AustralieFrV1, Ncbi, Merge, bibRecord, 000496

Theileria Apicoplast as a Target for Chemotherapy▿ †

Identifieur interne : 000496 ( Ncbi/Merge ); précédent : 000495; suivant : 000497

Theileria Apicoplast as a Target for Chemotherapy▿ †

Auteurs : Regina Lizundia ; Dirk Werling ; Gordon Langsley ; Stuart A. Ralph

Source :

Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2008.

RBID : PMC:2650513

Abstract

Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650513

DOI: 10.1128/AAC.00126-08
PubMed: 19075064
PubMed Central: 2650513

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PMC:2650513

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Theileria</italic>
 Apicoplast as a Target for Chemotherapy<xref ref-type="fn" rid="fn2">▿</xref>
 <xref ref-type="fn" rid="fn1">†</xref>
</title>
<author><name sortKey="Lizundia, Regina" sort="Lizundia, Regina" uniqKey="Lizundia R" first="Regina" last="Lizundia">Regina Lizundia</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Werling, Dirk" sort="Werling, Dirk" uniqKey="Werling D" first="Dirk" last="Werling">Dirk Werling</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
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<author><name sortKey="Langsley, Gordon" sort="Langsley, Gordon" uniqKey="Langsley G" first="Gordon" last="Langsley">Gordon Langsley</name>
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<author><name sortKey="Ralph, Stuart A" sort="Ralph, Stuart A" uniqKey="Ralph S" first="Stuart A." last="Ralph">Stuart A. Ralph</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Theileria</italic>
 Apicoplast as a Target for Chemotherapy<xref ref-type="fn" rid="fn2">▿</xref>
 <xref ref-type="fn" rid="fn1">†</xref>
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<author><name sortKey="Lizundia, Regina" sort="Lizundia, Regina" uniqKey="Lizundia R" first="Regina" last="Lizundia">Regina Lizundia</name>
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<author><name sortKey="Werling, Dirk" sort="Werling, Dirk" uniqKey="Werling D" first="Dirk" last="Werling">Dirk Werling</name>
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<author><name sortKey="Langsley, Gordon" sort="Langsley, Gordon" uniqKey="Langsley G" first="Gordon" last="Langsley">Gordon Langsley</name>
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<author><name sortKey="Ralph, Stuart A" sort="Ralph, Stuart A" uniqKey="Ralph S" first="Stuart A." last="Ralph">Stuart A. Ralph</name>
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<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
<idno type="ISSN">0066-4804</idno>
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<front><div type="abstract" xml:lang="en"><p><italic>Theileria</italic>
 parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Antimicrob Agents Chemother</journal-id>
<journal-id journal-id-type="publisher-id">aac</journal-id>
<journal-title>Antimicrobial Agents and Chemotherapy</journal-title>
<issn pub-type="ppub">0066-4804</issn>
<issn pub-type="epub">1098-6596</issn>
<publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19075064</article-id>
<article-id pub-id-type="pmc">2650513</article-id>
<article-id pub-id-type="publisher-id">0126-08</article-id>
<article-id pub-id-type="doi">10.1128/AAC.00126-08</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Susceptibility</subject>
</subj-group>
</article-categories>
<title-group><article-title><italic>Theileria</italic>
 Apicoplast as a Target for Chemotherapy<xref ref-type="fn" rid="fn2">▿</xref>
 <xref ref-type="fn" rid="fn1">†</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lizundia</surname>
<given-names>Regina</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
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<contrib contrib-type="author"><name><surname>Werling</surname>
<given-names>Dirk</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Langsley</surname>
<given-names>Gordon</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ralph</surname>
<given-names>Stuart A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">3</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="aff1">Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, UMR 8104 CNRS/U567 INSERM, Département Maladies Infectieuses, Hôpital Cochin—Bâtiment Gustave Roussy, Institut Cochin, 27 rue du Faubourg-Saint-Jacques, 75014 Paris, France,<label>1</label>
 Royal Veterinary College, Department of Pathology and Infectious Diseases, Hawkshead Lane, Hatfield, Hertfordshire AL9 7TA, United Kingdom,<label>2</label>
 Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia<label>3</label>
</aff>
<author-notes><fn id="cor1"><label>*</label>
<p>Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. Phone: 61 3 8344 2284. Fax: 61 3 9348 1421. E-mail: <email>saralph@unimelb.edu.au</email>
</p>
</fn>
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<pub-date pub-type="ppub"><month>3</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>12</month>
<year>2008</year>
</pub-date>
<volume>53</volume>
<issue>3</issue>
<fpage>1213</fpage>
<lpage>1217</lpage>
<history><date date-type="received"><day>28</day>
<month>1</month>
<year>2008</year>
</date>
<date date-type="rev-recd"><day>1</day>
<month>4</month>
<year>2008</year>
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<date date-type="accepted"><day>3</day>
<month>12</month>
<year>2008</year>
</date>
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<permissions><copyright-statement>Copyright © 2009, American Society for Microbiology</copyright-statement>
</permissions>
<self-uri xlink:title="pdf" xlink:href="zac00309001213.pdf"></self-uri>
<abstract><p><italic>Theileria</italic>
 parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.</p>
</abstract>
</article-meta>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Langsley, Gordon" sort="Langsley, Gordon" uniqKey="Langsley G" first="Gordon" last="Langsley">Gordon Langsley</name>
<name sortKey="Lizundia, Regina" sort="Lizundia, Regina" uniqKey="Lizundia R" first="Regina" last="Lizundia">Regina Lizundia</name>
<name sortKey="Ralph, Stuart A" sort="Ralph, Stuart A" uniqKey="Ralph S" first="Stuart A." last="Ralph">Stuart A. Ralph</name>
<name sortKey="Werling, Dirk" sort="Werling, Dirk" uniqKey="Werling D" first="Dirk" last="Werling">Dirk Werling</name>
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Theileria Apicoplast as a Target for Chemotherapy▿ †

Theileria Apicoplast as a Target for Chemotherapy▿ †

Source :

Abstract

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