Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)
Identifieur interne : 001431 ( Ncbi/Merge ); précédent : 001430; suivant : 001432Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)
Auteurs : C. Bosetti ; E. Lucenteforte [Italie] ; P. M. Bracci [États-Unis] ; E. Negri ; R. E. Neale [Australie] ; H. A. Risch ; S. H. Olson [États-Unis] ; S. Gallinger ; A. B. Miller [Canada] ; H. B. Bueno-De-Mesquita [Pays-Bas] ; R. Talamini [Italie] ; J. Polesel [Italie] ; P. Ghadirian [Canada] ; P. A. Baghurst [Australie] ; W. Zatonski [Pologne] ; E. Fontham [États-Unis] ; E. A. Holly [États-Unis] ; Y. T. Gao [République populaire de Chine] ; H. Yu [États-Unis] ; R. C. Kurtz [États-Unis] ; M. Cotterchio [Canada] ; P. Maisonneuve [Italie] ; M. P. Zeegers [Pays-Bas] ; E. J. Duell [Espagne] ; P. Boffetta [États-Unis, France] ; C. La Vecchia [Italie]Source :
- Annals of Oncology [ 0923-7534 ] ; 2013.
Abstract
Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent.
We pooled 10 case–control studies within the Pancreatic Cancer Case–control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models.
The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98–1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15–2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82–20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors.
This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.
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DOI: 10.1093/annonc/mdt336
PubMed: 23970016
PubMed Central: 3811904
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af2"><addr-line>Department of Preclinical and Clinical Pharmacology ‘Mario Aiazzi Mancini’</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af4"><addr-line>Cancer and Population Studies Group</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Risch, H A" sort="Risch, H A" uniqKey="Risch H" first="H. A." last="Risch">H. A. Risch</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="mdt336_af7"><institution>Toronto General Hospital</institution>,<addr-line>Toronto</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdt336_af9"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af10"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af12"><addr-line>Epidemiology Research Unit</addr-line>,<institution>Research Centre (CRCHUM)</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af13"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide SA</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af14"><institution>Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af15"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af16"><institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, H" sort="Yu, H" uniqKey="Yu H" first="H." last="Yu">H. Yu</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af17"><addr-line>Cancer Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af18"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af19"><institution>European Institute of Oncology</institution>,<addr-line>Milano</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeegers, M P" sort="Zeegers, M P" uniqKey="Zeegers M" first="M. P." last="Zeegers">M. P. Zeegers</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af20"><addr-line>Unit of Complex Genetics, Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism</addr-line>,<institution>Maastricht University Medical Centre</institution>,<addr-line>Maastricht</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af21"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af22"><addr-line>The Tisch Cancer Institute and Institute for Translational Epidemiology</addr-line>,<institution>Mount Sinai School of Medicine</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af23"><institution>International Prevention Research Institute</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af24"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>University of Milan</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23970016</idno><idno type="pmc">3811904</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811904</idno><idno type="RBID">PMC:3811904</idno><idno type="doi">10.1093/annonc/mdt336</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001737</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001737</idno><idno type="wicri:Area/Pmc/Curation">001597</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001597</idno><idno type="wicri:Area/Pmc/Checkpoint">001814</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001814</idno><idno type="wicri:Area/Ncbi/Merge">001431</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af2"><addr-line>Department of Preclinical and Clinical Pharmacology ‘Mario Aiazzi Mancini’</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af4"><addr-line>Cancer and Population Studies Group</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Risch, H A" sort="Risch, H A" uniqKey="Risch H" first="H. A." last="Risch">H. A. Risch</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="mdt336_af7"><institution>Toronto General Hospital</institution>,<addr-line>Toronto</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdt336_af9"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af10"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af12"><addr-line>Epidemiology Research Unit</addr-line>,<institution>Research Centre (CRCHUM)</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af13"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide SA</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af14"><institution>Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af15"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af16"><institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, H" sort="Yu, H" uniqKey="Yu H" first="H." last="Yu">H. Yu</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af17"><addr-line>Cancer Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af18"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af19"><institution>European Institute of Oncology</institution>,<addr-line>Milano</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeegers, M P" sort="Zeegers, M P" uniqKey="Zeegers M" first="M. P." last="Zeegers">M. P. Zeegers</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af20"><addr-line>Unit of Complex Genetics, Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism</addr-line>,<institution>Maastricht University Medical Centre</institution>,<addr-line>Maastricht</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af21"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation wicri:level="1"><nlm:aff id="mdt336_af22"><addr-line>The Tisch Cancer Institute and Institute for Translational Epidemiology</addr-line>,<institution>Mount Sinai School of Medicine</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af23"><institution>International Prevention Research Institute</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdt336_af24"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>University of Milan</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent.</p></sec><sec><title>Methods</title><p>We pooled 10 case–control studies within the Pancreatic Cancer Case–control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models.</p></sec><sec><title>Results</title><p>The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98–1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15–2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82–20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors.</p></sec><sec><title>Conclusions</title><p>This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Oncol</journal-id><journal-id journal-id-type="publisher-id">annonc</journal-id><journal-id journal-id-type="hwp">annonc</journal-id><journal-title-group><journal-title>Annals of Oncology</journal-title></journal-title-group><issn pub-type="ppub">0923-7534</issn><issn pub-type="epub">1569-8041</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23970016</article-id><article-id pub-id-type="pmc">3811904</article-id><article-id pub-id-type="doi">10.1093/annonc/mdt336</article-id><article-id pub-id-type="publisher-id">mdt336</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject><subj-group subj-group-type="heading"><subject>Epidemiology</subject></subj-group></subj-group></article-categories><title-group><article-title>Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bosetti</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="mdt336_af1">1</xref><xref ref-type="corresp" rid="mdt336_cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lucenteforte</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdt336_af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bracci</surname><given-names>P. M.</given-names></name><xref ref-type="aff" rid="mdt336_af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Negri</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdt336_af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Neale</surname><given-names>R. E.</given-names></name><xref ref-type="aff" rid="mdt336_af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Risch</surname><given-names>H. A.</given-names></name><xref ref-type="aff" rid="mdt336_af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>S. H.</given-names></name><xref ref-type="aff" rid="mdt336_af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gallinger</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="mdt336_af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>A. B.</given-names></name><xref ref-type="aff" rid="mdt336_af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H. B.</given-names></name><xref ref-type="aff" rid="mdt336_af9">9</xref><xref ref-type="aff" rid="mdt336_af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Talamini</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="mdt336_af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Polesel</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="mdt336_af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Ghadirian</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdt336_af12">12</xref></contrib><contrib contrib-type="author"><name><surname>Baghurst</surname><given-names>P. A.</given-names></name><xref ref-type="aff" rid="mdt336_af13">13</xref></contrib><contrib contrib-type="author"><name><surname>Zatonski</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="mdt336_af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Fontham</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdt336_af15">15</xref></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>E. A.</given-names></name><xref ref-type="aff" rid="mdt336_af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Y. T.</given-names></name><xref ref-type="aff" rid="mdt336_af16">16</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="mdt336_af5">5</xref><xref ref-type="aff" rid="mdt336_af17">17</xref></contrib><contrib contrib-type="author"><name><surname>Kurtz</surname><given-names>R. C.</given-names></name><xref ref-type="aff" rid="mdt336_af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Cotterchio</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="mdt336_af8">8</xref><xref ref-type="aff" rid="mdt336_af18">18</xref></contrib><contrib contrib-type="author"><name><surname>Maisonneuve</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdt336_af19">19</xref></contrib><contrib contrib-type="author"><name><surname>Zeegers</surname><given-names>M. P.</given-names></name><xref ref-type="aff" rid="mdt336_af20">20</xref></contrib><contrib contrib-type="author"><name><surname>Duell</surname><given-names>E. J.</given-names></name><xref ref-type="aff" rid="mdt336_af21">21</xref></contrib><contrib contrib-type="author"><name><surname>Boffetta</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdt336_af22">22</xref><xref ref-type="aff" rid="mdt336_af23">23</xref></contrib><contrib contrib-type="author"><name><surname>La Vecchia</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="mdt336_af1">1</xref><xref ref-type="aff" rid="mdt336_af24">24</xref></contrib></contrib-group><aff id="mdt336_af1"><label>1</label><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></aff><aff id="mdt336_af2"><label>2</label><addr-line>Department of Preclinical and Clinical Pharmacology ‘Mario Aiazzi Mancini’</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></aff><aff id="mdt336_af3"><label>3</label><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></aff><aff id="mdt336_af4"><label>4</label><addr-line>Cancer and Population Studies Group</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></aff><aff id="mdt336_af5"><label>5</label><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></aff><aff id="mdt336_af6"><label>6</label><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></aff><aff id="mdt336_af7"><label>7</label><institution>Toronto General Hospital</institution>,<addr-line>Toronto</addr-line></aff><aff id="mdt336_af8"><label>8</label><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></aff><aff id="mdt336_af9"><label>9</label><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></aff><aff id="mdt336_af10"><label>10</label><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></aff><aff id="mdt336_af11"><label>11</label><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></aff><aff id="mdt336_af12"><label>12</label><addr-line>Epidemiology Research Unit</addr-line>,<institution>Research Centre (CRCHUM)</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></aff><aff id="mdt336_af13"><label>13</label><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide SA</addr-line>,<country>Australia</country></aff><aff id="mdt336_af14"><label>14</label><institution>Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></aff><aff id="mdt336_af15"><label>15</label><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></aff><aff id="mdt336_af16"><label>16</label><institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></aff><aff id="mdt336_af17"><label>17</label><addr-line>Cancer Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country></aff><aff id="mdt336_af18"><label>18</label><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></aff><aff id="mdt336_af19"><label>19</label><institution>European Institute of Oncology</institution>,<addr-line>Milano</addr-line>,<country>Italy</country></aff><aff id="mdt336_af20"><label>20</label><addr-line>Unit of Complex Genetics, Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism</addr-line>,<institution>Maastricht University Medical Centre</institution>,<addr-line>Maastricht</addr-line>,<country>The Netherlands</country></aff><aff id="mdt336_af21"><label>21</label><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></aff><aff id="mdt336_af22"><label>22</label><addr-line>The Tisch Cancer Institute and Institute for Translational Epidemiology</addr-line>,<institution>Mount Sinai School of Medicine</institution>,<addr-line>New York</addr-line>,<country>USA</country></aff><aff id="mdt336_af23"><label>23</label><institution>International Prevention Research Institute</institution>,<addr-line>Lyon</addr-line>,<country>France</country></aff><aff id="mdt336_af24"><label>24</label><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>University of Milan</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff><author-notes><corresp id="mdt336_cor1"><label>*</label><italic>Correspondence to:</italic> Dr Cristina Bosetti, Department of Epidemiology, IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via La Masa 19-2056 Milan, Italy. Tel: +39-02-39014-526; Fax: +39-02-3320-0231; E-mail: <email>cristina.bosetti@marionegri.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>24</volume><issue>11</issue><fpage>2903</fpage><lpage>2910</lpage><history><date date-type="received"><day>21</day><month>12</month><year>2012</year></date><date date-type="rev-recd"><day>5</day><month>7</month><year>2013</year></date><date date-type="accepted"><day>8</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>© The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="mdt336.pdf"></self-uri><abstract><sec><title>Background</title><p>Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent.</p></sec><sec><title>Methods</title><p>We pooled 10 case–control studies within the Pancreatic Cancer Case–control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models.</p></sec><sec><title>Results</title><p>The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98–1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15–2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82–20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors.</p></sec><sec><title>Conclusions</title><p>This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.</p></sec></abstract><kwd-group><kwd>anti-ulcer drugs</kwd><kwd>case–control study</kwd><kwd>gastrectomy</kwd><kwd>pancreatic cancer</kwd><kwd>peptic ulcer</kwd><kwd>pooled analysis</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><name sortKey="Risch, H A" sort="Risch, H A" uniqKey="Risch H" first="H. A." last="Risch">H. A. Risch</name></noCountry><country name="Italie"><noRegion><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name></noRegion><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name></country><country name="États-Unis"><noRegion><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name></noRegion><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><name sortKey="Yu, H" sort="Yu, H" uniqKey="Yu H" first="H." last="Yu">H. Yu</name></country><country name="Australie"><noRegion><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name></noRegion><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name></country><country name="Canada"><noRegion><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name></noRegion><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name></country><country name="Pays-Bas"><noRegion><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name></noRegion><name sortKey="Zeegers, M P" sort="Zeegers, M P" uniqKey="Zeegers M" first="M. P." last="Zeegers">M. P. Zeegers</name></country><country name="Pologne"><noRegion><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name></noRegion></country><country name="France"><noRegion><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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