Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial
Identifieur interne : 002518 ( Ncbi/Merge ); précédent : 002517; suivant : 002519Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial
Auteurs : Xavier Castellsagué ; Jorma Paavonen [Finlande] ; Unnop Jaisamrarn [Thaïlande] ; Cosette M. Wheeler [États-Unis] ; S Rachel Skinner [Australie] ; Matti Lehtinen [Finlande] ; Paulo Naud [Brésil] ; Song-Nan Chow [Taïwan] ; Maria Rowena Del Rosario-Raymundo [Philippines] ; Julio C. Teixeira ; Johanna Palmroth [Finlande] ; Newton S. De Carvalho ; Maria Julieta V. Germar [Philippines] ; Klaus Peters [Allemagne] ; Suzanne M. Garland [Australie] ; Anne Szarewski [Royaume-Uni] ; Willy Aj Poppe [Belgique] ; Barbara Romanowski ; Tino F. Schwarz [Allemagne] ; Wiebren Aa Tjalma [Belgique] ; F Xavier Bosch [Espagne] ; Marie-Cecile Bozonnat [France] ; Frank Struyf [Belgique] ; Gary Dubin [États-Unis] ; Dominique Rosillon [Belgique] ; Laurence Baril [Belgique]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Comportement sexuel (), Espagne (épidémiologie), Essais contrôlés randomisés comme sujet, Facteurs de risque, Facteurs temps, Femelle, Humains, Incidence, Infections à papillomavirus (épidémiologie), Jeune adulte, Néoplasie intraépithéliale cervicale (épidémiologie), Partenaire sexuel, Sujet âgé de 80 ans ou plus, Tumeurs du col de l'utérus (épidémiologie).
- MESH :
- épidémiologie : Espagne, Infections à papillomavirus, Néoplasie intraépithéliale cervicale, Tumeurs du col de l'utérus.
- Adolescent, Adulte, Comportement sexuel, Essais contrôlés randomisés comme sujet, Facteurs de risque, Facteurs temps, Femelle, Humains, Incidence, Jeune adulte, Partenaire sexuel, Sujet âgé de 80 ans ou plus.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, 80 and over, Cervical Intraepithelial Neoplasia (epidemiology), Female, Humans, Incidence, Papillomavirus Infections (epidemiology), Randomized Controlled Trials as Topic, Risk Factors, Sexual Behavior (statistics & numerical data), Sexual Partners, Spain (epidemiology), Time Factors, Uterine Cervical Neoplasms (epidemiology), Young Adult.
- MESH :
- geographic , epidemiology : Spain.
- epidemiology : Cervical Intraepithelial Neoplasia, Papillomavirus Infections, Uterine Cervical Neoplasms.
- statistics & numerical data : Sexual Behavior.
- Adolescent, Adult, Aged, 80 and over, Female, Humans, Incidence, Randomized Controlled Trials as Topic, Risk Factors, Sexual Partners, Time Factors, Young Adult.
Abstract
More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer.
The objectives were to investigate the time between first sexual activity and detection of first cervical HPV infection or development of first cervical intraepithelial neoplasia (CIN), and associated factors in women from the double-blind, multinational, 4-year PATRICIA trial. PATRICIA enroled women aged 15-25 years with no more than 6 lifetime sexual partners. Women were randomized 1:1 to the HPV-16/18 AS04-adjuvanted vaccine or to control, but only women from the control arm who began sexual intercourse during the study or within 6 months before enrolment, and had no HPV infection detected before the recorded date of their first sexual intercourse, were included in the present analysis. The time between onset of sexual activity and detection of the first cervical HPV infection or development of the first CIN lesion was analyzed using Kaplan-Meier and univariate and multivariable Cox proportional-hazards models.
A total of 9337 women were enroled in the control arm of PATRICIA of whom 982 fulfilled the required inclusion criteria for analysis. A cumulative total of 28%, 44%, and 62% of the subjects had HPV infection within 12, 24, and 48 months, respectively. The overall incidence rate was 27.08 per 100 person-years. The most common oncogenic types associated with 6-month persistent infection were HPV-16 (incidence rate: 2.74 per 100 person-years), HPV-51 (2.70), HPV-52 (1.66), HPV-66 (1.14), and HPV-18 (1.09). Increased infection risk was associated with more lifetime sexual partners, being single,
More than 25% of women were infected with HPV within 1 year of beginning sexual activity. Without underestimating the value of vaccination at older ages, our findings emphasize its importance before sexual initiation.
clinicaltrials.gov:
The online version of this article (doi:10.1186/s12879-014-0551-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12879-014-0551-y
PubMed: 25927224
PubMed Central: 4251672
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Teixeira</name><affiliation><nlm:aff id="Aff10">Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo Brazil</nlm:aff><wicri:noCountry code="subfield">Sao Paulo Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Palmroth, Johanna" sort="Palmroth, Johanna" uniqKey="Palmroth J" first="Johanna" last="Palmroth">Johanna Palmroth</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu</wicri:regionArea><wicri:noRegion>Joensuu</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Newton S" sort="De Carvalho, Newton S" uniqKey="De Carvalho N" first="Newton S" last="De Carvalho">Newton S. 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Germar</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Klaus" sort="Peters, Klaus" uniqKey="Peters K" first="Klaus" last="Peters">Klaus Peters</name><affiliation wicri:level="3"><nlm:aff id="Aff14">Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. 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Schwarz</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Tjalma, Wiebren Aa" sort="Tjalma, Wiebren Aa" uniqKey="Tjalma W" first="Wiebren Aa" last="Tjalma">Wiebren Aa Tjalma</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name><affiliation><nlm:aff id="Aff1">Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain</nlm:aff><wicri:noCountry code="subfield">Catalonia Spain</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff21">Network on Cooperative Cancer Research, RTICC, Catalonia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Network on Cooperative Cancer Research, RTICC, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bozonnat, Marie Cecile" sort="Bozonnat, Marie Cecile" uniqKey="Bozonnat M" first="Marie-Cecile" last="Bozonnat">Marie-Cecile Bozonnat</name><affiliation wicri:level="3"><nlm:aff id="Aff22">4Clinics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>4Clinics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Dubin, Gary" sort="Dubin, Gary" uniqKey="Dubin G" first="Gary" last="Dubin">Gary Dubin</name><affiliation wicri:level="2"><nlm:aff id="Aff24">GlaxoSmithKline Vaccines, King of Prussia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>GlaxoSmithKline Vaccines, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Rosillon, Dominique" sort="Rosillon, Dominique" uniqKey="Rosillon D" first="Dominique" last="Rosillon">Dominique Rosillon</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25927224</idno><idno type="pmc">4251672</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251672</idno><idno type="RBID">PMC:4251672</idno><idno type="doi">10.1186/s12879-014-0551-y</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A96</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A96</idno><idno type="wicri:Area/Pmc/Curation">000A73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A73</idno><idno type="wicri:Area/Pmc/Checkpoint">001361</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001361</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003412</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003412</idno><idno type="wicri:Area/PubMed/Curation">003300</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003300</idno><idno type="wicri:Area/PubMed/Checkpoint">003300</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003300</idno><idno type="wicri:Area/Ncbi/Merge">002518</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial</title><author><name sortKey="Castellsague, Xavier" sort="Castellsague, Xavier" uniqKey="Castellsague X" first="Xavier" last="Castellsagué">Xavier Castellsagué</name><affiliation><nlm:aff id="Aff1">Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain</nlm:aff><wicri:noCountry code="subfield">Catalonia Spain</wicri:noCountry></affiliation></author><author><name sortKey="Paavonen, Jorma" sort="Paavonen, Jorma" uniqKey="Paavonen J" first="Jorma" last="Paavonen">Jorma Paavonen</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Jaisamrarn, Unnop" sort="Jaisamrarn, Unnop" uniqKey="Jaisamrarn U" first="Unnop" last="Jaisamrarn">Unnop Jaisamrarn</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Wheeler, Cosette M" sort="Wheeler, Cosette M" uniqKey="Wheeler C" first="Cosette M" last="Wheeler">Cosette M. Wheeler</name><affiliation wicri:level="2"><nlm:aff id="Aff4">Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName><wicri:cityArea>Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque</wicri:cityArea></affiliation></author><author><name sortKey="Skinner, S Rachel" sort="Skinner, S Rachel" uniqKey="Skinner S" first="S Rachel" last="Skinner">S Rachel Skinner</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, NSW Australia</nlm:aff><country>Australie</country><placeName><region type="state">Nouvelle-Galles du Sud</region></placeName><wicri:cityArea>Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney</wicri:cityArea></affiliation></author><author><name sortKey="Lehtinen, Matti" sort="Lehtinen, Matti" uniqKey="Lehtinen M" first="Matti" last="Lehtinen">Matti Lehtinen</name><affiliation wicri:level="1"><nlm:aff id="Aff6">University of Tampere, School of Public Health, Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Tampere, School of Public Health, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Naud, Paulo" sort="Naud, Paulo" uniqKey="Naud P" first="Paulo" last="Naud">Paulo Naud</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Hospital de Clínicas de Porto Alegre, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Chow, Song Nan" sort="Chow, Song Nan" uniqKey="Chow S" first="Song-Nan" last="Chow">Song-Nan Chow</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Del Rosario Raymundo, Maria Rowena" sort="Del Rosario Raymundo, Maria Rowena" uniqKey="Del Rosario Raymundo M" first="Maria Rowena" last="Del Rosario-Raymundo">Maria Rowena Del Rosario-Raymundo</name><affiliation wicri:level="1"><nlm:aff id="Aff9">San Pablo Colleges Medical Center, San Pablo City, Laguna, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>San Pablo Colleges Medical Center, San Pablo City, Laguna</wicri:regionArea><wicri:noRegion>Laguna</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Julio C" sort="Teixeira, Julio C" uniqKey="Teixeira J" first="Julio C" last="Teixeira">Julio C. Teixeira</name><affiliation><nlm:aff id="Aff10">Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo Brazil</nlm:aff><wicri:noCountry code="subfield">Sao Paulo Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Palmroth, Johanna" sort="Palmroth, Johanna" uniqKey="Palmroth J" first="Johanna" last="Palmroth">Johanna Palmroth</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu</wicri:regionArea><wicri:noRegion>Joensuu</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Newton S" sort="De Carvalho, Newton S" uniqKey="De Carvalho N" first="Newton S" last="De Carvalho">Newton S. De Carvalho</name><affiliation><nlm:aff id="Aff12">Department of Gynecology and Obstetrics, Infectious Diseases in Gynecology and Obstetrics Sector, Federal University of Paraná, Curitiba, Parana Brazil</nlm:aff><wicri:noCountry code="subfield">Parana Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Germar, Maria Julieta V" sort="Germar, Maria Julieta V" uniqKey="Germar M" first="Maria Julieta V" last="Germar">Maria Julieta V. Germar</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Klaus" sort="Peters, Klaus" uniqKey="Peters K" first="Klaus" last="Peters">Klaus Peters</name><affiliation wicri:level="3"><nlm:aff id="Aff14">Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. Garland</name><affiliation wicri:level="4"><nlm:aff id="Aff15">Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville/Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Children's Research Institute, Parkville/Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Szarewski, Anne" sort="Szarewski, Anne" uniqKey="Szarewski A" first="Anne" last="Szarewski">Anne Szarewski</name><affiliation wicri:level="4"><nlm:aff id="Aff16">Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Poppe, Willy Aj" sort="Poppe, Willy Aj" uniqKey="Poppe W" first="Willy Aj" last="Poppe">Willy Aj Poppe</name><affiliation wicri:level="1"><nlm:aff id="Aff17">Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Romanowski, Barbara" sort="Romanowski, Barbara" uniqKey="Romanowski B" first="Barbara" last="Romanowski">Barbara Romanowski</name><affiliation><nlm:aff id="Aff18">Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB Canada</nlm:aff><wicri:noCountry code="subfield">AB Canada</wicri:noCountry></affiliation></author><author><name sortKey="Schwarz, Tino F" sort="Schwarz, Tino F" uniqKey="Schwarz T" first="Tino F" last="Schwarz">Tino F. Schwarz</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Tjalma, Wiebren Aa" sort="Tjalma, Wiebren Aa" uniqKey="Tjalma W" first="Wiebren Aa" last="Tjalma">Wiebren Aa Tjalma</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name><affiliation><nlm:aff id="Aff1">Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain</nlm:aff><wicri:noCountry code="subfield">Catalonia Spain</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff21">Network on Cooperative Cancer Research, RTICC, Catalonia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Network on Cooperative Cancer Research, RTICC, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bozonnat, Marie Cecile" sort="Bozonnat, Marie Cecile" uniqKey="Bozonnat M" first="Marie-Cecile" last="Bozonnat">Marie-Cecile Bozonnat</name><affiliation wicri:level="3"><nlm:aff id="Aff22">4Clinics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>4Clinics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Dubin, Gary" sort="Dubin, Gary" uniqKey="Dubin G" first="Gary" last="Dubin">Gary Dubin</name><affiliation wicri:level="2"><nlm:aff id="Aff24">GlaxoSmithKline Vaccines, King of Prussia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>GlaxoSmithKline Vaccines, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Rosillon, Dominique" sort="Rosillon, Dominique" uniqKey="Rosillon D" first="Dominique" last="Rosillon">Dominique Rosillon</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged, 80 and over</term><term>Cervical Intraepithelial Neoplasia (epidemiology)</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Papillomavirus Infections (epidemiology)</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term><term>Sexual Behavior (statistics & numerical data)</term><term>Sexual Partners</term><term>Spain (epidemiology)</term><term>Time Factors</term><term>Uterine Cervical Neoplasms (epidemiology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Comportement sexuel ()</term><term>Espagne (épidémiologie)</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Infections à papillomavirus (épidémiologie)</term><term>Jeune adulte</term><term>Néoplasie intraépithéliale cervicale (épidémiologie)</term><term>Partenaire sexuel</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du col de l'utérus (épidémiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cervical Intraepithelial Neoplasia</term><term>Papillomavirus Infections</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Sexual Behavior</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Infections à papillomavirus</term><term>Néoplasie intraépithéliale cervicale</term><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term><term>Sexual Partners</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Comportement sexuel</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Partenaire sexuel</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer.</p></sec><sec><title>Methods</title><p>The objectives were to investigate the time between first sexual activity and detection of first cervical HPV infection or development of first cervical intraepithelial neoplasia (CIN), and associated factors in women from the double-blind, multinational, 4-year PATRICIA trial. PATRICIA enroled women aged 15-25 years with no more than 6 lifetime sexual partners. Women were randomized 1:1 to the HPV-16/18 AS04-adjuvanted vaccine or to control, but only women from the control arm who began sexual intercourse during the study or within 6 months before enrolment, and had no HPV infection detected before the recorded date of their first sexual intercourse, were included in the present analysis. The time between onset of sexual activity and detection of the first cervical HPV infection or development of the first CIN lesion was analyzed using Kaplan-Meier and univariate and multivariable Cox proportional-hazards models.</p></sec><sec><title>Results</title><p>A total of 9337 women were enroled in the control arm of PATRICIA of whom 982 fulfilled the required inclusion criteria for analysis. A cumulative total of 28%, 44%, and 62% of the subjects had HPV infection within 12, 24, and 48 months, respectively. The overall incidence rate was 27.08 per 100 person-years. The most common oncogenic types associated with 6-month persistent infection were HPV-16 (incidence rate: 2.74 per 100 person-years), HPV-51 (2.70), HPV-52 (1.66), HPV-66 (1.14), and HPV-18 (1.09). Increased infection risk was associated with more lifetime sexual partners, being single, <italic>Chlamydia trachomatis</italic> history, and duration of hormone use. CIN1+ and CIN2+ lesions were most commonly associated with HPV-16, with an overall incidence rate of 1.87 and 1.07 per 100 person-years, respectively. Previous cervical HPV infection was most strongly associated with CIN development.</p></sec><sec><title>Conclusions</title><p>More than 25% of women were infected with HPV within 1 year of beginning sexual activity. Without underestimating the value of vaccination at older ages, our findings emphasize its importance before sexual initiation.</p></sec><sec><title>Trial registration</title><p>clinicaltrials.gov: <ext-link ext-link-type="uri" xlink:href="http://www.NCT00122681">NCT00122681</ext-link>.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12879-014-0551-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Koshiol, J" uniqKey="Koshiol J">J Koshiol</name></author><author><name sortKey="Lindsey, L" uniqKey="Lindsey L">L Lindsey</name></author><author><name sortKey="Pimenta, Jm" uniqKey="Pimenta J">JM Pimenta</name></author><author><name sortKey="Poole, C" uniqKey="Poole C">C Poole</name></author><author><name sortKey="Jenkins, D" uniqKey="Jenkins D">D 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Glass</name></author><author><name sortKey="Anderson, Sm" uniqKey="Anderson S">SM Anderson</name></author><author><name sortKey="Schiffman, M" uniqKey="Schiffman M">M Schiffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mendez, F" uniqKey="Mendez F">F Mendez</name></author><author><name sortKey="Munoz, N" uniqKey="Munoz N">N Munoz</name></author><author><name sortKey="Posso, H" uniqKey="Posso H">H Posso</name></author><author><name sortKey="Molano, M" uniqKey="Molano M">M Molano</name></author><author><name sortKey="Moreno, V" uniqKey="Moreno V">V Moreno</name></author><author><name sortKey="Van Den Brule, Aj" uniqKey="Van Den Brule A">AJ van den Brule</name></author><author><name sortKey="Ronderos, M" uniqKey="Ronderos M">M Ronderos</name></author><author><name sortKey="Meijer, C" uniqKey="Meijer C">C Meijer</name></author><author><name sortKey="Munoz, A" uniqKey="Munoz A">A Munoz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rousseau, Mc" uniqKey="Rousseau M">MC Rousseau</name></author><author><name sortKey="Pereira, Js" uniqKey="Pereira J">JS Pereira</name></author><author><name sortKey="Prado, Jc" uniqKey="Prado J">JC Prado</name></author><author><name sortKey="Villa, Ll" uniqKey="Villa L">LL Villa</name></author><author><name sortKey="Rohan, Te" uniqKey="Rohan T">TE Rohan</name></author><author><name sortKey="Franco, El" uniqKey="Franco E">EL Franco</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="25927224"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial</title><author><name sortKey="Castellsague, Xavier" sort="Castellsague, Xavier" uniqKey="Castellsague X" first="Xavier" last="Castellsagué">Xavier Castellsagué</name><affiliation><nlm:aff id="Aff1">Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain</nlm:aff><wicri:noCountry code="subfield">Catalonia Spain</wicri:noCountry></affiliation></author><author><name sortKey="Paavonen, Jorma" sort="Paavonen, Jorma" uniqKey="Paavonen J" first="Jorma" last="Paavonen">Jorma Paavonen</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Jaisamrarn, Unnop" sort="Jaisamrarn, Unnop" uniqKey="Jaisamrarn U" first="Unnop" last="Jaisamrarn">Unnop Jaisamrarn</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Wheeler, Cosette M" sort="Wheeler, Cosette M" uniqKey="Wheeler C" first="Cosette M" last="Wheeler">Cosette M. Wheeler</name><affiliation wicri:level="2"><nlm:aff id="Aff4">Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName><wicri:cityArea>Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque</wicri:cityArea></affiliation></author><author><name sortKey="Skinner, S Rachel" sort="Skinner, S Rachel" uniqKey="Skinner S" first="S Rachel" last="Skinner">S Rachel Skinner</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, NSW Australia</nlm:aff><country>Australie</country><placeName><region type="state">Nouvelle-Galles du Sud</region></placeName><wicri:cityArea>Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney</wicri:cityArea></affiliation></author><author><name sortKey="Lehtinen, Matti" sort="Lehtinen, Matti" uniqKey="Lehtinen M" first="Matti" last="Lehtinen">Matti Lehtinen</name><affiliation wicri:level="1"><nlm:aff id="Aff6">University of Tampere, School of Public Health, Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Tampere, School of Public Health, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Naud, Paulo" sort="Naud, Paulo" uniqKey="Naud P" first="Paulo" last="Naud">Paulo Naud</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Hospital de Clínicas de Porto Alegre, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Chow, Song Nan" sort="Chow, Song Nan" uniqKey="Chow S" first="Song-Nan" last="Chow">Song-Nan Chow</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Del Rosario Raymundo, Maria Rowena" sort="Del Rosario Raymundo, Maria Rowena" uniqKey="Del Rosario Raymundo M" first="Maria Rowena" last="Del Rosario-Raymundo">Maria Rowena Del Rosario-Raymundo</name><affiliation wicri:level="1"><nlm:aff id="Aff9">San Pablo Colleges Medical Center, San Pablo City, Laguna, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>San Pablo Colleges Medical Center, San Pablo City, Laguna</wicri:regionArea><wicri:noRegion>Laguna</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Julio C" sort="Teixeira, Julio C" uniqKey="Teixeira J" first="Julio C" last="Teixeira">Julio C. Teixeira</name><affiliation><nlm:aff id="Aff10">Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo Brazil</nlm:aff><wicri:noCountry code="subfield">Sao Paulo Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Palmroth, Johanna" sort="Palmroth, Johanna" uniqKey="Palmroth J" first="Johanna" last="Palmroth">Johanna Palmroth</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu</wicri:regionArea><wicri:noRegion>Joensuu</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Newton S" sort="De Carvalho, Newton S" uniqKey="De Carvalho N" first="Newton S" last="De Carvalho">Newton S. De Carvalho</name><affiliation><nlm:aff id="Aff12">Department of Gynecology and Obstetrics, Infectious Diseases in Gynecology and Obstetrics Sector, Federal University of Paraná, Curitiba, Parana Brazil</nlm:aff><wicri:noCountry code="subfield">Parana Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Germar, Maria Julieta V" sort="Germar, Maria Julieta V" uniqKey="Germar M" first="Maria Julieta V" last="Germar">Maria Julieta V. Germar</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Klaus" sort="Peters, Klaus" uniqKey="Peters K" first="Klaus" last="Peters">Klaus Peters</name><affiliation wicri:level="3"><nlm:aff id="Aff14">Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. Garland</name><affiliation wicri:level="4"><nlm:aff id="Aff15">Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville/Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Children's Research Institute, Parkville/Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Szarewski, Anne" sort="Szarewski, Anne" uniqKey="Szarewski A" first="Anne" last="Szarewski">Anne Szarewski</name><affiliation wicri:level="4"><nlm:aff id="Aff16">Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Poppe, Willy Aj" sort="Poppe, Willy Aj" uniqKey="Poppe W" first="Willy Aj" last="Poppe">Willy Aj Poppe</name><affiliation wicri:level="1"><nlm:aff id="Aff17">Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Romanowski, Barbara" sort="Romanowski, Barbara" uniqKey="Romanowski B" first="Barbara" last="Romanowski">Barbara Romanowski</name><affiliation><nlm:aff id="Aff18">Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB Canada</nlm:aff><wicri:noCountry code="subfield">AB Canada</wicri:noCountry></affiliation></author><author><name sortKey="Schwarz, Tino F" sort="Schwarz, Tino F" uniqKey="Schwarz T" first="Tino F" last="Schwarz">Tino F. Schwarz</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Tjalma, Wiebren Aa" sort="Tjalma, Wiebren Aa" uniqKey="Tjalma W" first="Wiebren Aa" last="Tjalma">Wiebren Aa Tjalma</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name><affiliation><nlm:aff id="Aff1">Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain</nlm:aff><wicri:noCountry code="subfield">Catalonia Spain</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff21">Network on Cooperative Cancer Research, RTICC, Catalonia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Network on Cooperative Cancer Research, RTICC, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bozonnat, Marie Cecile" sort="Bozonnat, Marie Cecile" uniqKey="Bozonnat M" first="Marie-Cecile" last="Bozonnat">Marie-Cecile Bozonnat</name><affiliation wicri:level="3"><nlm:aff id="Aff22">4Clinics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>4Clinics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Dubin, Gary" sort="Dubin, Gary" uniqKey="Dubin G" first="Gary" last="Dubin">Gary Dubin</name><affiliation wicri:level="2"><nlm:aff id="Aff24">GlaxoSmithKline Vaccines, King of Prussia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>GlaxoSmithKline Vaccines, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Rosillon, Dominique" sort="Rosillon, Dominique" uniqKey="Rosillon D" first="Dominique" last="Rosillon">Dominique Rosillon</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25927224</idno><idno type="pmc">4251672</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251672</idno><idno type="RBID">PMC:4251672</idno><idno type="doi">10.1186/s12879-014-0551-y</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A96</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A96</idno><idno type="wicri:Area/Pmc/Curation">000A73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A73</idno><idno type="wicri:Area/Pmc/Checkpoint">001361</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001361</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial</title><author><name sortKey="Castellsague, Xavier" sort="Castellsague, Xavier" uniqKey="Castellsague X" first="Xavier" last="Castellsagué">Xavier Castellsagué</name><affiliation><nlm:aff id="Aff1">Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain</nlm:aff><wicri:noCountry code="subfield">Catalonia Spain</wicri:noCountry></affiliation></author><author><name sortKey="Paavonen, Jorma" sort="Paavonen, Jorma" uniqKey="Paavonen J" first="Jorma" last="Paavonen">Jorma Paavonen</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Jaisamrarn, Unnop" sort="Jaisamrarn, Unnop" uniqKey="Jaisamrarn U" first="Unnop" last="Jaisamrarn">Unnop Jaisamrarn</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Wheeler, Cosette M" sort="Wheeler, Cosette M" uniqKey="Wheeler C" first="Cosette M" last="Wheeler">Cosette M. Wheeler</name><affiliation wicri:level="2"><nlm:aff id="Aff4">Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName><wicri:cityArea>Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque</wicri:cityArea></affiliation></author><author><name sortKey="Skinner, S Rachel" sort="Skinner, S Rachel" uniqKey="Skinner S" first="S Rachel" last="Skinner">S Rachel Skinner</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, NSW Australia</nlm:aff><country>Australie</country><placeName><region type="state">Nouvelle-Galles du Sud</region></placeName><wicri:cityArea>Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney</wicri:cityArea></affiliation></author><author><name sortKey="Lehtinen, Matti" sort="Lehtinen, Matti" uniqKey="Lehtinen M" first="Matti" last="Lehtinen">Matti Lehtinen</name><affiliation wicri:level="1"><nlm:aff id="Aff6">University of Tampere, School of Public Health, Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Tampere, School of Public Health, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Naud, Paulo" sort="Naud, Paulo" uniqKey="Naud P" first="Paulo" last="Naud">Paulo Naud</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Hospital de Clínicas de Porto Alegre, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Chow, Song Nan" sort="Chow, Song Nan" uniqKey="Chow S" first="Song-Nan" last="Chow">Song-Nan Chow</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Del Rosario Raymundo, Maria Rowena" sort="Del Rosario Raymundo, Maria Rowena" uniqKey="Del Rosario Raymundo M" first="Maria Rowena" last="Del Rosario-Raymundo">Maria Rowena Del Rosario-Raymundo</name><affiliation wicri:level="1"><nlm:aff id="Aff9">San Pablo Colleges Medical Center, San Pablo City, Laguna, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>San Pablo Colleges Medical Center, San Pablo City, Laguna</wicri:regionArea><wicri:noRegion>Laguna</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Julio C" sort="Teixeira, Julio C" uniqKey="Teixeira J" first="Julio C" last="Teixeira">Julio C. Teixeira</name><affiliation><nlm:aff id="Aff10">Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo Brazil</nlm:aff><wicri:noCountry code="subfield">Sao Paulo Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Palmroth, Johanna" sort="Palmroth, Johanna" uniqKey="Palmroth J" first="Johanna" last="Palmroth">Johanna Palmroth</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Central Hospital of North Carelian, Joensuu</wicri:regionArea><wicri:noRegion>Joensuu</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Newton S" sort="De Carvalho, Newton S" uniqKey="De Carvalho N" first="Newton S" last="De Carvalho">Newton S. De Carvalho</name><affiliation><nlm:aff id="Aff12">Department of Gynecology and Obstetrics, Infectious Diseases in Gynecology and Obstetrics Sector, Federal University of Paraná, Curitiba, Parana Brazil</nlm:aff><wicri:noCountry code="subfield">Parana Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Germar, Maria Julieta V" sort="Germar, Maria Julieta V" uniqKey="Germar M" first="Maria Julieta V" last="Germar">Maria Julieta V. Germar</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Klaus" sort="Peters, Klaus" uniqKey="Peters K" first="Klaus" last="Peters">Klaus Peters</name><affiliation wicri:level="3"><nlm:aff id="Aff14">Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. Garland</name><affiliation wicri:level="4"><nlm:aff id="Aff15">Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville/Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Children's Research Institute, Parkville/Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Szarewski, Anne" sort="Szarewski, Anne" uniqKey="Szarewski A" first="Anne" last="Szarewski">Anne Szarewski</name><affiliation wicri:level="4"><nlm:aff id="Aff16">Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Poppe, Willy Aj" sort="Poppe, Willy Aj" uniqKey="Poppe W" first="Willy Aj" last="Poppe">Willy Aj Poppe</name><affiliation wicri:level="1"><nlm:aff id="Aff17">Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Romanowski, Barbara" sort="Romanowski, Barbara" uniqKey="Romanowski B" first="Barbara" last="Romanowski">Barbara Romanowski</name><affiliation><nlm:aff id="Aff18">Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB Canada</nlm:aff><wicri:noCountry code="subfield">AB Canada</wicri:noCountry></affiliation></author><author><name sortKey="Schwarz, Tino F" sort="Schwarz, Tino F" uniqKey="Schwarz T" first="Tino F" last="Schwarz">Tino F. Schwarz</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Tjalma, Wiebren Aa" sort="Tjalma, Wiebren Aa" uniqKey="Tjalma W" first="Wiebren Aa" last="Tjalma">Wiebren Aa Tjalma</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name><affiliation><nlm:aff id="Aff1">Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain</nlm:aff><wicri:noCountry code="subfield">Catalonia Spain</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff21">Network on Cooperative Cancer Research, RTICC, Catalonia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Network on Cooperative Cancer Research, RTICC, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bozonnat, Marie Cecile" sort="Bozonnat, Marie Cecile" uniqKey="Bozonnat M" first="Marie-Cecile" last="Bozonnat">Marie-Cecile Bozonnat</name><affiliation wicri:level="3"><nlm:aff id="Aff22">4Clinics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>4Clinics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Dubin, Gary" sort="Dubin, Gary" uniqKey="Dubin G" first="Gary" last="Dubin">Gary Dubin</name><affiliation wicri:level="2"><nlm:aff id="Aff24">GlaxoSmithKline Vaccines, King of Prussia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>GlaxoSmithKline Vaccines, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Rosillon, Dominique" sort="Rosillon, Dominique" uniqKey="Rosillon D" first="Dominique" last="Rosillon">Dominique Rosillon</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name><affiliation wicri:level="1"><nlm:aff id="Aff23">GlaxoSmithKline Vaccines, Wavre, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer.</p></sec><sec><title>Methods</title><p>The objectives were to investigate the time between first sexual activity and detection of first cervical HPV infection or development of first cervical intraepithelial neoplasia (CIN), and associated factors in women from the double-blind, multinational, 4-year PATRICIA trial. PATRICIA enroled women aged 15-25 years with no more than 6 lifetime sexual partners. Women were randomized 1:1 to the HPV-16/18 AS04-adjuvanted vaccine or to control, but only women from the control arm who began sexual intercourse during the study or within 6 months before enrolment, and had no HPV infection detected before the recorded date of their first sexual intercourse, were included in the present analysis. The time between onset of sexual activity and detection of the first cervical HPV infection or development of the first CIN lesion was analyzed using Kaplan-Meier and univariate and multivariable Cox proportional-hazards models.</p></sec><sec><title>Results</title><p>A total of 9337 women were enroled in the control arm of PATRICIA of whom 982 fulfilled the required inclusion criteria for analysis. A cumulative total of 28%, 44%, and 62% of the subjects had HPV infection within 12, 24, and 48 months, respectively. The overall incidence rate was 27.08 per 100 person-years. The most common oncogenic types associated with 6-month persistent infection were HPV-16 (incidence rate: 2.74 per 100 person-years), HPV-51 (2.70), HPV-52 (1.66), HPV-66 (1.14), and HPV-18 (1.09). Increased infection risk was associated with more lifetime sexual partners, being single, <italic>Chlamydia trachomatis</italic> history, and duration of hormone use. CIN1+ and CIN2+ lesions were most commonly associated with HPV-16, with an overall incidence rate of 1.87 and 1.07 per 100 person-years, respectively. Previous cervical HPV infection was most strongly associated with CIN development.</p></sec><sec><title>Conclusions</title><p>More than 25% of women were infected with HPV within 1 year of beginning sexual activity. Without underestimating the value of vaccination at older ages, our findings emphasize its importance before sexual initiation.</p></sec><sec><title>Trial registration</title><p>clinicaltrials.gov: <ext-link ext-link-type="uri" xlink:href="http://www.NCT00122681">NCT00122681</ext-link>.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12879-014-0551-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Koshiol, J" uniqKey="Koshiol J">J Koshiol</name></author><author><name sortKey="Lindsey, L" uniqKey="Lindsey L">L Lindsey</name></author><author><name sortKey="Pimenta, Jm" uniqKey="Pimenta J">JM Pimenta</name></author><author><name sortKey="Poole, C" uniqKey="Poole C">C Poole</name></author><author><name sortKey="Jenkins, D" uniqKey="Jenkins D">D 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Castellsagué</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. xcastellsague@iconcologia.net.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Paavonen, Jorma" sort="Paavonen, Jorma" uniqKey="Paavonen J" first="Jorma" last="Paavonen">Jorma Paavonen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland. Jorma.Paavonen@hus.fi.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Jaisamrarn, Unnop" sort="Jaisamrarn, Unnop" uniqKey="Jaisamrarn U" first="Unnop" last="Jaisamrarn">Unnop Jaisamrarn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. dr.unnop@yahoo.com.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Wheeler, Cosette M" sort="Wheeler, Cosette M" uniqKey="Wheeler C" first="Cosette M" last="Wheeler">Cosette M. Wheeler</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. CWheeler@salud.unm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Skinner, S Rachel" sort="Skinner, S Rachel" uniqKey="Skinner S" first="S Rachel" last="Skinner">S Rachel Skinner</name><affiliation wicri:level="1"><nlm:affiliation>Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, NSW, Australia. rachels5@chw.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Lehtinen, Matti" sort="Lehtinen, Matti" uniqKey="Lehtinen M" first="Matti" last="Lehtinen">Matti Lehtinen</name><affiliation wicri:level="1"><nlm:affiliation>University of Tampere, School of Public Health, Tampere, Finland. matti.lehtinen@uta.fi.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Tampere, School of Public Health, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Naud, Paulo" sort="Naud, Paulo" uniqKey="Naud P" first="Paulo" last="Naud">Paulo Naud</name><affiliation wicri:level="3"><nlm:affiliation>Hospital de Clínicas de Porto Alegre, Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Porto Alegre, Brazil. cacontrol@hcpa.ufrgs.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Clínicas de Porto Alegre, Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Chow, Song Nan" sort="Chow, Song Nan" uniqKey="Chow S" first="Song-Nan" last="Chow">Song-Nan Chow</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan. snchow@ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Del Rosario Raymundo, Maria Rowena" sort="Del Rosario Raymundo, Maria Rowena" uniqKey="Del Rosario Raymundo M" first="Maria Rowena" last="Del Rosario-Raymundo">Maria Rowena Del Rosario-Raymundo</name><affiliation wicri:level="1"><nlm:affiliation>San Pablo Colleges Medical Center, San Pablo City, Laguna, Philippines. runnymeadow@yahoo.com.</nlm:affiliation><country xml:lang="fr">Philippines</country><wicri:regionArea>San Pablo Colleges Medical Center, San Pablo City, Laguna</wicri:regionArea><wicri:noRegion>Laguna</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Julio C" sort="Teixeira, Julio C" uniqKey="Teixeira J" first="Julio C" last="Teixeira">Julio C. Teixeira</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo, Brazil. juliotex@uol.com.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Palmroth, Johanna" sort="Palmroth, Johanna" uniqKey="Palmroth J" first="Johanna" last="Palmroth">Johanna Palmroth</name><affiliation wicri:level="1"><nlm:affiliation>Central Hospital of North Carelian, Department of Obstetrics and Gynecology, Joensuu, Finland. johanna.palmroth@dnainternet.net.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Hospital of North Carelian, Department of Obstetrics and Gynecology, Joensuu</wicri:regionArea><wicri:noRegion>Joensuu</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Newton S" sort="De Carvalho, Newton S" uniqKey="De Carvalho N" first="Newton S" last="De Carvalho">Newton S. De Carvalho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynecology and Obstetrics, Federal University of Paraná, Infectious Diseases in Gynecology and Obstetrics Sector, Curitiba, Parana, Brazil. infectogin@ufpr.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Gynecology and Obstetrics, Federal University of Paraná, Infectious Diseases in Gynecology and Obstetrics Sector, Curitiba, Parana</wicri:regionArea><wicri:noRegion>Parana</wicri:noRegion></affiliation></author><author><name sortKey="Germar, Maria Julieta V" sort="Germar, Maria Julieta V" uniqKey="Germar M" first="Maria Julieta V" last="Germar">Maria Julieta V. Germar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila, Philippines. jvgermar@yahoo.com.</nlm:affiliation><country xml:lang="fr">Philippines</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Klaus" sort="Peters, Klaus" uniqKey="Peters K" first="Klaus" last="Peters">Klaus Peters</name><affiliation wicri:level="3"><nlm:affiliation>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, Germany. klaus@dr-peters.net.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. Garland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville/Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Children's Research Institute, Parkville/Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia. suzanne.garland@thewomens.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville/Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Children's Research Institute, Parkville/Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Szarewski, Anne" sort="Szarewski, Anne" uniqKey="Szarewski A" first="Anne" last="Szarewski">Anne Szarewski</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Poppe, Willy A J" sort="Poppe, Willy A J" uniqKey="Poppe W" first="Willy A J" last="Poppe">Willy A J. Poppe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven, Belgium. willy.Poppe@uz.kuleuven.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Romanowski, Barbara" sort="Romanowski, Barbara" uniqKey="Romanowski B" first="Barbara" last="Romanowski">Barbara Romanowski</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. broman@docromanowski.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Schwarz, Tino F" sort="Schwarz, Tino F" uniqKey="Schwarz T" first="Tino F" last="Schwarz">Tino F. Schwarz</name><affiliation wicri:level="1"><nlm:affiliation>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany. t.schwarz@juliusspital.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Tjalma, Wiebren A A" sort="Tjalma, Wiebren A A" uniqKey="Tjalma W" first="Wiebren A A" last="Tjalma">Wiebren A A. Tjalma</name><affiliation wicri:level="1"><nlm:affiliation>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium. wiebren.tjalma@uza.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. x.bosch@iconcologia.net.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bozonnat, Marie Cecile" sort="Bozonnat, Marie Cecile" uniqKey="Bozonnat M" first="Marie-Cecile" last="Bozonnat">Marie-Cecile Bozonnat</name><affiliation wicri:level="3"><nlm:affiliation>4Clinics, Paris, France. mcbozonnat@4clinics.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>4Clinics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline Vaccines, Wavre, Belgium. FRANK.STRUYF@GSK.COM.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Dubin, Gary" sort="Dubin, Gary" uniqKey="Dubin G" first="Gary" last="Dubin">Gary Dubin</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline Vaccines, King of Prussia, PA, USA. Gary.O.Dubin@gsk.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline Vaccines, King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Rosillon, Dominique" sort="Rosillon, Dominique" uniqKey="Rosillon D" first="Dominique" last="Rosillon">Dominique Rosillon</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline Vaccines, Wavre, Belgium. DOMINIQUE.X.ROSILLON@GSK.COM.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline Vaccines, Wavre, Belgium. LAURENCE.X.BARIL@GSK.COM.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25927224</idno><idno type="pmid">25927224</idno><idno type="doi">10.1186/s12879-014-0551-y</idno><idno type="wicri:Area/PubMed/Corpus">003412</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003412</idno><idno type="wicri:Area/PubMed/Curation">003300</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003300</idno><idno type="wicri:Area/PubMed/Checkpoint">003300</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003300</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial.</title><author><name sortKey="Castellsague, Xavier" sort="Castellsague, Xavier" uniqKey="Castellsague X" first="Xavier" last="Castellsagué">Xavier Castellsagué</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. xcastellsague@iconcologia.net.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Paavonen, Jorma" sort="Paavonen, Jorma" uniqKey="Paavonen J" first="Jorma" last="Paavonen">Jorma Paavonen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland. Jorma.Paavonen@hus.fi.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Jaisamrarn, Unnop" sort="Jaisamrarn, Unnop" uniqKey="Jaisamrarn U" first="Unnop" last="Jaisamrarn">Unnop Jaisamrarn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. dr.unnop@yahoo.com.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Wheeler, Cosette M" sort="Wheeler, Cosette M" uniqKey="Wheeler C" first="Cosette M" last="Wheeler">Cosette M. Wheeler</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. CWheeler@salud.unm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Skinner, S Rachel" sort="Skinner, S Rachel" uniqKey="Skinner S" first="S Rachel" last="Skinner">S Rachel Skinner</name><affiliation wicri:level="1"><nlm:affiliation>Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, NSW, Australia. rachels5@chw.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Lehtinen, Matti" sort="Lehtinen, Matti" uniqKey="Lehtinen M" first="Matti" last="Lehtinen">Matti Lehtinen</name><affiliation wicri:level="1"><nlm:affiliation>University of Tampere, School of Public Health, Tampere, Finland. matti.lehtinen@uta.fi.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Tampere, School of Public Health, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Naud, Paulo" sort="Naud, Paulo" uniqKey="Naud P" first="Paulo" last="Naud">Paulo Naud</name><affiliation wicri:level="3"><nlm:affiliation>Hospital de Clínicas de Porto Alegre, Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Porto Alegre, Brazil. cacontrol@hcpa.ufrgs.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Clínicas de Porto Alegre, Department of Gynecology & Obstetrics Federal University of Rio Grande do Sul - UFRGS/HCPA, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Chow, Song Nan" sort="Chow, Song Nan" uniqKey="Chow S" first="Song-Nan" last="Chow">Song-Nan Chow</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan. snchow@ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Del Rosario Raymundo, Maria Rowena" sort="Del Rosario Raymundo, Maria Rowena" uniqKey="Del Rosario Raymundo M" first="Maria Rowena" last="Del Rosario-Raymundo">Maria Rowena Del Rosario-Raymundo</name><affiliation wicri:level="1"><nlm:affiliation>San Pablo Colleges Medical Center, San Pablo City, Laguna, Philippines. runnymeadow@yahoo.com.</nlm:affiliation><country xml:lang="fr">Philippines</country><wicri:regionArea>San Pablo Colleges Medical Center, San Pablo City, Laguna</wicri:regionArea><wicri:noRegion>Laguna</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Julio C" sort="Teixeira, Julio C" uniqKey="Teixeira J" first="Julio C" last="Teixeira">Julio C. Teixeira</name><affiliation wicri:level="3"><nlm:affiliation>Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo, Brazil. juliotex@uol.com.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Tocoginecologia da Unicamp, University of Campinas, Campinas, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Palmroth, Johanna" sort="Palmroth, Johanna" uniqKey="Palmroth J" first="Johanna" last="Palmroth">Johanna Palmroth</name><affiliation wicri:level="1"><nlm:affiliation>Central Hospital of North Carelian, Department of Obstetrics and Gynecology, Joensuu, Finland. johanna.palmroth@dnainternet.net.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Hospital of North Carelian, Department of Obstetrics and Gynecology, Joensuu</wicri:regionArea><wicri:noRegion>Joensuu</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Newton S" sort="De Carvalho, Newton S" uniqKey="De Carvalho N" first="Newton S" last="De Carvalho">Newton S. De Carvalho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynecology and Obstetrics, Federal University of Paraná, Infectious Diseases in Gynecology and Obstetrics Sector, Curitiba, Parana, Brazil. infectogin@ufpr.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Gynecology and Obstetrics, Federal University of Paraná, Infectious Diseases in Gynecology and Obstetrics Sector, Curitiba, Parana</wicri:regionArea><wicri:noRegion>Parana</wicri:noRegion></affiliation></author><author><name sortKey="Germar, Maria Julieta V" sort="Germar, Maria Julieta V" uniqKey="Germar M" first="Maria Julieta V" last="Germar">Maria Julieta V. Germar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila, Philippines. jvgermar@yahoo.com.</nlm:affiliation><country xml:lang="fr">Philippines</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of the Philippines College of Medicine, Philippines General Hospital, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Klaus" sort="Peters, Klaus" uniqKey="Peters K" first="Klaus" last="Peters">Klaus Peters</name><affiliation wicri:level="3"><nlm:affiliation>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg, Germany. klaus@dr-peters.net.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Facharzt für Frauenheilkunde und Geburtshilfe, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garland, Suzanne M" sort="Garland, Suzanne M" uniqKey="Garland S" first="Suzanne M" last="Garland">Suzanne M. Garland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville/Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Children's Research Institute, Parkville/Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia. suzanne.garland@thewomens.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville/Department of Microbiology, The Royal Children's Hospital, Parkville/Murdoch Children's Research Institute, Parkville/Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Szarewski, Anne" sort="Szarewski, Anne" uniqKey="Szarewski A" first="Anne" last="Szarewski">Anne Szarewski</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Poppe, Willy A J" sort="Poppe, Willy A J" uniqKey="Poppe W" first="Willy A J" last="Poppe">Willy A J. Poppe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven, Belgium. willy.Poppe@uz.kuleuven.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Romanowski, Barbara" sort="Romanowski, Barbara" uniqKey="Romanowski B" first="Barbara" last="Romanowski">Barbara Romanowski</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. broman@docromanowski.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Schwarz, Tino F" sort="Schwarz, Tino F" uniqKey="Schwarz T" first="Tino F" last="Schwarz">Tino F. Schwarz</name><affiliation wicri:level="1"><nlm:affiliation>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany. t.schwarz@juliusspital.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Central Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Tjalma, Wiebren A A" sort="Tjalma, Wiebren A A" uniqKey="Tjalma W" first="Wiebren A A" last="Tjalma">Wiebren A A. Tjalma</name><affiliation wicri:level="1"><nlm:affiliation>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium. wiebren.tjalma@uza.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Clinic and Gynaecological Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Bosch, F Xavier" sort="Bosch, F Xavier" uniqKey="Bosch F" first="F Xavier" last="Bosch">F Xavier Bosch</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. x.bosch@iconcologia.net.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Avda. Gran via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bozonnat, Marie Cecile" sort="Bozonnat, Marie Cecile" uniqKey="Bozonnat M" first="Marie-Cecile" last="Bozonnat">Marie-Cecile Bozonnat</name><affiliation wicri:level="3"><nlm:affiliation>4Clinics, Paris, France. mcbozonnat@4clinics.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>4Clinics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline Vaccines, Wavre, Belgium. FRANK.STRUYF@GSK.COM.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Dubin, Gary" sort="Dubin, Gary" uniqKey="Dubin G" first="Gary" last="Dubin">Gary Dubin</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline Vaccines, King of Prussia, PA, USA. Gary.O.Dubin@gsk.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline Vaccines, King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Rosillon, Dominique" sort="Rosillon, Dominique" uniqKey="Rosillon D" first="Dominique" last="Rosillon">Dominique Rosillon</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline Vaccines, Wavre, Belgium. DOMINIQUE.X.ROSILLON@GSK.COM.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline Vaccines, Wavre, Belgium. LAURENCE.X.BARIL@GSK.COM.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC infectious diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged, 80 and over</term><term>Cervical Intraepithelial Neoplasia (epidemiology)</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Papillomavirus Infections (epidemiology)</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term><term>Sexual Behavior (statistics & numerical data)</term><term>Sexual Partners</term><term>Spain (epidemiology)</term><term>Time Factors</term><term>Uterine Cervical Neoplasms (epidemiology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Comportement sexuel ()</term><term>Espagne (épidémiologie)</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Infections à papillomavirus (épidémiologie)</term><term>Jeune adulte</term><term>Néoplasie intraépithéliale cervicale (épidémiologie)</term><term>Partenaire sexuel</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du col de l'utérus (épidémiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cervical Intraepithelial Neoplasia</term><term>Papillomavirus Infections</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Sexual Behavior</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Infections à papillomavirus</term><term>Néoplasie intraépithéliale cervicale</term><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term><term>Sexual Partners</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Comportement sexuel</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Partenaire sexuel</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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