Cost-effectiveness of Pharmaceutical-based Pandemic Influenza Mitigation Strategies1
Identifieur interne : 000713 ( Ncbi/Merge ); précédent : 000712; suivant : 000714Cost-effectiveness of Pharmaceutical-based Pandemic Influenza Mitigation Strategies1
Auteurs : Anthony T. Newall ; James G. Wood ; Noemie Oudin ; C. Raina MacintyreSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2010.
Abstract
Population prepandemic vaccine and antiviral treatment strategies may be cost-effective.
Url:
DOI: 10.3201/eid1602.090571
PubMed: 20113551
PubMed Central: 2957998
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PMC:2957998Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Population prepandemic vaccine and antiviral treatment strategies may be cost-effective.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id>
<journal-id journal-id-type="publisher-id">EID</journal-id>
<journal-title-group><journal-title>Emerging Infectious Diseases</journal-title>
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<issn pub-type="ppub">1080-6040</issn>
<issn pub-type="epub">1080-6059</issn>
<publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name>
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<article-id pub-id-type="publisher-id">09-0571</article-id>
<article-id pub-id-type="doi">10.3201/eid1602.090571</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
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<title-group><article-title>Cost-effectiveness of Pharmaceutical-based Pandemic Influenza Mitigation Strategies<xref ref-type="fn" rid="FN1"><sup>1</sup>
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<alt-title alt-title-type="running-head">Pandemic Influenza Mitigation Strategies</alt-title>
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<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Newall</surname>
<given-names>Anthony T.</given-names>
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<contrib contrib-type="author"><name><surname>Wood</surname>
<given-names>James G.</given-names>
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<contrib contrib-type="author"><name><surname>Oudin</surname>
<given-names>Noemie</given-names>
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<contrib contrib-type="author"><name><surname>MacIntyre</surname>
<given-names>C. Raina</given-names>
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<aff id="aff1">University of New South Wales, Sydney, New South Wales, Australia (A.T. Newall, J.G. Wood, C.R. MacIntyre)</aff>
<aff id="aff2">National Institute for Applied Sciences, Lyon, France (N. Oudin)</aff>
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<author-notes><corresp id="cor1">Address for correspondence: Anthony T. Newall, School of Public Health and Community Medicine, The University of New South Wales, Samuals Bldg, Sydney, New South Wales 2052, Australia; email: <email xlink:href="a.newall@unsw.edu.au">a.newall@unsw.edu.au</email>
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<pub-date pub-type="ppub"><month>2</month>
<year>2010</year>
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<volume>16</volume>
<issue>2</issue>
<fpage>224</fpage>
<lpage>230</lpage>
<abstract abstract-type="toc"><p>Population prepandemic vaccine and antiviral treatment strategies may be cost-effective.</p>
</abstract>
<abstract><p>We used a hybrid transmission and economic model to evaluate the relative merits of stockpiling antiviral drugs and vaccine for pandemic influenza mitigation. In the absence of any intervention, our base-case assumptions generated a population clinical attack rate of 31.1%. For at least some parameter values, population prepandemic vaccination strategies were effective at containing an outbreak of pandemic influenza until the arrival of a matched vaccine. Because of the uncertain nature of many parameters, we used a probabilistic approach to determine the most cost-effective strategies. At a willingness to pay of >A$24,000 per life-year saved, more than half the simulations showed that a prepandemic vaccination program combined with antiviral treatment was cost-effective in Australia.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords: </title>
<kwd>Influenza</kwd>
<kwd>viruses</kwd>
<kwd>pandemic</kwd>
<kwd>mitigation</kwd>
<kwd>cost-effectiveness</kwd>
<kwd>vaccines</kwd>
<kwd>research</kwd>
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<tree><noCountry><name sortKey="Macintyre, C Raina" sort="Macintyre, C Raina" uniqKey="Macintyre C" first="C. Raina" last="Macintyre">C. Raina Macintyre</name>
<name sortKey="Newall, Anthony T" sort="Newall, Anthony T" uniqKey="Newall A" first="Anthony T." last="Newall">Anthony T. Newall</name>
<name sortKey="Oudin, Noemie" sort="Oudin, Noemie" uniqKey="Oudin N" first="Noemie" last="Oudin">Noemie Oudin</name>
<name sortKey="Wood, James G" sort="Wood, James G" uniqKey="Wood J" first="James G." last="Wood">James G. Wood</name>
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