The role of defensive ecological interactions in the evolution of conotoxins.
Identifieur interne : 002E07 ( Ncbi/Merge ); précédent : 002E06; suivant : 002E08The role of defensive ecological interactions in the evolution of conotoxins.
Auteurs : J R Prashanth [Australie] ; S. Dutertre [Australie] ; A H Jin [Australie] ; V. Lavergne [Australie] ; B. Hamilton [Australie] ; F C Cardoso [Australie] ; J. Griffin [Australie] ; D J Venter [Australie] ; P F Alewood [Australie] ; R J Lewis [Australie]Source :
- Molecular ecology [ 1365-294X ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Conotoxins.
- chemical , genetics : Conotoxins.
- geographic : Australia.
- genetics : Conus Snail.
- Amino Acid Sequence, Animals, Cell Line, Evolution, Molecular, Humans, Molecular Sequence Data, Phylogeny, Sequence Analysis, RNA, Tandem Mass Spectrometry, Transcriptome.
Abstract
Venoms comprise of complex mixtures of peptides evolved for predation and defensive purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in response to predatory or defensive stimuli, providing a unique opportunity to study separately how different ecological pressures contribute to toxin diversification. Here, we report the extraordinary defensive strategy of the Rhizoconus subgenus of cone snails. The defensive venom from this worm-hunting subgenus is unusually simple, almost exclusively composed of αD-conotoxins instead of the ubiquitous αA-conotoxins found in the more complex defensive venom of mollusc- and fish-hunting cone snails. A similarly compartmentalized venom gland as those observed in the other dietary groups facilitates the deployment of this defensive venom. Transcriptomic analysis of a Conus vexillum venom gland revealed the αD-conotoxins as the major transcripts, with lower amounts of 15 known and four new conotoxin superfamilies also detected with likely roles in prey capture. Our phylogenetic and molecular evolution analysis of the αD-conotoxins from five subgenera of cone snails suggests they evolved episodically as part of a defensive strategy in the Rhizoconus subgenus. Thus, our results demonstrate an important role for defence in the evolution of conotoxins.
DOI: 10.1111/mec.13504
PubMed: 26614983
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Dutertre</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Jin, A H" sort="Jin, A H" uniqKey="Jin A" first="A H" last="Jin">A H Jin</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Lavergne, V" sort="Lavergne, V" uniqKey="Lavergne V" first="V" last="Lavergne">V. 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Hamilton</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101</wicri:regionArea><wicri:noRegion>4101</wicri:noRegion></affiliation></author><author><name sortKey="Cardoso, F C" sort="Cardoso, F C" uniqKey="Cardoso F" first="F C" last="Cardoso">F C Cardoso</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Griffin, J" sort="Griffin, J" uniqKey="Griffin J" first="J" last="Griffin">J. Griffin</name><affiliation wicri:level="1"><nlm:affiliation>ACRF Microscopy Facility, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ACRF Microscopy Facility, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Venter, D J" sort="Venter, D J" uniqKey="Venter D" first="D J" last="Venter">D J Venter</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101</wicri:regionArea><wicri:noRegion>4101</wicri:noRegion></affiliation></author><author><name sortKey="Alewood, P F" sort="Alewood, P F" uniqKey="Alewood P" first="P F" last="Alewood">P F Alewood</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, R J" sort="Lewis, R J" uniqKey="Lewis R" first="R J" last="Lewis">R J Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular ecology</title><idno type="eISSN">1365-294X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Australia</term><term>Cell Line</term><term>Conotoxins (chemistry)</term><term>Conotoxins (genetics)</term><term>Conus Snail (genetics)</term><term>Evolution, Molecular</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Analysis, RNA</term><term>Tandem Mass Spectrometry</term><term>Transcriptome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Australie</term><term>Conotoxines ()</term><term>Conotoxines (génétique)</term><term>Conus (génétique)</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Spectrométrie de masse en tandem</term><term>Séquence d'acides aminés</term><term>Transcriptome</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Conotoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Conotoxins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Australia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conus Snail</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Conotoxines</term><term>Conus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cell Line</term><term>Evolution, Molecular</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Analysis, RNA</term><term>Tandem Mass Spectrometry</term><term>Transcriptome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Australie</term><term>Conotoxines</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Spectrométrie de masse en tandem</term><term>Séquence d'acides aminés</term><term>Transcriptome</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Venoms comprise of complex mixtures of peptides evolved for predation and defensive purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in response to predatory or defensive stimuli, providing a unique opportunity to study separately how different ecological pressures contribute to toxin diversification. Here, we report the extraordinary defensive strategy of the Rhizoconus subgenus of cone snails. The defensive venom from this worm-hunting subgenus is unusually simple, almost exclusively composed of αD-conotoxins instead of the ubiquitous αA-conotoxins found in the more complex defensive venom of mollusc- and fish-hunting cone snails. A similarly compartmentalized venom gland as those observed in the other dietary groups facilitates the deployment of this defensive venom. Transcriptomic analysis of a Conus vexillum venom gland revealed the αD-conotoxins as the major transcripts, with lower amounts of 15 known and four new conotoxin superfamilies also detected with likely roles in prey capture. Our phylogenetic and molecular evolution analysis of the αD-conotoxins from five subgenera of cone snails suggests they evolved episodically as part of a defensive strategy in the Rhizoconus subgenus. Thus, our results demonstrate an important role for defence in the evolution of conotoxins.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26614983</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>23</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>08</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-294X</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>01</Month></PubDate></JournalIssue><Title>Molecular ecology</Title><ISOAbbreviation>Mol. Ecol.</ISOAbbreviation></Journal><ArticleTitle>The role of defensive ecological interactions in the evolution of conotoxins.</ArticleTitle><Pagination><MedlinePgn>598-615</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/mec.13504</ELocationID><Abstract><AbstractText>Venoms comprise of complex mixtures of peptides evolved for predation and defensive purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in response to predatory or defensive stimuli, providing a unique opportunity to study separately how different ecological pressures contribute to toxin diversification. Here, we report the extraordinary defensive strategy of the Rhizoconus subgenus of cone snails. The defensive venom from this worm-hunting subgenus is unusually simple, almost exclusively composed of αD-conotoxins instead of the ubiquitous αA-conotoxins found in the more complex defensive venom of mollusc- and fish-hunting cone snails. A similarly compartmentalized venom gland as those observed in the other dietary groups facilitates the deployment of this defensive venom. Transcriptomic analysis of a Conus vexillum venom gland revealed the αD-conotoxins as the major transcripts, with lower amounts of 15 known and four new conotoxin superfamilies also detected with likely roles in prey capture. Our phylogenetic and molecular evolution analysis of the αD-conotoxins from five subgenera of cone snails suggests they evolved episodically as part of a defensive strategy in the Rhizoconus subgenus. Thus, our results demonstrate an important role for defence in the evolution of conotoxins.</AbstractText><CopyrightInformation>© 2015 John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Prashanth</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dutertre</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier-CNRS, Place Eugène Bataillon, 34095, Montpellier Cedex 5, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>A H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavergne</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamilton</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Mater Research Institute, The University of Queensland, St. Lucia, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cardoso</LastName><ForeName>F C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griffin</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>ACRF Microscopy Facility, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venter</LastName><ForeName>D J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Mater Research Institute, The University of Queensland, St. Lucia, Qld, 4072, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alewood</LastName><ForeName>P F</ForeName><Initials>PF</Initials><AffiliationInfo><Affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>R J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>Dryad</DataBankName><AccessionNumberList><AccessionNumber>10.5061/dryad.MB6870</AccessionNumber></AccessionNumberList></DataBank><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>SRR2890189</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol Ecol</MedlineTA><NlmUniqueID>9214478</NlmUniqueID><ISSNLinking>0962-1083</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020916">Conotoxins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001315" MajorTopicYN="N" Type="Geographic">Australia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020916" MajorTopicYN="N">Conotoxins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052078" MajorTopicYN="N">Conus Snail</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="Y">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017423" MajorTopicYN="N">Sequence Analysis, RNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053719" MajorTopicYN="N">Tandem Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059467" MajorTopicYN="Y">Transcriptome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">conotoxins</Keyword><Keyword MajorTopicYN="Y">defence</Keyword><Keyword MajorTopicYN="Y">evolution</Keyword><Keyword MajorTopicYN="Y">predator-prey interactions</Keyword><Keyword MajorTopicYN="Y">venomics</Keyword><Keyword MajorTopicYN="Y">venoms</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26614983</ArticleId><ArticleId IdType="doi">10.1111/mec.13504</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Prashanth, J R" sort="Prashanth, J R" uniqKey="Prashanth J" first="J R" last="Prashanth">J R Prashanth</name></noRegion><name sortKey="Alewood, P F" sort="Alewood, P F" uniqKey="Alewood P" first="P F" last="Alewood">P F Alewood</name><name sortKey="Cardoso, F C" sort="Cardoso, F C" uniqKey="Cardoso F" first="F C" last="Cardoso">F C Cardoso</name><name sortKey="Dutertre, S" sort="Dutertre, S" uniqKey="Dutertre S" first="S" last="Dutertre">S. Dutertre</name><name sortKey="Griffin, J" sort="Griffin, J" uniqKey="Griffin J" first="J" last="Griffin">J. Griffin</name><name sortKey="Hamilton, B" sort="Hamilton, B" uniqKey="Hamilton B" first="B" last="Hamilton">B. Hamilton</name><name sortKey="Jin, A H" sort="Jin, A H" uniqKey="Jin A" first="A H" last="Jin">A H Jin</name><name sortKey="Lavergne, V" sort="Lavergne, V" uniqKey="Lavergne V" first="V" last="Lavergne">V. Lavergne</name><name sortKey="Lewis, R J" sort="Lewis, R J" uniqKey="Lewis R" first="R J" last="Lewis">R J Lewis</name><name sortKey="Venter, D J" sort="Venter, D J" uniqKey="Venter D" first="D J" last="Venter">D J Venter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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