Report from the National Institute of Allergy and Infectious Disease Workshop on Drug Allergy
Identifieur interne : 002921 ( Ncbi/Merge ); précédent : 002920; suivant : 002922Report from the National Institute of Allergy and Infectious Disease Workshop on Drug Allergy
Auteurs : Lisa M. Wheatley [États-Unis] ; Marshall Plaut [États-Unis] ; Julie M. Schwaninger [États-Unis] ; Aleena Banerji [États-Unis] ; Mariana Castells [États-Unis] ; Fred D. Finkelman [États-Unis] ; Gerald J. Gleich [États-Unis] ; Emma Guttman-Yassky [États-Unis] ; Simon A. K. Mallal [États-Unis, Australie] ; Dean J. Naisbitt [Royaume-Uni] ; David A. Ostrov [États-Unis] ; Elizabeth J. Phillips [États-Unis, Australie] ; Werner J. Pichler [Suisse] ; Thomas A. E. Platts-Mills [États-Unis] ; Jean-Claude Roujeau [France] ; Lawrence B. Schwartz [États-Unis] ; Lauren A. Trepanier [États-Unis]Source :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2015.
Descripteurs français
- KwdFr :
- Antigènes HLA (génétique), Antigènes HLA (immunologie), Carbamazépine (effets indésirables), Didéoxynucléosides (effets indésirables), Expression des gènes, Guides de bonnes pratiques cliniques comme sujet, Haptènes (immunologie), Humains, Hypersensibilité médicamenteuse (), Hypersensibilité médicamenteuse (diagnostic), Hypersensibilité médicamenteuse (épidémiologie), Hypersensibilité médicamenteuse (étiologie), Immunoglobuline E (sang), Maladies virales (), Maladies virales (diagnostic), Maladies virales (immunologie), Maladies virales (épidémiologie), National Institute of Allergy and Infectious Diseases (USA), Recherche médicale translationnelle (tendances), Récepteurs aux antigènes des cellules T (génétique), Récepteurs aux antigènes des cellules T (immunologie), Syndrome de Stevens-Johnson (), Syndrome de Stevens-Johnson (diagnostic), Syndrome de Stevens-Johnson (épidémiologie), Syndrome de Stevens-Johnson (étiologie), Terminologie comme sujet, États-Unis d'Amérique (épidémiologie).
- MESH :
- diagnostic : Hypersensibilité médicamenteuse, Maladies virales, Syndrome de Stevens-Johnson.
- effets indésirables : Carbamazépine, Didéoxynucléosides.
- génétique : Antigènes HLA, Récepteurs aux antigènes des cellules T.
- immunologie : Antigènes HLA, Haptènes, Maladies virales, Récepteurs aux antigènes des cellules T.
- sang : Immunoglobuline E.
- tendances : Recherche médicale translationnelle.
- épidémiologie : Hypersensibilité médicamenteuse, Maladies virales, Syndrome de Stevens-Johnson, États-Unis d'Amérique.
- étiologie : Hypersensibilité médicamenteuse, Syndrome de Stevens-Johnson.
- Expression des gènes, Guides de bonnes pratiques cliniques comme sujet, Humains, Hypersensibilité médicamenteuse, Maladies virales, National Institute of Allergy and Infectious Diseases (USA), Syndrome de Stevens-Johnson, Terminologie comme sujet.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Carbamazepine (adverse effects), Dideoxynucleosides (adverse effects), Drug Hypersensitivity (diagnosis), Drug Hypersensitivity (epidemiology), Drug Hypersensitivity (etiology), Drug Hypersensitivity (prevention & control), Gene Expression, HLA Antigens (genetics), HLA Antigens (immunology), Haptens (immunology), Humans, Immunoglobulin E (blood), National Institute of Allergy and Infectious Diseases (U.S.), Practice Guidelines as Topic, Receptors, Antigen, T-Cell (genetics), Receptors, Antigen, T-Cell (immunology), Stevens-Johnson Syndrome (diagnosis), Stevens-Johnson Syndrome (epidemiology), Stevens-Johnson Syndrome (etiology), Stevens-Johnson Syndrome (prevention & control), Terminology as Topic, Translational Medical Research (trends), United States (epidemiology), Virus Diseases (diagnosis), Virus Diseases (epidemiology), Virus Diseases (immunology), Virus Diseases (prevention & control).
- MESH :
- chemical , adverse effects : Carbamazepine, Dideoxynucleosides.
- chemical , blood : Immunoglobulin E.
- geographic , epidemiology : United States.
- diagnosis : Drug Hypersensitivity, Stevens-Johnson Syndrome, Virus Diseases.
- epidemiology : Drug Hypersensitivity, Stevens-Johnson Syndrome, Virus Diseases.
- etiology : Drug Hypersensitivity, Stevens-Johnson Syndrome.
- chemical , genetics : HLA Antigens, Receptors, Antigen, T-Cell.
- chemical , immunology : HLA Antigens, Haptens, Receptors, Antigen, T-Cell, Virus Diseases.
- prevention & control : Drug Hypersensitivity, Stevens-Johnson Syndrome, Virus Diseases.
- trends : Translational Medical Research.
- Gene Expression, Humans, National Institute of Allergy and Infectious Diseases (U.S.), Practice Guidelines as Topic, Terminology as Topic.
Abstract
Allergic reactions to drugs are a serious public health concern. In 2013, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several NIH Institutes and the U.S. Food and Drug Administration (FDA). The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein.
Url:
DOI: 10.1016/j.jaci.2015.05.027
PubMed: 26254053
PubMed Central: 4529958
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Schwartz</name><affiliation wicri:level="2"><nlm:aff id="A14">Virginia Commonwealth University, Richmond, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virginia Commonwealth University, Richmond, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Trepanier, Lauren A" sort="Trepanier, Lauren A" uniqKey="Trepanier L" first="Lauren A." last="Trepanier">Lauren A. Trepanier</name><affiliation wicri:level="2"><nlm:aff id="A15">School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26254053</idno><idno type="pmc">4529958</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529958</idno><idno type="RBID">PMC:4529958</idno><idno type="doi">10.1016/j.jaci.2015.05.027</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001F08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F08</idno><idno type="wicri:Area/Pmc/Curation">001D64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D64</idno><idno type="wicri:Area/Pmc/Checkpoint">000D43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D43</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002A43</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A43</idno><idno type="wicri:Area/PubMed/Curation">002973</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002973</idno><idno type="wicri:Area/PubMed/Checkpoint">002973</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002973</idno><idno type="wicri:Area/Ncbi/Merge">002921</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Report from the National Institute of Allergy and Infectious Disease Workshop on Drug Allergy</title><author><name sortKey="Wheatley, Lisa M" sort="Wheatley, Lisa M" uniqKey="Wheatley L" first="Lisa M" last="Wheatley">Lisa M. Wheatley</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Plaut, Marshall" sort="Plaut, Marshall" uniqKey="Plaut M" first="Marshall" last="Plaut">Marshall Plaut</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Schwaninger, Julie M" sort="Schwaninger, Julie M" uniqKey="Schwaninger J" first="Julie M" last="Schwaninger">Julie M. Schwaninger</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Banerji, Aleena" sort="Banerji, Aleena" uniqKey="Banerji A" first="Aleena" last="Banerji">Aleena Banerji</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Allergy, Immunology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology and Rheumatology, Massachusetts General Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Castells, Mariana" sort="Castells, Mariana" uniqKey="Castells M" first="Mariana" last="Castells">Mariana Castells</name><affiliation wicri:level="2"><nlm:aff id="A3">Drug Hypersensitivity and Desensitization Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drug Hypersensitivity and Desensitization Center, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Finkelman, Fred D" sort="Finkelman, Fred D" uniqKey="Finkelman F" first="Fred D." last="Finkelman">Fred D. Finkelman</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Cincinnati, Cincinnati, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gleich, Gerald J" sort="Gleich, Gerald J" uniqKey="Gleich G" first="Gerald J." last="Gleich">Gerald J. Gleich</name><affiliation wicri:level="2"><nlm:aff id="A5">Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Dermatology, Immunology Institute, Icahn Medical School at Mount Sinai Medical Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Immunology Institute, Icahn Medical School at Mount Sinai Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mallal, Simon A K" sort="Mallal, Simon A K" uniqKey="Mallal S" first="Simon A. K." last="Mallal">Simon A. K. Mallal</name><affiliation wicri:level="2"><nlm:aff id="A7">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:cityArea></affiliation></author><author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J." last="Naisbitt">Dean J. Naisbitt</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Ostrov, David A" sort="Ostrov, David A" uniqKey="Ostrov D" first="David A." last="Ostrov">David A. Ostrov</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J." last="Phillips">Elizabeth J. Phillips</name><affiliation wicri:level="2"><nlm:aff id="A7">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:cityArea></affiliation></author><author><name sortKey="Pichler, Werner J" sort="Pichler, Werner J" uniqKey="Pichler W" first="Werner J." last="Pichler">Werner J. Pichler</name><affiliation wicri:level="3"><nlm:aff id="A11">ADR-AC GmbH, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>ADR-AC GmbH, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Platts Mills, Thomas A E" sort="Platts Mills, Thomas A E" uniqKey="Platts Mills T" first="Thomas A. E." last="Platts-Mills">Thomas A. E. Platts-Mills</name><affiliation wicri:level="2"><nlm:aff id="A12">Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name><affiliation wicri:level="3"><nlm:aff id="A13">Université Paris-Est Créteil, Antony, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Est Créteil, Antony</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Antony</settlement></placeName></affiliation></author><author><name sortKey="Schwartz, Lawrence B" sort="Schwartz, Lawrence B" uniqKey="Schwartz L" first="Lawrence B." last="Schwartz">Lawrence B. Schwartz</name><affiliation wicri:level="2"><nlm:aff id="A14">Virginia Commonwealth University, Richmond, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virginia Commonwealth University, Richmond, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Trepanier, Lauren A" sort="Trepanier, Lauren A" uniqKey="Trepanier L" first="Lauren A." last="Trepanier">Lauren A. Trepanier</name><affiliation wicri:level="2"><nlm:aff id="A15">School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of allergy and clinical immunology</title><idno type="ISSN">0091-6749</idno><idno type="eISSN">1097-6825</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carbamazepine (adverse effects)</term><term>Dideoxynucleosides (adverse effects)</term><term>Drug Hypersensitivity (diagnosis)</term><term>Drug Hypersensitivity (epidemiology)</term><term>Drug Hypersensitivity (etiology)</term><term>Drug Hypersensitivity (prevention & control)</term><term>Gene Expression</term><term>HLA Antigens (genetics)</term><term>HLA Antigens (immunology)</term><term>Haptens (immunology)</term><term>Humans</term><term>Immunoglobulin E (blood)</term><term>National Institute of Allergy and Infectious Diseases (U.S.)</term><term>Practice Guidelines as Topic</term><term>Receptors, Antigen, T-Cell (genetics)</term><term>Receptors, Antigen, T-Cell (immunology)</term><term>Stevens-Johnson Syndrome (diagnosis)</term><term>Stevens-Johnson Syndrome (epidemiology)</term><term>Stevens-Johnson Syndrome (etiology)</term><term>Stevens-Johnson Syndrome (prevention & control)</term><term>Terminology as Topic</term><term>Translational Medical Research (trends)</term><term>United States (epidemiology)</term><term>Virus Diseases (diagnosis)</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (immunology)</term><term>Virus Diseases (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes HLA (génétique)</term><term>Antigènes HLA (immunologie)</term><term>Carbamazépine (effets indésirables)</term><term>Didéoxynucléosides (effets indésirables)</term><term>Expression des gènes</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Haptènes (immunologie)</term><term>Humains</term><term>Hypersensibilité médicamenteuse ()</term><term>Hypersensibilité médicamenteuse (diagnostic)</term><term>Hypersensibilité médicamenteuse (épidémiologie)</term><term>Hypersensibilité médicamenteuse (étiologie)</term><term>Immunoglobuline E (sang)</term><term>Maladies virales ()</term><term>Maladies virales (diagnostic)</term><term>Maladies virales (immunologie)</term><term>Maladies virales (épidémiologie)</term><term>National Institute of Allergy and Infectious Diseases (USA)</term><term>Recherche médicale translationnelle (tendances)</term><term>Récepteurs aux antigènes des cellules T (génétique)</term><term>Récepteurs aux antigènes des cellules T (immunologie)</term><term>Syndrome de Stevens-Johnson ()</term><term>Syndrome de Stevens-Johnson (diagnostic)</term><term>Syndrome de Stevens-Johnson (épidémiologie)</term><term>Syndrome de Stevens-Johnson (étiologie)</term><term>Terminologie comme sujet</term><term>États-Unis d'Amérique (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Carbamazepine</term><term>Dideoxynucleosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term><term>Maladies virales</term><term>Syndrome de Stevens-Johnson</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Carbamazépine</term><term>Didéoxynucléosides</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA Antigens</term><term>Receptors, Antigen, T-Cell</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA</term><term>Récepteurs aux antigènes des cellules T</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes HLA</term><term>Haptènes</term><term>Maladies virales</term><term>Récepteurs aux antigènes des cellules T</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>HLA Antigens</term><term>Haptens</term><term>Receptors, Antigen, T-Cell</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline E</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Recherche médicale translationnelle</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Translational Medical Research</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term><term>Maladies virales</term><term>Syndrome de Stevens-Johnson</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term><term>Syndrome de Stevens-Johnson</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression</term><term>Humans</term><term>National Institute of Allergy and Infectious Diseases (U.S.)</term><term>Practice Guidelines as Topic</term><term>Terminology as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Expression des gènes</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Hypersensibilité médicamenteuse</term><term>Maladies virales</term><term>National Institute of Allergy and Infectious Diseases (USA)</term><term>Syndrome de Stevens-Johnson</term><term>Terminologie comme sujet</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Allergic reactions to drugs are a serious public health concern. In 2013, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several NIH Institutes and the U.S. Food and Drug Administration (FDA). The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein.</p></div></front></TEI><double pmid="26254053"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Report from the National Institute of Allergy and Infectious Disease Workshop on Drug Allergy</title><author><name sortKey="Wheatley, Lisa M" sort="Wheatley, Lisa M" uniqKey="Wheatley L" first="Lisa M" last="Wheatley">Lisa M. Wheatley</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Plaut, Marshall" sort="Plaut, Marshall" uniqKey="Plaut M" first="Marshall" last="Plaut">Marshall Plaut</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Schwaninger, Julie M" sort="Schwaninger, Julie M" uniqKey="Schwaninger J" first="Julie M" last="Schwaninger">Julie M. Schwaninger</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Banerji, Aleena" sort="Banerji, Aleena" uniqKey="Banerji A" first="Aleena" last="Banerji">Aleena Banerji</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Allergy, Immunology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology and Rheumatology, Massachusetts General Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Castells, Mariana" sort="Castells, Mariana" uniqKey="Castells M" first="Mariana" last="Castells">Mariana Castells</name><affiliation wicri:level="2"><nlm:aff id="A3">Drug Hypersensitivity and Desensitization Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drug Hypersensitivity and Desensitization Center, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Finkelman, Fred D" sort="Finkelman, Fred D" uniqKey="Finkelman F" first="Fred D." last="Finkelman">Fred D. Finkelman</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Cincinnati, Cincinnati, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gleich, Gerald J" sort="Gleich, Gerald J" uniqKey="Gleich G" first="Gerald J." last="Gleich">Gerald J. Gleich</name><affiliation wicri:level="2"><nlm:aff id="A5">Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Dermatology, Immunology Institute, Icahn Medical School at Mount Sinai Medical Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Immunology Institute, Icahn Medical School at Mount Sinai Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mallal, Simon A K" sort="Mallal, Simon A K" uniqKey="Mallal S" first="Simon A. K." last="Mallal">Simon A. K. Mallal</name><affiliation wicri:level="2"><nlm:aff id="A7">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:cityArea></affiliation></author><author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J." last="Naisbitt">Dean J. Naisbitt</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Ostrov, David A" sort="Ostrov, David A" uniqKey="Ostrov D" first="David A." last="Ostrov">David A. Ostrov</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J." last="Phillips">Elizabeth J. Phillips</name><affiliation wicri:level="2"><nlm:aff id="A7">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:cityArea></affiliation></author><author><name sortKey="Pichler, Werner J" sort="Pichler, Werner J" uniqKey="Pichler W" first="Werner J." last="Pichler">Werner J. Pichler</name><affiliation wicri:level="3"><nlm:aff id="A11">ADR-AC GmbH, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>ADR-AC GmbH, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Platts Mills, Thomas A E" sort="Platts Mills, Thomas A E" uniqKey="Platts Mills T" first="Thomas A. E." last="Platts-Mills">Thomas A. E. Platts-Mills</name><affiliation wicri:level="2"><nlm:aff id="A12">Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name><affiliation wicri:level="3"><nlm:aff id="A13">Université Paris-Est Créteil, Antony, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Est Créteil, Antony</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Antony</settlement></placeName></affiliation></author><author><name sortKey="Schwartz, Lawrence B" sort="Schwartz, Lawrence B" uniqKey="Schwartz L" first="Lawrence B." last="Schwartz">Lawrence B. Schwartz</name><affiliation wicri:level="2"><nlm:aff id="A14">Virginia Commonwealth University, Richmond, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virginia Commonwealth University, Richmond, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Trepanier, Lauren A" sort="Trepanier, Lauren A" uniqKey="Trepanier L" first="Lauren A." last="Trepanier">Lauren A. Trepanier</name><affiliation wicri:level="2"><nlm:aff id="A15">School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26254053</idno><idno type="pmc">4529958</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529958</idno><idno type="RBID">PMC:4529958</idno><idno type="doi">10.1016/j.jaci.2015.05.027</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001F08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F08</idno><idno type="wicri:Area/Pmc/Curation">001D64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D64</idno><idno type="wicri:Area/Pmc/Checkpoint">000D43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Report from the National Institute of Allergy and Infectious Disease Workshop on Drug Allergy</title><author><name sortKey="Wheatley, Lisa M" sort="Wheatley, Lisa M" uniqKey="Wheatley L" first="Lisa M" last="Wheatley">Lisa M. Wheatley</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Plaut, Marshall" sort="Plaut, Marshall" uniqKey="Plaut M" first="Marshall" last="Plaut">Marshall Plaut</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Schwaninger, Julie M" sort="Schwaninger, Julie M" uniqKey="Schwaninger J" first="Julie M" last="Schwaninger">Julie M. Schwaninger</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Banerji, Aleena" sort="Banerji, Aleena" uniqKey="Banerji A" first="Aleena" last="Banerji">Aleena Banerji</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Allergy, Immunology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology and Rheumatology, Massachusetts General Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Castells, Mariana" sort="Castells, Mariana" uniqKey="Castells M" first="Mariana" last="Castells">Mariana Castells</name><affiliation wicri:level="2"><nlm:aff id="A3">Drug Hypersensitivity and Desensitization Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drug Hypersensitivity and Desensitization Center, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Finkelman, Fred D" sort="Finkelman, Fred D" uniqKey="Finkelman F" first="Fred D." last="Finkelman">Fred D. Finkelman</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Cincinnati, Cincinnati, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gleich, Gerald J" sort="Gleich, Gerald J" uniqKey="Gleich G" first="Gerald J." last="Gleich">Gerald J. Gleich</name><affiliation wicri:level="2"><nlm:aff id="A5">Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Dermatology, Immunology Institute, Icahn Medical School at Mount Sinai Medical Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Immunology Institute, Icahn Medical School at Mount Sinai Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mallal, Simon A K" sort="Mallal, Simon A K" uniqKey="Mallal S" first="Simon A. K." last="Mallal">Simon A. K. Mallal</name><affiliation wicri:level="2"><nlm:aff id="A7">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:cityArea></affiliation></author><author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J." last="Naisbitt">Dean J. Naisbitt</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Ostrov, David A" sort="Ostrov, David A" uniqKey="Ostrov D" first="David A." last="Ostrov">David A. Ostrov</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J." last="Phillips">Elizabeth J. Phillips</name><affiliation wicri:level="2"><nlm:aff id="A7">Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:cityArea></affiliation></author><author><name sortKey="Pichler, Werner J" sort="Pichler, Werner J" uniqKey="Pichler W" first="Werner J." last="Pichler">Werner J. Pichler</name><affiliation wicri:level="3"><nlm:aff id="A11">ADR-AC GmbH, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>ADR-AC GmbH, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Platts Mills, Thomas A E" sort="Platts Mills, Thomas A E" uniqKey="Platts Mills T" first="Thomas A. E." last="Platts-Mills">Thomas A. E. Platts-Mills</name><affiliation wicri:level="2"><nlm:aff id="A12">Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name><affiliation wicri:level="3"><nlm:aff id="A13">Université Paris-Est Créteil, Antony, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Est Créteil, Antony</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Antony</settlement></placeName></affiliation></author><author><name sortKey="Schwartz, Lawrence B" sort="Schwartz, Lawrence B" uniqKey="Schwartz L" first="Lawrence B." last="Schwartz">Lawrence B. Schwartz</name><affiliation wicri:level="2"><nlm:aff id="A14">Virginia Commonwealth University, Richmond, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virginia Commonwealth University, Richmond, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Trepanier, Lauren A" sort="Trepanier, Lauren A" uniqKey="Trepanier L" first="Lauren A." last="Trepanier">Lauren A. Trepanier</name><affiliation wicri:level="2"><nlm:aff id="A15">School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of allergy and clinical immunology</title><idno type="ISSN">0091-6749</idno><idno type="eISSN">1097-6825</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Allergic reactions to drugs are a serious public health concern. In 2013, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several NIH Institutes and the U.S. Food and Drug Administration (FDA). The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.</title><author><name sortKey="Wheatley, Lisa M" sort="Wheatley, Lisa M" uniqKey="Wheatley L" first="Lisa M" last="Wheatley">Lisa M. Wheatley</name><affiliation><nlm:affiliation>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md. Electronic address: lisa.wheatley@nih.gov.</nlm:affiliation><wicri:noCountry code="subField">Md</wicri:noCountry></affiliation></author><author><name sortKey="Plaut, Marshall" sort="Plaut, Marshall" uniqKey="Plaut M" first="Marshall" last="Plaut">Marshall Plaut</name><affiliation><nlm:affiliation>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.</nlm:affiliation><wicri:noCountry code="subField">Md</wicri:noCountry></affiliation></author><author><name sortKey="Schwaninger, Julie M" sort="Schwaninger, Julie M" uniqKey="Schwaninger J" first="Julie M" last="Schwaninger">Julie M. Schwaninger</name><affiliation><nlm:affiliation>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.</nlm:affiliation><wicri:noCountry code="subField">Md</wicri:noCountry></affiliation></author><author><name sortKey="Banerji, Aleena" sort="Banerji, Aleena" uniqKey="Banerji A" first="Aleena" last="Banerji">Aleena Banerji</name><affiliation><nlm:affiliation>Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Castells, Mariana" sort="Castells, Mariana" uniqKey="Castells M" first="Mariana" last="Castells">Mariana Castells</name><affiliation><nlm:affiliation>Drug Hypersensitivity and Desensitization Center, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Finkelman, Fred D" sort="Finkelman, Fred D" uniqKey="Finkelman F" first="Fred D" last="Finkelman">Fred D. Finkelman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, University of Cincinnati College of Medicine, the Department of Medicine, Cincinnati Veterans Affairs Medical Center, and the Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, University of Cincinnati College of Medicine, the Department of Medicine, Cincinnati Veterans Affairs Medical Center, and the Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Gleich, Gerald J" sort="Gleich, Gerald J" uniqKey="Gleich G" first="Gerald J" last="Gleich">Gerald J. Gleich</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Mallal, Simon A K" sort="Mallal, Simon A K" uniqKey="Mallal S" first="Simon A K" last="Mallal">Simon A K. Mallal</name><affiliation wicri:level="1"><nlm:affiliation>Center for Translational Immunology and Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Center for Translational Immunology and Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:regionArea><wicri:noRegion>Murdoch</wicri:noRegion></affiliation></author><author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J" last="Naisbitt">Dean J. Naisbitt</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Ostrov, David A" sort="Ostrov, David A" uniqKey="Ostrov D" first="David A" last="Ostrov">David A. Ostrov</name><affiliation><nlm:affiliation>Department of Pathology, Immunology and Laboratory Medicine, Division of Experimental Pathology, University of Florida College of Medicine, Gainesville, Fla.</nlm:affiliation><wicri:noCountry code="subField">Fla</wicri:noCountry></affiliation></author><author><name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J" last="Phillips">Elizabeth J. Phillips</name><affiliation><nlm:affiliation>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.</nlm:affiliation><wicri:noCountry code="subField">Tenn</wicri:noCountry></affiliation></author><author><name sortKey="Pichler, Werner J" sort="Pichler, Werner J" uniqKey="Pichler W" first="Werner J" last="Pichler">Werner J. Pichler</name><affiliation wicri:level="3"><nlm:affiliation>ADR-AC GMBH, Holligenstr. 91, CH 3008, Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>ADR-AC GMBH, Holligenstr. 91, CH 3008, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Platts Mills, Thomas A E" sort="Platts Mills, Thomas A E" uniqKey="Platts Mills T" first="Thomas A E" last="Platts-Mills">Thomas A E. Platts-Mills</name><affiliation><nlm:affiliation>Asthma and Allergic Diseases Center, Department of Medicine, University of Virginia, Charlottesville, Va.</nlm:affiliation><wicri:noCountry code="subField">Va</wicri:noCountry></affiliation></author><author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name><affiliation wicri:level="3"><nlm:affiliation>Université Paris-Est Créteil, 94010, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Est Créteil, 94010, Créteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Schwartz, Lawrence B" sort="Schwartz, Lawrence B" uniqKey="Schwartz L" first="Lawrence B" last="Schwartz">Lawrence B. Schwartz</name><affiliation><nlm:affiliation>Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Va.</nlm:affiliation><wicri:noCountry code="subField">Va</wicri:noCountry></affiliation></author><author><name sortKey="Trepanier, Lauren A" sort="Trepanier, Lauren A" uniqKey="Trepanier L" first="Lauren A" last="Trepanier">Lauren A. Trepanier</name><affiliation><nlm:affiliation>Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wis.</nlm:affiliation><wicri:noCountry code="subField">Wis</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26254053</idno><idno type="pmid">26254053</idno><idno type="doi">10.1016/j.jaci.2015.05.027</idno><idno type="wicri:Area/PubMed/Corpus">002A43</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A43</idno><idno type="wicri:Area/PubMed/Curation">002973</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002973</idno><idno type="wicri:Area/PubMed/Checkpoint">002973</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002973</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.</title><author><name sortKey="Wheatley, Lisa M" sort="Wheatley, Lisa M" uniqKey="Wheatley L" first="Lisa M" last="Wheatley">Lisa M. Wheatley</name><affiliation><nlm:affiliation>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md. Electronic address: lisa.wheatley@nih.gov.</nlm:affiliation><wicri:noCountry code="subField">Md</wicri:noCountry></affiliation></author><author><name sortKey="Plaut, Marshall" sort="Plaut, Marshall" uniqKey="Plaut M" first="Marshall" last="Plaut">Marshall Plaut</name><affiliation><nlm:affiliation>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.</nlm:affiliation><wicri:noCountry code="subField">Md</wicri:noCountry></affiliation></author><author><name sortKey="Schwaninger, Julie M" sort="Schwaninger, Julie M" uniqKey="Schwaninger J" first="Julie M" last="Schwaninger">Julie M. Schwaninger</name><affiliation><nlm:affiliation>Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.</nlm:affiliation><wicri:noCountry code="subField">Md</wicri:noCountry></affiliation></author><author><name sortKey="Banerji, Aleena" sort="Banerji, Aleena" uniqKey="Banerji A" first="Aleena" last="Banerji">Aleena Banerji</name><affiliation><nlm:affiliation>Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Castells, Mariana" sort="Castells, Mariana" uniqKey="Castells M" first="Mariana" last="Castells">Mariana Castells</name><affiliation><nlm:affiliation>Drug Hypersensitivity and Desensitization Center, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Finkelman, Fred D" sort="Finkelman, Fred D" uniqKey="Finkelman F" first="Fred D" last="Finkelman">Fred D. Finkelman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, University of Cincinnati College of Medicine, the Department of Medicine, Cincinnati Veterans Affairs Medical Center, and the Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, University of Cincinnati College of Medicine, the Department of Medicine, Cincinnati Veterans Affairs Medical Center, and the Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Gleich, Gerald J" sort="Gleich, Gerald J" uniqKey="Gleich G" first="Gerald J" last="Gleich">Gerald J. Gleich</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Departments of Dermatology and Internal Medicine, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Mallal, Simon A K" sort="Mallal, Simon A K" uniqKey="Mallal S" first="Simon A K" last="Mallal">Simon A K. Mallal</name><affiliation wicri:level="1"><nlm:affiliation>Center for Translational Immunology and Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Center for Translational Immunology and Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:regionArea><wicri:noRegion>Murdoch</wicri:noRegion></affiliation></author><author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J" last="Naisbitt">Dean J. Naisbitt</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Ostrov, David A" sort="Ostrov, David A" uniqKey="Ostrov D" first="David A" last="Ostrov">David A. Ostrov</name><affiliation><nlm:affiliation>Department of Pathology, Immunology and Laboratory Medicine, Division of Experimental Pathology, University of Florida College of Medicine, Gainesville, Fla.</nlm:affiliation><wicri:noCountry code="subField">Fla</wicri:noCountry></affiliation></author><author><name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J" last="Phillips">Elizabeth J. Phillips</name><affiliation><nlm:affiliation>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.</nlm:affiliation><wicri:noCountry code="subField">Tenn</wicri:noCountry></affiliation></author><author><name sortKey="Pichler, Werner J" sort="Pichler, Werner J" uniqKey="Pichler W" first="Werner J" last="Pichler">Werner J. Pichler</name><affiliation wicri:level="3"><nlm:affiliation>ADR-AC GMBH, Holligenstr. 91, CH 3008, Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>ADR-AC GMBH, Holligenstr. 91, CH 3008, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Platts Mills, Thomas A E" sort="Platts Mills, Thomas A E" uniqKey="Platts Mills T" first="Thomas A E" last="Platts-Mills">Thomas A E. Platts-Mills</name><affiliation><nlm:affiliation>Asthma and Allergic Diseases Center, Department of Medicine, University of Virginia, Charlottesville, Va.</nlm:affiliation><wicri:noCountry code="subField">Va</wicri:noCountry></affiliation></author><author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name><affiliation wicri:level="3"><nlm:affiliation>Université Paris-Est Créteil, 94010, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Est Créteil, 94010, Créteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Schwartz, Lawrence B" sort="Schwartz, Lawrence B" uniqKey="Schwartz L" first="Lawrence B" last="Schwartz">Lawrence B. Schwartz</name><affiliation><nlm:affiliation>Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Va.</nlm:affiliation><wicri:noCountry code="subField">Va</wicri:noCountry></affiliation></author><author><name sortKey="Trepanier, Lauren A" sort="Trepanier, Lauren A" uniqKey="Trepanier L" first="Lauren A" last="Trepanier">Lauren A. Trepanier</name><affiliation><nlm:affiliation>Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wis.</nlm:affiliation><wicri:noCountry code="subField">Wis</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of allergy and clinical immunology</title><idno type="eISSN">1097-6825</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carbamazepine (adverse effects)</term><term>Dideoxynucleosides (adverse effects)</term><term>Drug Hypersensitivity (diagnosis)</term><term>Drug Hypersensitivity (epidemiology)</term><term>Drug Hypersensitivity (etiology)</term><term>Drug Hypersensitivity (prevention & control)</term><term>Gene Expression</term><term>HLA Antigens (genetics)</term><term>HLA Antigens (immunology)</term><term>Haptens (immunology)</term><term>Humans</term><term>Immunoglobulin E (blood)</term><term>National Institute of Allergy and Infectious Diseases (U.S.)</term><term>Practice Guidelines as Topic</term><term>Receptors, Antigen, T-Cell (genetics)</term><term>Receptors, Antigen, T-Cell (immunology)</term><term>Stevens-Johnson Syndrome (diagnosis)</term><term>Stevens-Johnson Syndrome (epidemiology)</term><term>Stevens-Johnson Syndrome (etiology)</term><term>Stevens-Johnson Syndrome (prevention & control)</term><term>Terminology as Topic</term><term>Translational Medical Research (trends)</term><term>United States (epidemiology)</term><term>Virus Diseases (diagnosis)</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (immunology)</term><term>Virus Diseases (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes HLA (génétique)</term><term>Antigènes HLA (immunologie)</term><term>Carbamazépine (effets indésirables)</term><term>Didéoxynucléosides (effets indésirables)</term><term>Expression des gènes</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Haptènes (immunologie)</term><term>Humains</term><term>Hypersensibilité médicamenteuse ()</term><term>Hypersensibilité médicamenteuse (diagnostic)</term><term>Hypersensibilité médicamenteuse (épidémiologie)</term><term>Hypersensibilité médicamenteuse (étiologie)</term><term>Immunoglobuline E (sang)</term><term>Maladies virales ()</term><term>Maladies virales (diagnostic)</term><term>Maladies virales (immunologie)</term><term>Maladies virales (épidémiologie)</term><term>National Institute of Allergy and Infectious Diseases (USA)</term><term>Recherche médicale translationnelle (tendances)</term><term>Récepteurs aux antigènes des cellules T (génétique)</term><term>Récepteurs aux antigènes des cellules T (immunologie)</term><term>Syndrome de Stevens-Johnson ()</term><term>Syndrome de Stevens-Johnson (diagnostic)</term><term>Syndrome de Stevens-Johnson (épidémiologie)</term><term>Syndrome de Stevens-Johnson (étiologie)</term><term>Terminologie comme sujet</term><term>États-Unis d'Amérique (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Carbamazepine</term><term>Dideoxynucleosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term><term>Maladies virales</term><term>Syndrome de Stevens-Johnson</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Carbamazépine</term><term>Didéoxynucléosides</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA Antigens</term><term>Receptors, Antigen, T-Cell</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA</term><term>Récepteurs aux antigènes des cellules T</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes HLA</term><term>Haptènes</term><term>Maladies virales</term><term>Récepteurs aux antigènes des cellules T</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>HLA Antigens</term><term>Haptens</term><term>Receptors, Antigen, T-Cell</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Drug Hypersensitivity</term><term>Stevens-Johnson Syndrome</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline E</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Recherche médicale translationnelle</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Translational Medical Research</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term><term>Maladies virales</term><term>Syndrome de Stevens-Johnson</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term><term>Syndrome de Stevens-Johnson</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression</term><term>Humans</term><term>National Institute of Allergy and Infectious Diseases (U.S.)</term><term>Practice Guidelines as Topic</term><term>Terminology as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Expression des gènes</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Hypersensibilité médicamenteuse</term><term>Maladies virales</term><term>National Institute of Allergy and Infectious Diseases (USA)</term><term>Syndrome de Stevens-Johnson</term><term>Terminologie comme sujet</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Allergic reactions to drugs are a serious public health concern. In 2013, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology, and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several National Institutes of Health institutes and the US Food and Drug Administration. The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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