Comparative genomics of Crohn's disease-associated adherent-invasive Escherichia coli.
Identifieur interne : 003564 ( Ncbi/Merge ); précédent : 003563; suivant : 003565Comparative genomics of Crohn's disease-associated adherent-invasive Escherichia coli.
Auteurs : Claire L. O'Brien [Australie] ; Marie-Agnès Bringer [France] ; Kathryn E. Holt [Australie] ; David M. Gordon [Australie] ; Anaëlle L. Dubois [France] ; Nicolas Barnich [France] ; Arlette Darfeuille-Michaud [France] ; Paul Pavli [Australie]Source :
- Gut [ 1468-3288 ] ; 2017.
Descripteurs français
- KwdFr :
- ADN bactérien (analyse), Adhérence bactérienne, Analyse de séquence d'ADN, Cellules épithéliales (microbiologie), Clustered regularly interspaced short palindromic repeats, Cytokines (sécrétion), Escherichia coli (croissance et développement), Escherichia coli (génétique), Facteur de nécrose tumorale alpha (sécrétion), Génome, Humains, Infections à Escherichia coli (), Interactions hôte-pathogène, Interleukine-10 (sécrétion), Interleukine-6 (sécrétion), Interleukine-8 (sécrétion), Lignée cellulaire, Macrophages (microbiologie), Macrophages (sécrétion), Maladie de Crohn (microbiologie), Phylogénie, Phénotype.
- MESH :
- analyse : ADN bactérien.
- croissance et développement : Escherichia coli.
- génétique : Escherichia coli.
- microbiologie : Cellules épithéliales, Macrophages, Maladie de Crohn.
- sécrétion : Cytokines, Facteur de nécrose tumorale alpha, Interleukine-10, Interleukine-6, Interleukine-8, Macrophages.
- Adhérence bactérienne, Analyse de séquence d'ADN, Clustered regularly interspaced short palindromic repeats, Génome, Humains, Infections à Escherichia coli, Interactions hôte-pathogène, Lignée cellulaire, Phylogénie, Phénotype.
English descriptors
- KwdEn :
- Bacterial Adhesion, Cell Line, Clustered Regularly Interspaced Short Palindromic Repeats, Crohn Disease (microbiology), Cytokines (secretion), DNA, Bacterial (analysis), Epithelial Cells (microbiology), Escherichia coli (genetics), Escherichia coli (growth & development), Escherichia coli Infections (complications), Genome, Host-Pathogen Interactions, Humans, Interleukin-10 (secretion), Interleukin-6 (secretion), Interleukin-8 (secretion), Macrophages (microbiology), Macrophages (secretion), Phenotype, Phylogeny, Sequence Analysis, DNA, Tumor Necrosis Factor-alpha (secretion).
- MESH :
- chemical , analysis : DNA, Bacterial.
- chemical , secretion : Cytokines, Interleukin-10, Interleukin-6, Interleukin-8, Tumor Necrosis Factor-alpha.
- complications : Escherichia coli Infections.
- genetics : Escherichia coli.
- growth & development : Escherichia coli.
- microbiology : Crohn Disease, Epithelial Cells, Macrophages.
- secretion : Macrophages.
- Bacterial Adhesion, Cell Line, Clustered Regularly Interspaced Short Palindromic Repeats, Genome, Host-Pathogen Interactions, Humans, Phenotype, Phylogeny, Sequence Analysis, DNA.
Abstract
Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular property common to the AIEC phenotype.
DOI: 10.1136/gutjnl-2015-311059
PubMed: 27196580
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000854
- to stream PubMed, to step Curation: 000851
- to stream PubMed, to step Checkpoint: 000851
Links to Exploration step
pubmed:27196580Le document en format XML
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<term>Cell Line</term>
<term>Clustered Regularly Interspaced Short Palindromic Repeats</term>
<term>Crohn Disease (microbiology)</term>
<term>Cytokines (secretion)</term>
<term>DNA, Bacterial (analysis)</term>
<term>Epithelial Cells (microbiology)</term>
<term>Escherichia coli (genetics)</term>
<term>Escherichia coli (growth & development)</term>
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<term>Interleukin-6 (secretion)</term>
<term>Interleukin-8 (secretion)</term>
<term>Macrophages (microbiology)</term>
<term>Macrophages (secretion)</term>
<term>Phenotype</term>
<term>Phylogeny</term>
<term>Sequence Analysis, DNA</term>
<term>Tumor Necrosis Factor-alpha (secretion)</term>
</keywords>
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<term>Adhérence bactérienne</term>
<term>Analyse de séquence d'ADN</term>
<term>Cellules épithéliales (microbiologie)</term>
<term>Clustered regularly interspaced short palindromic repeats</term>
<term>Cytokines (sécrétion)</term>
<term>Escherichia coli (croissance et développement)</term>
<term>Escherichia coli (génétique)</term>
<term>Facteur de nécrose tumorale alpha (sécrétion)</term>
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<term>Interleukine-8 (sécrétion)</term>
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<term>Macrophages (sécrétion)</term>
<term>Maladie de Crohn (microbiologie)</term>
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<term>Interleukin-6</term>
<term>Interleukin-8</term>
<term>Tumor Necrosis Factor-alpha</term>
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<term>Macrophages</term>
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<term>Macrophages</term>
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<term>Facteur de nécrose tumorale alpha</term>
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<term>Macrophages</term>
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<term>Cell Line</term>
<term>Clustered Regularly Interspaced Short Palindromic Repeats</term>
<term>Genome</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Phenotype</term>
<term>Phylogeny</term>
<term>Sequence Analysis, DNA</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adhérence bactérienne</term>
<term>Analyse de séquence d'ADN</term>
<term>Clustered regularly interspaced short palindromic repeats</term>
<term>Génome</term>
<term>Humains</term>
<term>Infections à Escherichia coli</term>
<term>Interactions hôte-pathogène</term>
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<front><div type="abstract" xml:lang="en">Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular property common to the AIEC phenotype.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27196580</PMID>
<DateCreated><Year>2016</Year>
<Month>05</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-3288</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>66</Volume>
<Issue>8</Issue>
<PubDate><Year>2017</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Gut</Title>
<ISOAbbreviation>Gut</ISOAbbreviation>
</Journal>
<ArticleTitle>Comparative genomics of Crohn's disease-associated adherent-invasive Escherichia coli.</ArticleTitle>
<Pagination><MedlinePgn>1382-1389</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/gutjnl-2015-311059</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular property common to the AIEC phenotype.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">41 B2 phylogroup E. coli strains were isolated from 36 Australian subjects: 19 patients with IBD and 17 without. Adherence/invasion assays were conducted using the I-407 epithelial cell line and survival/replication assays using the THP-1 macrophage cell line. Cytokine secretion tumour necrosis factor ((TNF)-α, interleukin (IL) 6, IL-8 and IL-10) was measured using ELISA. The genomes were assembled and annotated, and cluster analysis performed using CD-HIT. The resulting matrices were analysed to identify genes unique/more frequent in AIEC strains compared with non-AIEC strains. Base composition differences and clustered regularly interspaced palindromic repeat (CRISPR) analyses were conducted.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of all B2 phylogroup strains assessed, 79% could survive and replicate in macrophages. Among them, 11/41 strains (5 CD, 2 UCs, 5 non-IBD) also adhere to and invade epithelial cells, a phenotype assigning them to the AIEC pathovar. The AIEC strains were phylogenetically heterogeneous. We did not identify a gene (or nucleic acid base composition differences) common to all, or the majority of, AIEC. Cytokine secretion and CRISPRs were not associated with the AIEC phenotype.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Comparative genomic analysis of AIEC and non-AIEC strains did not identify a molecular property exclusive to the AIEC phenotype. We recommend a broader approach to the identification of the bacteria-host interactions that are important in the pathogenesis of Crohn's disease.</AbstractText>
<CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>O'Brien</LastName>
<ForeName>Claire L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Medical School, Australian National University, Canberra, Australian Capital Territory, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Gastroenterology and Hepatology Unit, Canberra Hospital, Canberra, Australian Capital Territory, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bringer</LastName>
<ForeName>Marie-Agnès</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>INRA UMR1324, CNRS UMR6265, Université Bourgogne-Franche-Comté, Centre des Sciences du Goût et de l'Alimentation, Dijon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UMR1071 Inserm/University of Auvergne, INRA USC2018, M2iSH, Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holt</LastName>
<ForeName>Kathryn E</ForeName>
<Initials>KE</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gordon</LastName>
<ForeName>David M</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dubois</LastName>
<ForeName>Anaëlle L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>UMR1071 Inserm/University of Auvergne, INRA USC2018, M2iSH, Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barnich</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>UMR1071 Inserm/University of Auvergne, INRA USC2018, M2iSH, Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Darfeuille-Michaud</LastName>
<ForeName>Arlette</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>UMR1071 Inserm/University of Auvergne, INRA USC2018, M2iSH, Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pavli</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Medical School, Australian National University, Canberra, Australian Capital Territory, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Gastroenterology and Hepatology Unit, Canberra Hospital, Canberra, Australian Capital Territory, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>04</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Gut</MedlineTA>
<NlmUniqueID>2985108R</NlmUniqueID>
<ISSNLinking>0017-5749</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004269">DNA, Bacterial</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016209">Interleukin-8</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>130068-27-8</RegistryNumber>
<NameOfSubstance UI="D016753">Interleukin-10</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001422" MajorTopicYN="N">Bacterial Adhesion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064112" MajorTopicYN="N">Clustered Regularly Interspaced Short Palindromic Repeats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003424" MajorTopicYN="N">Crohn Disease</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000557" MajorTopicYN="Y">secretion</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004269" MajorTopicYN="N">DNA, Bacterial</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004927" MajorTopicYN="N">Escherichia coli Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016678" MajorTopicYN="N">Genome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016753" MajorTopicYN="N">Interleukin-10</DescriptorName>
<QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016209" MajorTopicYN="N">Interleukin-8</DescriptorName>
<QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CROHN'S DISEASE</Keyword>
<Keyword MajorTopicYN="N">ENTERIC BACTERIAL MICROFLORA</Keyword>
<Keyword MajorTopicYN="N">INTESTINAL MICROBIOLOGY</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>11</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>03</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>5</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>9</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>5</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27196580</ArticleId>
<ArticleId IdType="pii">gutjnl-2015-311059</ArticleId>
<ArticleId IdType="doi">10.1136/gutjnl-2015-311059</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bourgogne</li>
<li>Bourgogne-Franche-Comté</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Clermont-Ferrand</li>
<li>Dijon</li>
<li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="O Brien, Claire L" sort="O Brien, Claire L" uniqKey="O Brien C" first="Claire L" last="O'Brien">Claire L. O'Brien</name>
</noRegion>
<name sortKey="Gordon, David M" sort="Gordon, David M" uniqKey="Gordon D" first="David M" last="Gordon">David M. Gordon</name>
<name sortKey="Holt, Kathryn E" sort="Holt, Kathryn E" uniqKey="Holt K" first="Kathryn E" last="Holt">Kathryn E. Holt</name>
<name sortKey="Pavli, Paul" sort="Pavli, Paul" uniqKey="Pavli P" first="Paul" last="Pavli">Paul Pavli</name>
</country>
<country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Bringer, Marie Agnes" sort="Bringer, Marie Agnes" uniqKey="Bringer M" first="Marie-Agnès" last="Bringer">Marie-Agnès Bringer</name>
</region>
<name sortKey="Barnich, Nicolas" sort="Barnich, Nicolas" uniqKey="Barnich N" first="Nicolas" last="Barnich">Nicolas Barnich</name>
<name sortKey="Darfeuille Michaud, Arlette" sort="Darfeuille Michaud, Arlette" uniqKey="Darfeuille Michaud A" first="Arlette" last="Darfeuille-Michaud">Arlette Darfeuille-Michaud</name>
<name sortKey="Dubois, Anaelle L" sort="Dubois, Anaelle L" uniqKey="Dubois A" first="Anaëlle L" last="Dubois">Anaëlle L. Dubois</name>
</country>
</tree>
</affiliations>
</record>
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