Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Identifieur interne : 002A35 ( Ncbi/Merge ); précédent : 002A34; suivant : 002A36Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Auteurs : Emad A. Rakha [Royaume-Uni] ; Sunil Badve [États-Unis] ; Vincenzo Eusebi [Italie] ; Jorge S. Reis-Filho [États-Unis] ; Stephen B. Fox [Australie] ; David J. Dabbs [États-Unis] ; Thomas Decker [Allemagne] ; Zsolt Hodi [Royaume-Uni] ; Shu Ichihara [Japon] ; Andrew H S. Lee [Royaume-Uni] ; José Palacios [Espagne] ; Andrea L. Richardson [États-Unis] ; Anne Vincent-Salomon [France] ; Fernando C. Schmitt [Luxembourg (pays)] ; Puay-Hoon Tan [Singapour] ; Gary M. Tse [Hong Kong] ; Ian O. Ellis [Royaume-Uni]Source :
- Histopathology [ 1365-2559 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Carcinome adénosquameux, Carcinomes, Fibrome, Région mammaire, Tumeurs du sein.
- Diagnostic différentiel, Femelle, Humains.
English descriptors
- KwdEn :
- MESH :
- pathology : Breast, Breast Neoplasms, Carcinoma, Carcinoma, Adenosquamous, Fibroma.
- Diagnosis, Differential, Female, Humans.
Abstract
Breast lesions comprise a family of heterogeneous entities with variable patterns of presentation, morphology and clinical behaviour. The majority of breast lesions are classified traditionally into benign and malignant conditions and their behaviour can, in the vast majority of cases, be predicted with a reasonable degree of accuracy. However, there remain lesions which show borderline features and lie in a grey zone between benign and malignant, as their behaviour cannot be predicted reliably. Defined pathological categorization of such lesions is challenging, and for some entities is recognized to be subjective and include a range of diagnoses, and forms of terminology, which may trigger over- or undertreatment. The rarity of these lesions makes the acquisition of clinical evidence problematic and limits the development of a sufficient evidence base to support informed decision-making by clinicians and patients. Emerging molecular evidence is providing a greater understanding of the biology of these lesions, but this may or may not be reflected in their clinical behaviour. Herein we discuss some breast lesions that are associated with uncertainty regarding classification and behaviour, and hence management. These include biologically invasive malignant lesions associated with uncertain metastatic potential, such as low-grade adenosquamous carcinoma, low-grade fibromatosis-like spindle cell carcinoma and encapsulated papillary carcinoma. Other lesions of uncertain malignant nature remain, such as mammary cylindroma, atypical microglandular adenosis, mammary pleomorphic adenoma and infiltrating epitheliosis. The concept of categories of (1) breast lesions of uncertain malignant nature and (2) breast lesions of limited metastatic potential are proposed with details of which histological entities could be included in each category, and their management implications are discussed.
DOI: 10.1111/his.12861
PubMed: 26348644
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Rakha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Eusebi, Vincenzo" sort="Eusebi, Vincenzo" uniqKey="Eusebi V" first="Vincenzo" last="Eusebi">Vincenzo Eusebi</name><affiliation wicri:level="1"><nlm:affiliation>Sezione Anatomia Istologia e Citologia Patologica 'M. 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Schmitt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and Pathology, Laboratoire National De Santé, Luxembourg, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Medicine and Pathology, Laboratoire National De Santé, Luxembourg</wicri:regionArea><wicri:noRegion>Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Puay Hoon" sort="Tan, Puay Hoon" uniqKey="Tan P" first="Puay-Hoon" last="Tan">Puay-Hoon Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Singapore General Hospital, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Pathology, Singapore General Hospital, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Tse, Gary M" sort="Tse, Gary M" uniqKey="Tse G" first="Gary M" last="Tse">Gary M. Tse</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ellis, Ian O" sort="Ellis, Ian O" uniqKey="Ellis I" first="Ian O" last="Ellis">Ian O. Ellis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26348644</idno><idno type="pmid">26348644</idno><idno type="doi">10.1111/his.12861</idno><idno type="wicri:Area/PubMed/Corpus">002555</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002555</idno><idno type="wicri:Area/PubMed/Curation">002487</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002487</idno><idno type="wicri:Area/PubMed/Checkpoint">002487</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002487</idno><idno type="wicri:Area/Ncbi/Merge">002A35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.</title><author><name sortKey="Rakha, Emad A" sort="Rakha, Emad A" uniqKey="Rakha E" first="Emad A" last="Rakha">Emad A. Rakha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Eusebi, Vincenzo" sort="Eusebi, Vincenzo" uniqKey="Eusebi V" first="Vincenzo" last="Eusebi">Vincenzo Eusebi</name><affiliation wicri:level="1"><nlm:affiliation>Sezione Anatomia Istologia e Citologia Patologica 'M. Malpighi', Università-ASL Ospedale Bellaria, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sezione Anatomia Istologia e Citologia Patologica 'M. Malpighi', Università-ASL Ospedale Bellaria, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Reis Filho, Jorge S" sort="Reis Filho, Jorge S" uniqKey="Reis Filho J" first="Jorge S" last="Reis-Filho">Jorge S. Reis-Filho</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fox, Stephen B" sort="Fox, Stephen B" uniqKey="Fox S" first="Stephen B" last="Fox">Stephen B. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Department, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Pathology Department, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Dabbs, David J" sort="Dabbs, David J" uniqKey="Dabbs D" first="David J" last="Dabbs">David J. Dabbs</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Decker, Thomas" sort="Decker, Thomas" uniqKey="Decker T" first="Thomas" last="Decker">Thomas Decker</name><affiliation wicri:level="1"><nlm:affiliation>German Breast-Screening Program, Reference Centres Berlin and Muenster, Department of Pathology, Dietrich Bonhoeffer Medical Centre, Neubrandenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast-Screening Program, Reference Centres Berlin and Muenster, Department of Pathology, Dietrich Bonhoeffer Medical Centre, Neubrandenburg</wicri:regionArea><wicri:noRegion>Neubrandenburg</wicri:noRegion><wicri:noRegion>Neubrandenburg</wicri:noRegion><wicri:noRegion>Neubrandenburg</wicri:noRegion></affiliation></author><author><name sortKey="Hodi, Zsolt" sort="Hodi, Zsolt" uniqKey="Hodi Z" first="Zsolt" last="Hodi">Zsolt Hodi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Ichihara, Shu" sort="Ichihara, Shu" uniqKey="Ichihara S" first="Shu" last="Ichihara">Shu Ichihara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Nagoya Medical Center, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Nagoya Medical Center, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Andrew H S" sort="Lee, Andrew H S" uniqKey="Lee A" first="Andrew H S" last="Lee">Andrew H S. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Palacios, Jose" sort="Palacios, Jose" uniqKey="Palacios J" first="José" last="Palacios">José Palacios</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Hospital Universitario Ramón y Cajal, Instituto de Investigación Sanitaria Ramón y Cajal (IRYCIS), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Hospital Universitario Ramón y Cajal, Instituto de Investigación Sanitaria Ramón y Cajal (IRYCIS), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L" last="Richardson">Andrea L. Richardson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Institute Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Institute Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schmitt, Fernando C" sort="Schmitt, Fernando C" uniqKey="Schmitt F" first="Fernando C" last="Schmitt">Fernando C. Schmitt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and Pathology, Laboratoire National De Santé, Luxembourg, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Medicine and Pathology, Laboratoire National De Santé, Luxembourg</wicri:regionArea><wicri:noRegion>Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Puay Hoon" sort="Tan, Puay Hoon" uniqKey="Tan P" first="Puay-Hoon" last="Tan">Puay-Hoon Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Singapore General Hospital, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Pathology, Singapore General Hospital, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Tse, Gary M" sort="Tse, Gary M" uniqKey="Tse G" first="Gary M" last="Tse">Gary M. Tse</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ellis, Ian O" sort="Ellis, Ian O" uniqKey="Ellis I" first="Ian O" last="Ellis">Ian O. Ellis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author></analytic><series><title level="j">Histopathology</title><idno type="eISSN">1365-2559</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast (pathology)</term><term>Breast Neoplasms (pathology)</term><term>Carcinoma (pathology)</term><term>Carcinoma, Adenosquamous (pathology)</term><term>Diagnosis, Differential</term><term>Female</term><term>Fibroma (pathology)</term><term>Humans</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Carcinome adénosquameux (anatomopathologie)</term><term>Carcinomes (anatomopathologie)</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Fibrome (anatomopathologie)</term><term>Humains</term><term>Région mammaire (anatomopathologie)</term><term>Tumeurs du sein (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome adénosquameux</term><term>Carcinomes</term><term>Fibrome</term><term>Région mammaire</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast</term><term>Breast Neoplasms</term><term>Carcinoma</term><term>Carcinoma, Adenosquamous</term><term>Fibroma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Breast lesions comprise a family of heterogeneous entities with variable patterns of presentation, morphology and clinical behaviour. The majority of breast lesions are classified traditionally into benign and malignant conditions and their behaviour can, in the vast majority of cases, be predicted with a reasonable degree of accuracy. However, there remain lesions which show borderline features and lie in a grey zone between benign and malignant, as their behaviour cannot be predicted reliably. Defined pathological categorization of such lesions is challenging, and for some entities is recognized to be subjective and include a range of diagnoses, and forms of terminology, which may trigger over- or undertreatment. The rarity of these lesions makes the acquisition of clinical evidence problematic and limits the development of a sufficient evidence base to support informed decision-making by clinicians and patients. Emerging molecular evidence is providing a greater understanding of the biology of these lesions, but this may or may not be reflected in their clinical behaviour. Herein we discuss some breast lesions that are associated with uncertainty regarding classification and behaviour, and hence management. These include biologically invasive malignant lesions associated with uncertain metastatic potential, such as low-grade adenosquamous carcinoma, low-grade fibromatosis-like spindle cell carcinoma and encapsulated papillary carcinoma. Other lesions of uncertain malignant nature remain, such as mammary cylindroma, atypical microglandular adenosis, mammary pleomorphic adenoma and infiltrating epitheliosis. The concept of categories of (1) breast lesions of uncertain malignant nature and (2) breast lesions of limited metastatic potential are proposed with details of which histological entities could be included in each category, and their management implications are discussed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26348644</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>20</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1365-2559</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Histopathology</Title><ISOAbbreviation>Histopathology</ISOAbbreviation></Journal><ArticleTitle>Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.</ArticleTitle><Pagination><MedlinePgn>45-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/his.12861</ELocationID><Abstract><AbstractText>Breast lesions comprise a family of heterogeneous entities with variable patterns of presentation, morphology and clinical behaviour. The majority of breast lesions are classified traditionally into benign and malignant conditions and their behaviour can, in the vast majority of cases, be predicted with a reasonable degree of accuracy. However, there remain lesions which show borderline features and lie in a grey zone between benign and malignant, as their behaviour cannot be predicted reliably. Defined pathological categorization of such lesions is challenging, and for some entities is recognized to be subjective and include a range of diagnoses, and forms of terminology, which may trigger over- or undertreatment. The rarity of these lesions makes the acquisition of clinical evidence problematic and limits the development of a sufficient evidence base to support informed decision-making by clinicians and patients. Emerging molecular evidence is providing a greater understanding of the biology of these lesions, but this may or may not be reflected in their clinical behaviour. Herein we discuss some breast lesions that are associated with uncertainty regarding classification and behaviour, and hence management. These include biologically invasive malignant lesions associated with uncertain metastatic potential, such as low-grade adenosquamous carcinoma, low-grade fibromatosis-like spindle cell carcinoma and encapsulated papillary carcinoma. Other lesions of uncertain malignant nature remain, such as mammary cylindroma, atypical microglandular adenosis, mammary pleomorphic adenoma and infiltrating epitheliosis. The concept of categories of (1) breast lesions of uncertain malignant nature and (2) breast lesions of limited metastatic potential are proposed with details of which histological entities could be included in each category, and their management implications are discussed.</AbstractText><CopyrightInformation>© 2015 John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rakha</LastName><ForeName>Emad A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Badve</LastName><ForeName>Sunil</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eusebi</LastName><ForeName>Vincenzo</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Sezione Anatomia Istologia e Citologia Patologica 'M. Malpighi', Università-ASL Ospedale Bellaria, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reis-Filho</LastName><ForeName>Jorge S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Stephen B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Pathology Department, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dabbs</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>University of Pittsburgh Medical Center, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Decker</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>German Breast-Screening Program, Reference Centres Berlin and Muenster, Department of Pathology, Dietrich Bonhoeffer Medical Centre, Neubrandenburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hodi</LastName><ForeName>Zsolt</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ichihara</LastName><ForeName>Shu</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Nagoya Medical Center, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Andrew H S</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palacios</LastName><ForeName>José</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, Hospital Universitario Ramón y Cajal, Instituto de Investigación Sanitaria Ramón y Cajal (IRYCIS), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>Andrea L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vincent-Salomon</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology, Institute Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Fernando C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Department of Medicine and Pathology, Laboratoire National De Santé, Luxembourg, Luxembourg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Puay-Hoon</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Pathology, Singapore General Hospital, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tse</LastName><ForeName>Gary M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellis</LastName><ForeName>Ian O</ForeName><Initials>IO</Initials><AffiliationInfo><Affiliation>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 CA008748</GrantID><Acronym>CA</Acronym><Agency>NCI NIH 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UI="D002277" MajorTopicYN="N">Carcinoma</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018196" MajorTopicYN="N">Carcinoma, Adenosquamous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005350" MajorTopicYN="N">Fibroma</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS808734</OtherID><OtherID Source="NLM">PMC4987288</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">behaviour</Keyword><Keyword MajorTopicYN="N">breast lesions</Keyword><Keyword MajorTopicYN="N">differentiation</Keyword><Keyword MajorTopicYN="N">lesions of uncertain malignant potential</Keyword><Keyword MajorTopicYN="N">lesions of uncertain metastatic potential</Keyword><Keyword MajorTopicYN="N">terminology</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26348644</ArticleId><ArticleId IdType="doi">10.1111/his.12861</ArticleId><ArticleId IdType="pmc">PMC4987288</ArticleId><ArticleId IdType="mid">NIHMS808734</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Hong Kong</li><li>Italie</li><li>Japon</li><li>Luxembourg (pays)</li><li>Royaume-Uni</li><li>Singapour</li><li>États-Unis</li></country><region><li>Communauté de Madrid</li><li>Indiana</li><li>Massachusetts</li><li>Pennsylvanie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Madrid</li><li>Paris</li><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Rakha, Emad A" sort="Rakha, Emad A" uniqKey="Rakha E" first="Emad A" last="Rakha">Emad A. Rakha</name></noRegion><name sortKey="Ellis, Ian O" sort="Ellis, Ian O" uniqKey="Ellis I" first="Ian O" last="Ellis">Ian O. Ellis</name><name sortKey="Hodi, Zsolt" sort="Hodi, Zsolt" uniqKey="Hodi Z" first="Zsolt" last="Hodi">Zsolt Hodi</name><name sortKey="Lee, Andrew H S" sort="Lee, Andrew H S" uniqKey="Lee A" first="Andrew H S" last="Lee">Andrew H S. Lee</name></country><country name="États-Unis"><region name="Indiana"><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name></region><name sortKey="Dabbs, David J" sort="Dabbs, David J" uniqKey="Dabbs D" first="David J" last="Dabbs">David J. Dabbs</name><name sortKey="Reis Filho, Jorge S" sort="Reis Filho, Jorge S" uniqKey="Reis Filho J" first="Jorge S" last="Reis-Filho">Jorge S. Reis-Filho</name><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L" last="Richardson">Andrea L. Richardson</name></country><country name="Italie"><noRegion><name sortKey="Eusebi, Vincenzo" sort="Eusebi, Vincenzo" uniqKey="Eusebi V" first="Vincenzo" last="Eusebi">Vincenzo Eusebi</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Fox, Stephen B" sort="Fox, Stephen B" uniqKey="Fox S" first="Stephen B" last="Fox">Stephen B. Fox</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Decker, Thomas" sort="Decker, Thomas" uniqKey="Decker T" first="Thomas" last="Decker">Thomas Decker</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Ichihara, Shu" sort="Ichihara, Shu" uniqKey="Ichihara S" first="Shu" last="Ichihara">Shu Ichihara</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Palacios, Jose" sort="Palacios, Jose" uniqKey="Palacios J" first="José" last="Palacios">José Palacios</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name></region></country><country name="Luxembourg (pays)"><noRegion><name sortKey="Schmitt, Fernando C" sort="Schmitt, Fernando C" uniqKey="Schmitt F" first="Fernando C" last="Schmitt">Fernando C. Schmitt</name></noRegion></country><country name="Singapour"><noRegion><name sortKey="Tan, Puay Hoon" sort="Tan, Puay Hoon" uniqKey="Tan P" first="Puay-Hoon" last="Tan">Puay-Hoon Tan</name></noRegion></country><country name="Hong Kong"><noRegion><name sortKey="Tse, Gary M" sort="Tse, Gary M" uniqKey="Tse G" first="Gary M" last="Tse">Gary M. Tse</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= pubmed:26348644
|texte= Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
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