Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis
Identifieur interne : 003591 ( Ncbi/Merge ); précédent : 003590; suivant : 003592Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis
Auteurs : Daniel Sieiro [Australie, France] ; Anne C. Rios [Australie] ; Claire E. Hirst [Australie] ; Christophe Marcelle [Australie, France]Source :
- eLife [ 2050-084X ] ; ????.
Abstract
How cells in the embryo coordinate epithelial plasticity with cell fate decision in a fast changing cellular environment is largely unknown. In chick embryos, skeletal muscle formation is initiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiate. Here, we uncovered at the heart of this response a signaling module encompassing NOTCH, GSK-3β, SNAI1 and β-catenin. Independent of its transcriptional function, NOTCH profoundly inhibits GSK-3β activity. As a result SNAI1 is stabilized, triggering an epithelial to mesenchymal transition. This allows the recruitment of β-catenin from the membrane, which acts as a transcriptional co-factor to activate myogenesis, independently of WNT ligand. Our results intimately associate the initiation of myogenesis to a change in cell adhesion and may reveal a general principle for coupling cell fate changes to EMT in many developmental and pathological processes.
Url:
DOI: 10.7554/eLife.14847
PubMed: 27218451
PubMed Central: 4917337
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Rios</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirst, Claire E" sort="Hirst, Claire E" uniqKey="Hirst C" first="Claire E" last="Hirst">Claire E. Hirst</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marcelle, Christophe" sort="Marcelle, Christophe" uniqKey="Marcelle C" first="Christophe" last="Marcelle">Christophe Marcelle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Institut NeuroMyoGene</institution>,<institution>University Lyon 1, CNRS UMR 5310, INSERM U 1217</institution>,<addr-line>Villeurbanne</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>How cells in the embryo coordinate epithelial plasticity with cell fate decision in a fast changing cellular environment is largely unknown. In chick embryos, skeletal muscle formation is initiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiate. Here, we uncovered at the heart of this response a signaling module encompassing NOTCH, GSK-3β, SNAI1 and β-catenin. Independent of its transcriptional function, NOTCH profoundly inhibits GSK-3β activity. As a result SNAI1 is stabilized, triggering an epithelial to mesenchymal transition. This allows the recruitment of β-catenin from the membrane, which acts as a transcriptional co-factor to activate myogenesis, independently of WNT ligand. Our results intimately associate the initiation of myogenesis to a change in cell adhesion and may reveal a general principle for coupling cell fate changes to EMT in many developmental and pathological processes.</p><p><bold>DOI:</bold><ext-link ext-link-type="doi" xlink:href="10.7554/eLife.14847.001">http://dx.doi.org/10.7554/eLife.14847.001</ext-link></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abu Elmagd, M" uniqKey="Abu Elmagd M">M Abu-Elmagd</name></author><author><name sortKey="Robson, L" uniqKey="Robson L">L Robson</name></author><author><name sortKey="Sweetman, D" uniqKey="Sweetman D">D Sweetman</name></author><author><name sortKey="Hadley, J" uniqKey="Hadley J">J Hadley</name></author><author><name sortKey="Francis West, P" uniqKey="Francis West P">P Francis-West</name></author><author><name sortKey="Munsterberg, A" uniqKey="Munsterberg A">A 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Bösl</name></author><author><name sortKey="Wegner, M" uniqKey="Wegner M">M Wegner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Bp" uniqKey="Zhou B">BP Zhou</name></author><author><name sortKey="Deng, J" uniqKey="Deng J">J Deng</name></author><author><name sortKey="Xia, W" uniqKey="Xia W">W Xia</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name></author><author><name sortKey="Gunduz, M" uniqKey="Gunduz M">M Gunduz</name></author><author><name sortKey="Hung, Mc" uniqKey="Hung M">MC Hung</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="27218451"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis</title><author><name sortKey="Sieiro, Daniel" sort="Sieiro, Daniel" uniqKey="Sieiro D" first="Daniel" last="Sieiro">Daniel Sieiro</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Institut NeuroMyoGene</institution>,<institution>University Lyon 1, CNRS UMR 5310, INSERM U 1217</institution>,<addr-line>Villeurbanne</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rios, Anne C" sort="Rios, Anne C" uniqKey="Rios A" first="Anne C" last="Rios">Anne C. Rios</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirst, Claire E" sort="Hirst, Claire E" uniqKey="Hirst C" first="Claire E" last="Hirst">Claire E. Hirst</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marcelle, Christophe" sort="Marcelle, Christophe" uniqKey="Marcelle C" first="Christophe" last="Marcelle">Christophe Marcelle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Institut NeuroMyoGene</institution>,<institution>University Lyon 1, CNRS UMR 5310, INSERM U 1217</institution>,<addr-line>Villeurbanne</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27218451</idno><idno type="pmc">4917337</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917337</idno><idno type="RBID">PMC:4917337</idno><idno type="doi">10.7554/eLife.14847</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">000648</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000648</idno><idno type="wicri:Area/Pmc/Curation">000647</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000647</idno><idno type="wicri:Area/Pmc/Checkpoint">002E18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002E18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis</title><author><name sortKey="Sieiro, Daniel" sort="Sieiro, Daniel" uniqKey="Sieiro D" first="Daniel" last="Sieiro">Daniel Sieiro</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Institut NeuroMyoGene</institution>,<institution>University Lyon 1, CNRS UMR 5310, INSERM U 1217</institution>,<addr-line>Villeurbanne</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rios, Anne C" sort="Rios, Anne C" uniqKey="Rios A" first="Anne C" last="Rios">Anne C. Rios</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirst, Claire E" sort="Hirst, Claire E" uniqKey="Hirst C" first="Claire E" last="Hirst">Claire E. Hirst</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marcelle, Christophe" sort="Marcelle, Christophe" uniqKey="Marcelle C" first="Christophe" last="Marcelle">Christophe Marcelle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Australian Regenerative Medicine Institute</institution>,<institution>Monash University</institution>,<addr-line>Clayton</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Institut NeuroMyoGene</institution>,<institution>University Lyon 1, CNRS UMR 5310, INSERM U 1217</institution>,<addr-line>Villeurbanne</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>How cells in the embryo coordinate epithelial plasticity with cell fate decision in a fast changing cellular environment is largely unknown. In chick embryos, skeletal muscle formation is initiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiate. Here, we uncovered at the heart of this response a signaling module encompassing NOTCH, GSK-3β, SNAI1 and β-catenin. Independent of its transcriptional function, NOTCH profoundly inhibits GSK-3β activity. As a result SNAI1 is stabilized, triggering an epithelial to mesenchymal transition. This allows the recruitment of β-catenin from the membrane, which acts as a transcriptional co-factor to activate myogenesis, independently of WNT ligand. Our results intimately associate the initiation of myogenesis to a change in cell adhesion and may reveal a general principle for coupling cell fate changes to EMT in many developmental and pathological processes.</p><p><bold>DOI:</bold><ext-link ext-link-type="doi" xlink:href="10.7554/eLife.14847.001">http://dx.doi.org/10.7554/eLife.14847.001</ext-link></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abu Elmagd, M" uniqKey="Abu Elmagd M">M Abu-Elmagd</name></author><author><name sortKey="Robson, L" uniqKey="Robson L">L Robson</name></author><author><name sortKey="Sweetman, D" uniqKey="Sweetman D">D Sweetman</name></author><author><name sortKey="Hadley, J" uniqKey="Hadley J">J Hadley</name></author><author><name sortKey="Francis West, P" uniqKey="Francis West P">P Francis-West</name></author><author><name sortKey="Munsterberg, A" uniqKey="Munsterberg A">A 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Bösl</name></author><author><name sortKey="Wegner, M" uniqKey="Wegner M">M Wegner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Bp" uniqKey="Zhou B">BP Zhou</name></author><author><name sortKey="Deng, J" uniqKey="Deng J">J Deng</name></author><author><name sortKey="Xia, W" uniqKey="Xia W">W Xia</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name></author><author><name sortKey="Gunduz, M" uniqKey="Gunduz M">M Gunduz</name></author><author><name sortKey="Hung, Mc" uniqKey="Hung M">MC Hung</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.</title><author><name sortKey="Sieiro, Daniel" sort="Sieiro, Daniel" uniqKey="Sieiro D" first="Daniel" last="Sieiro">Daniel Sieiro</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Rios, Anne C" sort="Rios, Anne C" uniqKey="Rios A" first="Anne C" last="Rios">Anne C. Rios</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Hirst, Claire E" sort="Hirst, Claire E" uniqKey="Hirst C" first="Claire E" last="Hirst">Claire E. Hirst</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Marcelle, Christophe" sort="Marcelle, Christophe" uniqKey="Marcelle C" first="Christophe" last="Marcelle">Christophe Marcelle</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27218451</idno><idno type="pmid">27218451</idno><idno type="doi">10.7554/eLife.14847</idno><idno type="wicri:Area/PubMed/Corpus">001F16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F16</idno><idno type="wicri:Area/PubMed/Curation">001E92</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001E92</idno><idno type="wicri:Area/PubMed/Checkpoint">001E92</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.</title><author><name sortKey="Sieiro, Daniel" sort="Sieiro, Daniel" uniqKey="Sieiro D" first="Daniel" last="Sieiro">Daniel Sieiro</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Rios, Anne C" sort="Rios, Anne C" uniqKey="Rios A" first="Anne C" last="Rios">Anne C. Rios</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Hirst, Claire E" sort="Hirst, Claire E" uniqKey="Hirst C" first="Claire E" last="Hirst">Claire E. Hirst</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Marcelle, Christophe" sort="Marcelle, Christophe" uniqKey="Marcelle C" first="Christophe" last="Marcelle">Christophe Marcelle</name><affiliation wicri:level="1"><nlm:affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">How cells in the embryo coordinate epithelial plasticity with cell fate decision in a fast changing cellular environment is largely unknown. In chick embryos, skeletal muscle formation is initiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiate. Here, we uncovered at the heart of this response a signaling module encompassing NOTCH, GSK-3β, SNAI1 and β-catenin. Independent of its transcriptional function, NOTCH profoundly inhibits GSK-3β activity. As a result SNAI1 is stabilized, triggering an epithelial to mesenchymal transition. This allows the recruitment of β-catenin from the membrane, which acts as a transcriptional co-factor to activate myogenesis, independently of WNT ligand. Our results intimately associate the initiation of myogenesis to a change in cell adhesion and may reveal a general principle for coupling cell fate changes to EMT in many developmental and pathological processes.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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