Resisting RECIST-Uniformity Versus Clinical Validity.
Identifieur interne : 004A99 ( Ncbi/Curation ); précédent : 004A98; suivant : 004B00Resisting RECIST-Uniformity Versus Clinical Validity.
Auteurs : Michelle K. Wilson [Canada] ; Michael L. Friedlander ; Stephanie Lheureux ; William Small ; Andrés Poveda ; Eric Pujade-Lauraine ; Katherine Karakasis ; Monica Bacon ; Valerie Bowering ; Tanya Chawla ; Amit M. OzaSource :
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [ 1525-1438 ] ; 2017.
Abstract
The Response Evaluation Criteria in Solid Tumors (RECIST) International Working Group developed criteria for tumor response and progression to standardize radiological assessment in patients receiving chemotherapy in phase 2 trials. However, it is unclear whether the defined percentage change in tumor size and volume reflects true clinical benefit for the patient. The RECIST criteria were designed to improve objectivity in trials, but not to replace clinical decision making. The aim of this study was to understand clinicians' opinions about RECIST in current oncology practice.
DOI: 10.1097/IGC.0000000000001062
PubMed: 28692635
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pubmed:28692635Le document en format XML
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<wicri:regionArea>*Auckland City Hospital, Auckland, New Zealand; †Prince of Wales Hospital, Sydney, Australia; ‡Princess Margaret Cancer Centre, Toronto, Ontario Canada; §Department of Radiation Oncology, Loyol University, Chicago, IL; ‖Instituto Valenciano de Oncologia, Valencia, Spain; ¶Université Paris Descartes, AP-HP, Hôpitaux Universitaires Paris Centre, Paris, France; and #Gynecologic Group Intergroup, Kingston</wicri:regionArea>
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<front><div type="abstract" xml:lang="en">The Response Evaluation Criteria in Solid Tumors (RECIST) International Working Group developed criteria for tumor response and progression to standardize radiological assessment in patients receiving chemotherapy in phase 2 trials. However, it is unclear whether the defined percentage change in tumor size and volume reflects true clinical benefit for the patient. The RECIST criteria were designed to improve objectivity in trials, but not to replace clinical decision making. The aim of this study was to understand clinicians' opinions about RECIST in current oncology practice.</div>
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