Neoadjuvant buparlisib plus trastuzumab and paclitaxel for women with HER2+ primary breast cancer: A randomised, double-blind, placebo-controlled phase II trial (NeoPHOEBE).
Identifieur interne : 004E85 ( Ncbi/Curation ); précédent : 004E84; suivant : 004E86Neoadjuvant buparlisib plus trastuzumab and paclitaxel for women with HER2+ primary breast cancer: A randomised, double-blind, placebo-controlled phase II trial (NeoPHOEBE).
Auteurs : Sibylle Loibl [Allemagne] ; Lorena De La Pena [Espagne] ; Valentina Nekljudova [Allemagne] ; Dimitrios Zardavas [Belgique] ; Stefan Michiels [France] ; Carsten Denkert [Allemagne] ; Mahdi Rezai [Allemagne] ; Bego A Bermejo [Espagne] ; Michael Untch [Allemagne] ; Soo Chin Lee [Singapour] ; Sabine Turri [France] ; Patrick Urban [Suisse] ; Sherko Kümmel [Allemagne] ; Guenther Steger [Autriche] ; Andrea Gombos [Belgique] ; Michael Lux [Allemagne] ; Martine J. Piccart [Belgique] ; Gunter Von Minckwitz [Allemagne] ; José Baselga [États-Unis] ; Sherene Loi [Australie]Source :
- European journal of cancer (Oxford, England : 1990) [ 1879-0852 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Aminopyridines (administration et posologie), Aminopyridines (effets indésirables), Antigène KI-67 (métabolisme), Arrêt précoce d'essais cliniques, Australie, Biopsie, Europe, Facteurs temps, Femelle, Humains, Inhibiteurs de protéines kinases (administration et posologie), Inhibiteurs de protéines kinases (effets indésirables), Lymphocytes TIL (), Lésions hépatiques dues aux substances (étiologie), Marqueurs biologiques tumoraux (antagonistes et inhibiteurs), Marqueurs biologiques tumoraux (génétique), Marqueurs biologiques tumoraux (métabolisme), Morpholines (administration et posologie), Morpholines (effets indésirables), Mutation, Méthode en double aveugle, Paclitaxel (administration et posologie), Paclitaxel (effets indésirables), Phosphatidylinositol 3-kinases de classe I (antagonistes et inhibiteurs), Phosphatidylinositol 3-kinases de classe I (génétique), Phosphatidylinositol 3-kinases de classe I (métabolisme), Protocoles de polychimiothérapie antinéoplasique (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Récepteur ErbB-2 (antagonistes et inhibiteurs), Récepteur ErbB-2 (métabolisme), Résultat thérapeutique, Sujet âgé, Traitement médicamenteux adjuvant, Traitement néoadjuvant (effets indésirables), Trastuzumab (administration et posologie), Trastuzumab (effets indésirables), Tumeurs du sein (anatomopathologie), Tumeurs du sein (enzymologie), Tumeurs du sein (traitement médicamenteux).
- MESH :
- administration et posologie : Aminopyridines, Inhibiteurs de protéines kinases, Morpholines, Paclitaxel, Trastuzumab.
- anatomopathologie : Tumeurs du sein.
- antagonistes et inhibiteurs : Marqueurs biologiques tumoraux, Phosphatidylinositol 3-kinases de classe I, Récepteur ErbB-2.
- effets indésirables : Aminopyridines, Inhibiteurs de protéines kinases, Morpholines, Paclitaxel, Protocoles de polychimiothérapie antinéoplasique, Traitement néoadjuvant, Trastuzumab.
- enzymologie : Tumeurs du sein.
- génétique : Marqueurs biologiques tumoraux, Phosphatidylinositol 3-kinases de classe I.
- métabolisme : Antigène KI-67, Marqueurs biologiques tumoraux, Phosphatidylinositol 3-kinases de classe I, Récepteur ErbB-2.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- étiologie : Lésions hépatiques dues aux substances.
- Adulte, Adulte d'âge moyen, Arrêt précoce d'essais cliniques, Australie, Biopsie, Europe, Facteurs temps, Femelle, Humains, Lymphocytes TIL, Mutation, Méthode en double aveugle, Résultat thérapeutique, Sujet âgé, Traitement médicamenteux adjuvant.
English descriptors
- KwdEn :
- Adult, Aged, Aminopyridines (administration & dosage), Aminopyridines (adverse effects), Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Australia, Biomarkers, Tumor (antagonists & inhibitors), Biomarkers, Tumor (genetics), Biomarkers, Tumor (metabolism), Biopsy, Breast Neoplasms (drug therapy), Breast Neoplasms (enzymology), Breast Neoplasms (pathology), Chemical and Drug Induced Liver Injury (etiology), Chemotherapy, Adjuvant, Class I Phosphatidylinositol 3-Kinases (antagonists & inhibitors), Class I Phosphatidylinositol 3-Kinases (genetics), Class I Phosphatidylinositol 3-Kinases (metabolism), Double-Blind Method, Early Termination of Clinical Trials, Europe, Female, Humans, Ki-67 Antigen (metabolism), Lymphocytes, Tumor-Infiltrating (drug effects), Middle Aged, Morpholines (administration & dosage), Morpholines (adverse effects), Mutation, Neoadjuvant Therapy (adverse effects), Paclitaxel (administration & dosage), Paclitaxel (adverse effects), Protein Kinase Inhibitors (administration & dosage), Protein Kinase Inhibitors (adverse effects), Receptor, ErbB-2 (antagonists & inhibitors), Receptor, ErbB-2 (metabolism), Time Factors, Trastuzumab (administration & dosage), Trastuzumab (adverse effects), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Aminopyridines, Morpholines, Paclitaxel, Protein Kinase Inhibitors, Trastuzumab.
- chemical , adverse effects : Aminopyridines, Morpholines, Paclitaxel, Protein Kinase Inhibitors, Trastuzumab.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols, Neoadjuvant Therapy.
- chemical , antagonists & inhibitors : Biomarkers, Tumor, Class I Phosphatidylinositol 3-Kinases, Receptor, ErbB-2.
- drug effects : Lymphocytes, Tumor-Infiltrating.
- drug therapy : Breast Neoplasms.
- enzymology : Breast Neoplasms.
- etiology : Chemical and Drug Induced Liver Injury.
- chemical , genetics : Biomarkers, Tumor, Class I Phosphatidylinositol 3-Kinases.
- chemical , metabolism : Biomarkers, Tumor, Class I Phosphatidylinositol 3-Kinases, Ki-67 Antigen, Receptor, ErbB-2.
- pathology : Breast Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Australia, Biopsy, Chemotherapy, Adjuvant, Double-Blind Method, Early Termination of Clinical Trials, Europe, Female, Humans, Middle Aged, Mutation, Time Factors, Treatment Outcome.
Abstract
The Neoadjuvant PI3K inhibition in HER2 OverExpressing Breast cancEr (NeoPHOEBE) trial evaluated the efficacy and safety of buparlisib, a pan-phosphatidylinositol 3-kinase (PI3K) inhibitor, plus trastuzumab and paclitaxel as neoadjuvant treatment for human epidermal growth factor receptor-2 positive (HER2+) breast cancer.
DOI: 10.1016/j.ejca.2017.08.020
PubMed: 28923573
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pubmed:28923573Le document en format XML
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<author><name sortKey="Loibl, Sibylle" sort="Loibl, Sibylle" uniqKey="Loibl S" first="Sibylle" last="Loibl">Sibylle Loibl</name>
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<author><name sortKey="Gombos, Andrea" sort="Gombos, Andrea" uniqKey="Gombos A" first="Andrea" last="Gombos">Andrea Gombos</name>
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<author><name sortKey="Baselga, Jose" sort="Baselga, Jose" uniqKey="Baselga J" first="José" last="Baselga">José Baselga</name>
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</placeName>
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<author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Neoadjuvant buparlisib plus trastuzumab and paclitaxel for women with HER2+ primary breast cancer: A randomised, double-blind, placebo-controlled phase II trial (NeoPHOEBE).</title>
<author><name sortKey="Loibl, Sibylle" sort="Loibl, Sibylle" uniqKey="Loibl S" first="Sibylle" last="Loibl">Sibylle Loibl</name>
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<author><name sortKey="De La Pena, Lorena" sort="De La Pena, Lorena" uniqKey="De La Pena L" first="Lorena" last="De La Pena">Lorena De La Pena</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>SOLTI Breast Cancer Research Group, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
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</affiliation>
</author>
<author><name sortKey="Nekljudova, Valentina" sort="Nekljudova, Valentina" uniqKey="Nekljudova V" first="Valentina" last="Nekljudova">Valentina Nekljudova</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Breast Group, Neu-Isenburg</wicri:regionArea>
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</author>
<author><name sortKey="Zardavas, Dimitrios" sort="Zardavas, Dimitrios" uniqKey="Zardavas D" first="Dimitrios" last="Zardavas">Dimitrios Zardavas</name>
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<author><name sortKey="Denkert, Carsten" sort="Denkert, Carsten" uniqKey="Denkert C" first="Carsten" last="Denkert">Carsten Denkert</name>
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<author><name sortKey="Rezai, Mahdi" sort="Rezai, Mahdi" uniqKey="Rezai M" first="Mahdi" last="Rezai">Mahdi Rezai</name>
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<wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Kliniken Essen-Mitte, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
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<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Internal Medicine I, Division of Oncology, Medical University of Vienna, Austria; Comprehensive Cancer Center Vienna</wicri:regionArea>
<wicri:noRegion>Austria; Comprehensive Cancer Center Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gombos, Andrea" sort="Gombos, Andrea" uniqKey="Gombos A" first="Andrea" last="Gombos">Andrea Gombos</name>
<affiliation wicri:level="4"><nlm:affiliation>Université Libre de Bruxelles, Institut Jules Rue Héger-Bordet 1, Medical Oncology Clinic, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Université Libre de Bruxelles, Institut Jules Rue Héger-Bordet 1, Medical Oncology Clinic</wicri:regionArea>
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<author><name sortKey="Lux, Michael" sort="Lux, Michael" uniqKey="Lux M" first="Michael" last="Lux">Michael Lux</name>
<affiliation wicri:level="1"><nlm:affiliation>University Breast Centre of Franconia, OBGYN Department, University Hospital Erlangen, CCC Erlangen-EMN, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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<wicri:noRegion>CCC Erlangen-EMN</wicri:noRegion>
<wicri:noRegion>CCC Erlangen-EMN</wicri:noRegion>
<wicri:noRegion>CCC Erlangen-EMN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Piccart, Martine J" sort="Piccart, Martine J" uniqKey="Piccart M" first="Martine J" last="Piccart">Martine J. Piccart</name>
<affiliation wicri:level="1"><nlm:affiliation>Breast International Group, Brussels, Belgium; Université Libre de Bruxelles, Institut Jules Rue Héger-Bordet 1, Medical Oncology Clinic, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Breast International Group, Brussels, Belgium; Université Libre de Bruxelles, Institut Jules Rue Héger-Bordet 1, Medical Oncology Clinic</wicri:regionArea>
<wicri:noRegion>Medical Oncology Clinic</wicri:noRegion>
</affiliation>
</author>
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<affiliation wicri:level="1"><nlm:affiliation>German Breast Group, Neu-Isenburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Breast Group, Neu-Isenburg</wicri:regionArea>
<wicri:noRegion>Neu-Isenburg</wicri:noRegion>
<wicri:noRegion>Neu-Isenburg</wicri:noRegion>
<wicri:noRegion>Neu-Isenburg</wicri:noRegion>
</affiliation>
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<author><name sortKey="Baselga, Jose" sort="Baselga, Jose" uniqKey="Baselga J" first="José" last="Baselga">José Baselga</name>
<affiliation wicri:level="2"><nlm:affiliation>SOLTI Breast Cancer Research Group, Barcelona, Spain; Memorial Sloan-Kettering Cancer Center, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>SOLTI Breast Cancer Research Group, Barcelona, Spain; Memorial Sloan-Kettering Cancer Center, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name>
<affiliation wicri:level="1"><nlm:affiliation>Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Australian New Zealand Breast Cancer Trials Group (ANZBCTG), Newcastle, Australia. Electronic address: sherene.loi@petermac.org.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Australian New Zealand Breast Cancer Trials Group (ANZBCTG), Newcastle</wicri:regionArea>
<wicri:noRegion>Newcastle</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">European journal of cancer (Oxford, England : 1990)</title>
<idno type="eISSN">1879-0852</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
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<front><div type="abstract" xml:lang="en">The Neoadjuvant PI3K inhibition in HER2 OverExpressing Breast cancEr (NeoPHOEBE) trial evaluated the efficacy and safety of buparlisib, a pan-phosphatidylinositol 3-kinase (PI3K) inhibitor, plus trastuzumab and paclitaxel as neoadjuvant treatment for human epidermal growth factor receptor-2 positive (HER2+) breast cancer.</div>
</front>
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