Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
Identifieur interne : 000915 ( Ncbi/Merge ); précédent : 000914; suivant : 000916Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
Auteurs : Capucine Picard ; Horst Von Bernuth ; Pegah Ghandil ; Maya Chrabieh ; Ofer Levy ; Peter D. Arkwright ; Douglas Mcdonald ; Raif S. Geha ; Hidetoshi Takada ; Jens C. Krause ; C. Buddy Creech ; Cheng-Lung Ku ; Stephan Ehl ; Asz O Ma Odi ; Saleh Al-Muhsen ; Sami Al-Hajjar ; Abdulaziz Al-Ghonaium ; Noorbibi K. Day-Good ; Steven M. Holland ; John Gallin ; Helen Chapel ; David P. Speert ; Carlos Rodriguez-Gallego ; Elena Colino ; Ben-Zion Garty ; Chaim Roifman ; Toshiro Hara ; Hideto Yoshikawa ; Shigeaki Nonoyama ; Joseph Domachowske ; Andrew C. Issekutz ; Mimi Tang ; Joanne Smart ; Simona Eva Zitnik ; Cyrille Hoarau ; Dinakantha Kumararatne ; Adrian Thrasher ; E. Graham Davies ; Claire Bethune ; Nicolas Sirvent ; Dominique De Ricaud ; Yildiz Camcioglu ; J Ulia Vasconcelos ; Margarida Guedes ; Artur Bonito Vitor ; Carlos Rodrigo ; Francisco Alma An ; Maria Ndez ; Juan Ignacio A Ostegui ; Laia Alsina ; Claudia Fortuny ; Janine Reichenbach ; James W. Verbsky ; Xavier Bossuyt ; Rainer Doffinger ; Laurent Abel ; Anne Puel ; Jean-Laurent CasanovaSource :
- Medicine [ 0025-7974 ] ; 2010.
Abstract
Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)- and interleukin-1 receptor-mediated immunity. We documented the clinical features and outcome of 48 patients with IRAK-4 deficiency and 12 patients with MyD88 deficiency, from 37 kindreds in 15 countries. The clinical features of IRAK-4 and MyD88 deficiency were indistinguishable. There were no severe viral, parasitic, and fungal diseases, and the range of bacterial infections was narrow. Noninvasive bacterial infections occurred in 52 patients, with a high incidence of infections of the upper respiratory tract and the skin, mostly caused by
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DOI: 10.1097/MD.0b013e3181fd8ec3
PubMed: 21057262
PubMed Central: 3103888
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency</title><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name></author><author><name sortKey="Von Bernuth, Horst" sort="Von Bernuth, Horst" uniqKey="Von Bernuth H" first="Horst" last="Von Bernuth">Horst Von Bernuth</name></author><author><name sortKey="Ghandil, Pegah" sort="Ghandil, Pegah" uniqKey="Ghandil P" first="Pegah" last="Ghandil">Pegah Ghandil</name></author><author><name sortKey="Chrabieh, Maya" sort="Chrabieh, Maya" uniqKey="Chrabieh M" first="Maya" last="Chrabieh">Maya Chrabieh</name></author><author><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name></author><author><name sortKey="Mcdonald, Douglas" sort="Mcdonald, Douglas" uniqKey="Mcdonald D" first="Douglas" last="Mcdonald">Douglas Mcdonald</name></author><author><name sortKey="Geha, Raif S" sort="Geha, Raif S" uniqKey="Geha R" first="Raif S." last="Geha">Raif S. Geha</name></author><author><name sortKey="Takada, Hidetoshi" sort="Takada, Hidetoshi" uniqKey="Takada H" first="Hidetoshi" last="Takada">Hidetoshi Takada</name></author><author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name></author><author><name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C. Buddy" last="Creech">C. Buddy Creech</name></author><author><name sortKey="Ku, Cheng Lung" sort="Ku, Cheng Lung" uniqKey="Ku C" first="Cheng-Lung" last="Ku">Cheng-Lung Ku</name></author><author><name sortKey="Ehl, Stephan" sort="Ehl, Stephan" uniqKey="Ehl S" first="Stephan" last="Ehl">Stephan Ehl</name></author><author><name sortKey="Ma Odi, Asz O" sort="Ma Odi, Asz O" uniqKey="Ma Odi " first=" Asz O" last="Ma Odi"> Asz O Ma Odi</name></author><author><name sortKey="Al Muhsen, Saleh" sort="Al Muhsen, Saleh" uniqKey="Al Muhsen S" first="Saleh" last="Al-Muhsen">Saleh Al-Muhsen</name></author><author><name sortKey="Al Hajjar, Sami" sort="Al Hajjar, Sami" uniqKey="Al Hajjar S" first="Sami" last="Al-Hajjar">Sami Al-Hajjar</name></author><author><name sortKey="Al Ghonaium, Abdulaziz" sort="Al Ghonaium, Abdulaziz" uniqKey="Al Ghonaium A" first="Abdulaziz" last="Al-Ghonaium">Abdulaziz Al-Ghonaium</name></author><author><name sortKey="Day Good, Noorbibi K" sort="Day Good, Noorbibi K" uniqKey="Day Good N" first="Noorbibi K." last="Day-Good">Noorbibi K. Day-Good</name></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name></author><author><name sortKey="Gallin, John" sort="Gallin, John" uniqKey="Gallin J" first="John" last="Gallin">John Gallin</name></author><author><name sortKey="Chapel, Helen" sort="Chapel, Helen" uniqKey="Chapel H" first="Helen" last="Chapel">Helen Chapel</name></author><author><name sortKey="Speert, David P" sort="Speert, David P" uniqKey="Speert D" first="David P." last="Speert">David P. Speert</name></author><author><name sortKey="Rodriguez Gallego, Carlos" sort="Rodriguez Gallego, Carlos" uniqKey="Rodriguez Gallego C" first="Carlos" last="Rodriguez-Gallego">Carlos Rodriguez-Gallego</name></author><author><name sortKey="Colino, Elena" sort="Colino, Elena" uniqKey="Colino E" first="Elena" last="Colino">Elena Colino</name></author><author><name sortKey="Garty, Ben Zion" sort="Garty, Ben Zion" uniqKey="Garty B" first="Ben-Zion" last="Garty">Ben-Zion Garty</name></author><author><name sortKey="Roifman, Chaim" sort="Roifman, Chaim" uniqKey="Roifman C" first="Chaim" last="Roifman">Chaim Roifman</name></author><author><name sortKey="Hara, Toshiro" sort="Hara, Toshiro" uniqKey="Hara T" first="Toshiro" last="Hara">Toshiro Hara</name></author><author><name sortKey="Yoshikawa, Hideto" sort="Yoshikawa, Hideto" uniqKey="Yoshikawa H" first="Hideto" last="Yoshikawa">Hideto Yoshikawa</name></author><author><name sortKey="Nonoyama, Shigeaki" sort="Nonoyama, Shigeaki" uniqKey="Nonoyama S" first="Shigeaki" last="Nonoyama">Shigeaki Nonoyama</name></author><author><name sortKey="Domachowske, Joseph" sort="Domachowske, Joseph" uniqKey="Domachowske J" first="Joseph" last="Domachowske">Joseph Domachowske</name></author><author><name sortKey="Issekutz, Andrew C" sort="Issekutz, Andrew C" uniqKey="Issekutz A" first="Andrew C." last="Issekutz">Andrew C. Issekutz</name></author><author><name sortKey="Tang, Mimi" sort="Tang, Mimi" uniqKey="Tang M" first="Mimi" last="Tang">Mimi Tang</name></author><author><name sortKey="Smart, Joanne" sort="Smart, Joanne" uniqKey="Smart J" first="Joanne" last="Smart">Joanne Smart</name></author><author><name sortKey="Zitnik, Simona Eva" sort="Zitnik, Simona Eva" uniqKey="Zitnik S" first="Simona Eva" last="Zitnik">Simona Eva Zitnik</name></author><author><name sortKey="Hoarau, Cyrille" sort="Hoarau, Cyrille" uniqKey="Hoarau C" first="Cyrille" last="Hoarau">Cyrille Hoarau</name></author><author><name sortKey="Kumararatne, Dinakantha" sort="Kumararatne, Dinakantha" uniqKey="Kumararatne D" first="Dinakantha" last="Kumararatne">Dinakantha Kumararatne</name></author><author><name sortKey="Thrasher, Adrian" sort="Thrasher, Adrian" uniqKey="Thrasher A" first="Adrian" last="Thrasher">Adrian Thrasher</name></author><author><name sortKey="Davies, E Graham" sort="Davies, E Graham" uniqKey="Davies E" first="E. Graham" last="Davies">E. Graham Davies</name></author><author><name sortKey="Bethune, Claire" sort="Bethune, Claire" uniqKey="Bethune C" first="Claire" last="Bethune">Claire Bethune</name></author><author><name sortKey="Sirvent, Nicolas" sort="Sirvent, Nicolas" uniqKey="Sirvent N" first="Nicolas" last="Sirvent">Nicolas Sirvent</name></author><author><name sortKey="De Ricaud, Dominique" sort="De Ricaud, Dominique" uniqKey="De Ricaud D" first="Dominique" last="De Ricaud">Dominique De Ricaud</name></author><author><name sortKey="Camcioglu, Yildiz" sort="Camcioglu, Yildiz" uniqKey="Camcioglu Y" first="Yildiz" last="Camcioglu">Yildiz Camcioglu</name></author><author><name sortKey="Vasconcelos, J Ulia" sort="Vasconcelos, J Ulia" uniqKey="Vasconcelos J" first="J Ulia" last="Vasconcelos">J Ulia Vasconcelos</name></author><author><name sortKey="Guedes, Margarida" sort="Guedes, Margarida" uniqKey="Guedes M" first="Margarida" last="Guedes">Margarida Guedes</name></author><author><name sortKey="Vitor, Artur Bonito" sort="Vitor, Artur Bonito" uniqKey="Vitor A" first="Artur Bonito" last="Vitor">Artur Bonito Vitor</name></author><author><name sortKey="Rodrigo, Carlos" sort="Rodrigo, Carlos" uniqKey="Rodrigo C" first="Carlos" last="Rodrigo">Carlos Rodrigo</name></author><author><name sortKey="Alma An, Francisco" sort="Alma An, Francisco" uniqKey="Alma An F" first="Francisco" last="Alma An">Francisco Alma An</name></author><author><name sortKey=" Ndez, Maria" sort=" Ndez, Maria" uniqKey=" Ndez M" first="Maria" last=" Ndez">Maria Ndez</name></author><author><name sortKey="A Ostegui, Juan Ignacio" sort="A Ostegui, Juan Ignacio" uniqKey="A Ostegui J" first="Juan Ignacio" last="A Ostegui">Juan Ignacio A Ostegui</name></author><author><name sortKey="Alsina, Laia" sort="Alsina, Laia" uniqKey="Alsina L" first="Laia" last="Alsina">Laia Alsina</name></author><author><name sortKey="Fortuny, Claudia" sort="Fortuny, Claudia" uniqKey="Fortuny C" first="Claudia" last="Fortuny">Claudia Fortuny</name></author><author><name sortKey="Reichenbach, Janine" sort="Reichenbach, Janine" uniqKey="Reichenbach J" first="Janine" last="Reichenbach">Janine Reichenbach</name></author><author><name sortKey="Verbsky, James W" sort="Verbsky, James W" uniqKey="Verbsky J" first="James W" last="Verbsky">James W. Verbsky</name></author><author><name sortKey="Bossuyt, Xavier" sort="Bossuyt, Xavier" uniqKey="Bossuyt X" first="Xavier" last="Bossuyt">Xavier Bossuyt</name></author><author><name sortKey="Doffinger, Rainer" sort="Doffinger, Rainer" uniqKey="Doffinger R" first="Rainer" last="Doffinger">Rainer Doffinger</name></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name></author><author><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21057262</idno><idno type="pmc">3103888</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103888</idno><idno type="RBID">PMC:3103888</idno><idno type="doi">10.1097/MD.0b013e3181fd8ec3</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001544</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001544</idno><idno type="wicri:Area/Pmc/Curation">001404</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001404</idno><idno type="wicri:Area/Pmc/Checkpoint">002626</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002626</idno><idno type="wicri:Area/Ncbi/Merge">000915</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency</title><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name></author><author><name sortKey="Von Bernuth, Horst" sort="Von Bernuth, Horst" uniqKey="Von Bernuth H" first="Horst" last="Von Bernuth">Horst Von Bernuth</name></author><author><name sortKey="Ghandil, Pegah" sort="Ghandil, Pegah" uniqKey="Ghandil P" first="Pegah" last="Ghandil">Pegah Ghandil</name></author><author><name sortKey="Chrabieh, Maya" sort="Chrabieh, Maya" uniqKey="Chrabieh M" first="Maya" last="Chrabieh">Maya Chrabieh</name></author><author><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name></author><author><name sortKey="Mcdonald, Douglas" sort="Mcdonald, Douglas" uniqKey="Mcdonald D" first="Douglas" last="Mcdonald">Douglas Mcdonald</name></author><author><name sortKey="Geha, Raif S" sort="Geha, Raif S" uniqKey="Geha R" first="Raif S." last="Geha">Raif S. Geha</name></author><author><name sortKey="Takada, Hidetoshi" sort="Takada, Hidetoshi" uniqKey="Takada H" first="Hidetoshi" last="Takada">Hidetoshi Takada</name></author><author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name></author><author><name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C. Buddy" last="Creech">C. Buddy Creech</name></author><author><name sortKey="Ku, Cheng Lung" sort="Ku, Cheng Lung" uniqKey="Ku C" first="Cheng-Lung" last="Ku">Cheng-Lung Ku</name></author><author><name sortKey="Ehl, Stephan" sort="Ehl, Stephan" uniqKey="Ehl S" first="Stephan" last="Ehl">Stephan Ehl</name></author><author><name sortKey="Ma Odi, Asz O" sort="Ma Odi, Asz O" uniqKey="Ma Odi " first=" Asz O" last="Ma Odi"> Asz O Ma Odi</name></author><author><name sortKey="Al Muhsen, Saleh" sort="Al Muhsen, Saleh" uniqKey="Al Muhsen S" first="Saleh" last="Al-Muhsen">Saleh Al-Muhsen</name></author><author><name sortKey="Al Hajjar, Sami" sort="Al Hajjar, Sami" uniqKey="Al Hajjar S" first="Sami" last="Al-Hajjar">Sami Al-Hajjar</name></author><author><name sortKey="Al Ghonaium, Abdulaziz" sort="Al Ghonaium, Abdulaziz" uniqKey="Al Ghonaium A" first="Abdulaziz" last="Al-Ghonaium">Abdulaziz Al-Ghonaium</name></author><author><name sortKey="Day Good, Noorbibi K" sort="Day Good, Noorbibi K" uniqKey="Day Good N" first="Noorbibi K." last="Day-Good">Noorbibi K. Day-Good</name></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name></author><author><name sortKey="Gallin, John" sort="Gallin, John" uniqKey="Gallin J" first="John" last="Gallin">John Gallin</name></author><author><name sortKey="Chapel, Helen" sort="Chapel, Helen" uniqKey="Chapel H" first="Helen" last="Chapel">Helen Chapel</name></author><author><name sortKey="Speert, David P" sort="Speert, David P" uniqKey="Speert D" first="David P." last="Speert">David P. Speert</name></author><author><name sortKey="Rodriguez Gallego, Carlos" sort="Rodriguez Gallego, Carlos" uniqKey="Rodriguez Gallego C" first="Carlos" last="Rodriguez-Gallego">Carlos Rodriguez-Gallego</name></author><author><name sortKey="Colino, Elena" sort="Colino, Elena" uniqKey="Colino E" first="Elena" last="Colino">Elena Colino</name></author><author><name sortKey="Garty, Ben Zion" sort="Garty, Ben Zion" uniqKey="Garty B" first="Ben-Zion" last="Garty">Ben-Zion Garty</name></author><author><name sortKey="Roifman, Chaim" sort="Roifman, Chaim" uniqKey="Roifman C" first="Chaim" last="Roifman">Chaim Roifman</name></author><author><name sortKey="Hara, Toshiro" sort="Hara, Toshiro" uniqKey="Hara T" first="Toshiro" last="Hara">Toshiro Hara</name></author><author><name sortKey="Yoshikawa, Hideto" sort="Yoshikawa, Hideto" uniqKey="Yoshikawa H" first="Hideto" last="Yoshikawa">Hideto Yoshikawa</name></author><author><name sortKey="Nonoyama, Shigeaki" sort="Nonoyama, Shigeaki" uniqKey="Nonoyama S" first="Shigeaki" last="Nonoyama">Shigeaki Nonoyama</name></author><author><name sortKey="Domachowske, Joseph" sort="Domachowske, Joseph" uniqKey="Domachowske J" first="Joseph" last="Domachowske">Joseph Domachowske</name></author><author><name sortKey="Issekutz, Andrew C" sort="Issekutz, Andrew C" uniqKey="Issekutz A" first="Andrew C." last="Issekutz">Andrew C. Issekutz</name></author><author><name sortKey="Tang, Mimi" sort="Tang, Mimi" uniqKey="Tang M" first="Mimi" last="Tang">Mimi Tang</name></author><author><name sortKey="Smart, Joanne" sort="Smart, Joanne" uniqKey="Smart J" first="Joanne" last="Smart">Joanne Smart</name></author><author><name sortKey="Zitnik, Simona Eva" sort="Zitnik, Simona Eva" uniqKey="Zitnik S" first="Simona Eva" last="Zitnik">Simona Eva Zitnik</name></author><author><name sortKey="Hoarau, Cyrille" sort="Hoarau, Cyrille" uniqKey="Hoarau C" first="Cyrille" last="Hoarau">Cyrille Hoarau</name></author><author><name sortKey="Kumararatne, Dinakantha" sort="Kumararatne, Dinakantha" uniqKey="Kumararatne D" first="Dinakantha" last="Kumararatne">Dinakantha Kumararatne</name></author><author><name sortKey="Thrasher, Adrian" sort="Thrasher, Adrian" uniqKey="Thrasher A" first="Adrian" last="Thrasher">Adrian Thrasher</name></author><author><name sortKey="Davies, E Graham" sort="Davies, E Graham" uniqKey="Davies E" first="E. Graham" last="Davies">E. Graham Davies</name></author><author><name sortKey="Bethune, Claire" sort="Bethune, Claire" uniqKey="Bethune C" first="Claire" last="Bethune">Claire Bethune</name></author><author><name sortKey="Sirvent, Nicolas" sort="Sirvent, Nicolas" uniqKey="Sirvent N" first="Nicolas" last="Sirvent">Nicolas Sirvent</name></author><author><name sortKey="De Ricaud, Dominique" sort="De Ricaud, Dominique" uniqKey="De Ricaud D" first="Dominique" last="De Ricaud">Dominique De Ricaud</name></author><author><name sortKey="Camcioglu, Yildiz" sort="Camcioglu, Yildiz" uniqKey="Camcioglu Y" first="Yildiz" last="Camcioglu">Yildiz Camcioglu</name></author><author><name sortKey="Vasconcelos, J Ulia" sort="Vasconcelos, J Ulia" uniqKey="Vasconcelos J" first="J Ulia" last="Vasconcelos">J Ulia Vasconcelos</name></author><author><name sortKey="Guedes, Margarida" sort="Guedes, Margarida" uniqKey="Guedes M" first="Margarida" last="Guedes">Margarida Guedes</name></author><author><name sortKey="Vitor, Artur Bonito" sort="Vitor, Artur Bonito" uniqKey="Vitor A" first="Artur Bonito" last="Vitor">Artur Bonito Vitor</name></author><author><name sortKey="Rodrigo, Carlos" sort="Rodrigo, Carlos" uniqKey="Rodrigo C" first="Carlos" last="Rodrigo">Carlos Rodrigo</name></author><author><name sortKey="Alma An, Francisco" sort="Alma An, Francisco" uniqKey="Alma An F" first="Francisco" last="Alma An">Francisco Alma An</name></author><author><name sortKey=" Ndez, Maria" sort=" Ndez, Maria" uniqKey=" Ndez M" first="Maria" last=" Ndez">Maria Ndez</name></author><author><name sortKey="A Ostegui, Juan Ignacio" sort="A Ostegui, Juan Ignacio" uniqKey="A Ostegui J" first="Juan Ignacio" last="A Ostegui">Juan Ignacio A Ostegui</name></author><author><name sortKey="Alsina, Laia" sort="Alsina, Laia" uniqKey="Alsina L" first="Laia" last="Alsina">Laia Alsina</name></author><author><name sortKey="Fortuny, Claudia" sort="Fortuny, Claudia" uniqKey="Fortuny C" first="Claudia" last="Fortuny">Claudia Fortuny</name></author><author><name sortKey="Reichenbach, Janine" sort="Reichenbach, Janine" uniqKey="Reichenbach J" first="Janine" last="Reichenbach">Janine Reichenbach</name></author><author><name sortKey="Verbsky, James W" sort="Verbsky, James W" uniqKey="Verbsky J" first="James W" last="Verbsky">James W. Verbsky</name></author><author><name sortKey="Bossuyt, Xavier" sort="Bossuyt, Xavier" uniqKey="Bossuyt X" first="Xavier" last="Bossuyt">Xavier Bossuyt</name></author><author><name sortKey="Doffinger, Rainer" sort="Doffinger, Rainer" uniqKey="Doffinger R" first="Rainer" last="Doffinger">Rainer Doffinger</name></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name></author><author><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name></author></analytic><series><title level="j">Medicine</title><idno type="ISSN">0025-7974</idno><idno type="eISSN">1536-5964</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)- and interleukin-1 receptor-mediated immunity. We documented the clinical features and outcome of 48 patients with IRAK-4 deficiency and 12 patients with MyD88 deficiency, from 37 kindreds in 15 countries. The clinical features of IRAK-4 and MyD88 deficiency were indistinguishable. There were no severe viral, parasitic, and fungal diseases, and the range of bacterial infections was narrow. Noninvasive bacterial infections occurred in 52 patients, with a high incidence of infections of the upper respiratory tract and the skin, mostly caused by <italic>Pseudomonas aeruginosa</italic> and <italic>Staphylococcus aureus,</italic> respectively. The leading threat was invasive pneumococcal disease, documented in 41 patients (68%) and causing 72 documented invasive infections (52.2%). <italic>P. aeruginosa</italic> and <italic>Staph. aureus</italic> documented invasive infections also occurred (16.7% and 16%, respectively, in 25% and 25% of patients). Systemic signs of inflammation were usually weak or delayed. The first invasive infection occurred before the age of 2 years in 53 (88.3%) and in the neonatal period in 19 (32.7%) patients. Multiple or recurrent invasive infections were observed in most survivors (n = 36/50, 72%).</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">2985248R</journal-id><journal-id journal-id-type="pubmed-jr-id">5748</journal-id><journal-id journal-id-type="nlm-ta">Medicine (Baltimore)</journal-id><journal-title-group><journal-title>Medicine</journal-title></journal-title-group><issn pub-type="ppub">0025-7974</issn><issn pub-type="epub">1536-5964</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21057262</article-id><article-id pub-id-type="pmc">3103888</article-id><article-id pub-id-type="doi">10.1097/MD.0b013e3181fd8ec3</article-id><article-id pub-id-type="manuscript">NIHMS292347</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Picard</surname><given-names>Capucine</given-names></name><degrees>MD, PhD</degrees><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>von Bernuth</surname><given-names>Horst</given-names></name><degrees>MD, PhD</degrees><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ghandil</surname><given-names>Pegah</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Chrabieh</surname><given-names>Maya</given-names></name></contrib><contrib contrib-type="author"><name><surname>Levy</surname><given-names>Ofer</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Arkwright</surname><given-names>Peter D.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>McDonald</surname><given-names>Douglas</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Geha</surname><given-names>Raif S.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Takada</surname><given-names>Hidetoshi</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Krause</surname><given-names>Jens C.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Creech</surname><given-names>C. Buddy</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Ku</surname><given-names>Cheng-Lung</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Ehl</surname><given-names>Stephan</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Maŕodi</surname><given-names>Ĺaszĺo</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Al-Muhsen</surname><given-names>Saleh</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Al-Hajjar</surname><given-names>Sami</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Al-Ghonaium</surname><given-names>Abdulaziz</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Day-Good</surname><given-names>Noorbibi K.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Holland</surname><given-names>Steven M.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Gallin</surname><given-names>John</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Chapel</surname><given-names>Helen</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Speert</surname><given-names>David P.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Rodriguez-Gallego</surname><given-names>Carlos</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Colino</surname><given-names>Elena</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Garty</surname><given-names>Ben-Zion</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Roifman</surname><given-names>Chaim</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Hara</surname><given-names>Toshiro</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Yoshikawa</surname><given-names>Hideto</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Nonoyama</surname><given-names>Shigeaki</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Domachowske</surname><given-names>Joseph</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Issekutz</surname><given-names>Andrew C.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Mimi</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Smart</surname><given-names>Joanne</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Zitnik</surname><given-names>Simona Eva</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Hoarau</surname><given-names>Cyrille</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Kumararatne</surname><given-names>Dinakantha</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Thrasher</surname><given-names>Adrian</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Davies</surname><given-names>E. Graham</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Bethune</surname><given-names>Claire</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Sirvent</surname><given-names>Nicolas</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>de Ricaud</surname><given-names>Dominique</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Camcioglu</surname><given-names>Yildiz</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Vasconcelos</surname><given-names>J́ulia</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Guedes</surname><given-names>Margarida</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Vitor</surname><given-names>Artur Bonito</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Rodrigo</surname><given-names>Carlos</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>AlmaŸan</surname><given-names>Francisco</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Ḿendez</surname><given-names>Maria</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Aŕostegui</surname><given-names>Juan Ignacio</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Alsina</surname><given-names>Laia</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Fortuny</surname><given-names>Claudia</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Reichenbach</surname><given-names>Janine</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Verbsky</surname><given-names>James W</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Bossuyt</surname><given-names>Xavier</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Doffinger</surname><given-names>Rainer</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Abel</surname><given-names>Laurent</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Puel</surname><given-names>Anne</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Casanova</surname><given-names>Jean-Laurent</given-names></name><degrees>MD, PhD</degrees></contrib><aff id="A1">Study Center of Primary Immunodeficiencies, Assistance Publique Ĥopitaux de Paris, Necker Hospital, Paris, France (CP). Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U550, Paris, France (CP, HvB, PG, MC, CLK, L. Abel, AP, JLC). Paris Descartes University, Paris, France (CP, HvB, PG, MC, CLK, L. Abel, AP, JLC). Department of Pediatric Pneumology and Immunology, Charit́e Hospital-Humboldt University, Berlin, Germany (HvB). Novel Primary Immunodeficiency and Infectious Diseases Program, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia (PG, SAM, SAH, AAG, JLC). Division of Infectious Diseases (OL); and Division of Immunology (DM, RSG), Children’s Hospital Boston, Boston, Massachusetts (OL). Harvard Medical School, Boston, Massachusetts (OL, DM, RSG). University of Manchester, Royal Manchester Children’s Hospital, Manchester, United Kingdom (PDA). Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (HT, TH). Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University, Nashville, Tennessee (JCK, CBC). Centre of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany (SE). Department of Infectious and Pediatric Immunology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (LM). Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia (SAM, SAH, AAG). Department of Pediatrics, Division of Allergy and Immunology, University of South Florida and All Children’s Hospital, St. Petersburg, Florida (NKDG). Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (SMH, JG). University of Oxford and Oxford Radcliffe Hospital, Oxford, United Kingdom (HC). Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (DPS). Department of Immunology, Dr Negrin University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain (CRG). Department of Pediatrics, Unit of Infectious Diseases, Insular-Materno-Infantil University Hospital, Las Palmas de Gran Canaria, Spain (EC). Schneider Children’s Medical Center, Petah Tiqva, Israel (BZG). Division of Immunology and Allergy, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (C. Roifman). Department of Neurology, Miyagi Children’s Hospital, Sendai, Japan (HY). Department of Pediatrics, National Defense Medical College, Saitama, Japan (SN). Pediatrics, Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York (JD). Dalhousie University, Halifax, Nova Scotia, Canada (ACI). Royal Children’s Hospital, Parkville, Victoria, Australia (MT, JS). University Children Hospital Ljubljana, Ljubljana, Slovenia (SEZ). Unit́e transversale d’Allergologie, Ńephrologie et Immunologie Clinique, Centre hospitalier universitaire de Tours, Tours, France (CH). Department of Clinical Biochemistry and Immunology, Addenbrookes Hospital, Cambridge, United Kingdom (DK, RD). Paediatric Immunology and Molecular Immunology Unit, Institute of Child Health, London, United Kingdom (AT). Department of Clinical Immunology, Great Ormond St Hospital, London, United Kingdom (EGD). Immunology Department, Derriford Hospital, Plymouth, United Kingdom (CB). University Hospital Archet 2, Nice, France (NS). Lenval Foundation, Children’s Hospital, Nice, France (DDR). Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey (YC). Pediatric Department, General Hospital of Santo Ant́onio, Porto, Portugal (JV, MG). Pediatric Department, Hospital S. Jõao, Porto, Portugal (ABV). Pediatric Department, Germans Trias i Pujol Hospital, Barcelona Autonomous University, Barcelona, Spain (C. Rodrigo, FA, MM). Immunology Department-CDB, Hospital Cĺinic-IDIBAPS, Barcelona University, Barcelona, Spain (JIA). Pediatric Department, Hospital Sant Joan de Deu, Barcelona University, Barcelona, Spain (L. Alsina, CF). Immunology Department, Universiẗats-Kinderspital Z̈urich, Z̈urich, Switzerland (JR). Pediatrics and Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin (JMV). Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Biomedical Science Group, Catholic University Leuven, Leuven, Belgium (XB). Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York (JLC). Pediatric Hematology-Immunology Unit, Necker Hospital, Assistance Publique Ĥopitaux de Paris, Paris, France (JLC)</aff></contrib-group><author-notes><corresp id="FN1">Jean-Laurent Casanova, MD, PhD, Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA (<email>jean-laurent.casanova@rockefeller.edu</email>); or Capucine Picard, MD, PhD, Laboratory of Human Genetics of Infectious Diseases, INSERM U980- Necker Faculty, 156 rue de Vaugirard, 75015, Paris, France (<email>capucine.picard@inserm.fr</email>)</corresp><fn id="FN2" fn-type="equal"><label>*</label><p>Both authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2011</year></pub-date><volume>89</volume><issue>6</issue><fpage>403</fpage><lpage>425</lpage><abstract><p id="P1">Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)- and interleukin-1 receptor-mediated immunity. We documented the clinical features and outcome of 48 patients with IRAK-4 deficiency and 12 patients with MyD88 deficiency, from 37 kindreds in 15 countries. The clinical features of IRAK-4 and MyD88 deficiency were indistinguishable. There were no severe viral, parasitic, and fungal diseases, and the range of bacterial infections was narrow. Noninvasive bacterial infections occurred in 52 patients, with a high incidence of infections of the upper respiratory tract and the skin, mostly caused by <italic>Pseudomonas aeruginosa</italic> and <italic>Staphylococcus aureus,</italic> respectively. The leading threat was invasive pneumococcal disease, documented in 41 patients (68%) and causing 72 documented invasive infections (52.2%). <italic>P. aeruginosa</italic> and <italic>Staph. aureus</italic> documented invasive infections also occurred (16.7% and 16%, respectively, in 25% and 25% of patients). Systemic signs of inflammation were usually weak or delayed. The first invasive infection occurred before the age of 2 years in 53 (88.3%) and in the neonatal period in 19 (32.7%) patients. Multiple or recurrent invasive infections were observed in most survivors (n = 36/50, 72%).</p></abstract><funding-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>UL1 RR024143-03 || RR</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey=" Ndez, Maria" sort=" Ndez, Maria" uniqKey=" Ndez M" first="Maria" last=" Ndez">Maria Ndez</name><name sortKey="A Ostegui, Juan Ignacio" sort="A Ostegui, Juan Ignacio" uniqKey="A Ostegui J" first="Juan Ignacio" last="A Ostegui">Juan Ignacio A Ostegui</name><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><name sortKey="Al Ghonaium, Abdulaziz" sort="Al Ghonaium, Abdulaziz" uniqKey="Al Ghonaium A" first="Abdulaziz" last="Al-Ghonaium">Abdulaziz Al-Ghonaium</name><name sortKey="Al Hajjar, Sami" sort="Al Hajjar, Sami" uniqKey="Al Hajjar S" first="Sami" last="Al-Hajjar">Sami Al-Hajjar</name><name sortKey="Al Muhsen, Saleh" sort="Al Muhsen, Saleh" uniqKey="Al Muhsen S" first="Saleh" last="Al-Muhsen">Saleh Al-Muhsen</name><name sortKey="Alma An, Francisco" sort="Alma An, Francisco" uniqKey="Alma An F" first="Francisco" last="Alma An">Francisco Alma An</name><name sortKey="Alsina, Laia" sort="Alsina, Laia" uniqKey="Alsina L" first="Laia" last="Alsina">Laia Alsina</name><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. 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Day-Good</name><name sortKey="De Ricaud, Dominique" sort="De Ricaud, Dominique" uniqKey="De Ricaud D" first="Dominique" last="De Ricaud">Dominique De Ricaud</name><name sortKey="Doffinger, Rainer" sort="Doffinger, Rainer" uniqKey="Doffinger R" first="Rainer" last="Doffinger">Rainer Doffinger</name><name sortKey="Domachowske, Joseph" sort="Domachowske, Joseph" uniqKey="Domachowske J" first="Joseph" last="Domachowske">Joseph Domachowske</name><name sortKey="Ehl, Stephan" sort="Ehl, Stephan" uniqKey="Ehl S" first="Stephan" last="Ehl">Stephan Ehl</name><name sortKey="Fortuny, Claudia" sort="Fortuny, Claudia" uniqKey="Fortuny C" first="Claudia" last="Fortuny">Claudia Fortuny</name><name sortKey="Gallin, John" sort="Gallin, John" uniqKey="Gallin J" first="John" last="Gallin">John Gallin</name><name sortKey="Garty, Ben Zion" sort="Garty, Ben Zion" uniqKey="Garty B" first="Ben-Zion" last="Garty">Ben-Zion Garty</name><name sortKey="Geha, Raif S" sort="Geha, Raif S" uniqKey="Geha R" first="Raif S." last="Geha">Raif S. Geha</name><name sortKey="Ghandil, Pegah" sort="Ghandil, Pegah" uniqKey="Ghandil P" first="Pegah" last="Ghandil">Pegah Ghandil</name><name sortKey="Guedes, Margarida" sort="Guedes, Margarida" uniqKey="Guedes M" first="Margarida" last="Guedes">Margarida Guedes</name><name sortKey="Hara, Toshiro" sort="Hara, Toshiro" uniqKey="Hara T" first="Toshiro" last="Hara">Toshiro Hara</name><name sortKey="Hoarau, Cyrille" sort="Hoarau, Cyrille" uniqKey="Hoarau C" first="Cyrille" last="Hoarau">Cyrille Hoarau</name><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name><name sortKey="Issekutz, Andrew C" sort="Issekutz, Andrew C" uniqKey="Issekutz A" first="Andrew C." last="Issekutz">Andrew C. Issekutz</name><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name><name sortKey="Ku, Cheng Lung" sort="Ku, Cheng Lung" uniqKey="Ku C" first="Cheng-Lung" last="Ku">Cheng-Lung Ku</name><name sortKey="Kumararatne, Dinakantha" sort="Kumararatne, Dinakantha" uniqKey="Kumararatne D" first="Dinakantha" last="Kumararatne">Dinakantha Kumararatne</name><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name><name sortKey="Ma Odi, Asz O" sort="Ma Odi, Asz O" uniqKey="Ma Odi " first=" Asz O" last="Ma Odi"> Asz O Ma Odi</name><name sortKey="Mcdonald, Douglas" sort="Mcdonald, Douglas" uniqKey="Mcdonald D" first="Douglas" last="Mcdonald">Douglas Mcdonald</name><name sortKey="Nonoyama, Shigeaki" sort="Nonoyama, Shigeaki" uniqKey="Nonoyama S" first="Shigeaki" last="Nonoyama">Shigeaki Nonoyama</name><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><name sortKey="Reichenbach, Janine" sort="Reichenbach, Janine" uniqKey="Reichenbach J" first="Janine" last="Reichenbach">Janine Reichenbach</name><name sortKey="Rodrigo, Carlos" sort="Rodrigo, Carlos" uniqKey="Rodrigo C" first="Carlos" last="Rodrigo">Carlos Rodrigo</name><name sortKey="Rodriguez Gallego, Carlos" sort="Rodriguez Gallego, Carlos" uniqKey="Rodriguez Gallego C" first="Carlos" last="Rodriguez-Gallego">Carlos Rodriguez-Gallego</name><name sortKey="Roifman, Chaim" sort="Roifman, Chaim" uniqKey="Roifman C" first="Chaim" last="Roifman">Chaim Roifman</name><name sortKey="Sirvent, Nicolas" sort="Sirvent, Nicolas" uniqKey="Sirvent N" first="Nicolas" last="Sirvent">Nicolas Sirvent</name><name sortKey="Smart, Joanne" sort="Smart, Joanne" uniqKey="Smart J" first="Joanne" last="Smart">Joanne Smart</name><name sortKey="Speert, David P" sort="Speert, David P" uniqKey="Speert D" first="David P." last="Speert">David P. Speert</name><name sortKey="Takada, Hidetoshi" sort="Takada, Hidetoshi" uniqKey="Takada H" first="Hidetoshi" last="Takada">Hidetoshi Takada</name><name sortKey="Tang, Mimi" sort="Tang, Mimi" uniqKey="Tang M" first="Mimi" last="Tang">Mimi Tang</name><name sortKey="Thrasher, Adrian" sort="Thrasher, Adrian" uniqKey="Thrasher A" first="Adrian" last="Thrasher">Adrian Thrasher</name><name sortKey="Vasconcelos, J Ulia" sort="Vasconcelos, J Ulia" uniqKey="Vasconcelos J" first="J Ulia" last="Vasconcelos">J Ulia Vasconcelos</name><name sortKey="Verbsky, James W" sort="Verbsky, James W" uniqKey="Verbsky J" first="James W" last="Verbsky">James W. Verbsky</name><name sortKey="Vitor, Artur Bonito" sort="Vitor, Artur Bonito" uniqKey="Vitor A" first="Artur Bonito" last="Vitor">Artur Bonito Vitor</name><name sortKey="Von Bernuth, Horst" sort="Von Bernuth, Horst" uniqKey="Von Bernuth H" first="Horst" last="Von Bernuth">Horst Von Bernuth</name><name sortKey="Yoshikawa, Hideto" sort="Yoshikawa, Hideto" uniqKey="Yoshikawa H" first="Hideto" last="Yoshikawa">Hideto Yoshikawa</name><name sortKey="Zitnik, Simona Eva" sort="Zitnik, Simona Eva" uniqKey="Zitnik S" first="Simona Eva" last="Zitnik">Simona Eva Zitnik</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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