Developmental Regulation of Sialoadhesin (Sheep Erythrocyte Receptor), a Macrophage-Cell Interaction Molecule Expressed in Lymphohemopoietic Tissues
Identifieur interne : 000111 ( Ncbi/Merge ); précédent : 000110; suivant : 000112Developmental Regulation of Sialoadhesin (Sheep Erythrocyte Receptor), a Macrophage-Cell Interaction Molecule Expressed in Lymphohemopoietic Tissues
Auteurs : Lynn Morris [Australie] ; Paul R. Crocker [France] ; Maxine Hill [Royaume-Uni] ; Siamon Gordon [Royaume-Uni]Source :
- Developmental Immunology [ 1044-6672 ] ; 1992.
Abstract
Stromal macrophages in lymphohemopoietic tissues express novel macrophagerestricted plasma membrane receptors involved in nonphagocytic interactions with other hemopoietic cells. One such receptor with lectinlike specificity for sialylated glycoconjugates on sheep erythrocytes and murine hemopoietic cells has been characterized immunochemically and termed sialoadhesin. We have examined sialoadhesin expression during mouse development to learn more about its regulation and function. Immunocytochemical, rosetting, and Western blot studies show that sialoadhesin is first detected on fetal liver macrophages on day 18 of development, 7 days after numerous F4/80+ macrophages are found within erythroblastic islands. In spleen and bone marrow, sialoadhesin appears between day 18 and birth, in parallel with myeloid development. Strongly labeled macrophages in the marginal zone of spleen, characteristic of adult lymphoid tissues, appeared gradually between 1–4 Isolation of fetal liver macrophages at day 14 confirmed that sialoadhesin was not involved in the binding of erythroblasts, which is mediated by a distinct cationdependent receptor (Morris et al., 1988, p. 649). Sialoadhesin could be expressed by isolated fetal liver macrophages after cultivation in adult mouse serum, a known source of inducer activity, but was not dependent on the presence of this inducer, unlike adultderived madrophages. Fetal plasma contained inducing activity on day 13, but adult levels were not reached until 2 weeks postnatally. These studies show that sialoadhesin is differentially regulated compared with the erythroblast receptor and F4/80 antigen, that it is not required for fetal erythropoiesis, and that its induction on stromal macrophages is delayed until the onset of myeloid and lymphoid development. Sialoadhesin provides a marker to study maturation and functions of macrophages during ontogeny of the lymphohemopoietic system.
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DOI: 10.1155/1992/74945
PubMed: 1521065
PubMed Central: 2275845
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Lymphohemopoietic Tissues</title>
<author><name sortKey="Morris, Lynn" sort="Morris, Lynn" uniqKey="Morris L" first="Lynn" last="Morris">Lynn Morris</name>
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<addr-line>Melbourne</addr-line>
<country>Australia</country>
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<author><name sortKey="Crocker, Paul R" sort="Crocker, Paul R" uniqKey="Crocker P" first="Paul R." last="Crocker">Paul R. Crocker</name>
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<addr-line>Paris</addr-line>
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<author><name sortKey="Hill, Maxine" sort="Hill, Maxine" uniqKey="Hill M" first="Maxine" last="Hill">Maxine Hill</name>
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<author><name sortKey="Gordon, Siamon" sort="Gordon, Siamon" uniqKey="Gordon S" first="Siamon" last="Gordon">Siamon Gordon</name>
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<author><name sortKey="Morris, Lynn" sort="Morris, Lynn" uniqKey="Morris L" first="Lynn" last="Morris">Lynn Morris</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Walter and Eliza Hall Institute</addr-line>
<addr-line>Melbourne</addr-line>
<country>Australia</country>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Crocker, Paul R" sort="Crocker, Paul R" uniqKey="Crocker P" first="Paul R." last="Crocker">Paul R. Crocker</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Pasteur Institute</addr-line>
<addr-line>Paris</addr-line>
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Hill, Maxine" sort="Hill, Maxine" uniqKey="Hill M" first="Maxine" last="Hill">Maxine Hill</name>
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<addr-line>OX1 3RE</addr-line>
<country>United Kingdom</country>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Gordon, Siamon" sort="Gordon, Siamon" uniqKey="Gordon S" first="Siamon" last="Gordon">Siamon Gordon</name>
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<addr-line>OX1 3RE</addr-line>
<country>United Kingdom</country>
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<country xml:lang="fr">Royaume-Uni</country>
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<series><title level="j">Developmental Immunology</title>
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<front><div type="abstract" xml:lang="en"><p>Stromal macrophages in lymphohemopoietic tissues express novel macrophagerestricted
plasma membrane receptors involved in nonphagocytic interactions with
other hemopoietic cells. One such receptor with lectinlike specificity for sialylated
glycoconjugates on sheep erythrocytes and murine hemopoietic cells has been
characterized immunochemically and termed sialoadhesin. We have examined
sialoadhesin expression during mouse development to learn more about its regulation
and function. Immunocytochemical, rosetting, and Western blot studies show that
sialoadhesin is first detected on fetal liver macrophages on day 18 of development, 7
days after numerous F4/80<sup>+</sup>
macrophages are found within erythroblastic islands. In
spleen and bone marrow, sialoadhesin appears between day 18 and birth, in parallel
with myeloid development. Strongly labeled macrophages in the marginal zone of
spleen, characteristic of adult lymphoid tissues, appeared gradually between 1–4
Isolation of fetal liver macrophages at day 14 confirmed that sialoadhesin was not
involved in the binding of erythroblasts, which is mediated by a distinct cationdependent
receptor (Morris et al., 1988, p. 649). Sialoadhesin could be expressed by
isolated fetal liver macrophages after cultivation in adult mouse serum, a known source
of inducer activity, but was not dependent on the presence of this inducer, unlike adultderived
madrophages. Fetal plasma contained inducing activity on day 13, but adult
levels were not reached until 2 weeks postnatally. These studies show that sialoadhesin
is differentially regulated compared with the erythroblast receptor and F4/80 antigen,
that it is not required for fetal erythropoiesis, and that its induction on stromal
macrophages is delayed until the onset of myeloid and lymphoid development.
Sialoadhesin provides a marker to study maturation and functions of macrophages
during ontogeny of the lymphohemopoietic system.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dev Immunol</journal-id>
<journal-title>Developmental Immunology</journal-title>
<issn pub-type="ppub">1044-6672</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">1521065</article-id>
<article-id pub-id-type="pmc">2275845</article-id>
<article-id pub-id-type="pii">S1740252292749452</article-id>
<article-id pub-id-type="doi">10.1155/1992/74945</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Developmental Regulation of Sialoadhesin (Sheep Erythrocyte
Receptor), a Macrophage-Cell Interaction Molecule Expressed in
Lymphohemopoietic Tissues</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Morris</surname>
<given-names>Lynn</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Crocker</surname>
<given-names>Paul R.</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hill</surname>
<given-names>Maxine</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Gordon</surname>
<given-names>Siamon</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Walter and Eliza Hall Institute</addr-line>
<addr-line>Melbourne</addr-line>
<country>Australia</country>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Pasteur Institute</addr-line>
<addr-line>Paris</addr-line>
<country>France</country>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Sir William Dunn School of Pathology</addr-line>
<addr-line>University of Oxford, South Parks Road</addr-line>
<addr-line>Oxford</addr-line>
<addr-line>OX1 3RE</addr-line>
<country>United Kingdom</country>
</aff>
<pub-date pub-type="ppub"><year>1992</year>
</pub-date>
<volume>2</volume>
<issue>1</issue>
<fpage>7</fpage>
<lpage>17</lpage>
<permissions><copyright-statement>Copyright © 1992 Hindawi Publishing Corporation.</copyright-statement>
<copyright-year>1992</copyright-year>
<copyright-holder>Hindawi Publishing Corporation</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/"><p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
</license>
</permissions>
<abstract><p>Stromal macrophages in lymphohemopoietic tissues express novel macrophagerestricted
plasma membrane receptors involved in nonphagocytic interactions with
other hemopoietic cells. One such receptor with lectinlike specificity for sialylated
glycoconjugates on sheep erythrocytes and murine hemopoietic cells has been
characterized immunochemically and termed sialoadhesin. We have examined
sialoadhesin expression during mouse development to learn more about its regulation
and function. Immunocytochemical, rosetting, and Western blot studies show that
sialoadhesin is first detected on fetal liver macrophages on day 18 of development, 7
days after numerous F4/80<sup>+</sup>
macrophages are found within erythroblastic islands. In
spleen and bone marrow, sialoadhesin appears between day 18 and birth, in parallel
with myeloid development. Strongly labeled macrophages in the marginal zone of
spleen, characteristic of adult lymphoid tissues, appeared gradually between 1–4
Isolation of fetal liver macrophages at day 14 confirmed that sialoadhesin was not
involved in the binding of erythroblasts, which is mediated by a distinct cationdependent
receptor (Morris et al., 1988, p. 649). Sialoadhesin could be expressed by
isolated fetal liver macrophages after cultivation in adult mouse serum, a known source
of inducer activity, but was not dependent on the presence of this inducer, unlike adultderived
madrophages. Fetal plasma contained inducing activity on day 13, but adult
levels were not reached until 2 weeks postnatally. These studies show that sialoadhesin
is differentially regulated compared with the erythroblast receptor and F4/80 antigen,
that it is not required for fetal erythropoiesis, and that its induction on stromal
macrophages is delayed until the onset of myeloid and lymphoid development.
Sialoadhesin provides a marker to study maturation and functions of macrophages
during ontogeny of the lymphohemopoietic system.</p>
</abstract>
<kwd-group><kwd>Sialoadhesin</kwd>
<kwd>macrophages</kwd>
<kwd>cell interaction</kwd>
<kwd>ontogeny</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
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<li>France</li>
<li>Royaume-Uni</li>
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<tree><country name="Australie"><noRegion><name sortKey="Morris, Lynn" sort="Morris, Lynn" uniqKey="Morris L" first="Lynn" last="Morris">Lynn Morris</name>
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<name sortKey="Gordon, Siamon" sort="Gordon, Siamon" uniqKey="Gordon S" first="Siamon" last="Gordon">Siamon Gordon</name>
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