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Serveur d'exploration sur les relations entre la France et l'Australie

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Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case–control study

Identifieur interne : 003942 ( Ncbi/Merge ); précédent : 003941; suivant : 003943

Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case–control study

Auteurs : Pierre-Antoine Dugué [Australie] ; Maree T. Brinkman [Australie] ; Roger L. Milne [Australie] ; Ee Ming Wong [Australie] ; Liesel M. Fitzgerald [Australie] ; Julie K. Bassett [Australie] ; Jihoon E. Joo [Australie] ; Chol-Hee Jung [Australie] ; Enes Makalic [Australie] ; Daniel F. Schmidt [Australie] ; Daniel J. Park [Australie] ; Jessica Chung [Australie] ; Anthony D. Ta [Australie] ; Damien M. Bolton [Australie] ; Andrew Lonie [Australie] ; Anthony Longano [Australie] ; John L. Hopper [Australie] ; Gianluca Severi [Australie, France, Italie] ; Richard Saffery [Australie] ; Dallas R. English [Australie] ; Melissa C. Southey [Australie] ; Graham G. Giles [Australie]

Source :

RBID : PMC:5023776

Descripteurs français

English descriptors

Abstract

Background:

Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk.

Methods:

We used 439 case–control pairs from the Melbourne Collaborative Cohort Study matched on age, sex, country of birth, DNA sample type, and collection period. Conditional logistic regression was used to compute odds ratios (OR) of UCC risk per s.d. of each genome-wide measure of DNA methylation and 95% confidence intervals (CIs), adjusted for potential confounders. We also investigated associations by disease subtype, sex, smoking, and time since blood collection.

Results:

The risk of superficial UCC was decreased for individuals with higher levels of our genome-wide DNA methylation measure (OR=0.71, 95% CI: 0.54–0.94; P=0.02). This association was particularly strong for current smokers at sample collection (OR=0.47, 95% CI: 0.27–0.83). Intermediate levels of our genome-wide measure were associated with decreased risk of invasive UCC. Some variation was observed between UCC subtypes and the location and regulatory function of the CpGs included in the genome-wide measures of methylation.

Conclusions:

Higher levels of our genome-wide DNA methylation measure were associated with decreased risk of superficial UCC and intermediate levels were associated with reduced risk of invasive disease. These findings require replication by other prospective studies.


Url:
DOI: 10.1038/bjc.2016.237
PubMed: 27490804
PubMed Central: 5023776

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PMC:5023776

Le document en format XML

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<name sortKey="Longano, Anthony" sort="Longano, Anthony" uniqKey="Longano A" first="Anthony" last="Longano">Anthony Longano</name>
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<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
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<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
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<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M" last="Fitzgerald">Liesel M. Fitzgerald</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Hobart, TAS 7000,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name>
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, Melbourne, VIC 3004,
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<name sortKey="Joo, Jihoon E" sort="Joo, Jihoon E" uniqKey="Joo J" first="Jihoon E" last="Joo">Jihoon E. Joo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jung, Chol Hee" sort="Jung, Chol Hee" uniqKey="Jung C" first="Chol-Hee" last="Jung">Chol-Hee Jung</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>
, Carlton, VIC 3053,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chung, Jessica" sort="Chung, Jessica" uniqKey="Chung J" first="Jessica" last="Chung">Jessica Chung</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Menzies Institute for Medical Research, University of Tasmania</institution>
, Hobart, TAS 7000,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ta, Anthony D" sort="Ta, Anthony D" uniqKey="Ta A" first="Anthony D" last="Ta">Anthony D. Ta</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Department of Surgery, University of Melbourne</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bolton, Damien M" sort="Bolton, Damien M" uniqKey="Bolton D" first="Damien M" last="Bolton">Damien M. Bolton</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Department of Surgery, University of Melbourne</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>
, Carlton, VIC 3053,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Longano, Anthony" sort="Longano, Anthony" uniqKey="Longano A" first="Anthony" last="Longano">Anthony Longano</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Anatomical Pathology, Monash Medical Centre</institution>
, Clayton, VIC 3800,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>
, Villejuif,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Gustave Roussy</institution>
, Villejuif F-94805,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>HuGeF, Human Genetics Foundation</institution>
, Torino 10126,
<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<institution>Department of Paediatrics, University of Melbourne</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Cancer, Disease and Developmental Epigenetics Group, Cell Biology, Development and Disease Theme, Murdoch Childrens Research Institute, Royal Children's Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
<idno type="eISSN">1532-1827</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
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<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Blood Specimen Collection</term>
<term>Carcinoma, Transitional Cell (blood)</term>
<term>Carcinoma, Transitional Cell (epidemiology)</term>
<term>Carcinoma, Transitional Cell (genetics)</term>
<term>Carcinoma, Transitional Cell (pathology)</term>
<term>Case-Control Studies</term>
<term>CpG Islands</term>
<term>DNA (blood)</term>
<term>DNA Methylation</term>
<term>Diet</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasm Invasiveness</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Smoking (epidemiology)</term>
<term>Time Factors</term>
<term>Urologic Neoplasms (blood)</term>
<term>Urologic Neoplasms (epidemiology)</term>
<term>Urologic Neoplasms (genetics)</term>
<term>Urologic Neoplasms (pathology)</term>
<term>Victoria (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ADN (sang)</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Carcinome transitionnel (anatomopathologie)</term>
<term>Carcinome transitionnel (génétique)</term>
<term>Carcinome transitionnel (sang)</term>
<term>Carcinome transitionnel (épidémiologie)</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Ilots CpG</term>
<term>Incidence</term>
<term>Invasion tumorale</term>
<term>Mâle</term>
<term>Méthylation de l'ADN</term>
<term>Prélèvement sanguin</term>
<term>Risque</term>
<term>Régime alimentaire</term>
<term>Sujet âgé</term>
<term>Tabagisme (épidémiologie)</term>
<term>Tumeurs urologiques (anatomopathologie)</term>
<term>Tumeurs urologiques (génétique)</term>
<term>Tumeurs urologiques (sang)</term>
<term>Tumeurs urologiques (épidémiologie)</term>
<term>Victoria (épidémiologie)</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>DNA</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Carcinome transitionnel</term>
<term>Tumeurs urologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en">
<term>Carcinoma, Transitional Cell</term>
<term>Urologic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Carcinoma, Transitional Cell</term>
<term>Smoking</term>
<term>Urologic Neoplasms</term>
<term>Victoria</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Carcinoma, Transitional Cell</term>
<term>Urologic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Carcinome transitionnel</term>
<term>Tumeurs urologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Carcinoma, Transitional Cell</term>
<term>Urologic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr">
<term>ADN</term>
<term>Carcinome transitionnel</term>
<term>Tumeurs urologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Carcinome transitionnel</term>
<term>Tabagisme</term>
<term>Tumeurs urologiques</term>
<term>Victoria</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Blood Specimen Collection</term>
<term>Case-Control Studies</term>
<term>CpG Islands</term>
<term>DNA Methylation</term>
<term>Diet</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasm Invasiveness</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Ilots CpG</term>
<term>Incidence</term>
<term>Invasion tumorale</term>
<term>Mâle</term>
<term>Méthylation de l'ADN</term>
<term>Prélèvement sanguin</term>
<term>Risque</term>
<term>Régime alimentaire</term>
<term>Sujet âgé</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background:</title>
<p>Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk.</p>
</sec>
<sec>
<title>Methods:</title>
<p>We used 439 case–control pairs from the Melbourne Collaborative Cohort Study matched on age, sex, country of birth, DNA sample type, and collection period. Conditional logistic regression was used to compute odds ratios (OR) of UCC risk per s.d. of each genome-wide measure of DNA methylation and 95% confidence intervals (CIs), adjusted for potential confounders. We also investigated associations by disease subtype, sex, smoking, and time since blood collection.</p>
</sec>
<sec>
<title>Results:</title>
<p>The risk of superficial UCC was decreased for individuals with higher levels of our genome-wide DNA methylation measure (OR=0.71, 95% CI: 0.54–0.94;
<italic>P</italic>
=0.02). This association was particularly strong for current smokers at sample collection (OR=0.47, 95% CI: 0.27–0.83). Intermediate levels of our genome-wide measure were associated with decreased risk of invasive UCC. Some variation was observed between UCC subtypes and the location and regulatory function of the CpGs included in the genome-wide measures of methylation.</p>
</sec>
<sec>
<title>Conclusions:</title>
<p>Higher levels of our genome-wide DNA methylation measure were associated with decreased risk of superficial UCC and intermediate levels were associated with reduced risk of invasive disease. These findings require replication by other prospective studies.</p>
</sec>
</div>
</front>
<back>
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</TEI>
<double pmid="27490804">
<pmc>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case–control study</title>
<author>
<name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brinkman, Maree T" sort="Brinkman, Maree T" uniqKey="Brinkman M" first="Maree T" last="Brinkman">Maree T. Brinkman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<name sortKey="Wong, Ee Ming" sort="Wong, Ee Ming" uniqKey="Wong E" first="Ee Ming" last="Wong">Ee Ming Wong</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M" last="Fitzgerald">Liesel M. Fitzgerald</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<institution>Menzies Institute for Medical Research, University of Tasmania</institution>
, Hobart, TAS 7000,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Joo, Jihoon E" sort="Joo, Jihoon E" uniqKey="Joo J" first="Jihoon E" last="Joo">Jihoon E. Joo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jung, Chol Hee" sort="Jung, Chol Hee" uniqKey="Jung C" first="Chol-Hee" last="Jung">Chol-Hee Jung</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>
, Carlton, VIC 3053,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chung, Jessica" sort="Chung, Jessica" uniqKey="Chung J" first="Jessica" last="Chung">Jessica Chung</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Menzies Institute for Medical Research, University of Tasmania</institution>
, Hobart, TAS 7000,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ta, Anthony D" sort="Ta, Anthony D" uniqKey="Ta A" first="Anthony D" last="Ta">Anthony D. Ta</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Department of Surgery, University of Melbourne</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bolton, Damien M" sort="Bolton, Damien M" uniqKey="Bolton D" first="Damien M" last="Bolton">Damien M. Bolton</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Department of Surgery, University of Melbourne</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>
, Carlton, VIC 3053,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Longano, Anthony" sort="Longano, Anthony" uniqKey="Longano A" first="Anthony" last="Longano">Anthony Longano</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Anatomical Pathology, Monash Medical Centre</institution>
, Clayton, VIC 3800,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>
, Villejuif,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Gustave Roussy</institution>
, Villejuif F-94805,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>HuGeF, Human Genetics Foundation</institution>
, Torino 10126,
<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<institution>Department of Paediatrics, University of Melbourne</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Cancer, Disease and Developmental Epigenetics Group, Cell Biology, Development and Disease Theme, Murdoch Childrens Research Institute, Royal Children's Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">27490804</idno>
<idno type="pmc">5023776</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023776</idno>
<idno type="RBID">PMC:5023776</idno>
<idno type="doi">10.1038/bjc.2016.237</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000711</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000711</idno>
<idno type="wicri:Area/Pmc/Curation">000710</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000710</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000901</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000901</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case–control study</title>
<author>
<name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brinkman, Maree T" sort="Brinkman, Maree T" uniqKey="Brinkman M" first="Maree T" last="Brinkman">Maree T. Brinkman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wong, Ee Ming" sort="Wong, Ee Ming" uniqKey="Wong E" first="Ee Ming" last="Wong">Ee Ming Wong</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M" last="Fitzgerald">Liesel M. Fitzgerald</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Menzies Institute for Medical Research, University of Tasmania</institution>
, Hobart, TAS 7000,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Joo, Jihoon E" sort="Joo, Jihoon E" uniqKey="Joo J" first="Jihoon E" last="Joo">Jihoon E. Joo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jung, Chol Hee" sort="Jung, Chol Hee" uniqKey="Jung C" first="Chol-Hee" last="Jung">Chol-Hee Jung</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>
, Carlton, VIC 3053,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chung, Jessica" sort="Chung, Jessica" uniqKey="Chung J" first="Jessica" last="Chung">Jessica Chung</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Menzies Institute for Medical Research, University of Tasmania</institution>
, Hobart, TAS 7000,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ta, Anthony D" sort="Ta, Anthony D" uniqKey="Ta A" first="Anthony D" last="Ta">Anthony D. Ta</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Department of Surgery, University of Melbourne</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bolton, Damien M" sort="Bolton, Damien M" uniqKey="Bolton D" first="Damien M" last="Bolton">Damien M. Bolton</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Department of Surgery, University of Melbourne</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>VLSCI Life Sciences Computation Centre, University of Melbourne</institution>
, Carlton, VIC 3053,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Longano, Anthony" sort="Longano, Anthony" uniqKey="Longano A" first="Anthony" last="Longano">Anthony Longano</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Anatomical Pathology, Monash Medical Centre</institution>
, Clayton, VIC 3800,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>
, Villejuif,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Gustave Roussy</institution>
, Villejuif F-94805,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>HuGeF, Human Genetics Foundation</institution>
, Torino 10126,
<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<institution>Department of Paediatrics, University of Melbourne</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Cancer, Disease and Developmental Epigenetics Group, Cell Biology, Development and Disease Theme, Murdoch Childrens Research Institute, Royal Children's Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
, Melbourne, VIC 3004,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne</institution>
, Parkville, VIC 3052,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
<idno type="eISSN">1532-1827</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background:</title>
<p>Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk.</p>
</sec>
<sec>
<title>Methods:</title>
<p>We used 439 case–control pairs from the Melbourne Collaborative Cohort Study matched on age, sex, country of birth, DNA sample type, and collection period. Conditional logistic regression was used to compute odds ratios (OR) of UCC risk per s.d. of each genome-wide measure of DNA methylation and 95% confidence intervals (CIs), adjusted for potential confounders. We also investigated associations by disease subtype, sex, smoking, and time since blood collection.</p>
</sec>
<sec>
<title>Results:</title>
<p>The risk of superficial UCC was decreased for individuals with higher levels of our genome-wide DNA methylation measure (OR=0.71, 95% CI: 0.54–0.94;
<italic>P</italic>
=0.02). This association was particularly strong for current smokers at sample collection (OR=0.47, 95% CI: 0.27–0.83). Intermediate levels of our genome-wide measure were associated with decreased risk of invasive UCC. Some variation was observed between UCC subtypes and the location and regulatory function of the CpGs included in the genome-wide measures of methylation.</p>
</sec>
<sec>
<title>Conclusions:</title>
<p>Higher levels of our genome-wide DNA methylation measure were associated with decreased risk of superficial UCC and intermediate levels were associated with reduced risk of invasive disease. These findings require replication by other prospective studies.</p>
</sec>
</div>
</front>
<back>
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<title xml:lang="en">Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case-control study.</title>
<author>
<name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name>
<affiliation wicri:level="1">
<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
</affiliation>
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<author>
<name sortKey="Brinkman, Maree T" sort="Brinkman, Maree T" uniqKey="Brinkman M" first="Maree T" last="Brinkman">Maree T. Brinkman</name>
<affiliation wicri:level="1">
<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
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<wicri:noRegion>VIC 3004</wicri:noRegion>
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<author>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name>
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<author>
<name sortKey="Wong, Ee Ming" sort="Wong, Ee Ming" uniqKey="Wong E" first="Ee Ming" last="Wong">Ee Ming Wong</name>
<affiliation wicri:level="4">
<nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M" last="Fitzgerald">Liesel M. Fitzgerald</name>
<affiliation wicri:level="1">
<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
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<author>
<name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name>
<affiliation wicri:level="1">
<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Joo, Jihoon E" sort="Joo, Jihoon E" uniqKey="Joo J" first="Jihoon E" last="Joo">Jihoon E. Joo</name>
<affiliation wicri:level="4">
<nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jung, Chol Hee" sort="Jung, Chol Hee" uniqKey="Jung C" first="Chol-Hee" last="Jung">Chol-Hee Jung</name>
<affiliation wicri:level="4">
<nlm:affiliation>VLSCI Life Sciences Computation Centre, University of Melbourne, Carlton, VIC 3053, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>VLSCI Life Sciences Computation Centre, University of Melbourne, Carlton, VIC 3053</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name>
<affiliation wicri:level="4">
<nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name>
<affiliation wicri:level="4">
<nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name>
<affiliation wicri:level="4">
<nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chung, Jessica" sort="Chung, Jessica" uniqKey="Chung J" first="Jessica" last="Chung">Jessica Chung</name>
<affiliation wicri:level="1">
<nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000</wicri:regionArea>
<wicri:noRegion>TAS 7000</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ta, Anthony D" sort="Ta, Anthony D" uniqKey="Ta A" first="Anthony D" last="Ta">Anthony D. Ta</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Surgery, University of Melbourne, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Surgery, University of Melbourne, Melbourne, VIC 3004</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bolton, Damien M" sort="Bolton, Damien M" uniqKey="Bolton D" first="Damien M" last="Bolton">Damien M. Bolton</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Surgery, University of Melbourne, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Surgery, University of Melbourne, Melbourne, VIC 3004</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name>
<affiliation wicri:level="4">
<nlm:affiliation>VLSCI Life Sciences Computation Centre, University of Melbourne, Carlton, VIC 3053, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>VLSCI Life Sciences Computation Centre, University of Melbourne, Carlton, VIC 3053</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Longano, Anthony" sort="Longano, Anthony" uniqKey="Longano A" first="Anthony" last="Longano">Anthony Longano</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Anatomical Pathology, Monash Medical Centre, Clayton, VIC 3800, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomical Pathology, Monash Medical Centre, Clayton, VIC 3800</wicri:regionArea>
<wicri:noRegion>VIC 3800</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4">
<nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
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<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name>
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<nlm:affiliation>Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Paediatrics, University of Melbourne, Melbourne, VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R" last="English">Dallas R. English</name>
<affiliation wicri:level="1">
<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4">
<nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
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<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
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</author>
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<title xml:lang="en">Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case-control study.</title>
<author>
<name sortKey="Dugue, Pierre Antoine" sort="Dugue, Pierre Antoine" uniqKey="Dugue P" first="Pierre-Antoine" last="Dugué">Pierre-Antoine Dugué</name>
<affiliation wicri:level="1">
<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Brinkman, Maree T" sort="Brinkman, Maree T" uniqKey="Brinkman M" first="Maree T" last="Brinkman">Maree T. Brinkman</name>
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<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004</wicri:regionArea>
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</affiliation>
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<author>
<name sortKey="Wong, Ee Ming" sort="Wong, Ee Ming" uniqKey="Wong E" first="Ee Ming" last="Wong">Ee Ming Wong</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, VIC 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
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<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
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<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
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<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
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</analytic>
<series>
<title level="j">British journal of cancer</title>
<idno type="eISSN">1532-1827</idno>
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<date when="2016" type="published">2016</date>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Blood Specimen Collection</term>
<term>Carcinoma, Transitional Cell (blood)</term>
<term>Carcinoma, Transitional Cell (epidemiology)</term>
<term>Carcinoma, Transitional Cell (genetics)</term>
<term>Carcinoma, Transitional Cell (pathology)</term>
<term>Case-Control Studies</term>
<term>CpG Islands</term>
<term>DNA (blood)</term>
<term>DNA Methylation</term>
<term>Diet</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasm Invasiveness</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Smoking (epidemiology)</term>
<term>Time Factors</term>
<term>Urologic Neoplasms (blood)</term>
<term>Urologic Neoplasms (epidemiology)</term>
<term>Urologic Neoplasms (genetics)</term>
<term>Urologic Neoplasms (pathology)</term>
<term>Victoria (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ADN (sang)</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Carcinome transitionnel (anatomopathologie)</term>
<term>Carcinome transitionnel (génétique)</term>
<term>Carcinome transitionnel (sang)</term>
<term>Carcinome transitionnel (épidémiologie)</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Ilots CpG</term>
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<term>Invasion tumorale</term>
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<term>Études prospectives</term>
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<term>DNA</term>
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</keywords>
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<term>Urologic Neoplasms</term>
</keywords>
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<term>Smoking</term>
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</keywords>
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<term>Urologic Neoplasms</term>
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</keywords>
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<term>Carcinoma, Transitional Cell</term>
<term>Urologic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr">
<term>ADN</term>
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<term>Carcinome transitionnel</term>
<term>Tabagisme</term>
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<term>Adult</term>
<term>Aged</term>
<term>Blood Specimen Collection</term>
<term>Case-Control Studies</term>
<term>CpG Islands</term>
<term>DNA Methylation</term>
<term>Diet</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasm Invasiveness</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Ilots CpG</term>
<term>Incidence</term>
<term>Invasion tumorale</term>
<term>Mâle</term>
<term>Méthylation de l'ADN</term>
<term>Prélèvement sanguin</term>
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<term>Sujet âgé</term>
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<front>
<div type="abstract" xml:lang="en">Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk.</div>
</front>
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