Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies.
Identifieur interne : 002176 ( Ncbi/Merge ); précédent : 002175; suivant : 002177Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies.
Auteurs : Susana Brun [France] ; Wissam Beaino [France] ; Laurent Kremer [France] ; Omar Taleb [France] ; Ayikoe Guy Mensah-Nyagan [France] ; Chanh D. Lam [France] ; Judith M. Greer [Australie] ; Jérôme De Seze [France] ; Elisabeth Trifilieff [France]Source :
- Journal of neuroimmunology [ 1872-8421 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Interleukine-17 (sang), Lymphocytes (anatomopathologie), Lymphocytes (métabolisme), Lymphocytes T (anatomopathologie), Macrophages (anatomopathologie), Modèles animaux de maladie humaine, Mâle, Nerf ischiatique (anatomopathologie), Nerf ischiatique (physiopathologie), Peptides (toxicité), Polyradiculonévrite inflammatoire démyélinisante chronique (), Polyradiculonévrite inflammatoire démyélinisante chronique (anatomopathologie), Polyradiculonévrite inflammatoire démyélinisante chronique (physiopathologie), Polyradiculonévrite inflammatoire démyélinisante chronique (sang), Potentiels évoqués (physiologie), Prolifération cellulaire (), Prolifération cellulaire (physiologie), Protéine P0 de la myéline (), Protéine P0 de la myéline (toxicité), Rats, Rats de lignée LEW, Électrophysiologie.
- MESH :
- anatomopathologie : Lymphocytes, Lymphocytes T, Macrophages, Nerf ischiatique, Polyradiculonévrite inflammatoire démyélinisante chronique.
- métabolisme : Lymphocytes.
- physiologie : Potentiels évoqués, Prolifération cellulaire.
- physiopathologie : Nerf ischiatique, Polyradiculonévrite inflammatoire démyélinisante chronique.
- sang : Interleukine-17, Polyradiculonévrite inflammatoire démyélinisante chronique.
- toxicité : Peptides, Protéine P0 de la myéline.
- Animaux, Modèles animaux de maladie humaine, Mâle, Polyradiculonévrite inflammatoire démyélinisante chronique, Prolifération cellulaire, Protéine P0 de la myéline, Rats, Rats de lignée LEW, Électrophysiologie.
English descriptors
- KwdEn :
- Animals, Cell Proliferation (drug effects), Cell Proliferation (physiology), Disease Models, Animal, Electrophysiology, Evoked Potentials (physiology), Interleukin-17 (blood), Lymphocytes (metabolism), Lymphocytes (pathology), Macrophages (pathology), Male, Myelin P0 Protein (chemistry), Myelin P0 Protein (toxicity), Peptides (toxicity), Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (blood), Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (chemically induced), Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (pathology), Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (physiopathology), Rats, Rats, Inbred Lew, Sciatic Nerve (pathology), Sciatic Nerve (physiopathology), T-Lymphocytes (pathology).
- MESH :
- chemical , blood : Interleukin-17.
- chemical , chemistry : Myelin P0 Protein.
- blood : Polyradiculoneuropathy, Chronic Inflammatory Demyelinating.
- chemically induced : Polyradiculoneuropathy, Chronic Inflammatory Demyelinating.
- drug effects : Cell Proliferation.
- metabolism : Lymphocytes.
- pathology : Lymphocytes, Macrophages, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Sciatic Nerve, T-Lymphocytes.
- physiology : Cell Proliferation, Evoked Potentials.
- physiopathology : Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Sciatic Nerve.
- chemical , toxicity : Myelin P0 Protein, Peptides.
- Animals, Disease Models, Animal, Electrophysiology, Male, Rats, Rats, Inbred Lew.
Abstract
Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17(+) cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.
DOI: 10.1016/j.jneuroim.2014.11.022
PubMed: 25595246
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Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg</wicri:regionArea><wicri:noRegion>Fédération de Médecine Translationnelle de Strasbourg</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Beaino, Wissam" sort="Beaino, Wissam" uniqKey="Beaino W" first="Wissam" last="Beaino">Wissam Beaino</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université de Strasbourg, CNRS, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université de Strasbourg, CNRS</wicri:regionArea><wicri:noRegion>CNRS</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Kremer, Laurent" sort="Kremer, Laurent" uniqKey="Kremer L" first="Laurent" last="Kremer">Laurent Kremer</name><affiliation wicri:level="4"><nlm:affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg</wicri:regionArea><wicri:noRegion>Fédération de Médecine Translationnelle de Strasbourg</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Taleb, Omar" sort="Taleb, Omar" uniqKey="Taleb O" first="Omar" last="Taleb">Omar Taleb</name><affiliation wicri:level="4"><nlm:affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg</wicri:regionArea><wicri:noRegion>Fédération de Médecine Translationnelle de Strasbourg</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Mensah Nyagan, Ayikoe Guy" sort="Mensah Nyagan, Ayikoe Guy" uniqKey="Mensah Nyagan A" first="Ayikoe Guy" last="Mensah-Nyagan">Ayikoe Guy Mensah-Nyagan</name><affiliation wicri:level="4"><nlm:affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg</wicri:regionArea><wicri:noRegion>Fédération de Médecine Translationnelle de Strasbourg</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Lam, Chanh D" sort="Lam, Chanh D" uniqKey="Lam C" first="Chanh D" last="Lam">Chanh D. Lam</name><affiliation wicri:level="4"><nlm:affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg</wicri:regionArea><wicri:noRegion>Fédération de Médecine Translationnelle de Strasbourg</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Greer, Judith M" sort="Greer, Judith M" uniqKey="Greer J" first="Judith M" last="Greer">Judith M. Greer</name><affiliation wicri:level="1"><nlm:affiliation>The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland, UQ Centre for Clinical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="De Seze, Jerome" sort="De Seze, Jerome" uniqKey="De Seze J" first="Jérôme" last="De Seze">Jérôme De Seze</name><affiliation wicri:level="4"><nlm:affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg</wicri:regionArea><wicri:noRegion>Fédération de Médecine Translationnelle de Strasbourg</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author><author><name sortKey="Trifilieff, Elisabeth" sort="Trifilieff, Elisabeth" uniqKey="Trifilieff E" first="Elisabeth" last="Trifilieff">Elisabeth Trifilieff</name><affiliation wicri:level="4"><nlm:affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France. Electronic address: trif@unistra.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg</wicri:regionArea><wicri:noRegion>Fédération de Médecine Translationnelle de Strasbourg</wicri:noRegion><orgName type="university">Université de Strasbourg</orgName><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName></affiliation></author></analytic><series><title level="j">Journal of neuroimmunology</title><idno type="eISSN">1872-8421</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Proliferation (drug 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(toxicité)</term><term>Rats</term><term>Rats de lignée LEW</term><term>Électrophysiologie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Interleukin-17</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Myelin P0 Protein</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphocytes</term><term>Lymphocytes T</term><term>Macrophages</term><term>Nerf ischiatique</term><term>Polyradiculonévrite inflammatoire démyélinisante chronique</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphocytes</term><term>Macrophages</term><term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</term><term>Sciatic Nerve</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Potentiels évoqués</term><term>Prolifération cellulaire</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Proliferation</term><term>Evoked Potentials</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Nerf ischiatique</term><term>Polyradiculonévrite inflammatoire démyélinisante chronique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</term><term>Sciatic Nerve</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Interleukine-17</term><term>Polyradiculonévrite inflammatoire démyélinisante chronique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Myelin P0 Protein</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Peptides</term><term>Protéine P0 de la myéline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Electrophysiology</term><term>Male</term><term>Rats</term><term>Rats, Inbred Lew</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Polyradiculonévrite inflammatoire démyélinisante chronique</term><term>Prolifération cellulaire</term><term>Protéine P0 de la myéline</term><term>Rats</term><term>Rats de lignée LEW</term><term>Électrophysiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17(+) cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25595246</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>17</Day></DateCreated><DateCompleted><Year>2015</Year><Month>03</Month><Day>23</Day></DateCompleted><DateRevised><Year>2015</Year><Month>01</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-8421</ISSN><JournalIssue CitedMedium="Internet"><Volume>278</Volume><PubDate><Year>2015</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of neuroimmunology</Title><ISOAbbreviation>J. Neuroimmunol.</ISOAbbreviation></Journal><ArticleTitle>Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies.</ArticleTitle><Pagination><MedlinePgn>1-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jneuroim.2014.11.022</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0165-5728(14)00983-7</ELocationID><Abstract><AbstractText>Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17(+) cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brun</LastName><ForeName>Susana</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beaino</LastName><ForeName>Wissam</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université de Strasbourg, CNRS, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kremer</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taleb</LastName><ForeName>Omar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mensah-Nyagan</LastName><ForeName>Ayikoe Guy</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lam</LastName><ForeName>Chanh D</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greer</LastName><ForeName>Judith M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Seze</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trifilieff</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France. Electronic address: trif@unistra.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Neuroimmunol</MedlineTA><NlmUniqueID>8109498</NlmUniqueID><ISSNLinking>0165-5728</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020381">Interleukin-17</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018993">Myelin P0 Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="Y">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004594" MajorTopicYN="N">Electrophysiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005071" MajorTopicYN="N">Evoked Potentials</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020381" MajorTopicYN="N">Interleukin-17</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008214" MajorTopicYN="N">Lymphocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018993" MajorTopicYN="N">Myelin P0 Protein</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020277" MajorTopicYN="N">Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011917" MajorTopicYN="N">Rats, Inbred Lew</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012584" MajorTopicYN="N">Sciatic Nerve</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Animal model</Keyword><Keyword MajorTopicYN="N">CIDP</Keyword><Keyword MajorTopicYN="N">Chronic EAN</Keyword><Keyword MajorTopicYN="N">Electrophysiology</Keyword><Keyword MajorTopicYN="N">Immunology</Keyword><Keyword MajorTopicYN="N">Sciatic nerve immunohistochemistry</Keyword><Keyword MajorTopicYN="N">Thiopalmitoylated P0 peptide</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>09</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>11</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25595246</ArticleId><ArticleId IdType="pii">S0165-5728(14)00983-7</ArticleId><ArticleId IdType="doi">10.1016/j.jneuroim.2014.11.022</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li></region><settlement><li>Strasbourg</li></settlement><orgName><li>Université de Strasbourg</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Brun, Susana" sort="Brun, Susana" uniqKey="Brun S" first="Susana" last="Brun">Susana Brun</name></region><name sortKey="Beaino, Wissam" sort="Beaino, Wissam" uniqKey="Beaino W" first="Wissam" last="Beaino">Wissam Beaino</name><name sortKey="De Seze, Jerome" sort="De Seze, Jerome" uniqKey="De Seze J" first="Jérôme" last="De Seze">Jérôme De Seze</name><name sortKey="Kremer, Laurent" sort="Kremer, Laurent" uniqKey="Kremer L" first="Laurent" last="Kremer">Laurent Kremer</name><name sortKey="Lam, Chanh D" sort="Lam, Chanh D" uniqKey="Lam C" first="Chanh D" last="Lam">Chanh D. Lam</name><name sortKey="Mensah Nyagan, Ayikoe Guy" sort="Mensah Nyagan, Ayikoe Guy" uniqKey="Mensah Nyagan A" first="Ayikoe Guy" last="Mensah-Nyagan">Ayikoe Guy Mensah-Nyagan</name><name sortKey="Taleb, Omar" sort="Taleb, Omar" uniqKey="Taleb O" first="Omar" last="Taleb">Omar Taleb</name><name sortKey="Trifilieff, Elisabeth" sort="Trifilieff, Elisabeth" uniqKey="Trifilieff E" first="Elisabeth" last="Trifilieff">Elisabeth Trifilieff</name></country><country name="Australie"><noRegion><name sortKey="Greer, Judith M" sort="Greer, Judith M" uniqKey="Greer J" first="Judith M" last="Greer">Judith M. Greer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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