receptor Antagonists (administration & dosage)</term><term>Endothelin B Receptor Antagonists (adverse effects)</term><term>Female</term><term>Humans</term><term>Hypertension, Pulmonary (diagnosis)</term><term>Hypertension, Pulmonary (drug therapy)</term><term>Hypertension, Pulmonary (physiopathology)</term><term>Hypertension, Pulmonary (psychology)</term><term>Male</term><term>Middle Aged</term><term>Patient Acuity</term><term>Pyrimidines (administration & dosage)</term><term>Pyrimidines (adverse effects)</term><term>Quality of Life</term><term>Sulfonamides (administration & dosage)</term><term>Sulfonamides (adverse effects)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acuité des besoins du patient</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antagonistes du récepteur de type B de l'endothéline (administration et posologie)</term><term>Antagonistes du récepteur de type B de l'endothéline (effets indésirables)</term><term>Femelle</term><term>Humains</term><term>Hypertension pulmonaire (diagnostic)</term><term>Hypertension pulmonaire (physiopathologie)</term><term>Hypertension pulmonaire (psychologie)</term><term>Hypertension pulmonaire (traitement médicamenteux)</term><term>Mâle</term><term>Pyrimidines (administration et posologie)</term><term>Pyrimidines (effets indésirables)</term><term>Qualité de vie</term><term>Relation dose-effet des médicaments</term><term>Résultat thérapeutique</term><term>Sulfonamides (administration et posologie)</term><term>Sulfonamides (effets indésirables)</term><term>Surveillance pharmacologique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Endothelin B Receptor Antagonists</term><term>Pyrimidines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Endothelin B Receptor Antagonists</term><term>Pyrimidines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antagonistes du récepteur de type B de l'endothéline</term><term>Pyrimidines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypertension, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hypertension pulmonaire</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypertension, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antagonistes du récepteur de type B de l'endothéline</term><term>Pyrimidines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Monitoring</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hypertension pulmonaire</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypertension, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Hypertension pulmonaire</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Hypertension, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hypertension pulmonaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Patient Acuity</term><term>Quality of Life</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acuité des besoins du patient</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Qualité de vie</term><term>Relation dose-effet des médicaments</term><term>Résultat thérapeutique</term><term>Surveillance pharmacologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pulmonary arterial hypertension (PAH) leads to reduced health-related quality of life (HRQoL). The objectives of this analysis were to evaluate the effect of macitentan on HRQoL in patients with PAH in the Study with an Endothelin Receptor Antagonist in Pulmonary Arterial Hypertension to Improve Clinical Outcome (SERAPHIN) study. The association between baseline HRQoL and long-term outcomes was also investigated.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27671974</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>27</Day></DateCreated><DateCompleted><Year>2017</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1931-3543</ISSN><JournalIssue CitedMedium="Internet"><Volume>151</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Chest</Title><ISOAbbreviation>Chest</ISOAbbreviation></Journal><ArticleTitle>Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.</ArticleTitle><Pagination><MedlinePgn>106-118</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0012-3692(16)59209-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chest.2016.08.1473</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pulmonary arterial hypertension (PAH) leads to reduced health-related quality of life (HRQoL). The objectives of this analysis were to evaluate the effect of macitentan on HRQoL in patients with PAH in the Study with an Endothelin Receptor Antagonist in Pulmonary Arterial Hypertension to Improve Clinical Outcome (SERAPHIN) study. The association between baseline HRQoL and long-term outcomes was also investigated.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients were randomized to placebo, macitentan 3 mg, or macitentan 10 mg once daily. Patients aged 14 years or older completed the 36-Item Short Form Survey (SF-36) at baseline, at month 6 and month 12, and at the end of treatment (EOT). The absolute change from baseline to month 6 in SF-36 scores was calculated. The time to a clinically meaningful deterioration in the SF-36 physical component summary and mental component summary (PCS and MCS) scores and associations between baseline PCS/MCS scores and time to morbidity/mortality events were also assessed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At month 6, macitentan 10 mg significantly improved seven of eight SF-36 domains and the PCS and MCS scores vs placebo. Macitentan 10 mg significantly reduced the risk of a three-point or greater deterioration in PCS (hazard ratio [HR], 0.60; 95% CI, 0.47-0.76; P < .0001) and MCS scores (HR, 0.76; 95% CI, 0.61-0.95; P = .0173) until EOT vs placebo. Patients with a baseline PCS score greater than the median baseline value had a significantly reduced risk of morbidity/mortality compared with patients with a PCS score less than the median; a similar result was observed for the MCS score.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Macitentan significantly improved HRQoL in patients with PAH compared with placebo and significantly reduced the risk of a clinically meaningful HRQoL deterioration. An association between better baseline HRQoL and improved long-term outcomes was shown.</AbstractText><AbstractText Label="TRIAL REGISTRY" NlmCategory="BACKGROUND">ClinicalTrials.gov; No.: NCT00660179; URL: clinicaltrials.gov.</AbstractText><CopyrightInformation>Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mehta</LastName><ForeName>Sanjay</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>London Health Sciences Centre, Victoria Hospital, Western University, London, ON, Canada. Electronic address: sanjay.mehta@lhsc.on.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sastry</LastName><ForeName>Bhagavatula Kutumba Srinivasa</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>CARE Hospitals, Hyderabad, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souza</LastName><ForeName>Rogério</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Heart Institute, University of São Paulo Medical School, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torbicki</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre of Postgraduate Medical Education, Europejskie Centrum Zdrowia, Otwock, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghofrani</LastName><ForeName>Hossein-Ardeschir</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>University of Giessen and Marburg Lung Center, Giessen, Germany, Member of the German Center of Lung Research (DZL), Giessen, Germany, and Department of Medicine, Imperial College London, London, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Channick</LastName><ForeName>Richard N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Massachusetts General Hospital, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delcroix</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Gasthuisberg University Hospital, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pulido</LastName><ForeName>Tomás</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Ignacio Chávez National Heart Institute, Mexico City, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonneau</LastName><ForeName>Gérald</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wlodarczyk</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>John Wlodarczyk Consulting Services, Newcastle, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubin</LastName><ForeName>Lewis J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>University of California, San Diego Medical School, San Diego, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jansa</LastName><ForeName>Pavel</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Charles University, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunsche</LastName><ForeName>Elke</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galiè</LastName><ForeName>Nazzareno</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Bologna University Hospital, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perchenet</LastName><ForeName>Loïc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sitbon</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00660179</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>09</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Chest</MedlineTA><NlmUniqueID>0231335</NlmUniqueID><ISSNLinking>0012-3692</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D065131">Endothelin B Receptor Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011743">Pyrimidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013449">Sulfonamides</NameOfSubstance></Chemical><Chemical><RegistryNumber>Z9K9Y9WMVL</RegistryNumber><NameOfSubstance UI="C533860">macitentan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016903" MajorTopicYN="N">Drug Monitoring</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065131" MajorTopicYN="N">Endothelin B Receptor Antagonists</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006976" MajorTopicYN="Y">Hypertension, Pulmonary</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062072" MajorTopicYN="N">Patient Acuity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011743" MajorTopicYN="Y">Pyrimidines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013449" MajorTopicYN="Y">Sulfonamides</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">health-related quality of life</Keyword><Keyword MajorTopicYN="Y">pharmacotherapy</Keyword><Keyword MajorTopicYN="Y">pulmonary arterial hypertension</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>07</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>08</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27671974</ArticleId><ArticleId 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