InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers
Identifieur interne : 000C72 ( Ncbi/Merge ); précédent : 000C71; suivant : 000C73InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers
Auteurs : Freddy Sitas ; Sam Egger ; Margaret I. Urban ; Philip R. Taylor ; Christian C. Abnet ; Paolo Boffetta ; Dianne L. O Onnell ; David C. Whiteman ; Paul Brennan ; Reza Malekzadeh ; Michael Pawlita ; Sanford M. Dawsey ; Tim WaterboerSource :
- JNCI Journal of the National Cancer Institute [ 0027-8874 ] ; 2012.
Abstract
The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case–control studies conducted in regions with differing background risks of esophageal cancer.
We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case–control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided.
We found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29,
We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers.
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DOI: 10.1093/jnci/djr499
PubMed: 22228147
PubMed Central: 3260131
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Abnet</name></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></author><author><name sortKey="O Onnell, Dianne L" sort="O Onnell, Dianne L" uniqKey="O Onnell D" first="Dianne L." last="O Onnell">Dianne L. O Onnell</name></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></author><author><name sortKey="Malekzadeh, Reza" sort="Malekzadeh, Reza" uniqKey="Malekzadeh R" first="Reza" last="Malekzadeh">Reza Malekzadeh</name></author><author><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name></author><author><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name></author><author><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22228147</idno><idno type="pmc">3260131</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260131</idno><idno type="RBID">PMC:3260131</idno><idno type="doi">10.1093/jnci/djr499</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001987</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001987</idno><idno type="wicri:Area/Pmc/Curation">001846</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001846</idno><idno type="wicri:Area/Pmc/Checkpoint">001E78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001E78</idno><idno type="wicri:Area/Ncbi/Merge">000C72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers</title><author><name sortKey="Sitas, Freddy" sort="Sitas, Freddy" uniqKey="Sitas F" first="Freddy" last="Sitas">Freddy Sitas</name></author><author><name sortKey="Egger, Sam" sort="Egger, Sam" uniqKey="Egger S" first="Sam" last="Egger">Sam Egger</name></author><author><name sortKey="Urban, Margaret I" sort="Urban, Margaret I" uniqKey="Urban M" first="Margaret I." last="Urban">Margaret I. Urban</name></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></author><author><name sortKey="O Onnell, Dianne L" sort="O Onnell, Dianne L" uniqKey="O Onnell D" first="Dianne L." last="O Onnell">Dianne L. O Onnell</name></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></author><author><name sortKey="Malekzadeh, Reza" sort="Malekzadeh, Reza" uniqKey="Malekzadeh R" first="Reza" last="Malekzadeh">Reza Malekzadeh</name></author><author><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name></author><author><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name></author><author><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name></author></analytic><series><title level="j">JNCI Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case–control studies conducted in regions with differing background risks of esophageal cancer.</p></sec><sec><title>Methods</title><p>We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case–control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided.</p></sec><sec><title>Results</title><p>We found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, <italic>P</italic> = .023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, <italic>P</italic> < .001) but not for other tested HPV types. There were no statistically significant associations between esophageal squamous cell carcinoma and antibodies to E7 for any of the tested HPV types. Simultaneous seropositivity for HPV16 E6 and E7 was rare (four case subjects, two control subjects; OR = 5.57, 95% CI = 0.90 to 34.35; <italic>P</italic> = .064). We also found statistically significant associations between esophageal squamous cell carcinoma and capsid antibodies for the high-risk mucosal type HPV33 L1 (OR = 1.30, 95% CI = 1.00 to 1.69; <italic>P</italic> = .047) and the low-risk mucosal types HPV6 (OR = 1.22, 95% CI = 1.05 to 1.42; <italic>P</italic> = .010) and HPV11 (OR = 1.30, 95% CI = 1.09 to 1.56, <italic>P</italic> = .0036).</p></sec><sec><title>Conclusions</title><p>We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Natl Cancer Inst</journal-id><journal-id journal-id-type="hwp">jnci</journal-id><journal-id journal-id-type="publisher-id">jnci</journal-id><journal-title-group><journal-title>JNCI Journal of the National Cancer Institute</journal-title></journal-title-group><issn pub-type="ppub">0027-8874</issn><issn pub-type="epub">1460-2105</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22228147</article-id><article-id pub-id-type="pmc">3260131</article-id><article-id pub-id-type="doi">10.1093/jnci/djr499</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Sitas</surname><given-names>Freddy</given-names></name></contrib><contrib contrib-type="author"><name><surname>Egger</surname><given-names>Sam</given-names></name></contrib><contrib contrib-type="author"><name><surname>Urban</surname><given-names>Margaret I.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Taylor</surname><given-names>Philip R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Abnet</surname><given-names>Christian C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Boffetta</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>O’Connell</surname><given-names>Dianne L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Whiteman</surname><given-names>David C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name></contrib><contrib contrib-type="author"><name><surname>Malekzadeh</surname><given-names>Reza</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pawlita</surname><given-names>Michael</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dawsey</surname><given-names>Sanford M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Waterboer</surname><given-names>Tim</given-names></name></contrib><on-behalf-of>on behalf of the InterSCOPE Collaboration.</on-behalf-of></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Webb</surname><given-names>Penelope M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Green</surname><given-names>Adèle C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Nicholas K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zaridze</surname><given-names>David</given-names></name></contrib><contrib contrib-type="author"><name><surname>Holcatova</surname><given-names>Ivana</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mates</surname><given-names>Dana</given-names></name></contrib><contrib contrib-type="author"><name><surname>Szeszenia-Dabrowska</surname><given-names>Neonila</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ferro</surname><given-names>Gilles</given-names></name></contrib><contrib contrib-type="author"><name><surname>Janout</surname><given-names>Vladimir</given-names></name></contrib><contrib contrib-type="author"><name><surname>Curado</surname><given-names>Maria Paula</given-names></name></contrib><contrib contrib-type="author"><name><surname>Menezes</surname><given-names>Ana Maria</given-names></name></contrib><contrib contrib-type="author"><name><surname>Koifman</surname><given-names>Sergio</given-names></name></contrib><contrib contrib-type="author"><name><surname>Islami</surname><given-names>Farhad</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nasrollahzadeh</surname><given-names>Dariush</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Nan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Goldstein</surname><given-names>Alisa M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Ying</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Ti</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kamangar</surname><given-names>Farin</given-names></name></contrib></contrib-group><aff><bold>Affiliations of authors:</bold> Cancer Council NSW, Cancer Epidemiology Research Unit, Sydney, NSW, Australia (FS, SE, DLO’C); Genome Modifications and Carcinogenesis Division, Infection and Cancer Program, German Cancer Research Center, Heidelberg, Germany (Deutsches Krebsforschungszentrum, DKFZ) (TW, MP); Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD (SMD, PRT, CCA); NHLS/MRC Cancer Epidemiology Research Group, National Health Laboratory Service, Johannesburg, South Africa; University of the Witwatersrand, Johannesburg, South Africa (MIU); The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY; International Prevention Research Institute, Lyon, France (PBo); Population Health Department, Queensland Institute of Medical Research, Brisbane, QLD, Australia (DCW); International Agency for Research on Cancer, Lyon, France (PBr); Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran (RM)</aff><author-notes><corresp><bold>Correspondence to:</bold> Freddy Sitas, DPhil, Cancer Epidemiology Research Unit, Cancer Council NSW, PO Box 572, Kings Cross, NSW 1340, Australia (e-mail: <email>freddys@nswcc.org.au</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>18</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>6</day><month>1</month><year>2012</year></pub-date><volume>104</volume><issue>2</issue><fpage>147</fpage><lpage>158</lpage><history><date date-type="received"><day>3</day><month>3</month><year>2011</year></date><date date-type="rev-recd"><day>18</day><month>10</month><year>2011</year></date><date date-type="accepted"><day>4</day><month>11</month><year>2011</year></date></history><permissions><copyright-statement>© The Author 2012. Published by Oxford University Press.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec><title>Background</title><p>The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case–control studies conducted in regions with differing background risks of esophageal cancer.</p></sec><sec><title>Methods</title><p>We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case–control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided.</p></sec><sec><title>Results</title><p>We found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, <italic>P</italic> = .023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, <italic>P</italic> < .001) but not for other tested HPV types. There were no statistically significant associations between esophageal squamous cell carcinoma and antibodies to E7 for any of the tested HPV types. Simultaneous seropositivity for HPV16 E6 and E7 was rare (four case subjects, two control subjects; OR = 5.57, 95% CI = 0.90 to 34.35; <italic>P</italic> = .064). We also found statistically significant associations between esophageal squamous cell carcinoma and capsid antibodies for the high-risk mucosal type HPV33 L1 (OR = 1.30, 95% CI = 1.00 to 1.69; <italic>P</italic> = .047) and the low-risk mucosal types HPV6 (OR = 1.22, 95% CI = 1.05 to 1.42; <italic>P</italic> = .010) and HPV11 (OR = 1.30, 95% CI = 1.09 to 1.56, <italic>P</italic> = .0036).</p></sec><sec><title>Conclusions</title><p>We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers.</p></sec></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name><name sortKey="Egger, Sam" sort="Egger, Sam" uniqKey="Egger S" first="Sam" last="Egger">Sam Egger</name><name sortKey="Malekzadeh, Reza" sort="Malekzadeh, Reza" uniqKey="Malekzadeh R" first="Reza" last="Malekzadeh">Reza Malekzadeh</name><name sortKey="O Onnell, Dianne L" sort="O Onnell, Dianne L" uniqKey="O Onnell D" first="Dianne L." last="O Onnell">Dianne L. O Onnell</name><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name><name sortKey="Sitas, Freddy" sort="Sitas, Freddy" uniqKey="Sitas F" first="Freddy" last="Sitas">Freddy Sitas</name><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><name sortKey="Urban, Margaret I" sort="Urban, Margaret I" uniqKey="Urban M" first="Margaret I." last="Urban">Margaret I. Urban</name><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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