Changing from single-drug to fixed-dose combinations: experience from Fiji
Identifieur interne : 002B08 ( Ncbi/Merge ); précédent : 002B07; suivant : 002B09Changing from single-drug to fixed-dose combinations: experience from Fiji
Auteurs : R. Mahadeo [Fidji] ; S. Gounder [Fidji] ; S. M. Graham [Australie, France]Source :
- Public Health Action [ 2220-8372 ] ; 2014.
Abstract
Url:
DOI: 10.5588/pha.14.0024
PubMed: 26400805
PubMed Central: 4533822
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PMC:4533822Le document en format XML
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Fixed-dose combinations (FDCs) of first-line anti-tuberculosis drugs were introduced in Fiji in 2011, and there have been concerns about treatment response.</p>
<p><bold>Objective:</bold>
To evaluate the treatment response to FDCs among tuberculosis (TB) patients.</p>
<p><bold>Methods:</bold>
A retrospective cohort study was undertaken of treatment outcomes of new TB cases registered from January 2010 to April 2013 and weighing ⩾30 kg. Sputum smear conversion of new sputum smear-positive cases and end-of-treatment outcomes of all cases were evaluated for those receiving FDCs and compared to outcomes with previous use of single-drug preparations.</p>
<p><bold>Results:</bold>
Among new TB patients, 240 received single-drug preparations and 259 received FDCs for the full duration of treatment. The groups were similar in terms of demographic and clinical characteristics. Treatment outcomes were available for 95% of cases. Unknown outcomes were more common in those receiving FDCs. When known, end-of-treatment outcome was the same in the two treatment groups and did not differ between TB types. Sputum smear conversion after the 2-month intensive phase of treatment was similar in the two treatment groups: 95% and 97%, respectively.</p>
<p><bold>Conclusion:</bold>
The introduction of FDCs in Fiji for the treatment of TB cases has not been associated with changes in treatment response.</p>
</div>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Fixed-dose combinations (FDCs) of first-line anti-tuberculosis drugs were introduced in Fiji in 2011, and there have been concerns about treatment response.</p>
<p><bold>Objective:</bold>
To evaluate the treatment response to FDCs among tuberculosis (TB) patients.</p>
<p><bold>Methods:</bold>
A retrospective cohort study was undertaken of treatment outcomes of new TB cases registered from January 2010 to April 2013 and weighing ⩾30 kg. Sputum smear conversion of new sputum smear-positive cases and end-of-treatment outcomes of all cases were evaluated for those receiving FDCs and compared to outcomes with previous use of single-drug preparations.</p>
<p><bold>Results:</bold>
Among new TB patients, 240 received single-drug preparations and 259 received FDCs for the full duration of treatment. The groups were similar in terms of demographic and clinical characteristics. Treatment outcomes were available for 95% of cases. Unknown outcomes were more common in those receiving FDCs. When known, end-of-treatment outcome was the same in the two treatment groups and did not differ between TB types. Sputum smear conversion after the 2-month intensive phase of treatment was similar in the two treatment groups: 95% and 97%, respectively.</p>
<p><bold>Conclusion:</bold>
The introduction of FDCs in Fiji for the treatment of TB cases has not been associated with changes in treatment response.</p>
</div>
</front>
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