Population attributable fractions and joint effects of key risk factors for multiple sclerosis.
Identifieur interne : 002866 ( Ncbi/Merge ); précédent : 002865; suivant : 002867Population attributable fractions and joint effects of key risk factors for multiple sclerosis.
Auteurs : Iaf Van Der Mei [Australie] ; R M Lucas [Australie] ; B V Taylor [Australie] ; P C Valery [Australie] ; T. Dwyer [France] ; T J Kilpatrick [Australie] ; M P Pender [Australie] ; D. Williams [Australie] ; C. Chapman [Australie] ; P. Otahal [Australie] ; A-L Ponsonby [Australie]Source :
- Multiple sclerosis (Houndmills, Basingstoke, England) [ 1477-0970 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse multivariée, Anticorps antiviraux (sang), Antigènes nucléaires du virus d'Epstein-Barr (immunologie), Australie (épidémiologie), Facteurs de risque, Facteurs temps, Femelle, Humains, Immunoglobuline G (sang), Incidence, Interaction entre gènes et environnement, Jeune adulte, Lumière du soleil, Modèles logistiques, Mononucléose infectieuse (épidémiologie), Mâle, Odds ratio, Polymorphisme de nucléotide simple, Prévalence, Saisons, Sclérose en plaques (diagnostic), Sclérose en plaques (génétique), Sclérose en plaques (immunologie), Sclérose en plaques (épidémiologie), Sous-types sérologiques HLA-DR (génétique), Sous-types sérologiques HLA-DR (immunologie), Tabagisme (effets indésirables), Tabagisme (épidémiologie), Études cas-témoins, Évaluation des risques.
- MESH :
- diagnostic : Sclérose en plaques.
- effets indésirables : Tabagisme.
- génétique : Sclérose en plaques, Sous-types sérologiques HLA-DR.
- immunologie : Antigènes nucléaires du virus d'Epstein-Barr, Sclérose en plaques, Sous-types sérologiques HLA-DR.
- sang : Anticorps antiviraux, Immunoglobuline G.
- épidémiologie : Australie, Mononucléose infectieuse, Sclérose en plaques, Tabagisme.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse multivariée, Facteurs de risque, Facteurs temps, Femelle, Humains, Incidence, Interaction entre gènes et environnement, Jeune adulte, Lumière du soleil, Modèles logistiques, Mâle, Odds ratio, Polymorphisme de nucléotide simple, Prévalence, Saisons, Études cas-témoins, Évaluation des risques.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Viral (blood), Australia (epidemiology), Case-Control Studies, Epstein-Barr Virus Nuclear Antigens (immunology), Female, Gene-Environment Interaction, HLA-DR Serological Subtypes (genetics), HLA-DR Serological Subtypes (immunology), Humans, Immunoglobulin G (blood), Incidence, Infectious Mononucleosis (epidemiology), Logistic Models, Male, Middle Aged, Multiple Sclerosis (diagnosis), Multiple Sclerosis (epidemiology), Multiple Sclerosis (genetics), Multiple Sclerosis (immunology), Multivariate Analysis, Odds Ratio, Polymorphism, Single Nucleotide, Prevalence, Risk Assessment, Risk Factors, Seasons, Smoking (adverse effects), Smoking (epidemiology), Sunlight, Time Factors, Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- adverse effects : Smoking.
- diagnosis : Multiple Sclerosis.
- epidemiology : Australia, Infectious Mononucleosis, Multiple Sclerosis, Smoking.
- chemical , genetics : HLA-DR Serological Subtypes, Multiple Sclerosis.
- chemical , immunology : Epstein-Barr Virus Nuclear Antigens, HLA-DR Serological Subtypes, Multiple Sclerosis.
- Adolescent, Adult, Case-Control Studies, Female, Gene-Environment Interaction, Humans, Incidence, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Polymorphism, Single Nucleotide, Prevalence, Risk Assessment, Risk Factors, Seasons, Sunlight, Time Factors, Young Adult.
Abstract
We examined the combined effect of having multiple key risk factors and the interactions between the key risk factors of multiple sclerosis (MS).
DOI: 10.1177/1352458515594040
PubMed: 26199349
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002090
- to stream PubMed, to step Curation: 002065
- to stream PubMed, to step Checkpoint: 002065
Links to Exploration step
pubmed:26199349Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Population attributable fractions and joint effects of key risk factors for multiple sclerosis.</title>
<author><name sortKey="Van Der Mei, Iaf" sort="Van Der Mei, Iaf" uniqKey="Van Der Mei I" first="Iaf" last="Van Der Mei">Iaf Van Der Mei</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute, Australia Ingrid.vanderMei@utas.edu.au.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>Menzies Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lucas, R M" sort="Lucas, R M" uniqKey="Lucas R" first="R M" last="Lucas">R M Lucas</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Epidemiology and Population Health, The Australian National University, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Centre for Epidemiology and Population Health, The Australian National University</wicri:regionArea>
<wicri:noRegion>The Australian National University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, B V" sort="Taylor, B V" uniqKey="Taylor B" first="B V" last="Taylor">B V Taylor</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Valery, P C" sort="Valery, P C" uniqKey="Valery P" first="P C" last="Valery">P C Valery</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dwyer, T" sort="Dwyer, T" uniqKey="Dwyer T" first="T" last="Dwyer">T. Dwyer</name>
<affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kilpatrick, T J" sort="Kilpatrick, T J" uniqKey="Kilpatrick T" first="T J" last="Kilpatrick">T J Kilpatrick</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Neuroscience, The University of Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Neuroscience, The University of Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Pender, M P" sort="Pender, M P" uniqKey="Pender M" first="M P" last="Pender">M P Pender</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurophysiology, John Hunter Hospital, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Neurophysiology, John Hunter Hospital</wicri:regionArea>
<wicri:noRegion>John Hunter Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams, D" sort="Williams, D" uniqKey="Williams D" first="D" last="Williams">D. Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurophysiology, John Hunter Hospital, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Neurophysiology, John Hunter Hospital</wicri:regionArea>
<wicri:noRegion>John Hunter Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chapman, C" sort="Chapman, C" uniqKey="Chapman C" first="C" last="Chapman">C. Chapman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Barwon Health, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Neurology, Barwon Health</wicri:regionArea>
<wicri:noRegion>Barwon Health</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Otahal, P" sort="Otahal, P" uniqKey="Otahal P" first="P" last="Otahal">P. Otahal</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ponsonby, A L" sort="Ponsonby, A L" uniqKey="Ponsonby A" first="A-L" last="Ponsonby">A-L Ponsonby</name>
<affiliation wicri:level="1"><nlm:affiliation>Murdoch Childrens Research Institute, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Murdoch Childrens Research Institute</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26199349</idno>
<idno type="pmid">26199349</idno>
<idno type="doi">10.1177/1352458515594040</idno>
<idno type="wicri:Area/PubMed/Corpus">002090</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002090</idno>
<idno type="wicri:Area/PubMed/Curation">002065</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002065</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002065</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002065</idno>
<idno type="wicri:Area/Ncbi/Merge">002866</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Population attributable fractions and joint effects of key risk factors for multiple sclerosis.</title>
<author><name sortKey="Van Der Mei, Iaf" sort="Van Der Mei, Iaf" uniqKey="Van Der Mei I" first="Iaf" last="Van Der Mei">Iaf Van Der Mei</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute, Australia Ingrid.vanderMei@utas.edu.au.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>Menzies Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lucas, R M" sort="Lucas, R M" uniqKey="Lucas R" first="R M" last="Lucas">R M Lucas</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Epidemiology and Population Health, The Australian National University, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Centre for Epidemiology and Population Health, The Australian National University</wicri:regionArea>
<wicri:noRegion>The Australian National University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, B V" sort="Taylor, B V" uniqKey="Taylor B" first="B V" last="Taylor">B V Taylor</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Valery, P C" sort="Valery, P C" uniqKey="Valery P" first="P C" last="Valery">P C Valery</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dwyer, T" sort="Dwyer, T" uniqKey="Dwyer T" first="T" last="Dwyer">T. Dwyer</name>
<affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kilpatrick, T J" sort="Kilpatrick, T J" uniqKey="Kilpatrick T" first="T J" last="Kilpatrick">T J Kilpatrick</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Neuroscience, The University of Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Neuroscience, The University of Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Pender, M P" sort="Pender, M P" uniqKey="Pender M" first="M P" last="Pender">M P Pender</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurophysiology, John Hunter Hospital, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Neurophysiology, John Hunter Hospital</wicri:regionArea>
<wicri:noRegion>John Hunter Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams, D" sort="Williams, D" uniqKey="Williams D" first="D" last="Williams">D. Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurophysiology, John Hunter Hospital, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Neurophysiology, John Hunter Hospital</wicri:regionArea>
<wicri:noRegion>John Hunter Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chapman, C" sort="Chapman, C" uniqKey="Chapman C" first="C" last="Chapman">C. Chapman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Barwon Health, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Neurology, Barwon Health</wicri:regionArea>
<wicri:noRegion>Barwon Health</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Otahal, P" sort="Otahal, P" uniqKey="Otahal P" first="P" last="Otahal">P. Otahal</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ponsonby, A L" sort="Ponsonby, A L" uniqKey="Ponsonby A" first="A-L" last="Ponsonby">A-L Ponsonby</name>
<affiliation wicri:level="1"><nlm:affiliation>Murdoch Childrens Research Institute, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Murdoch Childrens Research Institute</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Multiple sclerosis (Houndmills, Basingstoke, England)</title>
<idno type="eISSN">1477-0970</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Antibodies, Viral (blood)</term>
<term>Australia (epidemiology)</term>
<term>Case-Control Studies</term>
<term>Epstein-Barr Virus Nuclear Antigens (immunology)</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>HLA-DR Serological Subtypes (genetics)</term>
<term>HLA-DR Serological Subtypes (immunology)</term>
<term>Humans</term>
<term>Immunoglobulin G (blood)</term>
<term>Incidence</term>
<term>Infectious Mononucleosis (epidemiology)</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple Sclerosis (diagnosis)</term>
<term>Multiple Sclerosis (epidemiology)</term>
<term>Multiple Sclerosis (genetics)</term>
<term>Multiple Sclerosis (immunology)</term>
<term>Multivariate Analysis</term>
<term>Odds Ratio</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Prevalence</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Seasons</term>
<term>Smoking (adverse effects)</term>
<term>Smoking (epidemiology)</term>
<term>Sunlight</term>
<term>Time Factors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse multivariée</term>
<term>Anticorps antiviraux (sang)</term>
<term>Antigènes nucléaires du virus d'Epstein-Barr (immunologie)</term>
<term>Australie (épidémiologie)</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoglobuline G (sang)</term>
<term>Incidence</term>
<term>Interaction entre gènes et environnement</term>
<term>Jeune adulte</term>
<term>Lumière du soleil</term>
<term>Modèles logistiques</term>
<term>Mononucléose infectieuse (épidémiologie)</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prévalence</term>
<term>Saisons</term>
<term>Sclérose en plaques (diagnostic)</term>
<term>Sclérose en plaques (génétique)</term>
<term>Sclérose en plaques (immunologie)</term>
<term>Sclérose en plaques (épidémiologie)</term>
<term>Sous-types sérologiques HLA-DR (génétique)</term>
<term>Sous-types sérologiques HLA-DR (immunologie)</term>
<term>Tabagisme (effets indésirables)</term>
<term>Tabagisme (épidémiologie)</term>
<term>Études cas-témoins</term>
<term>Évaluation des risques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Sclérose en plaques</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Tabagisme</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Australia</term>
<term>Infectious Mononucleosis</term>
<term>Multiple Sclerosis</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-DR Serological Subtypes</term>
<term>Multiple Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sclérose en plaques</term>
<term>Sous-types sérologiques HLA-DR</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes nucléaires du virus d'Epstein-Barr</term>
<term>Sclérose en plaques</term>
<term>Sous-types sérologiques HLA-DR</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epstein-Barr Virus Nuclear Antigens</term>
<term>HLA-DR Serological Subtypes</term>
<term>Multiple Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Australie</term>
<term>Mononucléose infectieuse</term>
<term>Sclérose en plaques</term>
<term>Tabagisme</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Humans</term>
<term>Incidence</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Odds Ratio</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Prevalence</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Seasons</term>
<term>Sunlight</term>
<term>Time Factors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse multivariée</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Interaction entre gènes et environnement</term>
<term>Jeune adulte</term>
<term>Lumière du soleil</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prévalence</term>
<term>Saisons</term>
<term>Études cas-témoins</term>
<term>Évaluation des risques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We examined the combined effect of having multiple key risk factors and the interactions between the key risk factors of multiple sclerosis (MS).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26199349</PMID>
<DateCreated><Year>2016</Year>
<Month>03</Month>
<Day>18</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>12</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>12</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1477-0970</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>4</Issue>
<PubDate><Year>2016</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Multiple sclerosis (Houndmills, Basingstoke, England)</Title>
<ISOAbbreviation>Mult. Scler.</ISOAbbreviation>
</Journal>
<ArticleTitle>Population attributable fractions and joint effects of key risk factors for multiple sclerosis.</ArticleTitle>
<Pagination><MedlinePgn>461-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1177/1352458515594040</ELocationID>
<Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">We examined the combined effect of having multiple key risk factors and the interactions between the key risk factors of multiple sclerosis (MS).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed an incident case-control study including cases with a first clinical diagnosis of central nervous system demyelination (FCD) and population-based controls.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared to those without any risk factors, those with one, two, three, and four or five risk factors had increased odds of being an FCD case of 2.12 (95% confidence interval (CI), 1.11-4.03), 4.31 (95% CI, 2.24-8.31), 7.96 (95% CI, 3.84-16.49), and 21.24 (95% CI, 5.48-82.40), respectively. Only HLA-DR15 and history of infectious mononucleosis interacted significantly on the additive scale (Synergy index, 3.78; p = 0.03). The five key risk factors jointly accounted for 63.8% (95% CI, 43.9-91.4) of FCD onset. High anti-EBNA IgG was another important contributor.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A high proportion of FCD onset can be explained by the currently known risk factors, with HLA-DR15, ever smoking and low cumulative sun exposure explaining most. We identified a significant interaction between HLA-DR15 and history of IM in predicting an FCD of CNS demyelination, which together with previous observations suggests that this is a true interaction.</AbstractText>
<CopyrightInformation>© The Author(s), 2015.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van der Mei</LastName>
<ForeName>Iaf</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Menzies Research Institute, Australia Ingrid.vanderMei@utas.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lucas</LastName>
<ForeName>R M</ForeName>
<Initials>RM</Initials>
<AffiliationInfo><Affiliation>National Centre for Epidemiology and Population Health, The Australian National University, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taylor</LastName>
<ForeName>B V</ForeName>
<Initials>BV</Initials>
<AffiliationInfo><Affiliation>Menzies Research Institute, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Valery</LastName>
<ForeName>P C</ForeName>
<Initials>PC</Initials>
<AffiliationInfo><Affiliation>Queensland Institute of Medical Research, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dwyer</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>International Agency for Research on Cancer, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kilpatrick</LastName>
<ForeName>T J</ForeName>
<Initials>TJ</Initials>
<AffiliationInfo><Affiliation>Centre for Neuroscience, The University of Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pender</LastName>
<ForeName>M P</ForeName>
<Initials>MP</Initials>
<AffiliationInfo><Affiliation>Department of Neurophysiology, John Hunter Hospital, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Williams</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Neurophysiology, John Hunter Hospital, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chapman</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Barwon Health, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Otahal</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Menzies Research Institute, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ponsonby</LastName>
<ForeName>A-L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Murdoch Childrens Research Institute, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>07</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Mult Scler</MedlineTA>
<NlmUniqueID>9509185</NlmUniqueID>
<ISSNLinking>1352-4585</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019309">Epstein-Barr Virus Nuclear Antigens</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D059810">HLA-DR Serological Subtypes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C106559">HLA-DR15 antigen</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001315" MajorTopicYN="N">Australia</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019309" MajorTopicYN="N">Epstein-Barr Virus Nuclear Antigens</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059647" MajorTopicYN="N">Gene-Environment Interaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059810" MajorTopicYN="N">HLA-DR Serological Subtypes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007244" MajorTopicYN="N">Infectious Mononucleosis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013472" MajorTopicYN="N">Sunlight</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">First demyelinating event</Keyword>
<Keyword MajorTopicYN="N">gene-environment interaction</Keyword>
<Keyword MajorTopicYN="N">multiple sclerosis</Keyword>
<Keyword MajorTopicYN="N">population attributable fraction</Keyword>
<Keyword MajorTopicYN="N">risk factors</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>11</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>04</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>7</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>7</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>12</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26199349</ArticleId>
<ArticleId IdType="pii">1352458515594040</ArticleId>
<ArticleId IdType="doi">10.1177/1352458515594040</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Van Der Mei, Iaf" sort="Van Der Mei, Iaf" uniqKey="Van Der Mei I" first="Iaf" last="Van Der Mei">Iaf Van Der Mei</name>
</noRegion>
<name sortKey="Chapman, C" sort="Chapman, C" uniqKey="Chapman C" first="C" last="Chapman">C. Chapman</name>
<name sortKey="Kilpatrick, T J" sort="Kilpatrick, T J" uniqKey="Kilpatrick T" first="T J" last="Kilpatrick">T J Kilpatrick</name>
<name sortKey="Lucas, R M" sort="Lucas, R M" uniqKey="Lucas R" first="R M" last="Lucas">R M Lucas</name>
<name sortKey="Otahal, P" sort="Otahal, P" uniqKey="Otahal P" first="P" last="Otahal">P. Otahal</name>
<name sortKey="Pender, M P" sort="Pender, M P" uniqKey="Pender M" first="M P" last="Pender">M P Pender</name>
<name sortKey="Ponsonby, A L" sort="Ponsonby, A L" uniqKey="Ponsonby A" first="A-L" last="Ponsonby">A-L Ponsonby</name>
<name sortKey="Taylor, B V" sort="Taylor, B V" uniqKey="Taylor B" first="B V" last="Taylor">B V Taylor</name>
<name sortKey="Valery, P C" sort="Valery, P C" uniqKey="Valery P" first="P C" last="Valery">P C Valery</name>
<name sortKey="Williams, D" sort="Williams, D" uniqKey="Williams D" first="D" last="Williams">D. Williams</name>
</country>
<country name="France"><noRegion><name sortKey="Dwyer, T" sort="Dwyer, T" uniqKey="Dwyer T" first="T" last="Dwyer">T. Dwyer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002866 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002866 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:26199349 |texte= Population attributable fractions and joint effects of key risk factors for multiple sclerosis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:26199349" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |