Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study.
Identifieur interne : 002B50 ( Ncbi/Merge ); précédent : 002B49; suivant : 002B51Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study.
Auteurs : Nikos Pantazis [Grèce] ; Kholoud Porter [Royaume-Uni] ; Dominique Costagliola [France] ; Andrea De Luca [Italie] ; Jade Ghosn [France] ; Marguerite Guiguet [France] ; Anne M. Johnson [Royaume-Uni] ; Anthony D. Kelleher [Australie] ; Charles Morrison [États-Unis] ; Rodolphe Thiebaut [France] ; Linda Wittkop [France] ; Giota Touloumi [Grèce]Source :
- The lancet. HIV [ 2352-3018 ] ; 2014.
Abstract
Measures of CD4 T-cell count and HIV-1 plasma viral load before antiretroviral therapy are proxies for virulence. Whether these proxies are changing over time has implications for prevention and treatment. The aim of this study was to investigate those trends.
DOI: 10.1016/S2352-3018(14)00002-2
PubMed: 26424120
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Electronic address: npantaz@med.uoa.gr.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Athens University Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Porter, Kholoud" sort="Porter, Kholoud" uniqKey="Porter K" first="Kholoud" last="Porter">Kholoud Porter</name><affiliation wicri:level="3"><nlm:affiliation>MRC Clinical Trials Unit at UCL, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Clinical Trials Unit at UCL, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1136, Paris, France; UPMC Université Paris 06, UMR S1136, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Service des maladies infectieuses et tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1136, Paris, France; UPMC Université Paris 06, UMR S1136, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Service des maladies infectieuses et tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="De Luca, Andrea" sort="De Luca, Andrea" uniqKey="De Luca A" first="Andrea" last="De Luca">Andrea De Luca</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy; Unit of Infectious Diseases, Siena University Hospital, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinic of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy; Unit of Infectious Diseases, Siena University Hospital, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Ghosn, Jade" sort="Ghosn, Jade" uniqKey="Ghosn J" first="Jade" last="Ghosn">Jade Ghosn</name><affiliation wicri:level="4"><nlm:affiliation>AP-HP, Hôpital Bicêtre, Service de médecine interne, Le Kremlin-Bicêtre, Paris, France; Faculté de Médecine site Necker, Université Paris Descartes, EA 3620, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Bicêtre, Service de médecine interne, Le Kremlin-Bicêtre, Paris, France; Faculté de Médecine site Necker, Université Paris Descartes, EA 3620, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Guiguet, Marguerite" sort="Guiguet, Marguerite" uniqKey="Guiguet M" first="Marguerite" last="Guiguet">Marguerite Guiguet</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1136, Paris, France; UPMC Université Paris 06, UMR S1136, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1136, Paris, France; UPMC Université Paris 06, UMR S1136, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Johnson, Anne M" sort="Johnson, Anne M" uniqKey="Johnson A" first="Anne M" last="Johnson">Anne M. Johnson</name><affiliation wicri:level="4"><nlm:affiliation>Research Department of Infection and Population Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D" last="Kelleher">Anthony D. Kelleher</name><affiliation wicri:level="1"><nlm:affiliation>Kirby Institute, UNSW, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kirby Institute, UNSW, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Charles" sort="Morrison, Charles" uniqKey="Morrison C" first="Charles" last="Morrison">Charles Morrison</name><affiliation wicri:level="2"><nlm:affiliation>FHI 360, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>FHI 360, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U897 Centre of Epidemiology and Biostatistics, ISPED Bordeaux School of Public Health, University Bordeaux Segalen, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897 Centre of Epidemiology and Biostatistics, ISPED Bordeaux School of Public Health, University Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U897 Centre of Epidemiology and Biostatistics, ISPED Bordeaux School of Public Health, University Bordeaux Segalen, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897 Centre of Epidemiology and Biostatistics, ISPED Bordeaux School of Public Health, University Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Touloumi, Giota" sort="Touloumi, Giota" uniqKey="Touloumi G" first="Giota" last="Touloumi">Giota Touloumi</name><affiliation wicri:level="3"><nlm:affiliation>Athens University Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Athens University Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></analytic><series><title level="j">The lancet. HIV</title><idno type="eISSN">2352-3018</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Measures of CD4 T-cell count and HIV-1 plasma viral load before antiretroviral therapy are proxies for virulence. Whether these proxies are changing over time has implications for prevention and treatment. The aim of this study was to investigate those trends.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">26424120</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>01</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2352-3018</ISSN><JournalIssue CitedMedium="Internet"><Volume>1</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The lancet. HIV</Title><ISOAbbreviation>Lancet HIV</ISOAbbreviation></Journal><ArticleTitle>Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study.</ArticleTitle><Pagination><MedlinePgn>e119-26</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2352-3018(14)00002-2</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S2352-3018(14)00002-2</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Measures of CD4 T-cell count and HIV-1 plasma viral load before antiretroviral therapy are proxies for virulence. Whether these proxies are changing over time has implications for prevention and treatment. The aim of this study was to investigate those trends.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Data were derived from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration of mainly European seroconverter cohorts. Longitudinal CD4 cell counts and plasma viral load measurements before the initiation of antiretroviral therapy or AIDS onset were analysed by use of linear or fractional polynomials mixed models adjusting for all available potential confounders. Calendar time effects were modelled through natural cubic splines.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">15 875 individuals seroconverting from 1979 to 2008 fulfilled the inclusion criteria; 3215 (20·3%) were women; median follow-up was 31 months (IQR 14-62); dropout before starting antiretroviral therapy or AIDS onset was 8·1%. Estimated CD4 counts at seroconversion for a typical individual declined from about 770 cells per μL (95% CI 750-800) in the early 1980s to a plateau of about 570 cells per μL (555-585) after 2002. CD4 cell rate of loss increased up to 2002. Estimated set-point plasma viral loads increased from 4·05 log10 copies per mL (95% CI 3·98-4·12) in 1980 to 4·50 log10 copies per mL (4·45-4·54) in 2002 with a tendency of returning to lower loads thereafter. Results were similar when we restricted analyses to various subsets, including adjusting for plasma viral load assay, censored follow-up at 3 years, or used variations of the main statistical approach.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Our results provide strong indications of increased HIV-1 virulence and transmissibility during the course of the epidemic and a potential plateau effect after about 2002.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">European Union Seventh Framework Programme.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pantazis</LastName><ForeName>Nikos</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Athens University Medical School, Athens, Greece. Electronic address: npantaz@med.uoa.gr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Porter</LastName><ForeName>Kholoud</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>MRC Clinical Trials Unit at UCL, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costagliola</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>INSERM, U1136, Paris, France; UPMC Université Paris 06, UMR S1136, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Service des maladies infectieuses et tropicales, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Luca</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Clinic of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy; Unit of Infectious Diseases, Siena University Hospital, Siena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghosn</LastName><ForeName>Jade</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>AP-HP, Hôpital Bicêtre, Service de médecine interne, Le Kremlin-Bicêtre, Paris, France; Faculté de Médecine site Necker, Université Paris Descartes, EA 3620, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guiguet</LastName><ForeName>Marguerite</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM, U1136, Paris, France; UPMC Université Paris 06, UMR S1136, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Anne M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Research Department of Infection and Population Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelleher</LastName><ForeName>Anthony D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Kirby Institute, UNSW, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrison</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>FHI 360, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiebaut</LastName><ForeName>Rodolphe</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>INSERM U897 Centre of Epidemiology and Biostatistics, ISPED Bordeaux School of Public Health, University Bordeaux Segalen, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wittkop</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INSERM U897 Centre of Epidemiology and Biostatistics, ISPED Bordeaux School of Public Health, University Bordeaux Segalen, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Touloumi</LastName><ForeName>Giota</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Athens University Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>CASCADE Collaboration in EuroCoord</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MC_UU_12023/15</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Lancet HIV</MedlineTA><NlmUniqueID>101645355</NlmUniqueID><ISSNLinking>2352-3018</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>09</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26424120</ArticleId><ArticleId IdType="pii">S2352-3018(14)00002-2</ArticleId><ArticleId IdType="doi">10.1016/S2352-3018(14)00002-2</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Grèce</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Attique (région)</li><li>Caroline du Nord</li><li>Grand Londres</li><li>Nouvelle-Aquitaine</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Bordeaux</li><li>Londres</li><li>Paris</li></settlement><orgName><li>University College de Londres</li><li>Université Paris-Descartes</li></orgName></list><tree><country name="Grèce"><region name="Attique (région)"><name sortKey="Pantazis, Nikos" sort="Pantazis, Nikos" uniqKey="Pantazis N" first="Nikos" last="Pantazis">Nikos Pantazis</name></region><name sortKey="Touloumi, Giota" sort="Touloumi, Giota" uniqKey="Touloumi G" first="Giota" last="Touloumi">Giota Touloumi</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Porter, Kholoud" sort="Porter, Kholoud" uniqKey="Porter K" first="Kholoud" last="Porter">Kholoud Porter</name></region><name sortKey="Johnson, Anne M" sort="Johnson, Anne M" uniqKey="Johnson A" first="Anne M" last="Johnson">Anne M. Johnson</name></country><country name="France"><region name="Île-de-France"><name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name></region><name sortKey="Ghosn, Jade" sort="Ghosn, Jade" uniqKey="Ghosn J" first="Jade" last="Ghosn">Jade Ghosn</name><name sortKey="Guiguet, Marguerite" sort="Guiguet, Marguerite" uniqKey="Guiguet M" first="Marguerite" last="Guiguet">Marguerite Guiguet</name><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name></country><country name="Italie"><noRegion><name sortKey="De Luca, Andrea" sort="De Luca, Andrea" uniqKey="De Luca A" first="Andrea" last="De Luca">Andrea De Luca</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D" last="Kelleher">Anthony D. Kelleher</name></noRegion></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Morrison, Charles" sort="Morrison, Charles" uniqKey="Morrison C" first="Charles" last="Morrison">Charles Morrison</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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