Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.
Identifieur interne : 003607 ( Ncbi/Merge ); précédent : 003606; suivant : 003608Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.
Auteurs : B Rge G. Nordestgaard [Danemark] ; Anne Langsted [Danemark] ; Samia Mora [États-Unis] ; Genovefa Kolovou [Grèce] ; Hannsjörg Baum [Allemagne] ; Eric Bruckert [France] ; Gerald F. Watts [Australie] ; Grazyna Sypniewska [Pologne] ; Olov Wiklund [Suède] ; Jan Borén [Suède] ; M John Chapman [France] ; Christa Cobbaert [Pays-Bas] ; Olivier S. Descamps [Belgique] ; Arnold Von Eckardstein [Suisse] ; Pia R. Kamstrup [Danemark] ; Kari Pulkki [Finlande] ; Florian Kronenberg [Autriche] ; Alan T. Remaley [États-Unis] ; Nader Rifai [États-Unis] ; Emilio Ros [Espagne] ; Michel Langlois [Belgique]Source :
- Clinical chemistry [ 1530-8561 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- normes : Chimie clinique, Techniques de laboratoire clinique.
- sang : Athérosclérose, Jeûne, Lipides.
- Consensus, Europe, Humains, Sociétés médicales.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Lipids.
- blood : Atherosclerosis, Fasting.
- standards : Chemistry, Clinical, Clinical Laboratory Techniques.
- Consensus, Europe, Humans, Societies, Medical.
Abstract
To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles.
DOI: 10.1373/clinchem.2016.258897
PubMed: 27235445
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pubmed:27235445Le document en format XML
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<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.</title>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
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<author><name sortKey="Langsted, Anne" sort="Langsted, Anne" uniqKey="Langsted A" first="Anne" last="Langsted">Anne Langsted</name>
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<author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
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<author><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name>
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<author><name sortKey="Sypniewska, Grazyna" sort="Sypniewska, Grazyna" uniqKey="Sypniewska G" first="Grazyna" last="Sypniewska">Grazyna Sypniewska</name>
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<author><name sortKey="Wiklund, Olov" sort="Wiklund, Olov" uniqKey="Wiklund O" first="Olov" last="Wiklund">Olov Wiklund</name>
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<author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Borén">Jan Borén</name>
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<author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name>
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<author><name sortKey="Cobbaert, Christa" sort="Cobbaert, Christa" uniqKey="Cobbaert C" first="Christa" last="Cobbaert">Christa Cobbaert</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, the Netherlands;</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
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<author><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name>
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<country xml:lang="fr">Suisse</country>
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<author><name sortKey="Kamstrup, Pia R" sort="Kamstrup, Pia R" uniqKey="Kamstrup P" first="Pia R" last="Kamstrup">Pia R. Kamstrup</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark;</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev</wicri:regionArea>
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<author><name sortKey="Pulkki, Kari" sort="Pulkki, Kari" uniqKey="Pulkki K" first="Kari" last="Pulkki">Kari Pulkki</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland;</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Chemistry, University of Eastern Finland, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria;</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck</wicri:regionArea>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Remaley, Alan T" sort="Remaley, Alan T" uniqKey="Remaley A" first="Alan T" last="Remaley">Alan T. Remaley</name>
<affiliation wicri:level="2"><nlm:affiliation>Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rifai, Nader" sort="Rifai, Nader" uniqKey="Rifai N" first="Nader" last="Rifai">Nader Rifai</name>
<affiliation wicri:level="2"><nlm:affiliation>Children's Hospital, Laboratory Medicine, Harvard University, Boston, MA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Children's Hospital, Laboratory Medicine, Harvard University, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ros, Emilio" sort="Ros, Emilio" uniqKey="Ros E" first="Emilio" last="Ros">Emilio Ros</name>
<affiliation wicri:level="3"><nlm:affiliation>Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain; Ciber Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain; Ciber Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Langlois, Michel" sort="Langlois, Michel" uniqKey="Langlois M" first="Michel" last="Langlois">Michel Langlois</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, AZ St-Jan, Brugge, Belgium; and University of Ghent, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Laboratory Medicine, AZ St-Jan, Brugge, Belgium; and University of Ghent, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical chemistry</title>
<idno type="eISSN">1530-8561</idno>
<imprint><date when="2016" type="published">2016</date>
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<term>Chemistry, Clinical (standards)</term>
<term>Clinical Laboratory Techniques (standards)</term>
<term>Consensus</term>
<term>Europe</term>
<term>Fasting (blood)</term>
<term>Humans</term>
<term>Lipids (blood)</term>
<term>Societies, Medical</term>
</keywords>
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<term>Chimie clinique (normes)</term>
<term>Consensus</term>
<term>Europe</term>
<term>Humains</term>
<term>Jeûne (sang)</term>
<term>Lipides (sang)</term>
<term>Sociétés médicales</term>
<term>Techniques de laboratoire clinique (normes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lipids</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atherosclerosis</term>
<term>Fasting</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Chimie clinique</term>
<term>Techniques de laboratoire clinique</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Athérosclérose</term>
<term>Jeûne</term>
<term>Lipides</term>
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<term>Clinical Laboratory Techniques</term>
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<term>Humans</term>
<term>Societies, Medical</term>
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<front><div type="abstract" xml:lang="en">To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27235445</PMID>
<DateCreated><Year>2016</Year>
<Month>06</Month>
<Day>29</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>06</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1530-8561</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>62</Volume>
<Issue>7</Issue>
<PubDate><Year>2016</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Clinical chemistry</Title>
<ISOAbbreviation>Clin. Chem.</ISOAbbreviation>
</Journal>
<ArticleTitle>Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.</ArticleTitle>
<Pagination><MedlinePgn>930-46</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1373/clinchem.2016.258897</ELocationID>
<Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) for triglycerides; -0.2 mmol/L (8 mg/dL) for total cholesterol; -0.2 mmol/L (8 mg/dL) for LDL cholesterol; +0.2 mmol/L (8 mg/dL) for calculated remnant cholesterol; -0.2 mmol/L (8 mg/dL) for calculated non-HDL cholesterol]; concentrations of HDL cholesterol, apolipoprotein A1, apolipoprotein B, and lipoprotein(a) are not affected by fasting/non-fasting status. In addition, non-fasting and fasting concentrations vary similarly over time and are comparable in the prediction of cardiovascular disease. To improve patient compliance with lipid testing, we therefore recommend the routine use of non-fasting lipid profiles, whereas fasting sampling may be considered when non-fasting triglycerides are >5 mmol/L (440 mg/dL). For non-fasting samples, laboratory reports should flag abnormal concentrations as triglycerides ≥2 mmol/L (175 mg/dL), total cholesterol ≥5 mmol/L (190 mg/dL), LDL cholesterol ≥3 mmol/L (115 mg/dL), calculated remnant cholesterol ≥0.9 mmol/L (35 mg/dL), calculated non-HDL cholesterol ≥3.9 mmol/L (150 mg/dL), HDL cholesterol ≤1 mmol/L (40 mg/dL), apolipoprotein A1 ≤1.25 g/L (125 mg/dL), apolipoprotein B ≥1.0 g/L (100 mg/dL), and lipoprotein(a) ≥50 mg/dL (80th percentile); for fasting samples, abnormal concentrations correspond to triglycerides ≥1.7 mmol/L (150 mg/dL). Life-threatening concentrations require separate referral for the risk of pancreatitis when triglycerides are >10 mmol/L (880 mg/dL), for homozygous familial hypercholesterolemia when LDL cholesterol is >13 mmol/L (500 mg/dL), for heterozygous familial hypercholesterolemia when LDL cholesterol is >5 mmol/L (190 mg/dL), and for very high cardiovascular risk when lipoprotein(a) >150 mg/dL (99th percentile).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We recommend that non-fasting blood samples be routinely used for the assessment of plasma lipid profiles. Laboratory reports should flag abnormal values on the basis of desirable concentration cutpoints. Non-fasting and fasting measurements should be complementary but not mutually exclusive.</AbstractText>
<CopyrightInformation>© 2016 American Association for Clinical Chemistry.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nordestgaard</LastName>
<ForeName>Børge G</ForeName>
<Initials>BG</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark; boerge.nordestgaard@regionh.dk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langsted</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mora</LastName>
<ForeName>Samia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kolovou</LastName>
<ForeName>Genovefa</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baum</LastName>
<ForeName>Hannsjörg</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute for Laboratory Medicine, Blutdepot und Krankenhaushygiene, Regionale Kliniken Holding RKH GmbH, Ludwigsburg, Germany;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bruckert</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Pitié-Salpetriere University Hospital, Paris, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Watts</LastName>
<ForeName>Gerald F</ForeName>
<Initials>GF</Initials>
<AffiliationInfo><Affiliation>University of Western Australia, Perth, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sypniewska</LastName>
<ForeName>Grazyna</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, Collegium Medicum, NC University, Bydgoszcz, Poland;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wiklund</LastName>
<ForeName>Olov</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borén</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chapman</LastName>
<ForeName>M John</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>INSERM U939, Pitié-Salpetriere University Hospital, Paris, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cobbaert</LastName>
<ForeName>Christa</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, the Netherlands;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Descamps</LastName>
<ForeName>Olivier S</ForeName>
<Initials>OS</Initials>
<AffiliationInfo><Affiliation>Hopital de Jolimont, Haine-Saint-Paul, Belgium;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>von Eckardstein</LastName>
<ForeName>Arnold</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kamstrup</LastName>
<ForeName>Pia R</ForeName>
<Initials>PR</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pulkki</LastName>
<ForeName>Kari</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kronenberg</LastName>
<ForeName>Florian</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Remaley</LastName>
<ForeName>Alan T</ForeName>
<Initials>AT</Initials>
<AffiliationInfo><Affiliation>Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rifai</LastName>
<ForeName>Nader</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Children's Hospital, Laboratory Medicine, Harvard University, Boston, MA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ros</LastName>
<ForeName>Emilio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain; Ciber Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langlois</LastName>
<ForeName>Michel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, AZ St-Jan, Brugge, Belgium; and University of Ghent, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Joint Consensus Initiative</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016446">Consensus Development Conference</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>05</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Clin Chem</MedlineTA>
<NlmUniqueID>9421549</NlmUniqueID>
<ISSNLinking>0009-9147</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008055">Lipids</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ann Transl Med. 2016 Nov;4(21):430</RefSource>
<PMID Version="1">27942521</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Ann Transl Med. 2016 Nov;4(21):431</RefSource>
<PMID Version="1">27942522</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Clin Chem Lab Med. 2017 Aug 28;55(9):e187-e188</RefSource>
<PMID Version="1">28253194</PMID>
</CommentsCorrections>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D050197" MajorTopicYN="N">Atherosclerosis</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
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<MeshHeading><DescriptorName UI="D002624" MajorTopicYN="N">Chemistry, Clinical</DescriptorName>
<QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
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<MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName>
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<Month>04</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>04</Month>
<Day>19</Day>
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<li>Australie</li>
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<li>Finlande</li>
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<li>Maryland</li>
<li>Massachusetts</li>
<li>Tyrol (Land)</li>
<li>Île-de-France</li>
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<li>Innsbruck</li>
<li>Leyde</li>
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<orgName><li>Université de médecine d'Innsbruck</li>
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<tree><country name="Danemark"><noRegion><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name>
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<name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name>
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<country name="Belgique"><noRegion><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name>
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<name sortKey="Langlois, Michel" sort="Langlois, Michel" uniqKey="Langlois M" first="Michel" last="Langlois">Michel Langlois</name>
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<country name="Suisse"><noRegion><name sortKey="Von Eckardstein, Arnold" sort="Von Eckardstein, Arnold" uniqKey="Von Eckardstein A" first="Arnold" last="Von Eckardstein">Arnold Von Eckardstein</name>
</noRegion>
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<country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
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<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ros, Emilio" sort="Ros, Emilio" uniqKey="Ros E" first="Emilio" last="Ros">Emilio Ros</name>
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