Fixing DNA breaks during class switch recombination
Identifieur interne : 000354 ( Ncbi/Merge ); précédent : 000353; suivant : 000355Fixing DNA breaks during class switch recombination
Auteurs : Christopher J. Jolly ; Adam J. L. Cook ; John P. ManisSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2008.
Abstract
Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pathway, but the role of the NHEJ factor DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in this process has been unclear. A new study, in which broken IgH-containing chromosomes in switching B cells were visualized directly, clearly demonstrated that DNA-PKcs and, unexpectedly, the nuclease Artemis are involved in the resolution of switch breaks.
Url:
DOI: 10.1084/jem.20080356
PubMed: 18332183
PubMed Central: 2275374
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Med</journal-id><journal-id journal-id-type="publisher-id">jem</journal-id><journal-title>The Journal of Experimental Medicine</journal-title><issn pub-type="ppub">0022-1007</issn><issn pub-type="epub">1540-9538</issn><publisher><publisher-name>The Rockefeller University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18332183</article-id><article-id pub-id-type="pmc">2275374</article-id><article-id pub-id-type="publisher-id">20080356</article-id><article-id pub-id-type="doi">10.1084/jem.20080356</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentaries</subject><subj-group><subject>Commentary</subject></subj-group></subj-group></article-categories><title-group><article-title>Fixing DNA breaks during class switch recombination</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jolly</surname><given-names>Christopher J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cook</surname><given-names>Adam J.L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Manis</surname><given-names>John P.</given-names></name></contrib></contrib-group><aff id="N0x2050f10N0x1d87680">C.J. Jolly is at Centenary Institute, The University of Sydney, Sydney NSW 2006, Australia</aff><aff id="N0x2050f10N0x1d876c8">A.J.L. Cook is at UMR 218 Centre National de la Recherche Scientifique/Institut Curie, 75248 Paris, France</aff><aff id="N0x2050f10N0x1d87710">J.P. Manis is at Joint Program in Transfusion Medicine and Department of Laboratory Medicine, Children's Hospital Boston, and Department of Pathology, Harvard Medical School, Boston, MA 02115</aff><author-notes><fn><p>CORRESPONDENCE J.P.M.: <email>manis@enders.tch.harvard.edu</email></p></fn></author-notes><pub-date pub-type="ppub"><day>17</day><month>3</month><year>2008</year></pub-date><volume>205</volume><issue>3</issue><fpage>509</fpage><lpage>513</lpage><permissions><copyright-statement>Copyright © 2008, The Rockefeller University Press</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:href="jem2050509.pdf"></self-uri><abstract><p>Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pathway, but the role of the NHEJ factor DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in this process has been unclear. A new study, in which broken IgH-containing chromosomes in switching B cells were visualized directly, clearly demonstrated that DNA-PKcs and, unexpectedly, the nuclease Artemis are involved in the resolution of switch breaks.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Cook, Adam J L" sort="Cook, Adam J L" uniqKey="Cook A" first="Adam J. L." last="Cook">Adam J. L. Cook</name><name sortKey="Jolly, Christopher J" sort="Jolly, Christopher J" uniqKey="Jolly C" first="Christopher J." last="Jolly">Christopher J. Jolly</name><name sortKey="Manis, John P" sort="Manis, John P" uniqKey="Manis J" first="John P." last="Manis">John P. Manis</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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