Differences in Muscle Transcriptome among Pigs Phenotypically Extreme for Fatty Acid Composition
Identifieur interne : 001B18 ( Ncbi/Merge ); précédent : 001B17; suivant : 001B19Differences in Muscle Transcriptome among Pigs Phenotypically Extreme for Fatty Acid Composition
Auteurs : Anna Puig-Oliveras [Espagne] ; Yuliaxis Ramayo-Caldas [France] ; Jordi Corominas [Espagne] ; Jordi Estellé [France] ; Dafne Pérez-Montarelo [Espagne] ; Nicholas J. Hudson [Australie] ; Joaquim Casellas [Espagne] ; Josep M. Folch [Espagne] ; Maria Ballester [Espagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Transcriptome.
- métabolisme : Acides gras, Muscles squelettiques.
- Analyse de profil d'expression de gènes, Animaux, Femelle, Suidae, Sus scrofa.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Fatty Acids.
- genetics : Transcriptome.
- metabolism : Muscle, Skeletal.
- Animals, Female, Gene Expression Profiling, Sus scrofa, Swine.
Abstract
Besides having an impact on human health, the porcine muscle fatty acid profile determines meat quality and taste. The RNA-Seq technologies allowed us to explore the pig muscle transcriptome with an unprecedented detail. The aim of this study was to identify differentially-expressed genes between two groups of 6 sows belonging to an Iberian × Landrace backcross with extreme phenotypes according to FA profile.
We sequenced the muscle transcriptome acquiring 787.5 M of 75 bp paired-end reads. About 85.1% of reads were mapped to the reference genome. Of the total reads, 79.1% were located in exons, 6.0% in introns and 14.9% in intergenic regions, indicating expressed regions not annotated in the reference genome. We identified a 34.5% of the intergenic regions as interspersed repetitive regions. We predicted a total of 2,372 putative proteins. Pathway analysis with 131 differentially-expressed genes revealed that the most statistically-significant metabolic pathways were related with lipid metabolism. Moreover, 18 of the differentially-expressed genes were located in genomic regions associated with IMF composition in an independent GWAS study in the same genetic background. Thus, our results indicate that the lipid metabolism of FAs is differently modulated when the FA composition in muscle differs. For instance, a high content of PUFA may reduce FA and glucose uptake resulting in an inhibition of the lipogenesis. These results are consistent with previous studies of our group analysing the liver and the adipose tissue transcriptomes providing a view of each of the main organs involved in lipid metabolism.
The results obtained in the muscle transcriptome analysis increase the knowledge of the gene regulation of IMF deposition, FA profile and meat quality, in terms of taste and nutritional value. Besides, our results may be important in terms of human health.
Url:
DOI: 10.1371/journal.pone.0099720
PubMed: 24926690
PubMed Central: 4057286
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PMC:4057286Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differences in Muscle Transcriptome among Pigs Phenotypically Extreme for Fatty Acid Composition</title>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ballester, Maria" sort="Ballester, Maria" uniqKey="Ballester M" first="Maria" last="Ballester">Maria Ballester</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra</wicri:regionArea>
<wicri:noRegion>Bellaterra</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Fatty Acids (metabolism)</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Muscle, Skeletal (metabolism)</term>
<term>Sus scrofa</term>
<term>Swine</term>
<term>Transcriptome (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras (métabolisme)</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Muscles squelettiques (métabolisme)</term>
<term>Suidae</term>
<term>Sus scrofa</term>
<term>Transcriptome (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fatty Acids</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Transcriptome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Transcriptome</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acides gras</term>
<term>Muscles squelettiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Sus scrofa</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Suidae</term>
<term>Sus scrofa</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Besides having an impact on human health, the porcine muscle fatty acid profile determines meat quality and taste. The RNA-Seq technologies allowed us to explore the pig muscle transcriptome with an unprecedented detail. The aim of this study was to identify differentially-expressed genes between two groups of 6 sows belonging to an Iberian × Landrace backcross with extreme phenotypes according to FA profile.</p>
</sec>
<sec><title>Results</title>
<p>We sequenced the muscle transcriptome acquiring 787.5 M of 75 bp paired-end reads. About 85.1% of reads were mapped to the reference genome. Of the total reads, 79.1% were located in exons, 6.0% in introns and 14.9% in intergenic regions, indicating expressed regions not annotated in the reference genome. We identified a 34.5% of the intergenic regions as interspersed repetitive regions. We predicted a total of 2,372 putative proteins. Pathway analysis with 131 differentially-expressed genes revealed that the most statistically-significant metabolic pathways were related with lipid metabolism. Moreover, 18 of the differentially-expressed genes were located in genomic regions associated with IMF composition in an independent GWAS study in the same genetic background. Thus, our results indicate that the lipid metabolism of FAs is differently modulated when the FA composition in muscle differs. For instance, a high content of PUFA may reduce FA and glucose uptake resulting in an inhibition of the lipogenesis. These results are consistent with previous studies of our group analysing the liver and the adipose tissue transcriptomes providing a view of each of the main organs involved in lipid metabolism.</p>
</sec>
<sec><title>Conclusions</title>
<p>The results obtained in the muscle transcriptome analysis increase the knowledge of the gene regulation of IMF deposition, FA profile and meat quality, in terms of taste and nutritional value. Besides, our results may be important in terms of human health.</p>
</sec>
</div>
</front>
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<country xml:lang="fr">Espagne</country>
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<country xml:lang="fr">Espagne</country>
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<country xml:lang="fr">Espagne</country>
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<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
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</author>
<author><name sortKey="Ballester, Maria" sort="Ballester, Maria" uniqKey="Ballester M" first="Maria" last="Ballester">Maria Ballester</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra</wicri:regionArea>
<wicri:noRegion>Bellaterra</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
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<idno type="pmid">24926690</idno>
<idno type="pmc">4057286</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057286</idno>
<idno type="RBID">PMC:4057286</idno>
<idno type="doi">10.1371/journal.pone.0099720</idno>
<date when="2014">2014</date>
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<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001645</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differences in Muscle Transcriptome among Pigs Phenotypically Extreme for Fatty Acid Composition</title>
<author><name sortKey="Puig Oliveras, Anna" sort="Puig Oliveras, Anna" uniqKey="Puig Oliveras A" first="Anna" last="Puig-Oliveras">Anna Puig-Oliveras</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra</wicri:regionArea>
<wicri:noRegion>Bellaterra</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramayo Caldas, Yuliaxis" sort="Ramayo Caldas, Yuliaxis" uniqKey="Ramayo Caldas Y" first="Yuliaxis" last="Ramayo-Caldas">Yuliaxis Ramayo-Caldas</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Génétique Animale et Biologie Intégrative UMR1313 (GABI), Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Génétique Animale et Biologie Intégrative UMR1313 (GABI), Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Corominas, Jordi" sort="Corominas, Jordi" uniqKey="Corominas J" first="Jordi" last="Corominas">Jordi Corominas</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra</wicri:regionArea>
<wicri:noRegion>Bellaterra</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Estelle, Jordi" sort="Estelle, Jordi" uniqKey="Estelle J" first="Jordi" last="Estellé">Jordi Estellé</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Génétique Animale et Biologie Intégrative UMR1313 (GABI), Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Génétique Animale et Biologie Intégrative UMR1313 (GABI), Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Génétique Animale et Biologie Intégrative UMR1313 (GABI), AgroParisTech, Jouy-en-Josas, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Génétique Animale et Biologie Intégrative UMR1313 (GABI), AgroParisTech, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Laboratoire de Radiobiologie et Etude du Génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Jouy-en-Josas, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Radiobiologie et Etude du Génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perez Montarelo, Dafne" sort="Perez Montarelo, Dafne" uniqKey="Perez Montarelo D" first="Dafne" last="Pérez-Montarelo">Dafne Pérez-Montarelo</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Departamento de Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hudson, Nicholas J" sort="Hudson, Nicholas J" uniqKey="Hudson N" first="Nicholas J." last="Hudson">Nicholas J. Hudson</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Computational and Systems Biology, Commonwealth Scientific and Industrial Research Organisation (CSIRO) Animal, Food and Health SciencesQLD, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Computational and Systems Biology, Commonwealth Scientific and Industrial Research Organisation (CSIRO) Animal, Food and Health SciencesQLD, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Casellas, Joaquim" sort="Casellas, Joaquim" uniqKey="Casellas J" first="Joaquim" last="Casellas">Joaquim Casellas</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Departament de Genètica i Millora Animal, Institut de Recerca i Tecnologies Agroalimentàries (IRTA), Lleida, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica i Millora Animal, Institut de Recerca i Tecnologies Agroalimentàries (IRTA), Lleida</wicri:regionArea>
<wicri:noRegion>Lleida</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Folch, Josep M" sort="Folch, Josep M" uniqKey="Folch J" first="Josep M." last="Folch">Josep M. Folch</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra</wicri:regionArea>
<wicri:noRegion>Bellaterra</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ballester, Maria" sort="Ballester, Maria" uniqKey="Ballester M" first="Maria" last="Ballester">Maria Ballester</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra</wicri:regionArea>
<wicri:noRegion>Bellaterra</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Besides having an impact on human health, the porcine muscle fatty acid profile determines meat quality and taste. The RNA-Seq technologies allowed us to explore the pig muscle transcriptome with an unprecedented detail. The aim of this study was to identify differentially-expressed genes between two groups of 6 sows belonging to an Iberian × Landrace backcross with extreme phenotypes according to FA profile.</p>
</sec>
<sec><title>Results</title>
<p>We sequenced the muscle transcriptome acquiring 787.5 M of 75 bp paired-end reads. About 85.1% of reads were mapped to the reference genome. Of the total reads, 79.1% were located in exons, 6.0% in introns and 14.9% in intergenic regions, indicating expressed regions not annotated in the reference genome. We identified a 34.5% of the intergenic regions as interspersed repetitive regions. We predicted a total of 2,372 putative proteins. Pathway analysis with 131 differentially-expressed genes revealed that the most statistically-significant metabolic pathways were related with lipid metabolism. Moreover, 18 of the differentially-expressed genes were located in genomic regions associated with IMF composition in an independent GWAS study in the same genetic background. Thus, our results indicate that the lipid metabolism of FAs is differently modulated when the FA composition in muscle differs. For instance, a high content of PUFA may reduce FA and glucose uptake resulting in an inhibition of the lipogenesis. These results are consistent with previous studies of our group analysing the liver and the adipose tissue transcriptomes providing a view of each of the main organs involved in lipid metabolism.</p>
</sec>
<sec><title>Conclusions</title>
<p>The results obtained in the muscle transcriptome analysis increase the knowledge of the gene regulation of IMF deposition, FA profile and meat quality, in terms of taste and nutritional value. Besides, our results may be important in terms of human health.</p>
</sec>
</div>
</front>
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<orgName type="university">Université autonome de Barcelone</orgName>
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</placeName>
</affiliation>
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<placeName><settlement type="city">Barcelone</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Folch, Josep M" sort="Folch, Josep M" uniqKey="Folch J" first="Josep M" last="Folch">Josep M. Folch</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain; Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
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</author>
<author><name sortKey="Ballester, Maria" sort="Ballester, Maria" uniqKey="Ballester M" first="Maria" last="Ballester">Maria Ballester</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain; Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
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<author><name sortKey="Ramayo Caldas, Yuliaxis" sort="Ramayo Caldas, Yuliaxis" uniqKey="Ramayo Caldas Y" first="Yuliaxis" last="Ramayo-Caldas">Yuliaxis Ramayo-Caldas</name>
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<author><name sortKey="Corominas, Jordi" sort="Corominas, Jordi" uniqKey="Corominas J" first="Jordi" last="Corominas">Jordi Corominas</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain; Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
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<author><name sortKey="Estelle, Jordi" sort="Estelle, Jordi" uniqKey="Estelle J" first="Jordi" last="Estellé">Jordi Estellé</name>
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<author><name sortKey="Perez Montarelo, Dafne" sort="Perez Montarelo, Dafne" uniqKey="Perez Montarelo D" first="Dafne" last="Pérez-Montarelo">Dafne Pérez-Montarelo</name>
<affiliation wicri:level="3"><nlm:affiliation>Departamento de Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Hudson, Nicholas J" sort="Hudson, Nicholas J" uniqKey="Hudson N" first="Nicholas J" last="Hudson">Nicholas J. Hudson</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational and Systems Biology, Commonwealth Scientific and Industrial Research Organisation (CSIRO) Animal, Food and Health SciencesQLD, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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</author>
<author><name sortKey="Casellas, Joaquim" sort="Casellas, Joaquim" uniqKey="Casellas J" first="Joaquim" last="Casellas">Joaquim Casellas</name>
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<country xml:lang="fr">Espagne</country>
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<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Folch, Josep M" sort="Folch, Josep M" uniqKey="Folch J" first="Josep M" last="Folch">Josep M. Folch</name>
<affiliation wicri:level="4"><nlm:affiliation>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain; Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Genètica Animal, Centre de Recerca en Agrigenòmica (CRAG), Bellaterra, Spain; Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona (UAB), Bellaterra</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ballester, Maria" sort="Ballester, Maria" uniqKey="Ballester M" first="Maria" last="Ballester">Maria Ballester</name>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Fatty Acids (metabolism)</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Muscle, Skeletal (metabolism)</term>
<term>Sus scrofa</term>
<term>Swine</term>
<term>Transcriptome (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras (métabolisme)</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Muscles squelettiques (métabolisme)</term>
<term>Suidae</term>
<term>Sus scrofa</term>
<term>Transcriptome (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fatty Acids</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Transcriptome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Transcriptome</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acides gras</term>
<term>Muscles squelettiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Sus scrofa</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Suidae</term>
<term>Sus scrofa</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Besides having an impact on human health, the porcine muscle fatty acid profile determines meat quality and taste. The RNA-Seq technologies allowed us to explore the pig muscle transcriptome with an unprecedented detail. The aim of this study was to identify differentially-expressed genes between two groups of 6 sows belonging to an Iberian × Landrace backcross with extreme phenotypes according to FA profile.</div>
</front>
</TEI>
</pubmed>
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