Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer.
Identifieur interne : 002F59 ( Ncbi/Merge ); précédent : 002F58; suivant : 002F60Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer.
Auteurs : Inge C. Van Gool [Pays-Bas] ; Ellen Stelloo [Pays-Bas] ; Remi A. Nout [Pays-Bas] ; Hans W. Nijman [Pays-Bas] ; Richard J. Edmondson [Royaume-Uni] ; David N. Church [Royaume-Uni] ; Helen J. Mackay [Canada] ; Alexandra Leary [France] ; Melanie E. Powell [Royaume-Uni] ; Linda Mileshkin [Australie] ; Carien L. Creutzberg [Pays-Bas] ; Vincent T H B M. Smit [Pays-Bas] ; Tjalling Bosse [Pays-Bas]Source :
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [ 1530-0285 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de mutations d'ADN, Carcinome endométrioïde (), Carcinome endométrioïde (génétique), Carcinome endométrioïde (mortalité), Carcinome endométrioïde (secondaire), Estimation de Kaplan-Meier, Facteurs de risque, Femelle, Grading des tumeurs, Humains, Immunohistochimie, Invasion tumorale, Jeune adulte, Marqueurs biologiques tumoraux (analyse), Marqueurs biologiques tumoraux (génétique), Molécule d'adhérence cellulaire neurale L-1 (analyse), Mutation, Phénotype, Projets pilotes, Protéine p53 suppresseur de tumeur (génétique), Prédisposition génétique à une maladie, Récidive tumorale locale, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs de l'endomètre (), Tumeurs de l'endomètre (anatomopathologie), Tumeurs de l'endomètre (génétique), Tumeurs de l'endomètre (mortalité), Études rétrospectives, Évaluation des risques, Évolution de la maladie.
- MESH :
- analyse : Marqueurs biologiques tumoraux, Molécule d'adhérence cellulaire neurale L-1.
- anatomopathologie : Tumeurs de l'endomètre.
- génétique : Carcinome endométrioïde, Marqueurs biologiques tumoraux, Protéine p53 suppresseur de tumeur, Tumeurs de l'endomètre.
- mortalité : Carcinome endométrioïde, Tumeurs de l'endomètre.
- secondaire : Carcinome endométrioïde.
- Adulte, Adulte d'âge moyen, Analyse de mutations d'ADN, Carcinome endométrioïde, Estimation de Kaplan-Meier, Facteurs de risque, Femelle, Grading des tumeurs, Humains, Immunohistochimie, Invasion tumorale, Jeune adulte, Mutation, Phénotype, Projets pilotes, Prédisposition génétique à une maladie, Récidive tumorale locale, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs de l'endomètre, Études rétrospectives, Évaluation des risques, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Biomarkers, Tumor (analysis), Biomarkers, Tumor (genetics), Carcinoma, Endometrioid (chemistry), Carcinoma, Endometrioid (genetics), Carcinoma, Endometrioid (mortality), Carcinoma, Endometrioid (secondary), Carcinoma, Endometrioid (therapy), DNA Mutational Analysis, Disease Progression, Disease-Free Survival, Endometrial Neoplasms (chemistry), Endometrial Neoplasms (genetics), Endometrial Neoplasms (mortality), Endometrial Neoplasms (pathology), Endometrial Neoplasms (therapy), Female, Genetic Predisposition to Disease, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Mutation, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Staging, Neural Cell Adhesion Molecule L1 (analysis), Phenotype, Pilot Projects, Retrospective Studies, Risk Assessment, Risk Factors, Treatment Outcome, Tumor Suppressor Protein p53 (genetics), Young Adult.
- MESH :
- chemical , analysis : Biomarkers, Tumor, Neural Cell Adhesion Molecule L1.
- chemical , genetics : Biomarkers, Tumor, Tumor Suppressor Protein p53.
- chemistry : Carcinoma, Endometrioid, Endometrial Neoplasms.
- genetics : Carcinoma, Endometrioid, Endometrial Neoplasms.
- mortality : Carcinoma, Endometrioid, Endometrial Neoplasms.
- pathology : Endometrial Neoplasms.
- secondary : Carcinoma, Endometrioid.
- therapy : Carcinoma, Endometrioid, Endometrial Neoplasms.
- Adult, Aged, Aged, 80 and over, DNA Mutational Analysis, Disease Progression, Disease-Free Survival, Female, Genetic Predisposition to Disease, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Mutation, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Staging, Phenotype, Pilot Projects, Retrospective Studies, Risk Assessment, Risk Factors, Treatment Outcome, Young Adult.
Abstract
Studies in early-stage, predominantly low- and intermediate-risk endometrial cancer have demonstrated that L1 cell adhesion molecule (L1CAM) overexpression identifies patients at increased risk of recurrence, yet its prognostic significance in high-risk endometrial cancer is unclear. To evaluate this, its frequency, and the relationship of L1CAM with the established endometrial cancer biomarker p53, we analyzed the expression of both markers by immunohistochemistry in a pilot series of 116 endometrial cancers (86 endometrioid, 30 non-endometrioid subtype) with high-risk features (such as high tumor grade and deep myometrial invasion) and correlated results with clinical outcome. We used The Cancer Genome Atlas (TCGA) endometrial cancer series to validate our findings. Using the previously reported cutoff of 10% positive staining, 51/116 (44%) tumors were classified as L1CAM-positive, with no significant association between L1CAM positivity and the rate of distant metastasis (P=0.195). However, increasing the threshold for L1CAM positivity to 50% resulted in a reduction of the frequency of L1CAM-positive tumors to 24% (28/116), and a significant association with the rate of distant metastasis (P=0.018). L1CAM expression was strongly associated with mutant p53 in the high-risk and TCGA series (P<0.001), although a substantial fraction (36% of endometrioid, 10% of non-endometrioid morphology) of p53-mutant endometrial cancers displayed <10% L1CAM positivity. Moreover, 30% of p53-wild-type non-endometrioid endometrial cancers demonstrated diffuse L1CAM staining, suggesting p53-independent mechanisms of L1CAM overexpression. In conclusion, the previously proposed threshold for L1CAM positivity of >10% does not predict prognosis in high-risk endometrial cancer, whereas an alternative threshold (>50%) does. L1CAM expression is strongly, but not universally, associated with mutant p53, and may be strong enough for clinical implementation as prognostic marker in combination with p53. The high frequency of L1CAM expression in high-risk endometrial cancers suggests that it may also be a promising therapeutic target in this tumor subset.
DOI: 10.1038/modpathol.2015.147
PubMed: 26743472
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pubmed:26743472Le document en format XML
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<author><name sortKey="Powell, Melanie E" sort="Powell, Melanie E" uniqKey="Powell M" first="Melanie E" last="Powell">Melanie E. Powell</name>
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<term>Carcinoma, Endometrioid (genetics)</term>
<term>Carcinoma, Endometrioid (mortality)</term>
<term>Carcinoma, Endometrioid (secondary)</term>
<term>Carcinoma, Endometrioid (therapy)</term>
<term>DNA Mutational Analysis</term>
<term>Disease Progression</term>
<term>Disease-Free Survival</term>
<term>Endometrial Neoplasms (chemistry)</term>
<term>Endometrial Neoplasms (genetics)</term>
<term>Endometrial Neoplasms (mortality)</term>
<term>Endometrial Neoplasms (pathology)</term>
<term>Endometrial Neoplasms (therapy)</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Kaplan-Meier Estimate</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Invasiveness</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasm Staging</term>
<term>Neural Cell Adhesion Molecule L1 (analysis)</term>
<term>Phenotype</term>
<term>Pilot Projects</term>
<term>Retrospective Studies</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Treatment Outcome</term>
<term>Tumor Suppressor Protein p53 (genetics)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de mutations d'ADN</term>
<term>Carcinome endométrioïde ()</term>
<term>Carcinome endométrioïde (génétique)</term>
<term>Carcinome endométrioïde (mortalité)</term>
<term>Carcinome endométrioïde (secondaire)</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grading des tumeurs</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Invasion tumorale</term>
<term>Jeune adulte</term>
<term>Marqueurs biologiques tumoraux (analyse)</term>
<term>Marqueurs biologiques tumoraux (génétique)</term>
<term>Molécule d'adhérence cellulaire neurale L-1 (analyse)</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Projets pilotes</term>
<term>Protéine p53 suppresseur de tumeur (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récidive tumorale locale</term>
<term>Résultat thérapeutique</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Tumeurs de l'endomètre ()</term>
<term>Tumeurs de l'endomètre (anatomopathologie)</term>
<term>Tumeurs de l'endomètre (génétique)</term>
<term>Tumeurs de l'endomètre (mortalité)</term>
<term>Études rétrospectives</term>
<term>Évaluation des risques</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers, Tumor</term>
<term>Neural Cell Adhesion Molecule L1</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Biomarkers, Tumor</term>
<term>Tumor Suppressor Protein p53</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques tumoraux</term>
<term>Molécule d'adhérence cellulaire neurale L-1</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de l'endomètre</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome endométrioïde</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Protéine p53 suppresseur de tumeur</term>
<term>Tumeurs de l'endomètre</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Carcinome endométrioïde</term>
<term>Tumeurs de l'endomètre</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Carcinome endométrioïde</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Carcinoma, Endometrioid</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>DNA Mutational Analysis</term>
<term>Disease Progression</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Kaplan-Meier Estimate</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Invasiveness</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasm Staging</term>
<term>Phenotype</term>
<term>Pilot Projects</term>
<term>Retrospective Studies</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de mutations d'ADN</term>
<term>Carcinome endométrioïde</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grading des tumeurs</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Invasion tumorale</term>
<term>Jeune adulte</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Projets pilotes</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récidive tumorale locale</term>
<term>Résultat thérapeutique</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Tumeurs de l'endomètre</term>
<term>Études rétrospectives</term>
<term>Évaluation des risques</term>
<term>Évolution de la maladie</term>
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<front><div type="abstract" xml:lang="en">Studies in early-stage, predominantly low- and intermediate-risk endometrial cancer have demonstrated that L1 cell adhesion molecule (L1CAM) overexpression identifies patients at increased risk of recurrence, yet its prognostic significance in high-risk endometrial cancer is unclear. To evaluate this, its frequency, and the relationship of L1CAM with the established endometrial cancer biomarker p53, we analyzed the expression of both markers by immunohistochemistry in a pilot series of 116 endometrial cancers (86 endometrioid, 30 non-endometrioid subtype) with high-risk features (such as high tumor grade and deep myometrial invasion) and correlated results with clinical outcome. We used The Cancer Genome Atlas (TCGA) endometrial cancer series to validate our findings. Using the previously reported cutoff of 10% positive staining, 51/116 (44%) tumors were classified as L1CAM-positive, with no significant association between L1CAM positivity and the rate of distant metastasis (P=0.195). However, increasing the threshold for L1CAM positivity to 50% resulted in a reduction of the frequency of L1CAM-positive tumors to 24% (28/116), and a significant association with the rate of distant metastasis (P=0.018). L1CAM expression was strongly associated with mutant p53 in the high-risk and TCGA series (P<0.001), although a substantial fraction (36% of endometrioid, 10% of non-endometrioid morphology) of p53-mutant endometrial cancers displayed <10% L1CAM positivity. Moreover, 30% of p53-wild-type non-endometrioid endometrial cancers demonstrated diffuse L1CAM staining, suggesting p53-independent mechanisms of L1CAM overexpression. In conclusion, the previously proposed threshold for L1CAM positivity of >10% does not predict prognosis in high-risk endometrial cancer, whereas an alternative threshold (>50%) does. L1CAM expression is strongly, but not universally, associated with mutant p53, and may be strong enough for clinical implementation as prognostic marker in combination with p53. The high frequency of L1CAM expression in high-risk endometrial cancers suggests that it may also be a promising therapeutic target in this tumor subset.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26743472</PMID>
<DateCreated><Year>2016</Year>
<Month>01</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>10</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1530-0285</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>29</Volume>
<Issue>2</Issue>
<PubDate><Year>2016</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc</Title>
<ISOAbbreviation>Mod. Pathol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer.</ArticleTitle>
<Pagination><MedlinePgn>174-81</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/modpathol.2015.147</ELocationID>
<Abstract><AbstractText>Studies in early-stage, predominantly low- and intermediate-risk endometrial cancer have demonstrated that L1 cell adhesion molecule (L1CAM) overexpression identifies patients at increased risk of recurrence, yet its prognostic significance in high-risk endometrial cancer is unclear. To evaluate this, its frequency, and the relationship of L1CAM with the established endometrial cancer biomarker p53, we analyzed the expression of both markers by immunohistochemistry in a pilot series of 116 endometrial cancers (86 endometrioid, 30 non-endometrioid subtype) with high-risk features (such as high tumor grade and deep myometrial invasion) and correlated results with clinical outcome. We used The Cancer Genome Atlas (TCGA) endometrial cancer series to validate our findings. Using the previously reported cutoff of 10% positive staining, 51/116 (44%) tumors were classified as L1CAM-positive, with no significant association between L1CAM positivity and the rate of distant metastasis (P=0.195). However, increasing the threshold for L1CAM positivity to 50% resulted in a reduction of the frequency of L1CAM-positive tumors to 24% (28/116), and a significant association with the rate of distant metastasis (P=0.018). L1CAM expression was strongly associated with mutant p53 in the high-risk and TCGA series (P<0.001), although a substantial fraction (36% of endometrioid, 10% of non-endometrioid morphology) of p53-mutant endometrial cancers displayed <10% L1CAM positivity. Moreover, 30% of p53-wild-type non-endometrioid endometrial cancers demonstrated diffuse L1CAM staining, suggesting p53-independent mechanisms of L1CAM overexpression. In conclusion, the previously proposed threshold for L1CAM positivity of >10% does not predict prognosis in high-risk endometrial cancer, whereas an alternative threshold (>50%) does. L1CAM expression is strongly, but not universally, associated with mutant p53, and may be strong enough for clinical implementation as prognostic marker in combination with p53. The high frequency of L1CAM expression in high-risk endometrial cancers suggests that it may also be a promising therapeutic target in this tumor subset.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Van Gool</LastName>
<ForeName>Inge C</ForeName>
<Initials>IC</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stelloo</LastName>
<ForeName>Ellen</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nout</LastName>
<ForeName>Remi A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nijman</LastName>
<ForeName>Hans W</ForeName>
<Initials>HW</Initials>
<AffiliationInfo><Affiliation>Department of Gynecology, University Medical Center Groningen, Groningen, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Edmondson</LastName>
<ForeName>Richard J</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Institute of Cancer Sciences, University of Manchester, St Marys Hospital, Manchester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Church</LastName>
<ForeName>David N</ForeName>
<Initials>DN</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4617-962X</Identifier>
<AffiliationInfo><Affiliation>Molecular and Population Genetics Laboratory, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Oxford Cancer Centre, Churchill Hospital, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>MacKay</LastName>
<ForeName>Helen J</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leary</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Powell</LastName>
<ForeName>Melanie E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Oncology, Barts Health NHS Trust, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mileshkin</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Creutzberg</LastName>
<ForeName>Carien L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smit</LastName>
<ForeName>Vincent T H B M</ForeName>
<Initials>VT</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bosse</LastName>
<ForeName>Tjalling</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>01</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mod Pathol</MedlineTA>
<NlmUniqueID>8806605</NlmUniqueID>
<ISSNLinking>0893-3952</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014408">Biomarkers, Tumor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D039842">Neural Cell Adhesion Molecule L1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C495901">TP53 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016159">Tumor Suppressor Protein p53</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 1984 Jan;3(1):1-10</RefSource>
<PMID Version="1">6368220</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Cancer. 2015 Mar 1;136(5):E326-39</RefSource>
<PMID Version="1">25230579</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2009 May 15;69(10 ):4517-26</RefSource>
<PMID Version="1">19435915</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Oncotarget. 2014 Jan 30;5(2):462-72</RefSource>
<PMID Version="1">24497324</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Adh Migr. 2012 Jul-Aug;6(4):374-84</RefSource>
<PMID Version="1">22796939</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2011 Aug 04;12:323</RefSource>
<PMID Version="1">21816040</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Cancer. 2006 Aug 1;119(3):549-55</RefSource>
<PMID Version="1">16506207</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mod Pathol. 2007 Nov;20(11):1183-90</RefSource>
<PMID Version="1">17873897</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cancer. 2011 Oct 10;10:127</RefSource>
<PMID Version="1">21985405</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Cancer. 2014 Oct;50(15):2602-10</RefSource>
<PMID Version="1">25126672</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2003 Sep 13;362(9387):869-75</RefSource>
<PMID Version="1">13678974</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Hematol Oncol. 2013 Jun 27;6:43</RefSource>
<PMID Version="1">23806079</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Diagn Pathol. 2012 Aug 13;7:96</RefSource>
<PMID Version="1">22888955</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Exp Metastasis. 2014 Jan;31(1):87-100</RefSource>
<PMID Version="1">24002299</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Cancer. 2015 Jul 14;113(2):299-310</RefSource>
<PMID Version="1">26172027</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Oncol Rep. 2009 Nov;22(5):1109-17</RefSource>
<PMID Version="1">19787228</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mod Pathol. 2008 Aug;21(8):937-42</RefSource>
<PMID Version="1">18500258</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Pathol. 2011 Oct;42(10):1476-83</RefSource>
<PMID Version="1">21496863</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mod Pathol. 2015 Jun;28(6):836-44</RefSource>
<PMID Version="1">25720322</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 2005 Feb 14;168(4):633-42</RefSource>
<PMID Version="1">15716380</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pathol. 2010 Apr;220(5):551-61</RefSource>
<PMID Version="1">20077528</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 May 2;497(7447):67-73</RefSource>
<PMID Version="1">23636398</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 2012 Sep;126(3):466-73</RefSource>
<PMID Version="1">22609107</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Cell Biol. 1997 Oct;9(5):627-34</RefSource>
<PMID Version="1">9330865</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Lett. 2012 Jun 1;319(1):66-82</RefSource>
<PMID Version="1">22210381</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2014 Dec 12;107(1):402</RefSource>
<PMID Version="1">25505230</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2013 Aug 7;105(15):1142-50</RefSource>
<PMID Version="1">23781004</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mod Pathol. 2013 Nov;26(11):1525-35</RefSource>
<PMID Version="1">23702729</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2006 Jan 15;66(2):936-43</RefSource>
<PMID Version="1">16424028</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014408" MajorTopicYN="N">Biomarkers, Tumor</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018269" MajorTopicYN="N">Carcinoma, Endometrioid</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000556" MajorTopicYN="N">secondary</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016889" MajorTopicYN="N">Endometrial Neoplasms</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053208" MajorTopicYN="N">Kaplan-Meier Estimate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060787" MajorTopicYN="N">Neoplasm Grading</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009361" MajorTopicYN="N">Neoplasm Invasiveness</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName>
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