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Harmonization of measurement results of the alcohol biomarker carbohydrate-deficient transferrin by use of the toolbox of technical procedures of the International Consortium for Harmonization of Clinical Laboratory Results.

Identifieur interne : 001925 ( Ncbi/Merge ); précédent : 001924; suivant : 001926

Harmonization of measurement results of the alcohol biomarker carbohydrate-deficient transferrin by use of the toolbox of technical procedures of the International Consortium for Harmonization of Clinical Laboratory Results.

Auteurs : Cas Weykamp [Pays-Bas] ; Jos Wielders [Pays-Bas] ; Anders Helander [Suède] ; Raymond F. Anton [États-Unis] ; Vincenza Bianchi [Italie] ; Jan-Olof Jeppsson [Suède] ; Carla Siebelder [Pays-Bas] ; John B. Whitfield [Australie] ; François Schellenberg [France]

Source :

RBID : pubmed:24691685

Descripteurs français

English descriptors

Abstract

The need for equivalent results of routine measurement procedures for the alcohol biomarker carbohydrate-deficient transferrin (CDT) has been recognized by the IFCC. This article describes a project to harmonize CDT as conducted by an IFCC working group initiated for this purpose.

DOI: 10.1373/clinchem.2014.221531
PubMed: 24691685

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pubmed:24691685

Le document en format XML

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<div type="abstract" xml:lang="en">The need for equivalent results of routine measurement procedures for the alcohol biomarker carbohydrate-deficient transferrin (CDT) has been recognized by the IFCC. This article describes a project to harmonize CDT as conducted by an IFCC working group initiated for this purpose.</div>
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<Day>28</Day>
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<Month>08</Month>
<Day>14</Day>
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<Day>19</Day>
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<ISSN IssnType="Electronic">1530-8561</ISSN>
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<Volume>60</Volume>
<Issue>7</Issue>
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<Year>2014</Year>
<Month>Jul</Month>
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<Title>Clinical chemistry</Title>
<ISOAbbreviation>Clin. Chem.</ISOAbbreviation>
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<ArticleTitle>Harmonization of measurement results of the alcohol biomarker carbohydrate-deficient transferrin by use of the toolbox of technical procedures of the International Consortium for Harmonization of Clinical Laboratory Results.</ArticleTitle>
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<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The need for equivalent results of routine measurement procedures for the alcohol biomarker carbohydrate-deficient transferrin (CDT) has been recognized by the IFCC. This article describes a project to harmonize CDT as conducted by an IFCC working group initiated for this purpose.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used procedures for achieving harmonization as developed by the Consortium for Harmonization of Clinical Laboratory Results to assess the suitability of a candidate reference measurement procedure (cRMP), candidate reference materials (cRMs), and the success of efforts to achieve harmonization.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">CDT measurement procedures in routine use showed good reproducibility (CV 1.1%-2.8%) and linearity (r > 0.990) with variable slopes (0.766-1.065) and intercepts (-0.34 to 0.92) compared to the cRMP. Heterogeneity after simulated harmonization was 4.7%. cRMs of frozen human native sera demonstrated commutability and 3-year stability for routine measurement procedures. The cRMP provided reproducible value assignment to cRMs with an expanded uncertainty (k = 2) of 0.03% at the 1.2% CDT level and 0.06% at the 4.4% CDT level. Harmonization efforts reduced the intermeasurement CV from 8.8% to 3.4%, allowed 99% recovery of the values assigned with the cRMP, and demonstrated 99% of results within the desirable allowable total error. Harmonization was less successful in samples with low CDT and high trisialotransferrin concentrations.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Harmonization of CDT is possible with frozen human native sera as cRMs with values assigned by use of the cRMP. We propose the cRMP as a candidate international conventional reference measurement procedure and cRMs as candidate international calibrators.</AbstractText>
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<LastName>Weykamp</LastName>
<ForeName>Cas</ForeName>
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<Affiliation>Department of Clinical Chemistry, Queen Beatrix Hospital, Winterswijk, the Netherlands; c.w.weykamp@skbwinterswijk.nl.</Affiliation>
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<Affiliation>Department of Clinical Chemistry, Meander Medical Center, Amersfoort, the Netherlands;</Affiliation>
</AffiliationInfo>
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<Affiliation>Department of Laboratory Medicine, Karolinska Institutet, and Karolinska University Laboratory, Clinical Chemistry, Stockholm, Sweden;</Affiliation>
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<LastName>Anton</LastName>
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</AffiliationInfo>
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<LastName>Bianchi</LastName>
<ForeName>Vincenza</ForeName>
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<Affiliation>Toxicology Reference Laboratory, SS. Antonio e Biagio Hospital, Alessandria, Italy;</Affiliation>
</AffiliationInfo>
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<LastName>Jeppsson</LastName>
<ForeName>Jan-Olof</ForeName>
<Initials>JO</Initials>
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<Affiliation>Department of Laboratory Medicine, Malmö University Hospital, Malmö, Sweden;</Affiliation>
</AffiliationInfo>
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<LastName>Siebelder</LastName>
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<Affiliation>Department of Clinical Chemistry, Queen Beatrix Hospital, Winterswijk, the Netherlands;</Affiliation>
</AffiliationInfo>
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<Affiliation>Queensland Institute of Medical Research, Brisbane, Australia;</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Schellenberg</LastName>
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<Initials>F</Initials>
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<Affiliation>Laboratoire de Biochimie, Hôpital Trousseau, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
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<CollectiveName>IFCC Working Group on Standardization of Carbohydrate-Deficient Transferrin</CollectiveName>
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<Language>eng</Language>
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<Grant>
<GrantID>K05 AA 17435</GrantID>
<Acronym>AA</Acronym>
<Agency>NIAAA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
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<Year>2014</Year>
<Month>04</Month>
<Day>01</Day>
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<Country>United States</Country>
<MedlineTA>Clin Chem</MedlineTA>
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<ISSNLinking>0009-9147</ISSNLinking>
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<ChemicalList>
<Chemical>
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<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
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<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014168">Transferrin</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C056759">carbohydrate-deficient transferrin</NameOfSubstance>
</Chemical>
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<CitationSubset>IM</CitationSubset>
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<CommentsCorrections RefType="CommentIn">
<RefSource>Clin Chem. 2014 Jul;60(7):911-3</RefSource>
<PMID Version="1">24799526</PMID>
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<CommentsCorrections RefType="CommentIn">
<RefSource>Clin Chem. 2014 Oct;60(10):1347-8</RefSource>
<PMID Version="1">25125347</PMID>
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<MeshHeading>
<DescriptorName UI="D000428" MajorTopicYN="N">Alcohol Drinking</DescriptorName>
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