Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686).
Identifieur interne : 002F66 ( Ncbi/Merge ); précédent : 002F65; suivant : 002F67Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686).
Auteurs : Chris Karlovich [États-Unis] ; Jonathan W. Goldman [États-Unis] ; Jong-Mu Sun [Corée du Sud] ; Elaina Mann [États-Unis] ; Lecia V. Sequist [États-Unis] ; Krzysztof Konopa [Pologne] ; Wei Wen [États-Unis] ; Philipp Angenendt [Allemagne] ; Leora Horn [États-Unis] ; David Spigel ; Jean-Charles Soria [France] ; Benjamin Solomon [Australie] ; D Ross Camidge [États-Unis] ; Shirish Gadgeel [États-Unis] ; Cloud Paweletz [États-Unis] ; Lin Wu [États-Unis] ; Sean Chien [États-Unis] ; Patrick O'Donnell [États-Unis] ; Shannon Matheny [États-Unis] ; Darrin Despain [États-Unis] ; Lindsey Rolfe [États-Unis] ; Mitch Raponi [États-Unis] ; Andrew R. Allen [États-Unis] ; Keunchil Park [Corée du Sud] ; Heather Wakelee [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2016.
Abstract
The evaluation of plasma testing for the EGFR resistance mutation T790M in NSCLC patients has not been broadly explored. We investigated the detection of EGFR activating and T790M mutations in matched tumor tissue and plasma, mostly from patients with acquired resistance to first-generation EGFR inhibitors.
DOI: 10.1158/1078-0432.CCR-15-1260
PubMed: 26747242
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686).</title><author><name sortKey="Karlovich, Chris" sort="Karlovich, Chris" uniqKey="Karlovich C" first="Chris" last="Karlovich">Chris Karlovich</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Goldman, Jonathan W" sort="Goldman, Jonathan W" uniqKey="Goldman J" first="Jonathan W" last="Goldman">Jonathan W. Goldman</name><affiliation wicri:level="2"><nlm:affiliation>University of California Los Angeles, Los Angeles, California. JWGoldman@mednet.ucla.edu hwakelee@stanford.edu.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of California Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Sun, Jong Mu" sort="Sun, Jong Mu" uniqKey="Sun J" first="Jong-Mu" last="Sun">Jong-Mu Sun</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Mann, Elaina" sort="Mann, Elaina" uniqKey="Mann E" first="Elaina" last="Mann">Elaina Mann</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. 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California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="Angenendt, Philipp" sort="Angenendt, Philipp" uniqKey="Angenendt P" first="Philipp" last="Angenendt">Philipp Angenendt</name><affiliation wicri:level="3"><nlm:affiliation>Sysmex Inostics GmbH, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sysmex Inostics GmbH, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Horn, Leora" sort="Horn, Leora" uniqKey="Horn L" first="Leora" last="Horn">Leora Horn</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Spigel, David" sort="Spigel, David" uniqKey="Spigel D" first="David" last="Spigel">David Spigel</name><affiliation><nlm:affiliation>Sarah Cannon Research Institute, Nashville; Tennessee.</nlm:affiliation><wicri:noCountry code="subField">Nashville; Tennessee</wicri:noCountry></affiliation></author><author><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name><affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name><affiliation wicri:level="4"><nlm:affiliation>University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name><affiliation wicri:level="2"><nlm:affiliation>University of Colorado, Denver, Colorado.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>University of Colorado, Denver</wicri:cityArea></affiliation></author><author><name sortKey="Gadgeel, Shirish" sort="Gadgeel, Shirish" uniqKey="Gadgeel S" first="Shirish" last="Gadgeel">Shirish Gadgeel</name><affiliation wicri:level="2"><nlm:affiliation>Karmanos Cancer Institute/Wayne State University, Detroit, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Karmanos Cancer Institute/Wayne State University, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Paweletz, Cloud" sort="Paweletz, Cloud" uniqKey="Paweletz C" first="Cloud" last="Paweletz">Cloud Paweletz</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Wu, Lin" sort="Wu, Lin" uniqKey="Wu L" first="Lin" last="Wu">Lin Wu</name><affiliation wicri:level="2"><nlm:affiliation>Roche Molecular Systems, Pleasanton, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="Chien, Sean" sort="Chien, Sean" uniqKey="Chien S" first="Sean" last="Chien">Sean Chien</name><affiliation wicri:level="2"><nlm:affiliation>Roche Molecular Systems, Pleasanton, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="O Donnell, Patrick" sort="O Donnell, Patrick" uniqKey="O Donnell P" first="Patrick" last="O'Donnell">Patrick O'Donnell</name><affiliation wicri:level="2"><nlm:affiliation>Roche Molecular Systems, Pleasanton, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="Matheny, Shannon" sort="Matheny, Shannon" uniqKey="Matheny S" first="Shannon" last="Matheny">Shannon Matheny</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Despain, Darrin" sort="Despain, Darrin" uniqKey="Despain D" first="Darrin" last="Despain">Darrin Despain</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Park, Keunchil" sort="Park, Keunchil" uniqKey="Park K" first="Keunchil" last="Park">Keunchil Park</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Wakelee, Heather" sort="Wakelee, Heather" uniqKey="Wakelee H" first="Heather" last="Wakelee">Heather Wakelee</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, California. JWGoldman@mednet.ucla.edu hwakelee@stanford.edu.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Stanford</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26747242</idno><idno type="pmid">26747242</idno><idno type="doi">10.1158/1078-0432.CCR-15-1260</idno><idno type="wicri:Area/PubMed/Corpus">001F55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F55</idno><idno type="wicri:Area/PubMed/Curation">001F31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F31</idno><idno type="wicri:Area/PubMed/Checkpoint">001F31</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F31</idno><idno type="wicri:Area/Ncbi/Merge">002F66</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686).</title><author><name sortKey="Karlovich, Chris" sort="Karlovich, Chris" uniqKey="Karlovich C" first="Chris" last="Karlovich">Chris Karlovich</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Goldman, Jonathan W" sort="Goldman, Jonathan W" uniqKey="Goldman J" first="Jonathan W" last="Goldman">Jonathan W. Goldman</name><affiliation wicri:level="2"><nlm:affiliation>University of California Los Angeles, Los Angeles, California. JWGoldman@mednet.ucla.edu hwakelee@stanford.edu.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of California Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Sun, Jong Mu" sort="Sun, Jong Mu" uniqKey="Sun J" first="Jong-Mu" last="Sun">Jong-Mu Sun</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Mann, Elaina" sort="Mann, Elaina" uniqKey="Mann E" first="Elaina" last="Mann">Elaina Mann</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Konopa, Krzysztof" sort="Konopa, Krzysztof" uniqKey="Konopa K" first="Krzysztof" last="Konopa">Krzysztof Konopa</name><affiliation wicri:level="1"><nlm:affiliation>Medical University of Gdansk, Gdansk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University of Gdansk, Gdansk</wicri:regionArea><wicri:noRegion>Gdansk</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Wei" sort="Wen, Wei" uniqKey="Wen W" first="Wei" last="Wen">Wei Wen</name><affiliation wicri:level="2"><nlm:affiliation>Roche Molecular Systems, Pleasanton, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="Angenendt, Philipp" sort="Angenendt, Philipp" uniqKey="Angenendt P" first="Philipp" last="Angenendt">Philipp Angenendt</name><affiliation wicri:level="3"><nlm:affiliation>Sysmex Inostics GmbH, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sysmex Inostics GmbH, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Horn, Leora" sort="Horn, Leora" uniqKey="Horn L" first="Leora" last="Horn">Leora Horn</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Spigel, David" sort="Spigel, David" uniqKey="Spigel D" first="David" last="Spigel">David Spigel</name><affiliation><nlm:affiliation>Sarah Cannon Research Institute, Nashville; Tennessee.</nlm:affiliation><wicri:noCountry code="subField">Nashville; Tennessee</wicri:noCountry></affiliation></author><author><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name><affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name><affiliation wicri:level="4"><nlm:affiliation>University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name><affiliation wicri:level="2"><nlm:affiliation>University of Colorado, Denver, Colorado.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>University of Colorado, Denver</wicri:cityArea></affiliation></author><author><name sortKey="Gadgeel, Shirish" sort="Gadgeel, Shirish" uniqKey="Gadgeel S" first="Shirish" last="Gadgeel">Shirish Gadgeel</name><affiliation wicri:level="2"><nlm:affiliation>Karmanos Cancer Institute/Wayne State University, Detroit, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Karmanos Cancer Institute/Wayne State University, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Paweletz, Cloud" sort="Paweletz, Cloud" uniqKey="Paweletz C" first="Cloud" last="Paweletz">Cloud Paweletz</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Wu, Lin" sort="Wu, Lin" uniqKey="Wu L" first="Lin" last="Wu">Lin Wu</name><affiliation wicri:level="2"><nlm:affiliation>Roche Molecular Systems, Pleasanton, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="Chien, Sean" sort="Chien, Sean" uniqKey="Chien S" first="Sean" last="Chien">Sean Chien</name><affiliation wicri:level="2"><nlm:affiliation>Roche Molecular Systems, Pleasanton, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="O Donnell, Patrick" sort="O Donnell, Patrick" uniqKey="O Donnell P" first="Patrick" last="O'Donnell">Patrick O'Donnell</name><affiliation wicri:level="2"><nlm:affiliation>Roche Molecular Systems, Pleasanton, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Roche Molecular Systems, Pleasanton</wicri:cityArea></affiliation></author><author><name sortKey="Matheny, Shannon" sort="Matheny, Shannon" uniqKey="Matheny S" first="Shannon" last="Matheny">Shannon Matheny</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Despain, Darrin" sort="Despain, Darrin" uniqKey="Despain D" first="Darrin" last="Despain">Darrin Despain</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology Inc., San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Clovis Oncology Inc., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Park, Keunchil" sort="Park, Keunchil" uniqKey="Park K" first="Keunchil" last="Park">Keunchil Park</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Wakelee, Heather" sort="Wakelee, Heather" uniqKey="Wakelee H" first="Heather" last="Wakelee">Heather Wakelee</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, California. JWGoldman@mednet.ucla.edu hwakelee@stanford.edu.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Stanford</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The evaluation of plasma testing for the EGFR resistance mutation T790M in NSCLC patients has not been broadly explored. We investigated the detection of EGFR activating and T790M mutations in matched tumor tissue and plasma, mostly from patients with acquired resistance to first-generation EGFR inhibitors.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">26747242</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>14</Day></DateCreated><DateRevised><Year>2016</Year><Month>05</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1078-0432</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>10</Issue><PubDate><Year>2016</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>Clinical cancer research : an official journal of the American Association for Cancer Research</Title><ISOAbbreviation>Clin. Cancer Res.</ISOAbbreviation></Journal><ArticleTitle>Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686).</ArticleTitle><Pagination><MedlinePgn>2386-95</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/1078-0432.CCR-15-1260</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The evaluation of plasma testing for the EGFR resistance mutation T790M in NSCLC patients has not been broadly explored. We investigated the detection of EGFR activating and T790M mutations in matched tumor tissue and plasma, mostly from patients with acquired resistance to first-generation EGFR inhibitors.</AbstractText><AbstractText Label="EXPERIMENTAL DESIGN" NlmCategory="METHODS">Samples were obtained from two studies, an observational study and a phase I trial of rociletinib, a mutant-selective inhibitor of EGFR that targets both activating mutations and T790M. Plasma testing was performed with the cobas EGFR plasma test and BEAMing.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The positive percent agreement (PPA) between cobas plasma and tumor results was 73% (55/75) for activating mutations and 64% (21/33) for T790M. The PPA between BEAMing plasma and tumor results was 82% (49/60) for activating mutations and 73% (33/45) for T790M. Presence of extrathoracic (M1b) versus intrathoracic (M1a/M0) disease was found to be strongly associated with ability to identify EGFR mutations in plasma (P < 0.001). Rociletinib objective response rates (ORR) were 52% [95% confidence interval (CI), 31 - 74%] for cobas tumor T790M-positive and 44% (95% CI, 25 - 63%) for BEAMing plasma T790M-positive patients. A drop in plasma-mutant EGFR levels to ≤10 molecules/mL was seen by day 21 of treatment in 7 of 8 patients with documented partial response.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings suggest the cobas and BEAMing plasma tests can be useful tools for noninvasive assessment and monitoring of the T790M resistance mutation in NSCLC, and could complement tumor testing by identifying T790M mutations missed because of tumor heterogeneity or biopsy inadequacy. Clin Cancer Res; 22(10); 2386-95. ©2016 AACR.</AbstractText><CopyrightInformation>©2016 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Karlovich</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Clovis Oncology Inc., San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldman</LastName><ForeName>Jonathan W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>University of California Los Angeles, Los Angeles, California. JWGoldman@mednet.ucla.edu hwakelee@stanford.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Jong-Mu</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mann</LastName><ForeName>Elaina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clovis Oncology Inc., San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sequist</LastName><ForeName>Lecia V</ForeName><Initials>LV</Initials><AffiliationInfo><Affiliation>Massachusetts General Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Konopa</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medical University of Gdansk, Gdansk, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wen</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Roche Molecular Systems, Pleasanton, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Angenendt</LastName><ForeName>Philipp</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Sysmex Inostics GmbH, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horn</LastName><ForeName>Leora</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spigel</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Sarah Cannon Research Institute, Nashville; Tennessee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soria</LastName><ForeName>Jean-Charles</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Institut Gustave Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Solomon</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camidge</LastName><ForeName>D Ross</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>University of Colorado, Denver, Colorado.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gadgeel</LastName><ForeName>Shirish</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Karmanos Cancer Institute/Wayne State University, Detroit, Michigan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paweletz</LastName><ForeName>Cloud</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Roche Molecular Systems, Pleasanton, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chien</LastName><ForeName>Sean</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Roche Molecular Systems, Pleasanton, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donnell</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Roche Molecular Systems, Pleasanton, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matheny</LastName><ForeName>Shannon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clovis Oncology Inc., San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Despain</LastName><ForeName>Darrin</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clovis Oncology Inc., San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rolfe</LastName><ForeName>Lindsey</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Clovis Oncology Inc., San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raponi</LastName><ForeName>Mitch</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clovis Oncology Inc., San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>Andrew R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Clovis Oncology Inc., San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Keunchil</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wakelee</LastName><ForeName>Heather</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Stanford University, Stanford, California. JWGoldman@mednet.ucla.edu hwakelee@stanford.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Cancer Res</MedlineTA><NlmUniqueID>9502500</NlmUniqueID><ISSNLinking>1078-0432</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26747242</ArticleId><ArticleId IdType="pii">1078-0432.CCR-15-1260</ArticleId><ArticleId IdType="doi">10.1158/1078-0432.CCR-15-1260</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Corée du Sud</li><li>France</li><li>Pologne</li><li>États-Unis</li></country><region><li>Californie</li><li>Colorado</li><li>Hambourg</li><li>Massachusetts</li><li>Michigan</li><li>Région capitale de Séoul</li><li>Tennessee</li><li>Victoria (État)</li></region><settlement><li>Hambourg</li><li>Melbourne</li><li>Séoul</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Spigel, David" sort="Spigel, David" uniqKey="Spigel D" first="David" last="Spigel">David Spigel</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Karlovich, Chris" sort="Karlovich, Chris" uniqKey="Karlovich C" first="Chris" last="Karlovich">Chris Karlovich</name></region><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name><name sortKey="Chien, Sean" sort="Chien, Sean" uniqKey="Chien S" first="Sean" last="Chien">Sean Chien</name><name sortKey="Despain, Darrin" sort="Despain, Darrin" uniqKey="Despain D" first="Darrin" last="Despain">Darrin Despain</name><name sortKey="Gadgeel, Shirish" sort="Gadgeel, Shirish" uniqKey="Gadgeel S" first="Shirish" last="Gadgeel">Shirish Gadgeel</name><name sortKey="Goldman, Jonathan W" sort="Goldman, Jonathan W" uniqKey="Goldman J" first="Jonathan W" last="Goldman">Jonathan W. Goldman</name><name sortKey="Horn, Leora" sort="Horn, Leora" uniqKey="Horn L" first="Leora" last="Horn">Leora Horn</name><name sortKey="Mann, Elaina" sort="Mann, Elaina" uniqKey="Mann E" first="Elaina" last="Mann">Elaina Mann</name><name sortKey="Matheny, Shannon" sort="Matheny, Shannon" uniqKey="Matheny S" first="Shannon" last="Matheny">Shannon Matheny</name><name sortKey="O Donnell, Patrick" sort="O Donnell, Patrick" uniqKey="O Donnell P" first="Patrick" last="O'Donnell">Patrick O'Donnell</name><name sortKey="Paweletz, Cloud" sort="Paweletz, Cloud" uniqKey="Paweletz C" first="Cloud" last="Paweletz">Cloud Paweletz</name><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><name sortKey="Wakelee, Heather" sort="Wakelee, Heather" uniqKey="Wakelee H" first="Heather" last="Wakelee">Heather Wakelee</name><name sortKey="Wen, Wei" sort="Wen, Wei" uniqKey="Wen W" first="Wei" last="Wen">Wei Wen</name><name sortKey="Wu, Lin" sort="Wu, Lin" uniqKey="Wu L" first="Lin" last="Wu">Lin Wu</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Sun, Jong Mu" sort="Sun, Jong Mu" uniqKey="Sun J" first="Jong-Mu" last="Sun">Jong-Mu Sun</name></region><name sortKey="Park, Keunchil" sort="Park, Keunchil" uniqKey="Park K" first="Keunchil" last="Park">Keunchil Park</name></country><country name="Pologne"><noRegion><name sortKey="Konopa, Krzysztof" sort="Konopa, Krzysztof" uniqKey="Konopa K" first="Krzysztof" last="Konopa">Krzysztof Konopa</name></noRegion></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Angenendt, Philipp" sort="Angenendt, Philipp" uniqKey="Angenendt P" first="Philipp" last="Angenendt">Philipp Angenendt</name></region></country><country name="France"><noRegion><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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