Nasal Bone Shape Is under Complex Epistatic Genetic Control in Mouse Interspecific Recombinant Congenic Strains
Identifieur interne : 000E43 ( Ncbi/Merge ); précédent : 000E42; suivant : 000E44Nasal Bone Shape Is under Complex Epistatic Genetic Control in Mouse Interspecific Recombinant Congenic Strains
Auteurs : Gaétan Burgio [France, Australie] ; Michel Baylac [France] ; Evelyne Heyer [France] ; Xavier Montagutelli [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Genetic determinism of cranial morphology in the mouse is still largely unknown, despite the localization of putative QTLs and the identification of genes associated with Mendelian skull malformations. To approach the dissection of this multigenic control, we have used a set of interspecific recombinant congenic strains (IRCS) produced between C57BL/6 and mice of the distant species
The shape of the nasal bone was studied using outline analysis combined with Fourier descriptors, and differential features were identified between IRCS BcG-66H and C57BL/6. An F2 cross between BcG-66H and C57BL/6 revealed that, out of the three SEG/Pas-derived chromosomal regions present in BcG-66H, two were involved. Segments on chromosomes 1 (∼32 Mb) and 18 (∼13 Mb) showed additive effect on nasal bone shape. The three chromosomal regions present in BcG-66H were isolated in congenic strains to study their individual effect. Epistatic interactions were assessed in bicongenic strains.
Our results show that, besides a strong individual effect, the QTL on chromosome 1 interacts with genes on chromosomes 13 and 18. This study demonstrates that nasal bone shape is under complex genetic control but can be efficiently dissected in the mouse using appropriate genetic tools and shape descriptors.
Url:
DOI: 10.1371/journal.pone.0037721
PubMed: 22662199
PubMed Central: 3360618
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Scientifique, URA 2578, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Centre National de la Recherche Scientifique, URA 2578, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Unité d’Eco-Anthropologie, équipe, Génétique des Populations Humaines, Centre National de la Recherche Scientifique, Museum National d’Histoire Naturelle, Université Paris 7, UMR 7206, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité d’Eco-Anthropologie, équipe, Génétique des Populations Humaines, Centre National de la Recherche Scientifique, Museum National d’Histoire Naturelle, Université Paris 7, UMR 7206, Paris</wicri:regionArea><placeName><region 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France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Organisation, Structure et Evolution de la Biodiversité UMR 5202 et Plateforme de Morphométrie, Centre National de la Recherche Scientifique IFR 101 et UMR 5202, Laboratoire d’Entomologie du Muséum National d’Histoire Naturelle, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Heyer, Evelyne" sort="Heyer, Evelyne" uniqKey="Heyer E" first="Evelyne" last="Heyer">Evelyne Heyer</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Unité d’Eco-Anthropologie, équipe, Génétique des Populations Humaines, Centre National de la Recherche Scientifique, Museum National d’Histoire Naturelle, Université Paris 7, UMR 7206, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité d’Eco-Anthropologie, équipe, Génétique des Populations Humaines, Centre National de la Recherche Scientifique, Museum National d’Histoire Naturelle, Université Paris 7, UMR 7206, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Montagutelli, Xavier" sort="Montagutelli, Xavier" uniqKey="Montagutelli X" first="Xavier" last="Montagutelli">Xavier Montagutelli</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Centre National de la Recherche Scientifique, URA 2578, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Centre National de la Recherche Scientifique, URA 2578, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Genetic determinism of cranial morphology in the mouse is still largely unknown, despite the localization of putative QTLs and the identification of genes associated with Mendelian skull malformations. To approach the dissection of this multigenic control, we have used a set of interspecific recombinant congenic strains (IRCS) produced between C57BL/6 and mice of the distant species <italic>Mus spretus</italic> (SEG/Pas). Each strain has inherited 1.3% of its genome from SEG/Pas under the form of few, small-sized, chromosomal segments.</p></sec><sec><title>Results</title><p>The shape of the nasal bone was studied using outline analysis combined with Fourier descriptors, and differential features were identified between IRCS BcG-66H and C57BL/6. An F2 cross between BcG-66H and C57BL/6 revealed that, out of the three SEG/Pas-derived chromosomal regions present in BcG-66H, two were involved. Segments on chromosomes 1 (∼32 Mb) and 18 (∼13 Mb) showed additive effect on nasal bone shape. The three chromosomal regions present in BcG-66H were isolated in congenic strains to study their individual effect. Epistatic interactions were assessed in bicongenic strains.</p></sec><sec><title>Conclusions</title><p>Our results show that, besides a strong individual effect, the QTL on chromosome 1 interacts with genes on chromosomes 13 and 18. This study demonstrates that nasal bone shape is under complex genetic control but can be efficiently dissected in the mouse using appropriate genetic tools and shape descriptors.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Langlade, Nb" uniqKey="Langlade N">NB Langlade</name></author><author><name sortKey="Feng, X" uniqKey="Feng X">X Feng</name></author><author><name sortKey="Dransfield, T" uniqKey="Dransfield T">T Dransfield</name></author><author><name sortKey="Copsey, L" uniqKey="Copsey L">L Copsey</name></author><author><name sortKey="Hanna, Ai" uniqKey="Hanna A">AI Hanna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albertson, Rc" uniqKey="Albertson R">RC Albertson</name></author><author><name sortKey="Streelman, Jt" uniqKey="Streelman J">JT Streelman</name></author><author><name sortKey="Kocher, Td" uniqKey="Kocher T">TD Kocher</name></author><author><name sortKey="Yelick, Pc" uniqKey="Yelick P">PC Yelick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherwood, Rj" uniqKey="Sherwood R">RJ Sherwood</name></author><author><name sortKey="Duren, Dl" uniqKey="Duren D">DL Duren</name></author><author><name sortKey="Havill, Lm" uniqKey="Havill L">LM Havill</name></author><author><name sortKey="Rogers, J" uniqKey="Rogers J">J Rogers</name></author><author><name sortKey="Cox, La" uniqKey="Cox L">LA Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leamy, Lj" uniqKey="Leamy L">LJ Leamy</name></author><author><name sortKey="Routman, Ej" uniqKey="Routman E">EJ Routman</name></author><author><name sortKey="Cheverud, Jm" uniqKey="Cheverud J">JM Cheverud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dohmoto, A" uniqKey="Dohmoto A">A Dohmoto</name></author><author><name sortKey="Shimizu, K" uniqKey="Shimizu K">K Shimizu</name></author><author><name sortKey="Asada, Y" uniqKey="Asada Y">Y Asada</name></author><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheverud, Jm" uniqKey="Cheverud J">JM Cheverud</name></author><author><name sortKey="Routman, Ej" uniqKey="Routman E">EJ Routman</name></author><author><name sortKey="Irschick, Dj" uniqKey="Irschick D">DJ Irschick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klingenberg, Cp" uniqKey="Klingenberg C">CP Klingenberg</name></author><author><name sortKey="Leamy, Lj" uniqKey="Leamy L">LJ Leamy</name></author><author><name sortKey="Routman, Ej" uniqKey="Routman E">EJ Routman</name></author><author><name sortKey="Cheverud, Jm" uniqKey="Cheverud J">JM Cheverud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klingenberg, Cp" uniqKey="Klingenberg C">CP Klingenberg</name></author><author><name sortKey="Leamy, Lj" uniqKey="Leamy L">LJ Leamy</name></author><author><name sortKey="Cheverud, Jm" uniqKey="Cheverud J">JM Cheverud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demant, P" uniqKey="Demant P">P Demant</name></author><author><name sortKey="Hart, Aam" uniqKey="Hart A">AAM Hart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moen, Cj" uniqKey="Moen C">CJ Moen</name></author><author><name sortKey="Van Der Valk, Ma" uniqKey="Van Der Valk M">MA van der Valk</name></author><author><name sortKey="Snoek, M" uniqKey="Snoek M">M Snoek</name></author><author><name sortKey="Van Zutphen, Bf" uniqKey="Van Zutphen B">BF van Zutphen</name></author><author><name sortKey="Von Deimling, O" uniqKey="Von Deimling O">O von Deimling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogner, Uc" uniqKey="Rogner U">UC Rogner</name></author><author><name sortKey="Boitard, C" uniqKey="Boitard C">C Boitard</name></author><author><name sortKey="Morin, J" uniqKey="Morin J">J Morin</name></author><author><name sortKey="Melanitou, E" uniqKey="Melanitou E">E Melanitou</name></author><author><name sortKey="Avner, P" uniqKey="Avner P">P Avner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morel, L" uniqKey="Morel L">L Morel</name></author><author><name sortKey="Mohan, C" uniqKey="Mohan C">C Mohan</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Croker, Bp" uniqKey="Croker B">BP Croker</name></author><author><name sortKey="Tian, N" uniqKey="Tian N">N Tian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morel, L" uniqKey="Morel L">L Morel</name></author><author><name sortKey="Croker, Bp" uniqKey="Croker B">BP Croker</name></author><author><name sortKey="Blenman, Kr" uniqKey="Blenman K">KR Blenman</name></author><author><name sortKey="Mohan, C" uniqKey="Mohan C">C Mohan</name></author><author><name sortKey="Huang, G" uniqKey="Huang G">G Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burgio, G" uniqKey="Burgio G">G Burgio</name></author><author><name sortKey="Szatanik, M" uniqKey="Szatanik M">M Szatanik</name></author><author><name sortKey="Guenet, Jl" uniqKey="Guenet J">JL Guenet</name></author><author><name sortKey="Arnau, Mr" uniqKey="Arnau M">MR Arnau</name></author><author><name sortKey="Panthier, Jj" uniqKey="Panthier J">JJ Panthier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolf, Jb" uniqKey="Wolf J">JB Wolf</name></author><author><name sortKey="Leamy, Lj" uniqKey="Leamy L">LJ Leamy</name></author><author><name sortKey="Routman, Ej" uniqKey="Routman E">EJ Routman</name></author><author><name sortKey="Cheverud, Jm" uniqKey="Cheverud J">JM Cheverud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willmore, Ke" uniqKey="Willmore K">KE Willmore</name></author><author><name sortKey="Zelditch, Ml" uniqKey="Zelditch M">ML Zelditch</name></author><author><name sortKey="Young, N" uniqKey="Young N">N Young</name></author><author><name sortKey="Ah Seng, A" uniqKey="Ah Seng A">A Ah-Seng</name></author><author><name sortKey="Lozanoff, S" uniqKey="Lozanoff S">S Lozanoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawakami, M" uniqKey="Kawakami M">M Kawakami</name></author><author><name sortKey="Yamamura, K" uniqKey="Yamamura K">K Yamamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burgio, G" uniqKey="Burgio G">G Burgio</name></author><author><name sortKey="Baylac, M" uniqKey="Baylac M">M Baylac</name></author><author><name sortKey="Heyer, E" uniqKey="Heyer E">E Heyer</name></author><author><name sortKey="Montagutelli, X" uniqKey="Montagutelli X">X Montagutelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="L Hote, D" uniqKey="L Hote D">D L'Hote</name></author><author><name sortKey="Serres, C" uniqKey="Serres C">C Serres</name></author><author><name sortKey="Laissue, P" uniqKey="Laissue P">P Laissue</name></author><author><name sortKey="Oulmouden, A" uniqKey="Oulmouden A">A Oulmouden</name></author><author><name sortKey="Rogel Gaillard, C" uniqKey="Rogel Gaillard C">C Rogel-Gaillard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laissue, P" uniqKey="Laissue P">P Laissue</name></author><author><name sortKey="Burgio, G" uniqKey="Burgio G">G Burgio</name></author><author><name sortKey="L Hote, D" uniqKey="L Hote D">D l'Hote</name></author><author><name sortKey="Renault, G" uniqKey="Renault G">G Renault</name></author><author><name sortKey="Marchiol Fournigault, C" uniqKey="Marchiol Fournigault C">C Marchiol-Fournigault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friess, M" uniqKey="Friess M">M Friess</name></author><author><name sortKey="Baylac, M" uniqKey="Baylac M">M Baylac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhl, Fp" uniqKey="Kuhl F">FP Kuhl</name></author><author><name sortKey="Giardina, Cr" uniqKey="Giardina C">CR Giardina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rohlf, Fj" uniqKey="Rohlf F">FJ Rohlf</name></author><author><name sortKey="Archie, Jw" uniqKey="Archie J">JW Archie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bookstein, Fl" uniqKey="Bookstein F">FL Bookstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dryden, Il" uniqKey="Dryden I">IL Dryden</name></author><author><name sortKey="Mardia, Kv" uniqKey="Mardia K">KV Mardia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monti, L" uniqKey="Monti L">L Monti</name></author><author><name sortKey="Baylac, M" uniqKey="Baylac M">M Baylac</name></author><author><name sortKey="Lalanne Cassou, B" uniqKey="Lalanne Cassou B">B Lalanne-Cassou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klingenberg, Cp" uniqKey="Klingenberg C">CP Klingenberg</name></author><author><name sortKey="Barluenga, M" uniqKey="Barluenga M">M Barluenga</name></author><author><name sortKey="Meyer, A" uniqKey="Meyer A">A Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broman, Kw" uniqKey="Broman K">KW Broman</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Sen, S" uniqKey="Sen S">S Sen</name></author><author><name sortKey="Churchill, Ga" uniqKey="Churchill G">GA Churchill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lachenbruch, Pa" uniqKey="Lachenbruch P">PA Lachenbruch</name></author><author><name sortKey="Michey, Mr" uniqKey="Michey M">MR Michey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Cr" uniqKey="Rao C">CR Rao</name></author><author><name sortKey="Suryawanshi, S" uniqKey="Suryawanshi S">S Suryawanshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelsey, J" uniqKey="Kelsey J">J Kelsey</name></author><author><name sortKey="Whittemore, A" uniqKey="Whittemore A">A Whittemore</name></author><author><name sortKey="Evans, A" uniqKey="Evans A">A Evans</name></author><author><name sortKey="Thompson, W" uniqKey="Thompson W">W Thompson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22662199</article-id><article-id pub-id-type="pmc">3360618</article-id><article-id pub-id-type="publisher-id">PONE-D-11-25556</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0037721</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Anatomy and Physiology</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Bone</subject></subj-group></subj-group></subj-group><subj-group><subject>Computational Biology</subject><subj-group><subject>Molecular Genetics</subject><subj-group><subject>Gene Identification and Analysis</subject></subj-group></subj-group></subj-group><subj-group><subject>Genetics</subject><subj-group><subject>Heredity</subject><subj-group><subject>Quantitative Traits</subject></subj-group></subj-group><subj-group><subject>Animal Genetics</subject><subject>Gene Function</subject></subj-group></subj-group><subj-group><subject>Genomics</subject><subj-group><subject>Chromosome Biology</subject></subj-group></subj-group><subj-group><subject>Model Organisms</subject><subj-group><subject>Animal Models</subject><subj-group><subject>Mouse</subject></subj-group></subj-group></subj-group><subj-group><subject>Molecular Cell Biology</subject><subj-group><subject>Chromosome Biology</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Anatomy and Physiology</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Bone</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Nasal Bone Shape Is under Complex Epistatic Genetic Control in Mouse Interspecific Recombinant Congenic Strains</article-title><alt-title alt-title-type="running-head">Nasal Bone Shape QTL in Mice</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Burgio</surname><given-names>Gaétan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baylac</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heyer</surname><given-names>Evelyne</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Montagutelli</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Centre National de la Recherche Scientifique, URA 2578, Paris, France</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Unité d’Eco-Anthropologie, équipe, Génétique des Populations Humaines, Centre National de la Recherche Scientifique, Museum National d’Histoire Naturelle, Université Paris 7, UMR 7206, Paris, France</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Genetics, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Organisation, Structure et Evolution de la Biodiversité UMR 5202 et Plateforme de Morphométrie, Centre National de la Recherche Scientifique IFR 101 et UMR 5202, Laboratoire d’Entomologie du Muséum National d’Histoire Naturelle, Paris, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Adamovic</surname><given-names>Tatjana</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1">Karolinska Institutet, Sweden</aff><author-notes><corresp id="cor1">* E-mail: <email>grburgio@utas.edu.au</email></corresp><fn fn-type="con"><p>Conceived and designed the experiments: GB EH XM. Performed the experiments: GB MB. Analyzed the data: GB MB EH XM. Contributed reagents/materials/analysis tools: GB MB XM. Wrote the paper: GB XM.</p></fn></author-notes><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>25</day><month>5</month><year>2012</year></pub-date><volume>7</volume><issue>5</issue><elocation-id>e37721</elocation-id><history><date date-type="received"><day>21</day><month>12</month><year>2011</year></date><date date-type="accepted"><day>23</day><month>4</month><year>2012</year></date></history><permissions><copyright-statement>Burgio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec><title>Background</title><p>Genetic determinism of cranial morphology in the mouse is still largely unknown, despite the localization of putative QTLs and the identification of genes associated with Mendelian skull malformations. To approach the dissection of this multigenic control, we have used a set of interspecific recombinant congenic strains (IRCS) produced between C57BL/6 and mice of the distant species <italic>Mus spretus</italic> (SEG/Pas). Each strain has inherited 1.3% of its genome from SEG/Pas under the form of few, small-sized, chromosomal segments.</p></sec><sec><title>Results</title><p>The shape of the nasal bone was studied using outline analysis combined with Fourier descriptors, and differential features were identified between IRCS BcG-66H and C57BL/6. An F2 cross between BcG-66H and C57BL/6 revealed that, out of the three SEG/Pas-derived chromosomal regions present in BcG-66H, two were involved. Segments on chromosomes 1 (∼32 Mb) and 18 (∼13 Mb) showed additive effect on nasal bone shape. The three chromosomal regions present in BcG-66H were isolated in congenic strains to study their individual effect. Epistatic interactions were assessed in bicongenic strains.</p></sec><sec><title>Conclusions</title><p>Our results show that, besides a strong individual effect, the QTL on chromosome 1 interacts with genes on chromosomes 13 and 18. This study demonstrates that nasal bone shape is under complex genetic control but can be efficiently dissected in the mouse using appropriate genetic tools and shape descriptors.</p></sec></abstract><counts><page-count count="9"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Burgio, Gaetan" sort="Burgio, Gaetan" uniqKey="Burgio G" first="Gaétan" last="Burgio">Gaétan Burgio</name></region><name sortKey="Baylac, Michel" sort="Baylac, Michel" uniqKey="Baylac M" first="Michel" last="Baylac">Michel Baylac</name><name sortKey="Burgio, Gaetan" sort="Burgio, Gaetan" uniqKey="Burgio G" first="Gaétan" last="Burgio">Gaétan Burgio</name><name sortKey="Heyer, Evelyne" sort="Heyer, Evelyne" uniqKey="Heyer E" first="Evelyne" last="Heyer">Evelyne Heyer</name><name sortKey="Montagutelli, Xavier" sort="Montagutelli, Xavier" uniqKey="Montagutelli X" first="Xavier" last="Montagutelli">Xavier Montagutelli</name></country><country name="Australie"><noRegion><name sortKey="Burgio, Gaetan" sort="Burgio, Gaetan" uniqKey="Burgio G" first="Gaétan" last="Burgio">Gaétan Burgio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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