Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models
Identifieur interne : 000F62 ( Ncbi/Merge ); précédent : 000F61; suivant : 000F63Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models
Auteurs : Dana L. Roldan [Argentine] ; Hélène Gilbert [France] ; John M. Henshall [Australie] ; Andrés Legarra [France] ; Jean-Michel Elsen [France]Source :
- Genetics Research [ 0016-6723 ] ; 2012.
Abstract
Recently, a Haley–Knott-type regression method using combined linkage disequilibrium and linkage analyses (LDLA) was proposed to map quantitative trait loci (QTLs). Chromosome of 5 and 25 cM with 0·25 and 0·05 cM, respectively, between markers were simulated. The differences between the LDLA approaches with regard to QTL position accuracy were very limited, with a significantly better mean square error (MSE) with the LDLA regression (LDLA_reg) in sparse map cases; the contrary was observed, but not significantly, in dense map situations. The computing time required for the LDLA variance components (LDLA_vc) model was much higher than the LDLA_reg model. The precision of QTL position estimation was compared for four numbers of half-sib families, four different family sizes and two experimental designs (half-sibs, and full- and half-sibs). Regarding the number of families, MSE values were lowest for 15 or 50 half-sib families, differences not being significant. We observed that the greater the number of progenies per sire, the more accurate the QTL position. However, for a fixed population size, reducing the number of families (e.g. using a small number of large full-sib families) could lead to less accuracy of estimated QTL position.
Url:
DOI: 10.1017/S0016672312000407
PubMed: 22950902
PubMed Central: 3487687
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002544
- to stream Pmc, to step Curation: 002394
- to stream Pmc, to step Checkpoint: 001F44
Links to Exploration step
PMC:3487687Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models</title>
<author><name sortKey="Roldan, Dana L" sort="Roldan, Dana L" uniqKey="Roldan D" first="Dana L" last="Roldan">Dana L. Roldan</name>
<affiliation wicri:level="1"><nlm:aff id="aff001">Instituto de Genética CICVyA-INTA Castelar, cc 1712, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Instituto de Genética CICVyA-INTA Castelar, cc 1712, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gilbert, Helene" sort="Gilbert, Helene" uniqKey="Gilbert H" first="Hélène" last="Gilbert">Hélène Gilbert</name>
<affiliation wicri:level="1"><nlm:aff id="aff002">INRA-Laboratoire de Génétique Cellulaire, Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA-Laboratoire de Génétique Cellulaire, Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex</wicri:regionArea>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Henshall, John M" sort="Henshall, John M" uniqKey="Henshall J" first="John M" last="Henshall">John M. Henshall</name>
<affiliation wicri:level="1"><nlm:aff id="aff003">CSIRO Livestock Industries FD McMaster Laboratory, Armidale, NSW 2350, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>CSIRO Livestock Industries FD McMaster Laboratory, Armidale, NSW 2350</wicri:regionArea>
<wicri:noRegion>NSW 2350</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Legarra, Andres" sort="Legarra, Andres" uniqKey="Legarra A" first="Andrés" last="Legarra">Andrés Legarra</name>
<affiliation wicri:level="1"><nlm:aff id="aff004">INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex</wicri:regionArea>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elsen, Jean Michel" sort="Elsen, Jean Michel" uniqKey="Elsen J" first="Jean-Michel" last="Elsen">Jean-Michel Elsen</name>
<affiliation wicri:level="1"><nlm:aff id="aff004">INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex</wicri:regionArea>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22950902</idno>
<idno type="pmc">3487687</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487687</idno>
<idno type="RBID">PMC:3487687</idno>
<idno type="doi">10.1017/S0016672312000407</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">002544</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002544</idno>
<idno type="wicri:Area/Pmc/Curation">002394</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002394</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001F44</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F44</idno>
<idno type="wicri:Area/Ncbi/Merge">000F62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models</title>
<author><name sortKey="Roldan, Dana L" sort="Roldan, Dana L" uniqKey="Roldan D" first="Dana L" last="Roldan">Dana L. Roldan</name>
<affiliation wicri:level="1"><nlm:aff id="aff001">Instituto de Genética CICVyA-INTA Castelar, cc 1712, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Instituto de Genética CICVyA-INTA Castelar, cc 1712, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gilbert, Helene" sort="Gilbert, Helene" uniqKey="Gilbert H" first="Hélène" last="Gilbert">Hélène Gilbert</name>
<affiliation wicri:level="1"><nlm:aff id="aff002">INRA-Laboratoire de Génétique Cellulaire, Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA-Laboratoire de Génétique Cellulaire, Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex</wicri:regionArea>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Henshall, John M" sort="Henshall, John M" uniqKey="Henshall J" first="John M" last="Henshall">John M. Henshall</name>
<affiliation wicri:level="1"><nlm:aff id="aff003">CSIRO Livestock Industries FD McMaster Laboratory, Armidale, NSW 2350, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>CSIRO Livestock Industries FD McMaster Laboratory, Armidale, NSW 2350</wicri:regionArea>
<wicri:noRegion>NSW 2350</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Legarra, Andres" sort="Legarra, Andres" uniqKey="Legarra A" first="Andrés" last="Legarra">Andrés Legarra</name>
<affiliation wicri:level="1"><nlm:aff id="aff004">INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex</wicri:regionArea>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elsen, Jean Michel" sort="Elsen, Jean Michel" uniqKey="Elsen J" first="Jean-Michel" last="Elsen">Jean-Michel Elsen</name>
<affiliation wicri:level="1"><nlm:aff id="aff004">INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex</wicri:regionArea>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
<wicri:noRegion>31326 Castanet Tolosan Cedex</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Genetics Research</title>
<idno type="ISSN">0016-6723</idno>
<idno type="eISSN">1469-5073</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Recently, a Haley–Knott-type regression method using combined linkage disequilibrium and linkage analyses (LDLA) was proposed to map quantitative trait loci (QTLs). Chromosome of 5 and 25 cM with 0·25 and 0·05 cM, respectively, between markers were simulated. The differences between the LDLA approaches with regard to QTL position accuracy were very limited, with a significantly better mean square error (MSE) with the LDLA regression (LDLA_reg) in sparse map cases; the contrary was observed, but not significantly, in dense map situations. The computing time required for the LDLA variance components (LDLA_vc) model was much higher than the LDLA_reg model. The precision of QTL position estimation was compared for four numbers of half-sib families, four different family sizes and two experimental designs (half-sibs, and full- and half-sibs). Regarding the number of families, MSE values were lowest for 15 or 50 half-sib families, differences not being significant. We observed that the greater the number of progenies per sire, the more accurate the QTL position. However, for a fixed population size, reducing the number of families (e.g. using a small number of large full-sib families) could lead to less accuracy of estimated QTL position.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Blott, S" uniqKey="Blott S">S. Blott</name>
</author>
<author><name sortKey="Kim, J J" uniqKey="Kim J">J. J. Kim</name>
</author>
<author><name sortKey="Moisio, S" uniqKey="Moisio S">S. Moisio</name>
</author>
<author><name sortKey="Schmidt Kuntzel, A" uniqKey="Schmidt Kuntzel A">A. Schmidt-Küntzel</name>
</author>
<author><name sortKey="Cornet, A" uniqKey="Cornet A">A. Cornet</name>
</author>
<author><name sortKey="Berzi, P" uniqKey="Berzi P">P. Berzi</name>
</author>
<author><name sortKey="Cambisano, N" uniqKey="Cambisano N">N. Cambisano</name>
</author>
<author><name sortKey="Ford, C" uniqKey="Ford C">C. Ford</name>
</author>
<author><name sortKey="Grisart, B" uniqKey="Grisart B">B. Grisart</name>
</author>
<author><name sortKey="Johnson, D" uniqKey="Johnson D">D. Johnson</name>
</author>
<author><name sortKey="Karim, L" uniqKey="Karim L">L. Karim</name>
</author>
<author><name sortKey="Simon, P" uniqKey="Simon P">P. Simon</name>
</author>
<author><name sortKey="Snell, R" uniqKey="Snell R">R. Snell</name>
</author>
<author><name sortKey="Spelman, R" uniqKey="Spelman R">R. Spelman</name>
</author>
<author><name sortKey="Wong, J" uniqKey="Wong J">J. Wong</name>
</author>
<author><name sortKey="Georges, M" uniqKey="Georges M">M. Georges</name>
</author>
<author><name sortKey="Farnir, F" uniqKey="Farnir F">F. Farnir</name>
</author>
<author><name sortKey="Coppieters, W" uniqKey="Coppieters W">W. Coppieters</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calus, M" uniqKey="Calus M">M. Calus</name>
</author>
<author><name sortKey="Meuwissen, T H E" uniqKey="Meuwissen T">T. H. E. Meuwissen</name>
</author>
<author><name sortKey="Winding, J J" uniqKey="Winding J">J. J. Winding</name>
</author>
<author><name sortKey="Knol, E F" uniqKey="Knol E">E. F. Knol</name>
</author>
<author><name sortKey="Schrooten, C" uniqKey="Schrooten C">C. Schrooten</name>
</author>
<author><name sortKey="Vereijken, A" uniqKey="Vereijken A">A. Vereijken</name>
</author>
<author><name sortKey="Veerkamp, R F" uniqKey="Veerkamp R">R. F. Veerkamp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cierco Ayrolles, C" uniqKey="Cierco Ayrolles C">C. Cierco-Ayrolles</name>
</author>
<author><name sortKey="Dejean, S" uniqKey="Dejean S">S. Dejean</name>
</author>
<author><name sortKey="Legarra, A" uniqKey="Legarra A">A. Legarra</name>
</author>
<author><name sortKey="Gilbert, H" uniqKey="Gilbert H">H. Gilbert</name>
</author>
<author><name sortKey="Druet, T" uniqKey="Druet T">T. Druet</name>
</author>
<author><name sortKey="Ytournel, F" uniqKey="Ytournel F">F. Ytournel</name>
</author>
<author><name sortKey="Estivals, D" uniqKey="Estivals D">D. Estivals</name>
</author>
<author><name sortKey="Oumouhou, N" uniqKey="Oumouhou N">N. Oumouhou</name>
</author>
<author><name sortKey="Mangin, B" uniqKey="Mangin B">B. Mangin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Druet, T" uniqKey="Druet T">T. Druet</name>
</author>
<author><name sortKey="Fritz, S" uniqKey="Fritz S">S. Fritz</name>
</author>
<author><name sortKey="Boussaha, M" uniqKey="Boussaha M">M. Boussaha</name>
</author>
<author><name sortKey="Ben Jemaa, S" uniqKey="Ben Jemaa S">S. Ben-Jemaa</name>
</author>
<author><name sortKey="Guillaume, F" uniqKey="Guillaume F">F. Guillaume</name>
</author>
<author><name sortKey="Derbala, D" uniqKey="Derbala D">D. Derbala</name>
</author>
<author><name sortKey="Zelenika, D" uniqKey="Zelenika D">D. Zelenika</name>
</author>
<author><name sortKey="Lechner, D" uniqKey="Lechner D">D. Lechner</name>
</author>
<author><name sortKey="Charon, C" uniqKey="Charon C">C. Charon</name>
</author>
<author><name sortKey="Boichard, D" uniqKey="Boichard D">D. Boichard</name>
</author>
<author><name sortKey="Gut, I" uniqKey="Gut I">I. Gut</name>
</author>
<author><name sortKey="Eggen, A" uniqKey="Eggen A">A. Eggen</name>
</author>
<author><name sortKey="Gautier, M" uniqKey="Gautier M">M. Gautier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elsen, J M" uniqKey="Elsen J">J. M. Elsen</name>
</author>
<author><name sortKey="Mangin, B" uniqKey="Mangin B">B. Mangin</name>
</author>
<author><name sortKey="Goffinet, B" uniqKey="Goffinet B">B. Goffinet</name>
</author>
<author><name sortKey="Boichard, D" uniqKey="Boichard D">D. Boichard</name>
</author>
<author><name sortKey="Le Roy, P" uniqKey="Le Roy P">P. Le Roy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farnir, F" uniqKey="Farnir F">F. Farnir</name>
</author>
<author><name sortKey="Coppieters, W" uniqKey="Coppieters W">W. Coppieters</name>
</author>
<author><name sortKey="Arranz, J J" uniqKey="Arranz J">J. J. Arranz</name>
</author>
<author><name sortKey="Berzi, P" uniqKey="Berzi P">P. Berzi</name>
</author>
<author><name sortKey="Combisano, N" uniqKey="Combisano N">N. Combisano</name>
</author>
<author><name sortKey="Grisart, B" uniqKey="Grisart B">B. Grisart</name>
</author>
<author><name sortKey="Karim, L" uniqKey="Karim L">L. Karim</name>
</author>
<author><name sortKey="Marcq, F" uniqKey="Marcq F">F. Marcq</name>
</author>
<author><name sortKey="Moreau, L" uniqKey="Moreau L">L. Moreau</name>
</author>
<author><name sortKey="Mni, M" uniqKey="Mni M">M. Mni</name>
</author>
<author><name sortKey="Nezer, C" uniqKey="Nezer C">C. Nezer</name>
</author>
<author><name sortKey="Simon, P" uniqKey="Simon P">P. Simon</name>
</author>
<author><name sortKey="Vanmanshoven, P" uniqKey="Vanmanshoven P">P. Vanmanshoven</name>
</author>
<author><name sortKey="Wagenaar, D" uniqKey="Wagenaar D">D. Wagenaar</name>
</author>
<author><name sortKey="Georges, M" uniqKey="Georges M">M. Georges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farnir, F" uniqKey="Farnir F">F. Farnir</name>
</author>
<author><name sortKey="Grisart, B" uniqKey="Grisart B">B. Grisart</name>
</author>
<author><name sortKey="Coppieters, W" uniqKey="Coppieters W">W. Coppieters</name>
</author>
<author><name sortKey="Riquet, J" uniqKey="Riquet J">J. Riquet</name>
</author>
<author><name sortKey="Berzi, P" uniqKey="Berzi P">P. Berzi</name>
</author>
<author><name sortKey="Cambisano, N" uniqKey="Cambisano N">N. Cambisano</name>
</author>
<author><name sortKey="Karim, L" uniqKey="Karim L">L. Karim</name>
</author>
<author><name sortKey="Mni, M" uniqKey="Mni M">M. Mni</name>
</author>
<author><name sortKey="Moisio, S" uniqKey="Moisio S">S. Moisio</name>
</author>
<author><name sortKey="Simon, P" uniqKey="Simon P">P. Simon</name>
</author>
<author><name sortKey="Wagenaar, D" uniqKey="Wagenaar D">D. Wagenaar</name>
</author>
<author><name sortKey="Vilkki, J" uniqKey="Vilkki J">J. Vilkki</name>
</author>
<author><name sortKey="Georges, M" uniqKey="Georges M">M. Georges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Favier, A" uniqKey="Favier A">A. Favier</name>
</author>
<author><name sortKey="Elsen, J M" uniqKey="Elsen J">J-M. Elsen</name>
</author>
<author><name sortKey="De Givry, S" uniqKey="De Givry S">S. de Givry</name>
</author>
<author><name sortKey="Legarra, A" uniqKey="Legarra A">A. Legarra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernando, R L" uniqKey="Fernando R">R. L. Fernando</name>
</author>
<author><name sortKey="Grossman, M" uniqKey="Grossman M">M. Grossman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Filangi, O" uniqKey="Filangi O">O. Filangi</name>
</author>
<author><name sortKey="Elsen, J M" uniqKey="Elsen J">J. M. Elsen</name>
</author>
<author><name sortKey="Gilbert, H" uniqKey="Gilbert H">H. Gilbert</name>
</author>
<author><name sortKey="Legarra, A" uniqKey="Legarra A">A. Legarra</name>
</author>
<author><name sortKey="Le Roy, P" uniqKey="Le Roy P">P. Le Roy</name>
</author>
<author><name sortKey="Moreno, C" uniqKey="Moreno C">C. Moreno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grapes, L" uniqKey="Grapes L">L. Grapes</name>
</author>
<author><name sortKey="Dekkers, J C M" uniqKey="Dekkers J">J. C. M. Dekkers</name>
</author>
<author><name sortKey="Rothschild, M F" uniqKey="Rothschild M">M. F. Rothschild</name>
</author>
<author><name sortKey="Fernando, R L" uniqKey="Fernando R">R. L. Fernando</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grapes, L" uniqKey="Grapes L">L. Grapes</name>
</author>
<author><name sortKey="Firat, M Z" uniqKey="Firat M">M. Z. Firat</name>
</author>
<author><name sortKey="Dekkers, J C M" uniqKey="Dekkers J">J. C. M. Dekkers</name>
</author>
<author><name sortKey="Rothschild, M F" uniqKey="Rothschild M">M. F. Rothschild</name>
</author>
<author><name sortKey="Fernando, R L" uniqKey="Fernando R">R. L. Fernando</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hayes, B J" uniqKey="Hayes B">B. J. Hayes</name>
</author>
<author><name sortKey="Gjuvsland, A" uniqKey="Gjuvsland A">A. Gjuvsland</name>
</author>
<author><name sortKey="Omholt, S" uniqKey="Omholt S">S. Omholt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heuven, H C M" uniqKey="Heuven H">H. C. M. Heuven</name>
</author>
<author><name sortKey="Bovenhuis, H" uniqKey="Bovenhuis H">H. Bovenhuis</name>
</author>
<author><name sortKey="Janss, L L G" uniqKey="Janss L">L. L. G. Janss</name>
</author>
<author><name sortKey="Arendonk, J A M Van" uniqKey="Arendonk J">J. A. M van. Arendonk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hurtagh, F" uniqKey="Hurtagh F">F. Hurtagh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knott, S A" uniqKey="Knott S">S. A. Knott</name>
</author>
<author><name sortKey="Elsen, J M" uniqKey="Elsen J">J. M. Elsen</name>
</author>
<author><name sortKey="Haley, C S" uniqKey="Haley C">C. S. Haley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, S H" uniqKey="Lee S">S. H. Lee</name>
</author>
<author><name sortKey="Van Der, Werf J" uniqKey="Van Der W">Werf J. van der</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, S H" uniqKey="Lee S">S. H. Lee</name>
</author>
<author><name sortKey="Van Der, Werf J" uniqKey="Van Der W">Werf J. van der</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, S H" uniqKey="Lee S">S. H. Lee</name>
</author>
<author><name sortKey="Van Der, Werf J" uniqKey="Van Der W">Werf J. van der</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Legarra, A" uniqKey="Legarra A">A. Legarra</name>
</author>
<author><name sortKey="Fernando, R L" uniqKey="Fernando R">R. L. Fernando</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcrae, A F" uniqKey="Mcrae A">A. F. McRae</name>
</author>
<author><name sortKey="Mcewan, J C" uniqKey="Mcewan J">J. C. McEwan</name>
</author>
<author><name sortKey="Dodds, K G" uniqKey="Dodds K">K. G. Dodds</name>
</author>
<author><name sortKey="Wilson, T" uniqKey="Wilson T">T. Wilson</name>
</author>
<author><name sortKey="Crawford, A M" uniqKey="Crawford A">A. M. Crawford</name>
</author>
<author><name sortKey="Slate, J" uniqKey="Slate J">J. Slate</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcrae, A F" uniqKey="Mcrae A">A. F. McRae</name>
</author>
<author><name sortKey="Pemberton, J M" uniqKey="Pemberton J">J. M. Pemberton</name>
</author>
<author><name sortKey="Visscher, P M" uniqKey="Visscher P">P. M. Visscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meuwissen, T H E" uniqKey="Meuwissen T">T. H. E. Meuwissen</name>
</author>
<author><name sortKey="Goddard, M E" uniqKey="Goddard M">M. E. Goddard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meuwissen, T H E" uniqKey="Meuwissen T">T. H. E. Meuwissen</name>
</author>
<author><name sortKey="Goddard, M E" uniqKey="Goddard M">M. E. Goddard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meuwissen, T H E" uniqKey="Meuwissen T">T. H. E. Meuwissen</name>
</author>
<author><name sortKey="Karlsen, A" uniqKey="Karlsen A">A. Karlsen</name>
</author>
<author><name sortKey="Lien, S" uniqKey="Lien S">S. Lien</name>
</author>
<author><name sortKey="Olsaker, I" uniqKey="Olsaker I">I. Olsaker</name>
</author>
<author><name sortKey="Goddard, M E" uniqKey="Goddard M">M. E. Goddard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nsengimana, J" uniqKey="Nsengimana J">J. Nsengimana</name>
</author>
<author><name sortKey="Baret, P" uniqKey="Baret P">P. Baret</name>
</author>
<author><name sortKey="Haley, C S" uniqKey="Haley C">C. S. Haley</name>
</author>
<author><name sortKey="Vischer, P M" uniqKey="Vischer P">P. M. Vischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perez Enciso, M" uniqKey="Perez Enciso M">M. Pérez-Enciso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tenesa, A" uniqKey="Tenesa A">A. Tenesa</name>
</author>
<author><name sortKey="Knott, S A" uniqKey="Knott S">S. A. Knott</name>
</author>
<author><name sortKey="Ward, D" uniqKey="Ward D">D. Ward</name>
</author>
<author><name sortKey="Smith, D" uniqKey="Smith D">D. Smith</name>
</author>
<author><name sortKey="Williams, J L" uniqKey="Williams J">J. L. Williams</name>
</author>
<author><name sortKey="Vischer, P M" uniqKey="Vischer P">P. M. Vischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Visscher, P M" uniqKey="Visscher P">P. M. Visscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ytournel, F" uniqKey="Ytournel F">F. Ytournel</name>
</author>
<author><name sortKey="Gilbert, H" uniqKey="Gilbert H">H. Gilbert</name>
</author>
<author><name sortKey="Boichard, D" uniqKey="Boichard D">D. Boichard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ytournel, F" uniqKey="Ytournel F">F. Ytournel</name>
</author>
<author><name sortKey="Teyssedre, S" uniqKey="Teyssedre S">S. Teyssèdre</name>
</author>
<author><name sortKey="Roldan, D" uniqKey="Roldan D">D. Roldan</name>
</author>
<author><name sortKey="Erbe, M" uniqKey="Erbe M">M. Erbe</name>
</author>
<author><name sortKey="Simianer, H" uniqKey="Simianer H">H. Simianer</name>
</author>
<author><name sortKey="Boichard, D" uniqKey="Boichard D">D. Boichard</name>
</author>
<author><name sortKey="Gilbert, H" uniqKey="Gilbert H">H. Gilbert</name>
</author>
<author><name sortKey="Druet, T" uniqKey="Druet T">T. Druet</name>
</author>
<author><name sortKey="Legarra, A" uniqKey="Legarra A">A. Legarra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, H H" uniqKey="Zhao H">H. H. Zhao</name>
</author>
<author><name sortKey="Fernando, R L" uniqKey="Fernando R">R. L. Fernando</name>
</author>
<author><name sortKey="Dekkers, J C M" uniqKey="Dekkers J">J. C. M. Dekkers</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genet Res (Camb)</journal-id>
<journal-id journal-id-type="iso-abbrev">Genet Res (Camb)</journal-id>
<journal-id journal-id-type="publisher-id">GRH</journal-id>
<journal-title-group><journal-title>Genetics Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0016-6723</issn>
<issn pub-type="epub">1469-5073</issn>
<publisher><publisher-name>Cambridge University Press</publisher-name>
<publisher-loc>Cambridge, UK</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22950902</article-id>
<article-id pub-id-type="pmc">3487687</article-id>
<article-id pub-id-type="doi">10.1017/S0016672312000407</article-id>
<article-id pub-id-type="pii">S0016672312000407</article-id>
<article-id pub-id-type="publisher-id">00040</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models</article-title>
<alt-title alt-title-type="left-running">D. L. Roldan <italic>et al</italic>
.</alt-title>
<alt-title alt-title-type="right-running">Comparison of fine QTL mapping models</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>ROLDAN</surname>
<given-names>DANA L</given-names>
</name>
<xref ref-type="aff" rid="aff001">1</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>GILBERT</surname>
<given-names>HÉLÈNE</given-names>
</name>
<xref ref-type="aff" rid="aff002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>HENSHALL</surname>
<given-names>JOHN M</given-names>
</name>
<xref ref-type="aff" rid="aff003">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>LEGARRA</surname>
<given-names>ANDRÉS</given-names>
</name>
<xref ref-type="aff" rid="aff004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>ELSEN</surname>
<given-names>JEAN-MICHEL</given-names>
</name>
<xref ref-type="aff" rid="aff004">4</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
Instituto de Genética CICVyA-INTA Castelar, cc 1712, Buenos Aires, Argentina</aff>
<aff id="aff002"><label>2</label>
INRA-Laboratoire de Génétique Cellulaire, Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</aff>
<aff id="aff003"><label>3</label>
CSIRO Livestock Industries FD McMaster Laboratory, Armidale, NSW 2350, Australia</aff>
<aff id="aff004"><label>4</label>
INRA-SAGA Auzeville, B.P. 52627, 31326 Castanet Tolosan Cedex, France</aff>
<author-notes><corresp id="cor001"><label>*</label>
Corresponding author: Present address: Dana L. Roldan, INRA-SAGA Auzeville BP 52627, 31326 Castanet Tolosan Cedex, France. E-mail: <email xlink:href="droldan@cnia.inta.gov.ar">droldan@cnia.inta.gov.ar</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>8</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><month>8</month>
<year>2012</year>
</pub-date>
<volume>94</volume>
<issue>4</issue>
<fpage>223</fpage>
<lpage>234</lpage>
<history><date date-type="received"><day>01</day>
<month>1</month>
<year>2012</year>
</date>
<date date-type="rev-recd"><day>27</day>
<month>6</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>02</day>
<month>7</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright © Cambridge University Press 2012 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence . The written permission of Cambridge University Press must be obtained for commercial re-use.</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Cambridge University Press</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/2.5/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/>">http://creativecommons.org/licenses/by-nc-sa/3.0/>.</ext-link>
The written permission of Cambridge University Press must be obtained for commercial re-use.</license-p>
</license>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="S0016672312000407a.pdf"></self-uri>
<abstract><title>Summary</title>
<p>Recently, a Haley–Knott-type regression method using combined linkage disequilibrium and linkage analyses (LDLA) was proposed to map quantitative trait loci (QTLs). Chromosome of 5 and 25 cM with 0·25 and 0·05 cM, respectively, between markers were simulated. The differences between the LDLA approaches with regard to QTL position accuracy were very limited, with a significantly better mean square error (MSE) with the LDLA regression (LDLA_reg) in sparse map cases; the contrary was observed, but not significantly, in dense map situations. The computing time required for the LDLA variance components (LDLA_vc) model was much higher than the LDLA_reg model. The precision of QTL position estimation was compared for four numbers of half-sib families, four different family sizes and two experimental designs (half-sibs, and full- and half-sibs). Regarding the number of families, MSE values were lowest for 15 or 50 half-sib families, differences not being significant. We observed that the greater the number of progenies per sire, the more accurate the QTL position. However, for a fixed population size, reducing the number of families (e.g. using a small number of large full-sib families) could lead to less accuracy of estimated QTL position.</p>
</abstract>
<counts><page-count count="12"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Argentine</li>
<li>Australie</li>
<li>France</li>
</country>
</list>
<tree><country name="Argentine"><noRegion><name sortKey="Roldan, Dana L" sort="Roldan, Dana L" uniqKey="Roldan D" first="Dana L" last="Roldan">Dana L. Roldan</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Gilbert, Helene" sort="Gilbert, Helene" uniqKey="Gilbert H" first="Hélène" last="Gilbert">Hélène Gilbert</name>
</noRegion>
<name sortKey="Elsen, Jean Michel" sort="Elsen, Jean Michel" uniqKey="Elsen J" first="Jean-Michel" last="Elsen">Jean-Michel Elsen</name>
<name sortKey="Legarra, Andres" sort="Legarra, Andres" uniqKey="Legarra A" first="Andrés" last="Legarra">Andrés Legarra</name>
</country>
<country name="Australie"><noRegion><name sortKey="Henshall, John M" sort="Henshall, John M" uniqKey="Henshall J" first="John M" last="Henshall">John M. Henshall</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000F62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:3487687 |texte= Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:22950902" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |