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Incidence and imaging outcomes of acute scaffold disruption and late structural discontinuity after implantation of the absorb Everolimus-Eluting fully bioresorbable vascular scaffold: optical coherence tomography assessment in the ABSORB cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions).

Identifieur interne : 002111 ( Ncbi/Merge ); précédent : 002110; suivant : 002112

Incidence and imaging outcomes of acute scaffold disruption and late structural discontinuity after implantation of the absorb Everolimus-Eluting fully bioresorbable vascular scaffold: optical coherence tomography assessment in the ABSORB cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions).

Auteurs : Yoshinobu Onuma [Pays-Bas] ; Patrick W. Serruys [Pays-Bas] ; Takashi Muramatsu [Pays-Bas] ; Shimpei Nakatani [Pays-Bas] ; Robert-Jan Van Geuns [Pays-Bas] ; Bernard De Bruyne [Belgique] ; Dariusz Dudek [Pologne] ; Evald Christiansen [Danemark] ; Pieter C. Smits [Pays-Bas] ; Bernard Chevalier [France] ; Dougal Mcclean [Nouvelle-Zélande] ; Jacques Koolen [Pays-Bas] ; Stephan Windecker [Suisse] ; Robert Whitbourn [Australie] ; Ian Meredith [Australie] ; Hector M. Garcia-Garcia [Pays-Bas] ; Susan Veldhof [Belgique] ; Richard Rapoza [États-Unis] ; John A. Ormiston [Nouvelle-Zélande]

Source :

RBID : pubmed:25523532

Descripteurs français

English descriptors

Abstract

This study sought to describe the frequency and clinical impact of acute scaffold disruption and late strut discontinuity of the second-generation Absorb bioresorbable polymeric vascular scaffolds (Absorb BVS, Abbott Vascular, Santa Clara, California) in the ABSORB (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) cohort B study by optical coherence tomography (OCT) post-procedure and at 6, 12, 24, and 36 months.

DOI: 10.1016/j.jcin.2014.06.016
PubMed: 25523532

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pubmed:25523532

Le document en format XML

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<nlm:affiliation>Department of Interventional Cardiology, Cardiovascular Center, Aalst, Belgium.</nlm:affiliation>
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<name sortKey="Dudek, Dariusz" sort="Dudek, Dariusz" uniqKey="Dudek D" first="Dariusz" last="Dudek">Dariusz Dudek</name>
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<nlm:affiliation>Department of Cardiology and Cardiovascular Interventions, Jagiellonian University, Krakow, Poland.</nlm:affiliation>
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<name sortKey="Christiansen, Evald" sort="Christiansen, Evald" uniqKey="Christiansen E" first="Evald" last="Christiansen">Evald Christiansen</name>
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<nlm:affiliation>Department of Cardiology, Skejby Sygehus University Hospital, Aarhus, Denmark.</nlm:affiliation>
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<wicri:regionArea>Department of Cardiology, Skejby Sygehus University Hospital, Aarhus</wicri:regionArea>
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<nlm:affiliation>Department of Interventional Cardiology, Maasstad Hospital, Rotterdam, the Netherlands.</nlm:affiliation>
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<name sortKey="Chevalier, Bernard" sort="Chevalier, Bernard" uniqKey="Chevalier B" first="Bernard" last="Chevalier">Bernard Chevalier</name>
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<nlm:affiliation>Institut Cardiovasculaire Paris Sud, Institut Jacques Cartier, Massy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Cardiovasculaire Paris Sud, Institut Jacques Cartier, Massy</wicri:regionArea>
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<name sortKey="Mcclean, Dougal" sort="Mcclean, Dougal" uniqKey="Mcclean D" first="Dougal" last="Mcclean">Dougal Mcclean</name>
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<nlm:affiliation>Department of Interventional Cardiology, Christchurch Hospital, Christchurch, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Interventional Cardiology, Christchurch Hospital, Christchurch</wicri:regionArea>
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<name sortKey="Koolen, Jacques" sort="Koolen, Jacques" uniqKey="Koolen J" first="Jacques" last="Koolen">Jacques Koolen</name>
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<nlm:affiliation>Department of Interventional Cardiology, Catharina Hospital, Eindhoven, the Netherlands.</nlm:affiliation>
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<wicri:regionArea>Department of Interventional Cardiology, Catharina Hospital, Eindhoven</wicri:regionArea>
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<name sortKey="Windecker, Stephan" sort="Windecker, Stephan" uniqKey="Windecker S" first="Stephan" last="Windecker">Stephan Windecker</name>
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<nlm:affiliation>Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Interventional Cardiology, Bern University Hospital, Bern</wicri:regionArea>
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<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
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<name sortKey="Whitbourn, Robert" sort="Whitbourn, Robert" uniqKey="Whitbourn R" first="Robert" last="Whitbourn">Robert Whitbourn</name>
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<nlm:affiliation>Cardiac Investigation Unit, St. Vincents Hospital, Fitzroy, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cardiac Investigation Unit, St. Vincents Hospital, Fitzroy</wicri:regionArea>
<wicri:noRegion>Fitzroy</wicri:noRegion>
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<name sortKey="Meredith, Ian" sort="Meredith, Ian" uniqKey="Meredith I" first="Ian" last="Meredith">Ian Meredith</name>
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<nlm:affiliation>Department of Medicine, Cardiology, Monash Cardiovascular Research Centre, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, Cardiology, Monash Cardiovascular Research Centre, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
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<author>
<name sortKey="Garcia Garcia, Hector M" sort="Garcia Garcia, Hector M" uniqKey="Garcia Garcia H" first="Hector M" last="Garcia-Garcia">Hector M. Garcia-Garcia</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Interventional Cardiology, Cardialysis, Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Interventional Cardiology, Cardialysis, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
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<name sortKey="Veldhof, Susan" sort="Veldhof, Susan" uniqKey="Veldhof S" first="Susan" last="Veldhof">Susan Veldhof</name>
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<nlm:affiliation>Department of Clinical Research, Abbott Vascular, Diegem, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Clinical Research, Abbott Vascular, Diegem</wicri:regionArea>
<wicri:noRegion>Diegem</wicri:noRegion>
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<name sortKey="Rapoza, Richard" sort="Rapoza, Richard" uniqKey="Rapoza R" first="Richard" last="Rapoza">Richard Rapoza</name>
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<nlm:affiliation>Research and Development, Abbott Vascular, Santa Clara, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Research and Development, Abbott Vascular, Santa Clara</wicri:cityArea>
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<name sortKey="Ormiston, John A" sort="Ormiston, John A" uniqKey="Ormiston J" first="John A" last="Ormiston">John A. Ormiston</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Interventional Cardiology, Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Interventional Cardiology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
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<title xml:lang="en">Incidence and imaging outcomes of acute scaffold disruption and late structural discontinuity after implantation of the absorb Everolimus-Eluting fully bioresorbable vascular scaffold: optical coherence tomography assessment in the ABSORB cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions).</title>
<author>
<name sortKey="Onuma, Yoshinobu" sort="Onuma, Yoshinobu" uniqKey="Onuma Y" first="Yoshinobu" last="Onuma">Yoshinobu Onuma</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<name sortKey="Serruys, Patrick W" sort="Serruys, Patrick W" uniqKey="Serruys P" first="Patrick W" last="Serruys">Patrick W. Serruys</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: patrick.w.j.c.serruys@gmail.com.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
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<name sortKey="Muramatsu, Takashi" sort="Muramatsu, Takashi" uniqKey="Muramatsu T" first="Takashi" last="Muramatsu">Takashi Muramatsu</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<nlm:affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<name sortKey="Van Geuns, Robert Jan" sort="Van Geuns, Robert Jan" uniqKey="Van Geuns R" first="Robert-Jan" last="Van Geuns">Robert-Jan Van Geuns</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<settlement type="city">Rotterdam</settlement>
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<author>
<name sortKey="De Bruyne, Bernard" sort="De Bruyne, Bernard" uniqKey="De Bruyne B" first="Bernard" last="De Bruyne">Bernard De Bruyne</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Interventional Cardiology, Cardiovascular Center, Aalst, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Interventional Cardiology, Cardiovascular Center, Aalst</wicri:regionArea>
<wicri:noRegion>Aalst</wicri:noRegion>
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</author>
<author>
<name sortKey="Dudek, Dariusz" sort="Dudek, Dariusz" uniqKey="Dudek D" first="Dariusz" last="Dudek">Dariusz Dudek</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Cardiology and Cardiovascular Interventions, Jagiellonian University, Krakow, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Cardiology and Cardiovascular Interventions, Jagiellonian University, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Christiansen, Evald" sort="Christiansen, Evald" uniqKey="Christiansen E" first="Evald" last="Christiansen">Evald Christiansen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Cardiology, Skejby Sygehus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Cardiology, Skejby Sygehus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Smits, Pieter C" sort="Smits, Pieter C" uniqKey="Smits P" first="Pieter C" last="Smits">Pieter C. Smits</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Interventional Cardiology, Maasstad Hospital, Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Interventional Cardiology, Maasstad Hospital, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chevalier, Bernard" sort="Chevalier, Bernard" uniqKey="Chevalier B" first="Bernard" last="Chevalier">Bernard Chevalier</name>
<affiliation wicri:level="1">
<nlm:affiliation>Institut Cardiovasculaire Paris Sud, Institut Jacques Cartier, Massy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Cardiovasculaire Paris Sud, Institut Jacques Cartier, Massy</wicri:regionArea>
<wicri:noRegion>Massy</wicri:noRegion>
<wicri:noRegion>Massy</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mcclean, Dougal" sort="Mcclean, Dougal" uniqKey="Mcclean D" first="Dougal" last="Mcclean">Dougal Mcclean</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Interventional Cardiology, Christchurch Hospital, Christchurch, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Interventional Cardiology, Christchurch Hospital, Christchurch</wicri:regionArea>
<wicri:noRegion>Christchurch</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Koolen, Jacques" sort="Koolen, Jacques" uniqKey="Koolen J" first="Jacques" last="Koolen">Jacques Koolen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Interventional Cardiology, Catharina Hospital, Eindhoven, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Interventional Cardiology, Catharina Hospital, Eindhoven</wicri:regionArea>
<wicri:noRegion>Eindhoven</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Windecker, Stephan" sort="Windecker, Stephan" uniqKey="Windecker S" first="Stephan" last="Windecker">Stephan Windecker</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Interventional Cardiology, Bern University Hospital, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Whitbourn, Robert" sort="Whitbourn, Robert" uniqKey="Whitbourn R" first="Robert" last="Whitbourn">Robert Whitbourn</name>
<affiliation wicri:level="1">
<nlm:affiliation>Cardiac Investigation Unit, St. Vincents Hospital, Fitzroy, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cardiac Investigation Unit, St. Vincents Hospital, Fitzroy</wicri:regionArea>
<wicri:noRegion>Fitzroy</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Meredith, Ian" sort="Meredith, Ian" uniqKey="Meredith I" first="Ian" last="Meredith">Ian Meredith</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Medicine, Cardiology, Monash Cardiovascular Research Centre, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, Cardiology, Monash Cardiovascular Research Centre, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Garcia Garcia, Hector M" sort="Garcia Garcia, Hector M" uniqKey="Garcia Garcia H" first="Hector M" last="Garcia-Garcia">Hector M. Garcia-Garcia</name>
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<name sortKey="Rapoza, Richard" sort="Rapoza, Richard" uniqKey="Rapoza R" first="Richard" last="Rapoza">Richard Rapoza</name>
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<nlm:affiliation>Department of Interventional Cardiology, Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
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<title level="j">JACC. Cardiovascular interventions</title>
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<term>Absorbable Implants</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Angioplasty, Balloon, Coronary (adverse effects)</term>
<term>Angioplasty, Balloon, Coronary (instrumentation)</term>
<term>Cardiovascular Agents (administration & dosage)</term>
<term>Coronary Artery Disease (diagnosis)</term>
<term>Coronary Artery Disease (therapy)</term>
<term>Coronary Vessels (pathology)</term>
<term>Drug-Eluting Stents</term>
<term>Everolimus</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Predictive Value of Tests</term>
<term>Prosthesis Design</term>
<term>Sirolimus (administration & dosage)</term>
<term>Sirolimus (analogs & derivatives)</term>
<term>Time Factors</term>
<term>Tomography, Optical Coherence</term>
<term>Treatment Outcome</term>
</keywords>
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<term>Agents cardiovasculaires (administration et posologie)</term>
<term>Angioplastie coronaire par ballonnet (effets indésirables)</term>
<term>Angioplastie coronaire par ballonnet (instrumentation)</term>
<term>Conception de prothèse</term>
<term>Endoprothèses à élution de substances</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implant résorbable</term>
<term>Maladie des artères coronaires ()</term>
<term>Maladie des artères coronaires (diagnostic)</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sirolimus (administration et posologie)</term>
<term>Sirolimus (analogues et dérivés)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tomographie par cohérence optique</term>
<term>Vaisseaux coronaires (anatomopathologie)</term>
<term>Valeur prédictive des tests</term>
<term>Évérolimus</term>
</keywords>
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<term>Cardiovascular Agents</term>
<term>Sirolimus</term>
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<term>Agents cardiovasculaires</term>
<term>Sirolimus</term>
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<term>Angioplasty, Balloon, Coronary</term>
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<term>Sirolimus</term>
</keywords>
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<term>Sirolimus</term>
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<term>Vaisseaux coronaires</term>
</keywords>
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<term>Coronary Artery Disease</term>
</keywords>
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<term>Maladie des artères coronaires</term>
</keywords>
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<term>Angioplastie coronaire par ballonnet</term>
</keywords>
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<term>Angioplasty, Balloon, Coronary</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Coronary Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Coronary Artery Disease</term>
</keywords>
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<term>Absorbable Implants</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Drug-Eluting Stents</term>
<term>Everolimus</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Predictive Value of Tests</term>
<term>Prosthesis Design</term>
<term>Time Factors</term>
<term>Tomography, Optical Coherence</term>
<term>Treatment Outcome</term>
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<term>Angioplastie coronaire par ballonnet</term>
<term>Conception de prothèse</term>
<term>Endoprothèses à élution de substances</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implant résorbable</term>
<term>Maladie des artères coronaires</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tomographie par cohérence optique</term>
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<front>
<div type="abstract" xml:lang="en">This study sought to describe the frequency and clinical impact of acute scaffold disruption and late strut discontinuity of the second-generation Absorb bioresorbable polymeric vascular scaffolds (Absorb BVS, Abbott Vascular, Santa Clara, California) in the ABSORB (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) cohort B study by optical coherence tomography (OCT) post-procedure and at 6, 12, 24, and 36 months.</div>
</front>
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<DateCreated>
<Year>2014</Year>
<Month>12</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted>
<Year>2015</Year>
<Month>08</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised>
<Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1876-7605</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>7</Volume>
<Issue>12</Issue>
<PubDate>
<Year>2014</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>JACC. Cardiovascular interventions</Title>
<ISOAbbreviation>JACC Cardiovasc Interv</ISOAbbreviation>
</Journal>
<ArticleTitle>Incidence and imaging outcomes of acute scaffold disruption and late structural discontinuity after implantation of the absorb Everolimus-Eluting fully bioresorbable vascular scaffold: optical coherence tomography assessment in the ABSORB cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions).</ArticleTitle>
<Pagination>
<MedlinePgn>1400-11</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcin.2014.06.016</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1936-8798(14)01357-0</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This study sought to describe the frequency and clinical impact of acute scaffold disruption and late strut discontinuity of the second-generation Absorb bioresorbable polymeric vascular scaffolds (Absorb BVS, Abbott Vascular, Santa Clara, California) in the ABSORB (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) cohort B study by optical coherence tomography (OCT) post-procedure and at 6, 12, 24, and 36 months.</AbstractText>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Fully bioresorbable scaffolds are a novel approach to treatment for coronary narrowing that provides transient vessel support with drug delivery capability without the long-term limitations of metallic drug-eluting stents. However, a potential drawback of the bioresorbable scaffold is the potential for disruption of the strut network when overexpanded. Conversely, the structural discontinuity of the polymeric struts at a late stage is a biologically programmed fate of the scaffold during the course of bioresorption.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The ABSORB cohort B trial is a multicenter single-arm trial assessing the safety and performance of the Absorb BVS in the treatment of 101 patients with de novo native coronary artery lesions. The current analysis included 51 patients with 143 OCT pullbacks who underwent OCT at baseline and follow-up. The presence of acute disruption or late discontinuities was diagnosed by the presence on OCT of stacked, overhung struts or isolated intraluminal struts disconnected from the expected circularity of the device.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 51 patients with OCT imaging post-procedure, acute scaffold disruption was observed in 2 patients (3.9%), which could be related to overexpansion of the scaffold at the time of implantation. One patient had a target lesion revascularization that was presumably related to the disruption. Of 49 patients without acute disruption, late discontinuities were observed in 21 patients. There were no major adverse cardiac events associated with this finding except for 1 patient who had a non-ischemia-driven target lesion revascularization.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Acute scaffold disruption is a rare iatrogenic phenomenon that has been anecdotally associated with anginal symptoms, whereas late strut discontinuity is observed in approximately 40% of patients and could be viewed as a serendipitous OCT finding of a normal bioresorption process without clinical implications. (ABSORB Clinical Investigation, Cohort B [ABSORB B]; NCT00856856).</AbstractText>
<CopyrightInformation>Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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<Author ValidYN="Y">
<LastName>Onuma</LastName>
<ForeName>Yoshinobu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Serruys</LastName>
<ForeName>Patrick W</ForeName>
<Initials>PW</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: patrick.w.j.c.serruys@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Muramatsu</LastName>
<ForeName>Takashi</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Nakatani</LastName>
<ForeName>Shimpei</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>van Geuns</LastName>
<ForeName>Robert-Jan</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>de Bruyne</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, Cardiovascular Center, Aalst, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Dudek</LastName>
<ForeName>Dariusz</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Department of Cardiology and Cardiovascular Interventions, Jagiellonian University, Krakow, Poland.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Christiansen</LastName>
<ForeName>Evald</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>Department of Cardiology, Skejby Sygehus University Hospital, Aarhus, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Smits</LastName>
<ForeName>Pieter C</ForeName>
<Initials>PC</Initials>
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<Affiliation>Department of Interventional Cardiology, Maasstad Hospital, Rotterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Chevalier</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
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<Affiliation>Institut Cardiovasculaire Paris Sud, Institut Jacques Cartier, Massy, France.</Affiliation>
</AffiliationInfo>
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<LastName>McClean</LastName>
<ForeName>Dougal</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, Christchurch Hospital, Christchurch, New Zealand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Koolen</LastName>
<ForeName>Jacques</ForeName>
<Initials>J</Initials>
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<Affiliation>Department of Interventional Cardiology, Catharina Hospital, Eindhoven, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Windecker</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Whitbourn</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
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<Affiliation>Cardiac Investigation Unit, St. Vincents Hospital, Fitzroy, Australia.</Affiliation>
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<LastName>Meredith</LastName>
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<Initials>I</Initials>
<AffiliationInfo>
<Affiliation>Department of Medicine, Cardiology, Monash Cardiovascular Research Centre, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Garcia-Garcia</LastName>
<ForeName>Hector M</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, Cardialysis, Rotterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Veldhof</LastName>
<ForeName>Susan</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Clinical Research, Abbott Vascular, Diegem, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Rapoza</LastName>
<ForeName>Richard</ForeName>
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<Author ValidYN="Y">
<LastName>Ormiston</LastName>
<ForeName>John A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo>
<Affiliation>Department of Interventional Cardiology, Auckland City Hospital, Auckland, New Zealand.</Affiliation>
</AffiliationInfo>
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<Keyword MajorTopicYN="N">atherosclerosis</Keyword>
<Keyword MajorTopicYN="N">biodegradable polymer</Keyword>
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