A perspective on the contribution of animal models to the pharmacological treatment of posttraumatic stress disorder.
Identifieur interne : 004B88 ( Ncbi/Curation ); précédent : 004B87; suivant : 004B89A perspective on the contribution of animal models to the pharmacological treatment of posttraumatic stress disorder.
Auteurs : Valerie Bertaina-Anglade [France] ; Susan M. O'Connor [Australie] ; Emile Andriambeloson [France]Source :
- Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists [ 1440-1665 ] ; 2017.
Abstract
Posttraumatic stress disorder (PTSD) is a prevalent, chronic, disabling disorder that may develop following exposure to a traumatic event. This review summarizes currently used animal models of PTSD and their potential role in the development of better therapeutics. Heterogeneity is one of the main characteristics of PTSD with the consequence that many pharmacological approaches are used to relieve symptoms of PTSD. To address the translational properties of the animal models, we discuss the types of stressors used, the rodent correlates of human PTSD (DSM-5) symptoms, and the efficacy of approved, recommended and off-label drugs used to treat PTSD in 'PTSD-animals'.
DOI: 10.1177/1039856217716288
PubMed: 28747120
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<front><div type="abstract" xml:lang="en">Posttraumatic stress disorder (PTSD) is a prevalent, chronic, disabling disorder that may develop following exposure to a traumatic event. This review summarizes currently used animal models of PTSD and their potential role in the development of better therapeutics. Heterogeneity is one of the main characteristics of PTSD with the consequence that many pharmacological approaches are used to relieve symptoms of PTSD. To address the translational properties of the animal models, we discuss the types of stressors used, the rodent correlates of human PTSD (DSM-5) symptoms, and the efficacy of approved, recommended and off-label drugs used to treat PTSD in 'PTSD-animals'.</div>
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