Poor utility of grading scales in acute intracerebral hemorrhage: results from the INTERACT2 trial.
Identifieur interne : 002668 ( Ncbi/Merge ); précédent : 002667; suivant : 002669Poor utility of grading scales in acute intracerebral hemorrhage: results from the INTERACT2 trial.
Auteurs : Emma Heeley [Australie] ; Craig S. Anderson [Australie] ; Mark Woodward [Australie] ; Hisatomi Arima [Australie] ; Thompson Robinson [Royaume-Uni] ; Christian Stapf [France] ; Mark Parsons [Australie] ; Pablo M. Lavados [Chili] ; Yining Huang [République populaire de Chine] ; Yanxia Wang [République populaire de Chine] ; Sophie Crozier [France] ; Adrian Parry-Jones [Royaume-Uni] ; Jiguang Wang [République populaire de Chine] ; John Chalmers [Australie]Source :
- International journal of stroke : official journal of the International Stroke Society [ 1747-4949 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antihypertenseurs (usage thérapeutique), Coopération internationale, Courbe ROC, Données de la recherche comme sujet, Facteurs temps, Femelle, Humains, Hémorragie cérébrale (mortalité), Hémorragie cérébrale (traitement médicamenteux), Indice de gravité médicale, Maladie aigüe, Mâle, Pression sanguine (physiologie), Résultat thérapeutique, Sujet âgé, Valeur prédictive des tests, Études rétrospectives.
- MESH :
- mortalité : Hémorragie cérébrale.
- physiologie : Pression sanguine.
- traitement médicamenteux : Hémorragie cérébrale.
- usage thérapeutique : Antihypertenseurs.
- Adulte d'âge moyen, Coopération internationale, Courbe ROC, Données de la recherche comme sujet, Facteurs temps, Femelle, Humains, Indice de gravité médicale, Maladie aigüe, Mâle, Résultat thérapeutique, Sujet âgé, Valeur prédictive des tests, Études rétrospectives.
English descriptors
- KwdEn :
- Acute Disease, Aged, Antihypertensive Agents (therapeutic use), Blood Pressure (physiology), Cerebral Hemorrhage (drug therapy), Cerebral Hemorrhage (mortality), Datasets as Topic, Female, Humans, International Cooperation, Male, Middle Aged, Predictive Value of Tests, ROC Curve, Retrospective Studies, Severity of Illness Index, Time Factors, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antihypertensive Agents.
- drug therapy : Cerebral Hemorrhage.
- mortality : Cerebral Hemorrhage.
- physiology : Blood Pressure.
- Acute Disease, Aged, Datasets as Topic, Female, Humans, International Cooperation, Male, Middle Aged, Predictive Value of Tests, ROC Curve, Retrospective Studies, Severity of Illness Index, Time Factors, Treatment Outcome.
Abstract
Several simple clinical grading scores have been developed for intracerebral hemorrhage, primarily to predict 30-day mortality.
DOI: 10.1111/ijs.12518
PubMed: 26044442
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pubmed:26044442Le document en format XML
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Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, APHP - Hôpital Lariboisière and DHU NeuroVasc Paris - Sorbonne, Univ Paris Diderot - Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, APHP - Hôpital Lariboisière and DHU NeuroVasc Paris - Sorbonne, Univ Paris Diderot - Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Parsons, Mark" sort="Parsons, Mark" uniqKey="Parsons M" first="Mark" last="Parsons">Mark Parsons</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Lavados, Pablo M" sort="Lavados, Pablo M" uniqKey="Lavados P" first="Pablo M" last="Lavados">Pablo M. Lavados</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Neurología, Departamento de Medicina, Clínica Alemana, Centro de Neurociencias, Universidad del Desarrollo, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Servicio de Neurología, Departamento de Medicina, Clínica Alemana, Centro de Neurociencias, Universidad del Desarrollo, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Peking University First Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Peking University First Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Yanxia" sort="Wang, Yanxia" uniqKey="Wang Y" first="Yanxia" last="Wang">Yanxia Wang</name><affiliation wicri:level="1"><nlm:affiliation>Hejian City People's Hospital, Hebei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hejian City People's Hospital, Hebei</wicri:regionArea><wicri:noRegion>Hebei</wicri:noRegion></affiliation></author><author><name sortKey="Crozier, Sophie" sort="Crozier, Sophie" uniqKey="Crozier S" first="Sophie" last="Crozier">Sophie Crozier</name><affiliation wicri:level="1"><nlm:affiliation>Stroke unit, Pitié-Salpêtriere Hospital, Paris, AP-HP, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Stroke unit, Pitié-Salpêtriere Hospital, Paris, AP-HP</wicri:regionArea><wicri:noRegion>AP-HP</wicri:noRegion><wicri:noRegion>AP-HP</wicri:noRegion></affiliation></author><author><name sortKey="Parry Jones, Adrian" sort="Parry Jones, Adrian" uniqKey="Parry Jones A" first="Adrian" last="Parry-Jones">Adrian Parry-Jones</name><affiliation wicri:level="1"><nlm:affiliation>Salford Royal NHS Foundation Trust, Salford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Salford Royal NHS Foundation Trust, Salford</wicri:regionArea><wicri:noRegion>Salford</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name><affiliation wicri:level="1"><nlm:affiliation>The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">International journal of stroke : official journal of the International Stroke Society</title><idno type="eISSN">1747-4949</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Aged</term><term>Antihypertensive Agents (therapeutic use)</term><term>Blood Pressure (physiology)</term><term>Cerebral Hemorrhage (drug therapy)</term><term>Cerebral Hemorrhage (mortality)</term><term>Datasets as Topic</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>ROC Curve</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Antihypertenseurs (usage thérapeutique)</term><term>Coopération internationale</term><term>Courbe ROC</term><term>Données de la recherche comme sujet</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Hémorragie cérébrale (mortalité)</term><term>Hémorragie cérébrale (traitement médicamenteux)</term><term>Indice de gravité médicale</term><term>Maladie aigüe</term><term>Mâle</term><term>Pression sanguine (physiologie)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antihypertensive Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Pression sanguine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihypertenseurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Aged</term><term>Datasets as Topic</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>ROC Curve</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Coopération internationale</term><term>Courbe ROC</term><term>Données de la recherche comme sujet</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Maladie aigüe</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several simple clinical grading scores have been developed for intracerebral hemorrhage, primarily to predict 30-day mortality.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26044442</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>25</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>27</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1747-4949</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>International journal of stroke : official journal of the International Stroke Society</Title><ISOAbbreviation>Int J Stroke</ISOAbbreviation></Journal><ArticleTitle>Poor utility of grading scales in acute intracerebral hemorrhage: results from the INTERACT2 trial.</ArticleTitle><Pagination><MedlinePgn>1101-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ijs.12518</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several simple clinical grading scores have been developed for intracerebral hemorrhage, primarily to predict 30-day mortality.</AbstractText><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">We aimed to determine the accuracy of three popular scores (original intracerebral hemorrhage, modified intracerebral hemorrhage, and intracerebral hemorrhage grading scale) on 30-day mortality and 90-day death or major disability, and whether the magnitude of benefit varies according to prognosis graded by the three predictive scores.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Data from the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial which included 2839 intracerebral hemorrhage patients (<6 hours) and elevated systolic blood pressure (150-220 mmHg), randomized to intensive (target systolic blood pressure <140 mmHg) or guideline-based (<180 mmHg) blood pressure management. Discrimination of scales for predicting death and poor outcome (modified Rankin scale 3-6) was evaluated in area under receiver operator characteristic curves.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 2556 (90%) participants with available data, the modified intracerebral hemorrhage had the highest discrimination (receiver operator characteristic 0·75) for 90-day poor outcome compared with the original intracerebral hemorrhage (receiver operator characteristic 0·68) and intracerebral hemorrhage grading scale (receiver operator characteristic 0·69). All scores had good positive predictive value (approximately 80-90%) for poor outcome but poor sensitivity and positive predictive value for death. The scores do not clearly discriminate a patient group most likely to benefit from blood pressure lowering.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Intracerebral hemorrhage prognostic scores are not useful in defining patients at high probability of early death, but they are reliable for predicting poor outcome, defined by death or major disability. Potential benefits of early intensive blood pressure lowering are broadly applicable across grades of severity defined by such scores.</AbstractText><CopyrightInformation>© 2015 World Stroke Organization.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Heeley</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Craig S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Royal Prince Alfred Hospital, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woodward</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arima</LastName><ForeName>Hisatomi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Seta University of Medical Science, Tsukinowa-cho, Otsu, Shiga, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Thompson</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stapf</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, APHP - Hôpital Lariboisière and DHU NeuroVasc Paris - Sorbonne, Univ Paris Diderot - Sorbonne Paris Cité, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parsons</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavados</LastName><ForeName>Pablo M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Servicio de Neurología, Departamento de Medicina, Clínica Alemana, Centro de Neurociencias, Universidad del Desarrollo, Santiago, Chile.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departamento de Ciencias Neurológicas, Universidad de Chile, Santiago, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yining</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Peking University First Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yanxia</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Hejian City People's Hospital, Hebei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crozier</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Stroke unit, Pitié-Salpêtriere Hospital, Paris, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parry-Jones</LastName><ForeName>Adrian</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Salford Royal NHS Foundation Trust, Salford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jiguang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chalmers</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>INTERACT2 Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00716079</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D017427">Clinical Trial, Phase II</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Stroke</MedlineTA><NlmUniqueID>101274068</NlmUniqueID><ISSNLinking>1747-4930</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000959">Antihypertensive Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000208" MajorTopicYN="N">Acute Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000959" MajorTopicYN="N">Antihypertensive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002543" MajorTopicYN="N">Cerebral Hemorrhage</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066264" MajorTopicYN="N">Datasets as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007391" MajorTopicYN="N">International Cooperation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012372" MajorTopicYN="N">ROC Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BP lowering treatment</Keyword><Keyword MajorTopicYN="N">ICH scales</Keyword><Keyword MajorTopicYN="N">INTERACT2</Keyword><Keyword MajorTopicYN="N">intracerebral hemorrhage</Keyword><Keyword MajorTopicYN="N">prognosis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26044442</ArticleId><ArticleId IdType="doi">10.1111/ijs.12518</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Chili</li><li>France</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><region><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Pékin</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Heeley, Emma" sort="Heeley, Emma" uniqKey="Heeley E" first="Emma" last="Heeley">Emma Heeley</name></region><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Parsons, Mark" sort="Parsons, Mark" uniqKey="Parsons M" first="Mark" last="Parsons">Mark Parsons</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name></noRegion><name sortKey="Parry Jones, Adrian" sort="Parry Jones, Adrian" uniqKey="Parry Jones A" first="Adrian" last="Parry-Jones">Adrian Parry-Jones</name></country><country name="France"><region name="Île-de-France"><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name></region><name sortKey="Crozier, Sophie" sort="Crozier, Sophie" uniqKey="Crozier S" first="Sophie" last="Crozier">Sophie Crozier</name></country><country name="Chili"><noRegion><name sortKey="Lavados, Pablo M" sort="Lavados, Pablo M" uniqKey="Lavados P" first="Pablo M" last="Lavados">Pablo M. 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