The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss
Identifieur interne : 001142 ( Ncbi/Merge ); précédent : 001141; suivant : 001143The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss
Auteurs : Lyndon Da Cruz [Royaume-Uni] ; Brian F. Coley [Suisse] ; Jessy Dorn [États-Unis] ; Francesco Merlini [Suisse] ; Eugene Filley [États-Unis] ; Punita Christopher [États-Unis] ; Fred K. Chen [Royaume-Uni] ; Varalakshmi Wuyyuru [États-Unis] ; Jose Sahel [France] ; Paulo Stanga [Royaume-Uni] ; Mark Humayun [États-Unis] ; Robert J. Greenberg [États-Unis] ; Gislin Dagnelie [États-Unis]Source :
- The British Journal of Ophthalmology [ 0007-1161 ] ; 2013.
Abstract
Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life.
We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out.
The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months.
Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.
Url:
DOI: 10.1136/bjophthalmol-2012-301525
PubMed: 23426738
PubMed Central: 3632967
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Coley</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dorn, Jessy" sort="Dorn, Jessy" uniqKey="Dorn J" first="Jessy" last="Dorn">Jessy Dorn</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Sylmar, California</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Merlini, Francesco" sort="Merlini, Francesco" uniqKey="Merlini F" first="Francesco" last="Merlini">Francesco Merlini</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Filley, Eugene" sort="Filley, Eugene" uniqKey="Filley E" first="Eugene" last="Filley">Eugene Filley</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Retina Foundation of the Southwest</institution>,<addr-line>Dallas</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Christopher, Punita" sort="Christopher, Punita" uniqKey="Christopher P" first="Punita" last="Christopher">Punita Christopher</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Sylmar, California</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Fred K" sort="Chen, Fred K" uniqKey="Chen F" first="Fred K" last="Chen">Fred K. Chen</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>NIHR Biomedical Research Centre for Ophthalmology</institution>,<institution>Moorfields Eye Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af5"><institution>Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia</institution>,<addr-line>Nedlands</addr-line>,<country>Western Australia</country></nlm:aff><wicri:noCountry code="nlm country">Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Wuyyuru, Varalakshmi" sort="Wuyyuru, Varalakshmi" uniqKey="Wuyyuru V" first="Varalakshmi" last="Wuyyuru">Varalakshmi Wuyyuru</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Sylmar, California</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sahel, Jose" sort="Sahel, Jose" uniqKey="Sahel J" first="Jose" last="Sahel">Jose Sahel</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stanga, Paulo" sort="Stanga, Paulo" uniqKey="Stanga P" first="Paulo" last="Stanga">Paulo Stanga</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Manchester Biomedical Research Centre, Manchester Royal Eye Hospital, University of Manchester</institution>,<addr-line>Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Humayun, Mark" sort="Humayun, Mark" uniqKey="Humayun M" first="Mark" last="Humayun">Mark Humayun</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Sylmar, California</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af8"><institution>Doheny Eye Institute</institution>,<addr-line>Los Angeles, California</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greenberg, Robert J" sort="Greenberg, Robert J" uniqKey="Greenberg R" first="Robert J" last="Greenberg">Robert J. Greenberg</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Sylmar, California</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dagnelie, Gislin" sort="Dagnelie, Gislin" uniqKey="Dagnelie G" first="Gislin" last="Dagnelie">Gislin Dagnelie</name><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Johns Hopkins Hospital, Lions Vision Center</institution>,<addr-line>Baltimore, Maryland</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">The British Journal of Ophthalmology</title><idno type="ISSN">0007-1161</idno><idno type="eISSN">1468-2079</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life.</p></sec><sec><title>Methods</title><p>We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out.</p></sec><sec><title>Results</title><p>The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months.</p></sec><sec><title>Conclusions</title><p>Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zrenner, E" uniqKey="Zrenner E">E Zrenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rizzo, Jf" uniqKey="Rizzo J">JF Rizzo</name></author><author><name sortKey="O Malley, Er" uniqKey="O Malley E">ER O'Malley</name></author><author><name sortKey="Hessburg, Pc" uniqKey="Hessburg P">PC Hessburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiland, Jd" uniqKey="Weiland J">JD Weiland</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Humayun, Ms" uniqKey="Humayun M">MS Humayun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zrenner, E" uniqKey="Zrenner E">E 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Fujii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenberg, Rj" uniqKey="Greenberg R">RJ Greenberg</name></author><author><name sortKey="Velte, Tj" uniqKey="Velte T">TJ Velte</name></author><author><name sortKey="Humayun, Ms" uniqKey="Humayun M">MS Humayun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caspi, A" uniqKey="Caspi A">A Caspi</name></author><author><name sortKey="Dorn, Jd" uniqKey="Dorn J">JD Dorn</name></author><author><name sortKey="Mcclure, Kh" uniqKey="Mcclure K">KH McClure</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Ophthalmol</journal-id><journal-id journal-id-type="iso-abbrev">Br J Ophthalmol</journal-id><journal-id journal-id-type="publisher-id">bjo</journal-id><journal-id journal-id-type="hwp">bjophthalmol</journal-id><journal-title-group><journal-title>The British Journal of Ophthalmology</journal-title></journal-title-group><issn pub-type="ppub">0007-1161</issn><issn pub-type="epub">1468-2079</issn><publisher><publisher-name>BMJ Publishing Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23426738</article-id><article-id pub-id-type="pmc">3632967</article-id><article-id pub-id-type="publisher-id">bjophthalmol-2012-301525</article-id><article-id pub-id-type="doi">10.1136/bjophthalmol-2012-301525</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject></subj-group><subj-group subj-group-type="heading"><subject>Clinical Science</subject></subj-group></article-categories><title-group><article-title>The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>da Cruz</surname><given-names>Lyndon</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Coley</surname><given-names>Brian F</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dorn</surname><given-names>Jessy</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Merlini</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Filley</surname><given-names>Eugene</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Christopher</surname><given-names>Punita</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Fred K</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Wuyyuru</surname><given-names>Varalakshmi</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Sahel</surname><given-names>Jose</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Stanga</surname><given-names>Paulo</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Humayun</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Greenberg</surname><given-names>Robert J</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Dagnelie</surname><given-names>Gislin</given-names></name><xref ref-type="aff" rid="af9">9</xref></contrib><contrib contrib-type="author"><collab>for the Argus II Study Group</collab></contrib></contrib-group><aff id="af1"><label>1</label><institution>NIHR Biomedical Research Centre for Ophthalmology</institution>,<institution>Moorfields Eye Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></aff><aff id="af2"><label>2</label><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></aff><aff id="af3"><label>3</label><institution>Second Sight Medical Products, Inc</institution>,<addr-line>Sylmar, California</addr-line>,<country>USA</country></aff><aff id="af4"><label>4</label><institution>Retina Foundation of the Southwest</institution>,<addr-line>Dallas</addr-line>,<country>USA</country></aff><aff id="af5"><label>5</label><institution>Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia</institution>,<addr-line>Nedlands</addr-line>,<country>Western Australia</country></aff><aff id="af6"><label>6</label><institution>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts</institution>,<addr-line>Paris</addr-line>,<country>France</country></aff><aff id="af7"><label>7</label><institution>Manchester Biomedical Research Centre, Manchester Royal Eye Hospital, University of Manchester</institution>,<addr-line>Manchester</addr-line>,<country>UK</country></aff><aff id="af8"><label>8</label><institution>Doheny Eye Institute</institution>,<addr-line>Los Angeles, California</addr-line>,<country>USA</country></aff><aff id="af9"><label>9</label><institution>Johns Hopkins Hospital, Lions Vision Center</institution>,<addr-line>Baltimore, Maryland</addr-line>,<country>USA</country></aff><author-notes><corresp><label>Correspondence to</label> Lyndon da Cruz, NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK; <email>Lyndon.dacruz@moorfields.nhs.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>5</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>20</day><month>2</month><year>2013</year></pub-date><volume>97</volume><issue>5</issue><fpage>632</fpage><lpage>636</lpage><history><date date-type="received"><day>17</day><month>1</month><year>2013</year></date><date date-type="accepted"><day>28</day><month>1</month><year>2013</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link> and <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/legalcode">http://creativecommons.org/licenses/by-nc/3.0/legalcode</ext-link></license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="bjophthalmol-2012-301525.pdf"></self-uri><abstract><sec><title>Background</title><p>Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life.</p></sec><sec><title>Methods</title><p>We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out.</p></sec><sec><title>Results</title><p>The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months.</p></sec><sec><title>Conclusions</title><p>Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>special-feature</meta-name><meta-value>unlocked</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>France</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Da Cruz, Lyndon" sort="Da Cruz, Lyndon" uniqKey="Da Cruz L" first="Lyndon" last="Da Cruz">Lyndon Da Cruz</name></noRegion><name sortKey="Chen, Fred K" sort="Chen, Fred K" uniqKey="Chen F" first="Fred K" last="Chen">Fred K. Chen</name><name sortKey="Stanga, Paulo" sort="Stanga, Paulo" uniqKey="Stanga P" first="Paulo" last="Stanga">Paulo Stanga</name></country><country name="Suisse"><noRegion><name sortKey="Coley, Brian F" sort="Coley, Brian F" uniqKey="Coley B" first="Brian F" last="Coley">Brian F. Coley</name></noRegion><name sortKey="Merlini, Francesco" sort="Merlini, Francesco" uniqKey="Merlini F" first="Francesco" last="Merlini">Francesco Merlini</name></country><country name="États-Unis"><noRegion><name sortKey="Dorn, Jessy" sort="Dorn, Jessy" uniqKey="Dorn J" first="Jessy" last="Dorn">Jessy Dorn</name></noRegion><name sortKey="Christopher, Punita" sort="Christopher, Punita" uniqKey="Christopher P" first="Punita" last="Christopher">Punita Christopher</name><name sortKey="Dagnelie, Gislin" sort="Dagnelie, Gislin" uniqKey="Dagnelie G" first="Gislin" last="Dagnelie">Gislin Dagnelie</name><name sortKey="Filley, Eugene" sort="Filley, Eugene" uniqKey="Filley E" first="Eugene" last="Filley">Eugene Filley</name><name sortKey="Greenberg, Robert J" sort="Greenberg, Robert J" uniqKey="Greenberg R" first="Robert J" last="Greenberg">Robert J. Greenberg</name><name sortKey="Humayun, Mark" sort="Humayun, Mark" uniqKey="Humayun M" first="Mark" last="Humayun">Mark Humayun</name><name sortKey="Humayun, Mark" sort="Humayun, Mark" uniqKey="Humayun M" first="Mark" last="Humayun">Mark Humayun</name><name sortKey="Wuyyuru, Varalakshmi" sort="Wuyyuru, Varalakshmi" uniqKey="Wuyyuru V" first="Varalakshmi" last="Wuyyuru">Varalakshmi Wuyyuru</name></country><country name="France"><noRegion><name sortKey="Sahel, Jose" sort="Sahel, Jose" uniqKey="Sahel J" first="Jose" last="Sahel">Jose Sahel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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