Serveur d'exploration sur les relations entre la France et l'Australie

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Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis.

Identifieur interne : 002414 ( Ncbi/Merge ); précédent : 002413; suivant : 002415

Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis.

Auteurs : Laureline Legendre [France] ; Thomas Barnetche [France] ; Juliette Mazereeuw-Hautier [France] ; Nicolas Meyer [France] ; Dedee Murrell [Australie] ; Carle Paul [France]

Source :

RBID : pubmed:25840730

Descripteurs français

English descriptors

Abstract

There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD).

DOI: 10.1016/j.jaad.2015.02.1116
PubMed: 25840730

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pubmed:25840730

Le document en format XML

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<term>Administration, Topical</term>
<term>Adrenal Cortex Hormones (adverse effects)</term>
<term>Adrenal Cortex Hormones (therapeutic use)</term>
<term>Age Distribution</term>
<term>Calcineurin Inhibitors (adverse effects)</term>
<term>Calcineurin Inhibitors (therapeutic use)</term>
<term>Comorbidity</term>
<term>Dermatitis, Atopic (diagnosis)</term>
<term>Dermatitis, Atopic (drug therapy)</term>
<term>Dermatitis, Atopic (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunosuppressive Agents</term>
<term>Incidence</term>
<term>Lymphoma, T-Cell, Cutaneous (diagnosis)</term>
<term>Lymphoma, T-Cell, Cutaneous (epidemiology)</term>
<term>Male</term>
<term>Prognosis</term>
<term>Risk Assessment</term>
<term>Severity of Illness Index</term>
<term>Sex Distribution</term>
<term>Skin Neoplasms (diagnosis)</term>
<term>Skin Neoplasms (epidemiology)</term>
<term>Tacrolimus (adverse effects)</term>
<term>Tacrolimus (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Administration par voie topique</term>
<term>Comorbidité</term>
<term>Eczéma atopique (diagnostic)</term>
<term>Eczéma atopique (traitement médicamenteux)</term>
<term>Eczéma atopique (épidémiologie)</term>
<term>Femelle</term>
<term>Hormones corticosurrénaliennes (effets indésirables)</term>
<term>Hormones corticosurrénaliennes (usage thérapeutique)</term>
<term>Humains</term>
<term>Immunosuppresseurs</term>
<term>Incidence</term>
<term>Indice de gravité médicale</term>
<term>Inhibiteurs de la calcineurine (effets indésirables)</term>
<term>Inhibiteurs de la calcineurine (usage thérapeutique)</term>
<term>Lymphome T cutané (diagnostic)</term>
<term>Lymphome T cutané (épidémiologie)</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Répartition par sexe</term>
<term>Répartition par âge</term>
<term>Tacrolimus (effets indésirables)</term>
<term>Tacrolimus (usage thérapeutique)</term>
<term>Tumeurs cutanées (diagnostic)</term>
<term>Tumeurs cutanées (épidémiologie)</term>
<term>Évaluation des risques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en">
<term>Adrenal Cortex Hormones</term>
<term>Calcineurin Inhibitors</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Adrenal Cortex Hormones</term>
<term>Calcineurin Inhibitors</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Dermatitis, Atopic</term>
<term>Lymphoma, T-Cell, Cutaneous</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Eczéma atopique</term>
<term>Lymphome T cutané</term>
<term>Tumeurs cutanées</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Dermatitis, Atopic</term>
</keywords>
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<term>Hormones corticosurrénaliennes</term>
<term>Inhibiteurs de la calcineurine</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Dermatitis, Atopic</term>
<term>Lymphoma, T-Cell, Cutaneous</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Eczéma atopique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Hormones corticosurrénaliennes</term>
<term>Inhibiteurs de la calcineurine</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Eczéma atopique</term>
<term>Lymphome T cutané</term>
<term>Tumeurs cutanées</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Administration, Topical</term>
<term>Age Distribution</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Humans</term>
<term>Immunosuppressive Agents</term>
<term>Incidence</term>
<term>Male</term>
<term>Prognosis</term>
<term>Risk Assessment</term>
<term>Severity of Illness Index</term>
<term>Sex Distribution</term>
</keywords>
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<term>Administration par voie topique</term>
<term>Comorbidité</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunosuppresseurs</term>
<term>Incidence</term>
<term>Indice de gravité médicale</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Répartition par sexe</term>
<term>Répartition par âge</term>
<term>Évaluation des risques</term>
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<front>
<div type="abstract" xml:lang="en">There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD).</div>
</front>
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<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">25840730</PMID>
<DateCreated>
<Year>2015</Year>
<Month>05</Month>
<Day>18</Day>
</DateCreated>
<DateCompleted>
<Year>2015</Year>
<Month>08</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised>
<Year>2015</Year>
<Month>05</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1097-6787</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>72</Volume>
<Issue>6</Issue>
<PubDate>
<Year>2015</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Journal of the American Academy of Dermatology</Title>
<ISOAbbreviation>J. Am. Acad. Dermatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis.</ArticleTitle>
<Pagination>
<MedlinePgn>992-1002</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaad.2015.02.1116</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0190-9622(15)01356-0</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD).</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the risk of lymphoma and the role of topical treatments in patients with AD.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A systematic literature search and a separate meta-analysis were performed on case control and cohort studies.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 3979 articles retrieved, 24 references met the inclusion criteria. In cohort studies, the risk of lymphoma was slightly increased, with a relative risk (RR) of 1.43 (95% confidence interval [CI], 1.12-1.81). In case control studies, no significant increased risk of lymphoma was found, with an odds ratio (OR) of 1.18 (95% CI, 0.94-1.47). Severity of AD was a significant risk factor. Highly potent topical steroids were associated with an increased risk of lymphoma. For topical calcineurin inhibitors (TCIs), a significant association between tacrolimus and mostly skin lymphoma was found in 1 study.</AbstractText>
<AbstractText Label="LIMITATIONS" NlmCategory="CONCLUSIONS">Confusion between severe AD and cutaneous T-cell lymphoma may account for part of the increased risk of lymphoma in patients with AD.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This systematic literature review shows a slightly increased risk of lymphoma in patients with AD. Severity of AD appears to be a significant risk factor. The role of topical steroids and TCIs is unlikely to be significant.</AbstractText>
<CopyrightInformation>Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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<Author ValidYN="Y">
<LastName>Legendre</LastName>
<ForeName>Laureline</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Department of Dermatology, Paul Sabatier University, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Barnetche</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mazereeuw-Hautier</LastName>
<ForeName>Juliette</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>Department of Dermatology, Paul Sabatier University, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Meyer</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo>
<Affiliation>Department of Dermatology, Paul Sabatier University, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Murrell</LastName>
<ForeName>Dedee</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Department of Dermatology, University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Paul</LastName>
<ForeName>Carle</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Department of Dermatology, Paul Sabatier University, Toulouse, France. Electronic address: paul.c@chu-toulouse.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D017418">Meta-Analysis</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
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<ArticleDate DateType="Electronic">
<Year>2015</Year>
<Month>04</Month>
<Day>01</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>United States</Country>
<MedlineTA>J Am Acad Dermatol</MedlineTA>
<NlmUniqueID>7907132</NlmUniqueID>
<ISSNLinking>0190-9622</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D065095">Calcineurin Inhibitors</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>WM0HAQ4WNM</RegistryNumber>
<NameOfSubstance UI="D016559">Tacrolimus</NameOfSubstance>
</Chemical>
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<DescriptorName UI="D000287" MajorTopicYN="N">Administration, Topical</DescriptorName>
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<DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading>
<DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D065095" MajorTopicYN="N">Calcineurin Inhibitors</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading>
<DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D003876" MajorTopicYN="N">Dermatitis, Atopic</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
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<DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D017678" MajorTopicYN="N">Sex Distribution</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012878" MajorTopicYN="N">Skin Neoplasms</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016559" MajorTopicYN="N">Tacrolimus</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">atopic dermatitis</Keyword>
<Keyword MajorTopicYN="N">lymphoma</Keyword>
<Keyword MajorTopicYN="N">neoplasm</Keyword>
<Keyword MajorTopicYN="N">pimecrolimus</Keyword>
<Keyword MajorTopicYN="N">systematic review</Keyword>
<Keyword MajorTopicYN="N">tacrolimus</Keyword>
<Keyword MajorTopicYN="N">topical corticosteroids</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2014</Year>
<Month>10</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2015</Year>
<Month>02</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2015</Year>
<Month>02</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2015</Year>
<Month>4</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2015</Year>
<Month>4</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2015</Year>
<Month>8</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">25840730</ArticleId>
<ArticleId IdType="pii">S0190-9622(15)01356-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.jaad.2015.02.1116</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>France</li>
</country>
<region>
<li>Aquitaine</li>
<li>Midi-Pyrénées</li>
<li>Nouvelle-Aquitaine</li>
<li>Nouvelle-Galles du Sud</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement>
<li>Bordeaux</li>
<li>Sydney</li>
<li>Toulouse</li>
</settlement>
</list>
<tree>
<country name="France">
<region name="Occitanie (région administrative)">
<name sortKey="Legendre, Laureline" sort="Legendre, Laureline" uniqKey="Legendre L" first="Laureline" last="Legendre">Laureline Legendre</name>
</region>
<name sortKey="Barnetche, Thomas" sort="Barnetche, Thomas" uniqKey="Barnetche T" first="Thomas" last="Barnetche">Thomas Barnetche</name>
<name sortKey="Mazereeuw Hautier, Juliette" sort="Mazereeuw Hautier, Juliette" uniqKey="Mazereeuw Hautier J" first="Juliette" last="Mazereeuw-Hautier">Juliette Mazereeuw-Hautier</name>
<name sortKey="Meyer, Nicolas" sort="Meyer, Nicolas" uniqKey="Meyer N" first="Nicolas" last="Meyer">Nicolas Meyer</name>
<name sortKey="Paul, Carle" sort="Paul, Carle" uniqKey="Paul C" first="Carle" last="Paul">Carle Paul</name>
</country>
<country name="Australie">
<region name="Nouvelle-Galles du Sud">
<name sortKey="Murrell, Dedee" sort="Murrell, Dedee" uniqKey="Murrell D" first="Dedee" last="Murrell">Dedee Murrell</name>
</region>
</country>
</tree>
</affiliations>
</record>

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