Changing from single-drug to fixed-dose combinations: experience from Fiji
Identifieur interne : 002B08 ( Ncbi/Merge ); précédent : 002B07; suivant : 002B09Changing from single-drug to fixed-dose combinations: experience from Fiji
Auteurs : R. Mahadeo [Fidji] ; S. Gounder [Fidji] ; S. M. Graham [Australie, France]Source :
- Public Health Action [ 2220-8372 ] ; 2014.
Abstract
Url:
DOI: 10.5588/pha.14.0024
PubMed: 26400805
PubMed Central: 4533822
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changing from single-drug to fixed-dose combinations: experience from Fiji</title><author><name sortKey="Mahadeo, R" sort="Mahadeo, R" uniqKey="Mahadeo R" first="R." last="Mahadeo">R. Mahadeo</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gounder, S" sort="Gounder, S" uniqKey="Gounder S" first="S." last="Gounder">S. Gounder</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Graham, S M" sort="Graham, S M" uniqKey="Graham S" first="S. M." last="Graham">S. M. Graham</name><affiliation wicri:level="1"><nlm:aff id="aff2"> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"> International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> International Union Against Tuberculosis and Lung Disease, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26400805</idno><idno type="pmc">4533822</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533822</idno><idno type="RBID">PMC:4533822</idno><idno type="doi">10.5588/pha.14.0024</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000236</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000236</idno><idno type="wicri:Area/Pmc/Curation">000236</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000236</idno><idno type="wicri:Area/Pmc/Checkpoint">001717</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001717</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003445</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003445</idno><idno type="wicri:Area/PubMed/Curation">003332</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003332</idno><idno type="wicri:Area/PubMed/Checkpoint">003332</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003332</idno><idno type="wicri:Area/Ncbi/Merge">002B08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Changing from single-drug to fixed-dose combinations: experience from Fiji</title><author><name sortKey="Mahadeo, R" sort="Mahadeo, R" uniqKey="Mahadeo R" first="R." last="Mahadeo">R. Mahadeo</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gounder, S" sort="Gounder, S" uniqKey="Gounder S" first="S." last="Gounder">S. Gounder</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Graham, S M" sort="Graham, S M" uniqKey="Graham S" first="S. M." last="Graham">S. M. Graham</name><affiliation wicri:level="1"><nlm:aff id="aff2"> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"> International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> International Union Against Tuberculosis and Lung Disease, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Public Health Action</title><idno type="eISSN">2220-8372</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Fixed-dose combinations (FDCs) of first-line anti-tuberculosis drugs were introduced in Fiji in 2011, and there have been concerns about treatment response.</p><p><bold>Objective:</bold> To evaluate the treatment response to FDCs among tuberculosis (TB) patients.</p><p><bold>Methods:</bold> A retrospective cohort study was undertaken of treatment outcomes of new TB cases registered from January 2010 to April 2013 and weighing ⩾30 kg. Sputum smear conversion of new sputum smear-positive cases and end-of-treatment outcomes of all cases were evaluated for those receiving FDCs and compared to outcomes with previous use of single-drug preparations.</p><p><bold>Results:</bold> Among new TB patients, 240 received single-drug preparations and 259 received FDCs for the full duration of treatment. The groups were similar in terms of demographic and clinical characteristics. Treatment outcomes were available for 95% of cases. Unknown outcomes were more common in those receiving FDCs. When known, end-of-treatment outcome was the same in the two treatment groups and did not differ between TB types. Sputum smear conversion after the 2-month intensive phase of treatment was similar in the two treatment groups: 95% and 97%, respectively.</p><p><bold>Conclusion:</bold> The introduction of FDCs in Fiji for the treatment of TB cases has not been associated with changes in treatment response.</p></div></front></TEI><double pmid="26400805"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changing from single-drug to fixed-dose combinations: experience from Fiji</title><author><name sortKey="Mahadeo, R" sort="Mahadeo, R" uniqKey="Mahadeo R" first="R." last="Mahadeo">R. Mahadeo</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gounder, S" sort="Gounder, S" uniqKey="Gounder S" first="S." last="Gounder">S. Gounder</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Graham, S M" sort="Graham, S M" uniqKey="Graham S" first="S. M." last="Graham">S. M. Graham</name><affiliation wicri:level="1"><nlm:aff id="aff2"> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"> International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> International Union Against Tuberculosis and Lung Disease, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26400805</idno><idno type="pmc">4533822</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533822</idno><idno type="RBID">PMC:4533822</idno><idno type="doi">10.5588/pha.14.0024</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000236</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000236</idno><idno type="wicri:Area/Pmc/Curation">000236</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000236</idno><idno type="wicri:Area/Pmc/Checkpoint">001717</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001717</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Changing from single-drug to fixed-dose combinations: experience from Fiji</title><author><name sortKey="Mahadeo, R" sort="Mahadeo, R" uniqKey="Mahadeo R" first="R." last="Mahadeo">R. Mahadeo</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gounder, S" sort="Gounder, S" uniqKey="Gounder S" first="S." last="Gounder">S. Gounder</name><affiliation wicri:level="1"><nlm:aff id="aff1"> National Tuberculosis Programme, Ministry of Health, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea> National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Graham, S M" sort="Graham, S M" uniqKey="Graham S" first="S. M." last="Graham">S. M. Graham</name><affiliation wicri:level="1"><nlm:aff id="aff2"> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"> International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> International Union Against Tuberculosis and Lung Disease, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Public Health Action</title><idno type="eISSN">2220-8372</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Fixed-dose combinations (FDCs) of first-line anti-tuberculosis drugs were introduced in Fiji in 2011, and there have been concerns about treatment response.</p><p><bold>Objective:</bold> To evaluate the treatment response to FDCs among tuberculosis (TB) patients.</p><p><bold>Methods:</bold> A retrospective cohort study was undertaken of treatment outcomes of new TB cases registered from January 2010 to April 2013 and weighing ⩾30 kg. Sputum smear conversion of new sputum smear-positive cases and end-of-treatment outcomes of all cases were evaluated for those receiving FDCs and compared to outcomes with previous use of single-drug preparations.</p><p><bold>Results:</bold> Among new TB patients, 240 received single-drug preparations and 259 received FDCs for the full duration of treatment. The groups were similar in terms of demographic and clinical characteristics. Treatment outcomes were available for 95% of cases. Unknown outcomes were more common in those receiving FDCs. When known, end-of-treatment outcome was the same in the two treatment groups and did not differ between TB types. Sputum smear conversion after the 2-month intensive phase of treatment was similar in the two treatment groups: 95% and 97%, respectively.</p><p><bold>Conclusion:</bold> The introduction of FDCs in Fiji for the treatment of TB cases has not been associated with changes in treatment response.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changing from single-drug to fixed-dose combinations: experience from Fiji.</title><author><name sortKey="Mahadeo, R" sort="Mahadeo, R" uniqKey="Mahadeo R" first="R" last="Mahadeo">R. Mahadeo</name><affiliation wicri:level="1"><nlm:affiliation>National Tuberculosis Programme, Ministry of Health, Suva, Fiji.</nlm:affiliation><country xml:lang="fr">Fidji</country><wicri:regionArea>National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gounder, S" sort="Gounder, S" uniqKey="Gounder S" first="S" last="Gounder">S. Gounder</name><affiliation wicri:level="1"><nlm:affiliation>National Tuberculosis Programme, Ministry of Health, Suva, Fiji.</nlm:affiliation><country xml:lang="fr">Fidji</country><wicri:regionArea>National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Graham, S M" sort="Graham, S M" uniqKey="Graham S" first="S M" last="Graham">S M Graham</name><affiliation wicri:level="3"><nlm:affiliation>Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia ; International Union Against Tuberculosis and Lung Disease, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia ; International Union Against Tuberculosis and Lung Disease, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:26400805</idno><idno type="pmid">26400805</idno><idno type="doi">10.5588/pha.14.0024</idno><idno type="wicri:Area/PubMed/Corpus">003445</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003445</idno><idno type="wicri:Area/PubMed/Curation">003332</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003332</idno><idno type="wicri:Area/PubMed/Checkpoint">003332</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changing from single-drug to fixed-dose combinations: experience from Fiji.</title><author><name sortKey="Mahadeo, R" sort="Mahadeo, R" uniqKey="Mahadeo R" first="R" last="Mahadeo">R. Mahadeo</name><affiliation wicri:level="1"><nlm:affiliation>National Tuberculosis Programme, Ministry of Health, Suva, Fiji.</nlm:affiliation><country xml:lang="fr">Fidji</country><wicri:regionArea>National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gounder, S" sort="Gounder, S" uniqKey="Gounder S" first="S" last="Gounder">S. Gounder</name><affiliation wicri:level="1"><nlm:affiliation>National Tuberculosis Programme, Ministry of Health, Suva, Fiji.</nlm:affiliation><country xml:lang="fr">Fidji</country><wicri:regionArea>National Tuberculosis Programme, Ministry of Health, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Graham, S M" sort="Graham, S M" uniqKey="Graham S" first="S M" last="Graham">S M Graham</name><affiliation wicri:level="3"><nlm:affiliation>Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia ; International Union Against Tuberculosis and Lung Disease, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre for International Child Health, University of Melbourne and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia ; International Union Against Tuberculosis and Lung Disease, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Public health action</title><idno type="ISSN">2220-8372</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fixed-dose combinations (FDCs) of first-line anti-tuberculosis drugs were introduced in Fiji in 2011, and there have been concerns about treatment response.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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